Comparative Genomics of the Eukaryotes

• Published in: Science (American Association for the Advancement of Science) Vol. 287; no. 5461; pp. 2204 - 2215
• Main Authors: Rubin, Gerald M., Yandell, Mark D., Wortman, Jennifer R., George L. Gabor Miklos, Nelson, Catherine R., Hariharan, Iswar K., Fortini, Mark E., Li, Peter W., Apweiler, Rolf, Fleischmann, Wolfgang, Cherry, J. Michael, Henikoff, Steven, Skupski, Marian P., Misra, Sima, Ashburner, Michael, Birney, Ewan, Boguski, Mark S., Brody, Thomas, Brokstein, Peter, Celniker, Susan E., Chervitz, Stephen A., Coates, David, Cravchik, Anibal, Gabrielian, Andrei, Galle, Richard F., Gelbart, William M., George, Reed A., Lawrence S. B. Goldstein, Gong, Fangcheng, Guan, Ping, Harris, Nomi L., Hay, Bruce A., Hoskins, Roger A., Li, Jiayin, Li, Zhenya, Hynes, Richard O., Jones, S. J. M., Kuehl, Peter M., Lemaitre, Bruno, Littleton, J. Troy, Morrison, Deborah K., Mungall, Chris, O'Farrell, Patrick H., Pickeral, Oxana K., Shue, Chris, Vosshall, Leslie B., Zhang, Jiong, Zhao, Qi, Zheng, Xiangqun H., Zhong, Fei, Zhong, Wenyan, Gibbs, Richard, Venter, J. Craig, Adams, Mark D., Lewis, Suzanna
• Format: Journal Article
• Language: English
• Published: United States American Society for the Advancement of Science 24.03.2000; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Algorithms; animal models; Animals; Apoptosis; Apoptosis - genetics; Bacteria; Biological Evolution; Caenorhabditis elegans; Caenorhabditis elegans - chemistry; Caenorhabditis elegans - genetics; Caenorhabditis elegans - physiology; Cell Adhesion; Cell Adhesion - genetics; Cell Cycle; Cell Cycle - genetics; Cells; Cells (Biology); chemistry; Chromosome mapping; Coding; Comparative Analysis; Comparative studies; Drosophila; Drosophila melanogaster; Drosophila melanogaster - chemistry; Drosophila melanogaster - genetics; Drosophila melanogaster - physiology; Eukaryotes; Eukaryotic cells; Family (Sociological Unit); Fungal Proteins; Fungal Proteins - chemistry; Fungal Proteins - genetics; Genes; Genes, Duplicate; Genetic Diseases, Inborn; Genetic Diseases, Inborn - genetics; genetics; Genetics, Medical; Genome; Genomes; Genomics; Helminth Proteins; Helminth Proteins - chemistry; Helminth Proteins - genetics; Humans; Immunity; Immunity - genetics; Insect Proteins; Insect Proteins - chemistry; Insect Proteins - genetics; Insects; Multigene Family; Neoplasms; Neoplasms - genetics; physiology; Protein Structure, Tertiary; Proteins; Proteome; Proteomes; Receptors; Reviews; Saccharomyces; Saccharomyces cerevisiae; Saccharomyces cerevisiae - chemistry; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - physiology; Signal Transduction; Signal Transduction - genetics; Vertebrates; Worms; Yeasts
• ISSN: 0036-8075; 1095-9203; 1095-9203
• DOI: 10.1126/science.287.5461.2204

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.