Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with bone mineral density (BMD) and risk of fracture. Thirty-two new loci are found to be associated with BMD, and 6 loci confer higher risk for l...
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Published in | Nature genetics Vol. 44; no. 5; pp. 491 - 501 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.05.2012
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
ISSN | 1061-4036 1546-1718 1546-1718 |
DOI | 10.1038/ng.2249 |
Cover
Abstract | Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with bone mineral density (BMD) and risk of fracture. Thirty-two new loci are found to be associated with BMD, and 6 loci confer higher risk for low-trauma bone fracture.
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (
P
< 5 × 10
−8
). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (
P
< 5 × 10
−4
, Bonferroni corrected), of which six reached
P
< 5 × 10
−8
, including at 18p11.21 (
FAM210A
), 7q21.3 (
SLC25A13
), 11q13.2 (
LRP5)
, 4q22.1 (
MEPE
), 2p16.2 (
SPTBN1
) and 10q21.1 (
DKK1
). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. |
---|---|
AbstractList | Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10^sup -8^). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10^sup -4^, Bonferroni corrected), of which six reached P < 5 × 10^sup -8^, including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. [PUBLICATION ABSTRACT] Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 x 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 x 10(-4), Bonferroni corrected), of which six reached P < 5 x 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 x 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 x 10(-4), Bonferroni corrected), of which six reached P < 5 x 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Bone mineral density (BMD) is the most important predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and East Asian ancestry. We tested the top-associated BMD markers for replication in 50,933 independent subjects and for risk of low-trauma fracture in 31,016 cases and 102,444 controls. We identified 56 loci (32 novel)associated with BMD atgenome-wide significant level (P<5×10 −8 ). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal-stem-cell differentiation, endochondral ossification and the Wnt signalling pathways. However, we also discovered loci containing genes not known to play a role in bone biology. Fourteen BMD loci were also associated with fracture risk (P<5×10 −4 , Bonferroni corrected), of which six reached P<5×10 −8 including: 18p11.21 ( C18orf19 ), 7q21.3 ( SLC25A13 ), 11q13.2 ( LRP5) , 4q22.1 ( MEPE ), 2p16.2 ( SPTBN1 ) and 10q21.1 ( DKK1 ). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with bone mineral density (BMD) and risk of fracture. Thirty-two new loci are found to be associated with BMD, and 6 loci confer higher risk for low-trauma bone fracture. Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance ( P < 5 × 10 −8 ). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk ( P < 5 × 10 −4 , Bonferroni corrected), of which six reached P < 5 × 10 −8 , including at 18p11.21 ( FAM210A ), 7q21.3 ( SLC25A13 ), 11q13.2 ( LRP5) , 4q22.1 ( MEPE ), 2p16.2 ( SPTBN1 ) and 10q21.1 ( DKK1 ). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 x 10 super(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 x 10 super(-4), Bonferroni corrected), of which six reached P < 5 x 10 super(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10−8). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10−4, Bonferroni corrected), of which six reached P < 5 × 10−8, including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 x [10.sup.-8]). Several of these factors cluster within the RANKRANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 x [10.sup.-4], Bonferroni corrected), of which six reached P < 5 x [10.sup.-8], including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11 q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. |
Audience | Academic |
Author | Albagha, Omar M E Koromila, Theodora Eastell, Richard Jackson, Rebecca D Cupples, L Adrienne Spector, Timothy D Van Hul, Wim Herrera, Lizbeth Urreizti, Roser Pastinen, Tomi Gudnason, Vilmundur Streeten, Elizabeth A Frost, Morten Rotter, Jerome I Minster, Ryan L Harris, Tamara B Amin, Najaf Khaw, Kay-Tee Richards, J Brent Tang, Nelson L S Liu, Yongmei Pols, Huibert A P Oei, Ling Garcia, Melissa Econs, Michael J Kemp, John P Ljunggren, Östen Reid, Ian R Stefansson, Kari Jones, Graeme McCloskey, Eugene Khusnutdinova, Elza Hsu, Yi-Hsiang Masi, Laura Siggeirsdottir, Kristin Eisman, John A Nguyen, Tuan V Williams, Frances M K Sigurdsson, Gunnar Wilson, James F Lewis, Joshua R Sham, Pak Chung Aragaki, Aaron K Uitterlinden, André G Estrada, Karol Liu, Ching-Ti Karlsson, Magnus Zarrabeitia, María T Kähönen, Mika Wareham, Nick J Reid, David M Khusainova, Rita Lee, Seung Hun Jukema, J Wouter Lorenc, Roman S Nogues, Xavier Xiao, Su-Mei Christiansen, Claus Langdahl, Bente Lomholt Mellström, Dan Duggan, David J Peacock, Munro Psaty, Bruce M Koh, Jung-Min Viikari |
