Characteristics of adults with Down syndrome hospitalized in Spanish internal medicine departments during 2005–2014

The clinical problems of adults with Down syndrome (DS) seem to differ from those of the general population. To better understand these differences, we list the demographic and clinical characteristics of adults with DS admitted to Spanish internal medicine departments during 2005–2014. We conducted...

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Published inRevista clínica espanõla (English edition) Vol. 220; no. 9; pp. 553 - 560
Main Authors Aparicio, P., Barba, R., Moldenhauer, F., Suárez, C., Real de Asúa, D.
Format Journal Article
LanguageEnglish
Published Elsevier España, S.L.U 01.12.2020
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ISSN2254-8874
2254-8874
DOI10.1016/j.rceng.2019.11.003

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Abstract The clinical problems of adults with Down syndrome (DS) seem to differ from those of the general population. To better understand these differences, we list the demographic and clinical characteristics of adults with DS admitted to Spanish internal medicine departments during 2005–2014. We conducted an observational retrospective study using data collected from the minimum basic data set on hospitalisation episodes of adults with DS in the internal medicine departments of Spain’s National Health System from 2005 to 2014. We analysed the patients’ epidemiological, clinical and societal data. A total of 7548 hospitalisation episodes from 3786 patients were recorded. Some 56.6% of the patients were male with a mean age (±SD) of 47 ± 13 years, and 715 of the patients died (18.9%). The age-adjusted mortality was 26.6%, and the mean stay was 9.6 ± 12 days. The hospitalisation was for respiratory disease in 3684 episodes (48.8%) and for cardiac origin in 760 (10%). The most common comorbidities were hypothyroidism (27.1%, 2043 episodes), epilepsy (24.1%, 1819 episodes) and dementia (15.4%, 1162 episodes). The hospitalisation of adults with DS in internal medicine departments has increased in the past decade. Although the reasons for hospitalisation, mean stay and cost per episode for this population are similar to those of the general population treated by internal medicine departments, the age-adjusted hospital mortality was significantly greater. Los problemas clínicos de los adultos con síndrome de Down (SD) parecen diferir de los de la población general. Para entender mejor estas diferencias describimos las características demográficas y clínicas de los adultos con SD que ingresaron en los servicios de Medicina Interna españoles en el periodo de 2005–2014. Estudio observacional retrospectivo sobre datos recogidos en el conjunto mínimo básico de datos (CMBD) de los episodios de ingreso de adultos con SD en los servicios de Medicina Interna del Sistema Nacional de Salud desde 2005 a 2014. Se analizaron variables epidemiológicas, clínicas y sociales. Se registraron 7.548 episodios de ingreso de 3.786 pacientes. El 56,6% eran varones con una edad media (± DE) de 47 ± 13 años. Fallecieron 715 pacientes (18,9%). La mortalidad ajustada a la edad fue 26,6% y su estancia media fue de 9,6 ± 12 días. En 3.684 episodios (48,8%) el ingreso fue por patología respiratoria y en 760 (10%), de origen cardiológico. Las comorbilidades más frecuentes fueron el hipotiroidismo (27,1%, 2.043 episodios), la epilepsia (24.1%, 1.819 episodios) y la demencia (15.4%, 1.162 episodios). Los ingresos de adultos con SD en los servicios de Medicina Interna han aumentado en la última década. Si bien los motivos de ingreso, estancia media y coste por episodio de esta población son similares a los de la población general atendida en Medicina Interna, la mortalidad intrahospitalaria ajustada por edad fue significativamente mayor.
AbstractList The clinical problems of adults with Down syndrome (DS) seem to differ from those of the general population. To better understand these differences, we list the demographic and clinical characteristics of adults with DS admitted to Spanish internal medicine departments during 2005–2014. We conducted an observational retrospective study using data collected from the minimum basic data set on hospitalisation episodes of adults with DS in the internal medicine departments of Spain’s National Health System from 2005 to 2014. We analysed the patients’ epidemiological, clinical and societal data. A total of 7548 hospitalisation episodes from 3786 patients were recorded. Some 56.6% of the patients were male with a mean age (±SD) of 47 ± 13 years, and 715 of the patients died (18.9%). The age-adjusted mortality was 26.6%, and the mean stay was 9.6 ± 12 days. The hospitalisation was for respiratory disease in 3684 episodes (48.8%) and for cardiac origin in 760 (10%). The most common comorbidities were hypothyroidism (27.1%, 2043 episodes), epilepsy (24.1%, 1819 episodes) and dementia (15.4%, 1162 episodes). The hospitalisation of adults with DS in internal medicine departments has increased in the past decade. Although the reasons for hospitalisation, mean stay and cost per episode for this population are similar to those of the general population treated by internal medicine departments, the age-adjusted hospital mortality was significantly greater. Los problemas clínicos de los adultos con síndrome de Down (SD) parecen diferir de los de la población general. Para entender mejor estas diferencias describimos las características demográficas y clínicas de los adultos con SD que ingresaron en los servicios de Medicina Interna españoles en el periodo de 2005–2014. Estudio observacional retrospectivo sobre datos recogidos en el conjunto mínimo básico de datos (CMBD) de los episodios de ingreso de adultos con SD en los servicios de Medicina Interna del Sistema Nacional de Salud desde 2005 a 2014. Se analizaron variables epidemiológicas, clínicas y sociales. Se registraron 7.548 episodios de ingreso de 3.786 pacientes. El 56,6% eran varones con una edad media (± DE) de 47 ± 13 años. Fallecieron 715 pacientes (18,9%). La mortalidad ajustada a la edad fue 26,6% y su estancia media fue de 9,6 ± 12 días. En 3.684 episodios (48,8%) el ingreso fue por patología respiratoria y en 760 (10%), de origen cardiológico. Las comorbilidades más frecuentes fueron el hipotiroidismo (27,1%, 2.043 episodios), la epilepsia (24.1%, 1.819 episodios) y la demencia (15.4%, 1.162 episodios). Los ingresos de adultos con SD en los servicios de Medicina Interna han aumentado en la última década. Si bien los motivos de ingreso, estancia media y coste por episodio de esta población son similares a los de la población general atendida en Medicina Interna, la mortalidad intrahospitalaria ajustada por edad fue significativamente mayor.
Author Moldenhauer, F.
Real de Asúa, D.
Barba, R.
Aparicio, P.
Suárez, C.
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Hospitalización
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Snippet The clinical problems of adults with Down syndrome (DS) seem to differ from those of the general population. To better understand these differences, we list...
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SubjectTerms Down syndrome
Hospitalisation
Hospitalización
Internal medicine
Medicina interna
Síndrome de Down
Title Characteristics of adults with Down syndrome hospitalized in Spanish internal medicine departments during 2005–2014
URI https://dx.doi.org/10.1016/j.rceng.2019.11.003
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