The Genome of the Kinetoplastid Parasite, Leishmania major

Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36...

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Published in	Science (American Association for the Advancement of Science) Vol. 309; no. 5733; pp. 436 - 442
Main Authors	Ivens, Alasdair C., Peacock, Christopher S., Worthey, Elizabeth A., Murphy, Lee, Aggarwal, Gautam, Berriman, Matthew, Sisk, Ellen, Rajandream, Marie-Adele, Adlem, Ellen, Aert, Rita, Anupama, Atashi, Apostolou, Zina, Bason, Nathalie, Bauser, Christopher, Beck, Alfred, Beverley, Stephen M., Bianchettin, Gabriella, Borzym, Katja, Bothe, Gordana, Bruschi, Carlo V., Collins, Matt, Cadag, Eithon, Ciarloni, Laura, Clayton, Christine, Richard M. R. Coulson, Cronin, Ann, Cruz, Angela K., Davies, Robert M., De Gaudenzi, Javier, Dobson, Deborah E., Duesterhoeft, Andreas, Fazelina, Gholam, Fosker, Nigel, Frasch, Alberto Carlos, Fraser, Audrey, Fuchs, Monika, Gabel, Claudia, Goble, Arlette, Goffeau, André, Harris, David, Hertz-Fowler, Christiane, Hilbert, Helmut, Horn, David, Huang, Yiting, Klages, Sven, Knights, Andrew, Kube, Michael, Larke, Natasha, Litvin, Lyudmila, Lord, Angela, Louie, Tin, Marra, Marco, Masuy, David, Matthews, Keith, Michaeli, Shulamit, Mottram, Jeremy C., Müller-Auer, Silke, Munden, Heather, Nelson, Siri, Norbertczak, Halina, Oliver, Karen, O'Neil, Susan, Pentony, Martin, Pohl, Thomas M., Price, Claire, Purnelle, Bénédicte, Quail, Michael A., Rabbinowitsch, Ester, Reinhardt, Richard, Rieger, Michael, Rinta, Joel, Robben, Johan, Robertson, Laura, Ruiz, Jeronimo C., Rutter, Simon, Saunders, David, Schäfer, Melanie, Schein, Jacquie, Schwartz, David C., Seeger, Kathy, Seyler, Amber, Sharp, Sarah, Shin, Heesun, Sivam, Dhileep, Squares, Rob, Squares, Steve, Tosato, Valentina, Vogt, Christy, Volckaert, Guido, Wambutt, Rolf, Warren, Tim, Wedler, Holger, Woodward, John, Zhou, Shiguo, Zimmermann, Wolfgang, Smith, Deborah F., Blackwell, Jenefer M., Stuart, Kenneth D., Barrell, Bart, Myler, Peter J.
Format	Journal Article
Language	English
Published	United States American Association for the Advancement of Science 15.07.2005 The American Association for the Advancement of Science
Subjects	Algorithms Animals chromatin Chromatin - genetics Chromatin - metabolism Chromosomes Coding DNA-directed RNA polymerase Eukaryotic cells Gene Expression Regulation Genes Genes, Protozoan Genes, rRNA Genetic aspects Genetic loci Genome, Protozoan Genomes Genomics glycoconjugates Glycoconjugates - biosynthesis Glycoconjugates - metabolism haploidy host-pathogen relationships human diseases Infections Leishmania major Leishmania major - chemistry Leishmania major - genetics Leishmania major - metabolism Leishmaniasis Leishmaniasis, Cutaneous - parasitology Lipid Metabolism Macrophages Membrane Proteins - biosynthesis Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Multigene Family Parasites Protein Biosynthesis Protein Processing, Post-Translational Proteins proteolysis Protozoan Proteins - biosynthesis Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism pseudogenes RNA RNA polymerase RNA Processing, Post-Transcriptional RNA Splicing RNA, Protozoan - genetics RNA, Protozoan - metabolism RNA-binding proteins Sequence Analysis, DNA subtropics transcription (genetics) transcription factors Transcription, Genetic Translation Trypanosoma brucei Trypanosoma cruzi Zinc
Online Access	Get full text
ISSN	0036-8075 1095-9203 1095-9203
DOI	10.1126/science.1112680

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Abstract	Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.
AbstractList	Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression. Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression. Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression. [PUBLICATION ABSTRACT] Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei , and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase IIâdirected transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.
Audience	Academic
Author	Rabbinowitsch, Ester Bothe, Gordana Peacock, Christopher S. Murphy, Lee Attipoe, Philip Bianchettin, Gabriella Wambutt, Rolf Reinhardt, Richard Gabel, Claudia Schein, Jacquie Ciarloni, Laura Horn, David Beck, Alfred Munden, Heather Robertson, Laura Shin, Heesun Price, Claire Müller-Auer, Silke Knights, Andrew Stuart, Kenneth D. Duesterhoeft, Andreas Huang, Yiting Ivens, Alasdair C. Masuy, David De Gaudenzi, Javier Borzym, Katja Aert, Rita Litvin, Lyudmila Squares, Rob Fosker, Nigel Michaeli, Shulamit Robben, Johan Quail, Michael A. Davies, Robert M. Squares, Steve Cadag, Eithon Klages, Sven Pentony, Martin Fraser, Audrey Woodward, John Anupama, Atashi Ruiz, Jeronimo C. Kube, Michael Pohl, Thomas M. Richard M. R. Coulson Worthey, Elizabeth A. Nelson, Siri Rieger, Michael Barrell, Bart Blackwell, Jenefer M. Marra, Marco Smith, Deborah F. Apostolou, Zina Collins, Matt Norbertczak, Halina Berriman, Matthew Adlem, Ellen Rutter, Simon Volckaert, Guido Sisk, Ellen Hilbert, Helmut Zimmermann, Wolfgang Rajandream, Marie-Adele Schwartz, David C. Cruz, Angela
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/16020728$$D View this record in MEDLINE/PubMed
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Snippet	Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the... Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the...
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SubjectTerms	Algorithms Animals chromatin Chromatin - genetics Chromatin - metabolism Chromosomes Coding DNA-directed RNA polymerase Eukaryotic cells Gene Expression Regulation Genes Genes, Protozoan Genes, rRNA Genetic aspects Genetic loci Genome, Protozoan Genomes Genomics glycoconjugates Glycoconjugates - biosynthesis Glycoconjugates - metabolism haploidy host-pathogen relationships human diseases Infections Leishmania major Leishmania major - chemistry Leishmania major - genetics Leishmania major - metabolism Leishmaniasis Leishmaniasis, Cutaneous - parasitology Lipid Metabolism Macrophages Membrane Proteins - biosynthesis Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Multigene Family Parasites Protein Biosynthesis Protein Processing, Post-Translational Proteins proteolysis Protozoan Proteins - biosynthesis Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism pseudogenes RNA RNA polymerase RNA Processing, Post-Transcriptional RNA Splicing RNA, Protozoan - genetics RNA, Protozoan - metabolism RNA-binding proteins Sequence Analysis, DNA subtropics transcription (genetics) transcription factors Transcription, Genetic Translation Trypanosoma brucei Trypanosoma cruzi Zinc
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Title	The Genome of the Kinetoplastid Parasite, Leishmania major
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