AuthorAffiliation | 67 Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland 7 Department of Medicine, Harvard Medical School, Boston, USA 35 Department of Medicine, University of New South Wales, Sydney, Australia 41 Unité de recherche en génétique humaine et moléculaire, Centre de recherche du Centre hospitalier universitaire de Québec - Hôpital St-François-d’Assise (CHUQ/HSFA), Québec City, Canada 64 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China 97 Wellcome Trust Sanger Institute, Hinxton, UK 81 Department of Endocrinology, Vrije Universiteit (VU) University Medical Center, Amsterdam, The Netherlands 101 Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway 118 Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland 58 Department of Medicine, University of Cambridge, Cambridge, UK 100 Department of Epidemiology and Biostatistics, Lady Davis Institute, McGill University, Montreal, Canada 93 Depart |
AuthorAffiliation_xml | – name: 7 Department of Medicine, Harvard Medical School, Boston, USA – name: 115 Menzies Research Institute, University of Tasmania, Hobart, Australia – name: 26 Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK – name: 81 Department of Endocrinology, Vrije Universiteit (VU) University Medical Center, Amsterdam, The Netherlands – name: 87 The APOGEE-Net/CanGèneTest Network on Genetic Health Services and Policy, Université Laval, Québec City, Canada – name: 137 Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, Lady Davis Institute, McGill University, Montreal, Canada – name: 114 Center for Clinical and Translational Science, The Ohio State University, Columbus, USA – name: 19 Australian Centre for Ecogenomics, University of Queensland, Brisbane, Australia – name: 40 Department of Internal Medicine, Hospital del Mar, Instituto Municipal de Investigación Médica (IMIM), Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Universitat Autònoma de Barcelona (UAB), Barcelone, Spain – name: 93 Department of Medicine, University of Turku, Turku, Finland – name: 58 Department of Medicine, University of Cambridge, Cambridge, UK – name: 35 Department of Medicine, University of New South Wales, Sydney, Australia – name: 97 Wellcome Trust Sanger Institute, Hinxton, UK – name: 17 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK – name: 71 Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom – name: 8 Human Genetics Group, University of Queensland Diamantina Institute, Brisbane, Australia – name: 67 Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland – name: 60 Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands – name: 116 Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands – name: 5 Department of Hygiene and Epidemiology, University of Ioannina, Ioannina, Greece – name: 64 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China – name: 91 Department of Medical Genetics, University of Antwerp, Antwerp, Belgium – name: 3 Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands – name: 38 Translational Genomics Research Institute, Phoenix, USA – name: 46 Ufa Scientific Centre of Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia – name: 92 Department of Medicine, Turku University Hospital, Turku, Finland – name: 111 California Pacific Medical Center, San Francisco, CA, USA – name: 12 Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA – name: 78 Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland – name: 22 Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA – name: 33 Faculty of Medicine, University of Iceland, Reykjavik, Iceland – name: 104 Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, England – name: 14 Department of Biostatistics, Boston University School of Public Health, Boston, USA – name: 117 Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands – name: 105 Department of Clinical Biochemistry, Lovisenberg Deacon Hospital, Oslo, Norway – name: 1 Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands – name: 133 Framingham Heart Study, Framingham, USA – name: 76 Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain – name: 13 Cardiovascular Health Research Unit, University of Washington, Seattle, USA – name: 41 Unité de recherche en génétique humaine et moléculaire, Centre de recherche du Centre hospitalier universitaire de Québec - Hôpital St-François-d’Assise (CHUQ/HSFA), Québec City, Canada – name: 32 Icelandic Heart Association, Kopavogur, Iceland – name: 106 Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway – name: 37 Department of Orthopaedic Surgery, Medical School University of Thessalia, Larissa, Greece – name: 21 Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong, China – name: 119 Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland – name: 6 Institute for Aging Research, Hebrew SeniorLife, Boston, USA – name: 118 Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland – name: 88 Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands – name: 49 Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Athens, Greece – name: 70 Department of Nutrition and Dietetics, Harokopio University, Athens, Greece – name: 20 Department of Medicine, The University of Hong Kong, Hong Kong, China – name: 130 Geriatric Research and Education Clinical Center (GRECC), Veterans Administration Medical Center, Baltimore, MD, USA – name: 101 Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway – name: 77 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland – name: 69 Center for Clinical and Basic Research (CCBR)-Synarc, Ballerup, Denmark – name: 39 Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA – name: 95 Department of Human Genetics, McGill University, Montreal, Canada – name: 103 Department of Endocrinology and Metabolism, University Hospital, Reykjavik, Iceland – name: 66 Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland – name: 74 Department of Medicine, McGill University, Montreal, Canada – name: 79 Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Department of Orthopaedics, Lund University, Malmö, Sweden – name: 89 Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China – name: 131 Department of Preventive Medicine, University of Tennessee College of Medicine, Memphis, TN, USA – name: 53 Department of Internal Medicine, University of Florence, Florence, Italy – name: 42 Department of Public Health and Clinical Medicine, Umeå Unviersity, Umeå, Sweden – name: 98 Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland – name: 108 Division of Genetics and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, United States – name: 126 Department of Medicine, University of Davis, Sacramento, CA, USA – name: 11 Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK – name: 57 Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, USA – name: 80 Department of Internal Medicine, University of Manitoba, Winnipeg, Canada – name: 54 Department of Clinical Biochemistry, University of Ljubljana, Ljubljana, Slovenia – name: 61 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands – name: 82 Extramuraal Geneeskundig Onderzoek (EMGO) Institute for Health and Care Research, Vrije Universiteit (VU) University Medical Center, Amsterdam, The Netherlands – name: 112 National Institute for Health and Research (NIHR) Musculoskeletal Biomedical Research Unit, University of Sheffield, Sheffield, UK – name: 84 Department of Pharmacology and Neuroscience, Umeå University, Umeå, Sweden – name: 99 Institution of Health Science, University Of Akureyri, Akureyri, Iceland – name: 86 Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City, Canada – name: 110 Department of Epidemiology, University of Pittsburgh, Pittsburgh, USA – name: 113 Department of Internal Medicine, The Ohio State University, Columbus, USA – name: 90 Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China – name: 59 Department of Surgical and Perioperative Sciences, Umeå Unviersity, Umeå, Sweden – name: 129 Centre for Reproduction, Development and Growth, The University of Hong Kong, Hong Kong, China – name: 134 Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, USA – name: 47 Biological Department, Bashkir State University, Ufa, Russia – name: 100 Department of Epidemiology and Biostatistics, Lady Davis Institute, McGill University, Montreal, Canada – name: 136 Medicine box 157, University of Cambridge, Cambridge, UK – name: 10 Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK – name: 63 Department of Epidemiology and Biostatistics, Extramuraal Geneeskundig Onderzoek (EMGO) Institute for Health and Care Research, Vrije Universiteit (VU) University Medical Center, Amsterdam, The Netherlands – name: 132 MRC Epidemiology Unit Box 285, Medical Research Council, Cambridge, UK – name: 15 Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA – name: 50 Department of Biochemistry and Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, Poland – name: 96 McGill University and Genome Québec Innovation Centre, Montreal, Canada – name: 25 Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia – name: 120 Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA – name: 27 MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK – name: 4 deCODE Genetics, Reykjavik, Iceland – name: 62 Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University Graz, Graz, Austria – name: 55 Department of Medical Genetics, University of British Columbia, Vancouver, Canada – name: 30 Department of Medical Rehabilitation, Oulu University Hospital and Institute of Health Sciences, Oulu, Finland |
Author_xml | – sequence: 1 givenname: Karol surname: Estrada fullname: Estrada, Karol organization: Department of Internal Medicine, Erasmus Medical Center, Department of Epidemiology, Erasmus Medical Center, Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) – sequence: 2 givenname: Unnur surname: Styrkarsdottir fullname: Styrkarsdottir, Unnur organization: deCODE Genetics – sequence: 3 givenname: Evangelos surname: Evangelou fullname: Evangelou, Evangelos organization: Department of Hygiene and Epidemiology, University of Ioannina School of Medicine – sequence: 4 givenname: Yi-Hsiang surname: Hsu fullname: Hsu, Yi-Hsiang organization: Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Harvard Medical School – sequence: 6 givenname: Evangelia E surname: Ntzani fullname: Ntzani, Evangelia E organization: Department of Hygiene and Epidemiology, University of Ioannina School of Medicine – sequence: 8 givenname: Omar M E surname: Albagha fullname: Albagha, Omar M E organization: Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh – sequence: 11 givenname: Daniel L surname: Koller fullname: Koller, Daniel L organization: Department of Medical and Molecular Genetics, Indiana University School of Medicine – sequence: 14 givenname: Ryan L surname: Minster fullname: Minster, Ryan L organization: Department of Human Genetics, University of Pittsburgh – sequence: 15 givenname: Alireza surname: Moayyeri fullname: Moayyeri, Alireza organization: Department of Public Health and Primary Care, University of Cambridge, Department of Twin Research and Genetic Epidemiology, King's College London – sequence: 16 givenname: Liesbeth surname: Vandenput fullname: Vandenput, Liesbeth organization: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg – sequence: 17 givenname: Dana surname: Willner fullname: Willner, Dana organization: Human Genetics Group, University of Queensland Diamantina Institute, Australian Centre for Ecogenomics, University of Queensland – sequence: 18 givenname: Su-Mei surname: Xiao fullname: Xiao, Su-Mei organization: Department of Medicine, The University of Hong Kong, Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong – sequence: 20 givenname: Hou-Feng surname: Zheng fullname: Zheng, Hou-Feng organization: Department of Human Genetics, Lady Davis Institute, McGill University – sequence: 21 givenname: Nerea surname: Alonso fullname: Alonso, Nerea organization: Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh – sequence: 23 givenname: Candace M surname: Kammerer fullname: Kammerer, Candace M organization: Department of Human Genetics, University of Pittsburgh – sequence: 24 givenname: Stephen K surname: Kaptoge fullname: Kaptoge, Stephen K organization: Department of Public Health and Primary Care, University of Cambridge – sequence: 25 givenname: Paul J surname: Leo fullname: Leo, Paul J organization: Human Genetics Group, University of Queensland Diamantina Institute – sequence: 28 givenname: James F surname: Wilson fullname: Wilson, James F organization: Centre for Population Health Sciences, University of Edinburgh, MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh – sequence: 30 givenname: Markku surname: Alen fullname: Alen, Markku organization: Department of Medical Rehabilitation, Oulu University Hospital and Institute of Health Sciences – sequence: 32 givenname: Thor surname: Aspelund fullname: Aspelund, Thor organization: Icelandic Heart Association, Faculty of Medicine, University of Iceland – sequence: 33 givenname: Jacqueline R surname: Center fullname: Center, Jacqueline R organization: Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Department of Medicine, University of New South Wales, Department of Endocrinology, St. Vincent's Hospital – sequence: 34 givenname: Zoe surname: Dailiana fullname: Dailiana, Zoe organization: Department of Orthopaedic Surgery, Medical School University of Thessalia – sequence: 35 givenname: David J surname: Duggan fullname: Duggan, David J organization: Translational Genomics Research Institute – sequence: 36 givenname: Melissa surname: Garcia fullname: Garcia, Melissa organization: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging – sequence: 41 givenname: Lise Bjerre surname: Husted fullname: Husted, Lise Bjerre organization: Department of Endocrinology and Internal Medicine, Aarhus University Hospital – sequence: 42 givenname: Karen A surname: Jameson fullname: Jameson, Karen A organization: MRC Lifecourse Epidemiology Unit, University of Southampton – sequence: 44 givenname: Ghi Su surname: Kim fullname: Kim, Ghi Su organization: Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine – sequence: 45 givenname: Charles surname: Kooperberg fullname: Kooperberg, Charles organization: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center – sequence: 47 givenname: Marcin surname: Kruk fullname: Kruk, Marcin organization: Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute – sequence: 48 givenname: Marika surname: Laaksonen fullname: Laaksonen, Marika organization: Department of Food and Environmental Sciences, University of Helsinki – sequence: 51 givenname: Ping C surname: Leung fullname: Leung, Ping C organization: Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong – sequence: 52 givenname: Joshua R surname: Lewis fullname: Lewis, Joshua R organization: School of Medicine and Pharmacology, University of Western Australia, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital – sequence: 56 givenname: Xavier surname: Nogues fullname: Nogues, Xavier organization: Department of Internal Medicine, Hospital del Mar, Instituto Municipal de Investigación Médica (IMIM), Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Universitat Autònoma de Barcelona (UAB) – sequence: 58 givenname: Janez surname: Prezelj fullname: Prezelj, Janez organization: Department of Endocrinology, University Medical Center – sequence: 60 givenname: Serena surname: Scollen fullname: Scollen, Serena organization: Department of Medicine, University of Cambridge – sequence: 63 givenname: Olle surname: Svensson fullname: Svensson, Olle organization: Department of Surgical and Perioperative Sciences, Umeå Unviersity – sequence: 64 givenname: Stella surname: Trompet fullname: Trompet, Stella organization: Department of Cardiology, Leiden University Medical Center, Department of Gerontology and Geriatrics, Leiden University Medical Center – sequence: 67 givenname: Jean surname: Woo fullname: Woo, Jean organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong – sequence: 68 givenname: Kun surname: Zhu fullname: Zhu, Kun organization: School of Medicine and Pharmacology, University of Western Australia, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital – sequence: 72 givenname: Sulin surname: Cheng fullname: Cheng, Sulin organization: Department of Health Sciences, University of Jyväskylä, Department of Orthopaedics and Traumatology, Kuopio University Hospital – sequence: 75 givenname: George surname: Dedoussis fullname: Dedoussis, George organization: Department of Nutrition and Dietetics, Harokopio University – sequence: 77 givenname: Morten surname: Frost fullname: Frost, Morten organization: Department of Endocrinology, Odense University Hospital, Clinical Institute, University of Southern Denmark – sequence: 78 givenname: David surname: Goltzman fullname: Goltzman, David organization: Department of Medicine, McGill University – sequence: 80 givenname: Mika surname: Kähönen fullname: Kähönen, Mika organization: Department of Clinical Physiology, Tampere University Hospital, Department of Clinical Physiology, University of Tampere School of Medicine – sequence: 81 givenname: Magnus surname: Karlsson fullname: Karlsson, Magnus organization: Department of Clinical Sciences, Clinical and Molecular Osteoporosis Research Unit, Lund University, Department of Orthopaedics, Lund University – sequence: 85 givenname: Bente Lomholt surname: Langdahl fullname: Langdahl, Bente Lomholt organization: Department of Endocrinology and Internal Medicine, Aarhus University Hospital – sequence: 87 givenname: Paul surname: Lips fullname: Lips, Paul organization: Department of Endocrinology, VU University Medical Center, Extramuraal Geneeskundig Onderzoek (EMGO) Institute for Health and Care Research, VU University Medical Center – sequence: 89 givenname: Roman S surname: Lorenc fullname: Lorenc, Roman S organization: Department of Biochemistry and Experimental Medicine, The Children's Memorial Health Institute – sequence: 91 givenname: Dan surname: Mellström fullname: Mellström, Dan organization: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg – sequence: 93 givenname: José M surname: Olmos fullname: Olmos, José M organization: Department of Medicine, University of Cantabria, Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV) – sequence: 94 givenname: Ulrika surname: Pettersson-Kymmer fullname: Pettersson-Kymmer, Ulrika organization: Department of Pharmacology and Neuroscience, Umeå University – sequence: 96 givenname: José A surname: Riancho fullname: Riancho, José A organization: Department of Medicine, University of Cantabria, Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV) – sequence: 97 givenname: Paul M surname: Ridker fullname: Ridker, Paul M organization: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School – sequence: 98 givenname: François surname: Rousseau fullname: Rousseau, François organization: Unité de Recherche en Génétique Humaine et Moléculaire, Centre de Recherche du Centre Hospitalier Universitaire de Québec–Hôpital St-François-d'Assise (CHUQ-HSFA), Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, The APOGEE-Net/CanGèneTest Network on Genetic Health Services and Policy, Université Laval – sequence: 99 givenname: P Eline S surname: lagboom fullname: lagboom, P Eline S organization: Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Department of Molecular Epidemiology, Leiden University Medical Center – sequence: 101 givenname: Roser surname: Urreizti fullname: Urreizti, Roser organization: Department of Genetics, University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Institut de Biomedicina de la Universitat de Barcelona (IBUB) – sequence: 104 givenname: María T surname: Zarrabeitia fullname: Zarrabeitia, María T organization: Department of Legal Medicine, University of Cantabria – sequence: 106 givenname: Martha surname: Castano-Betancourt fullname: Castano-Betancourt, Martha organization: Department of Internal Medicine, Erasmus Medical Center, Department of Epidemiology, Erasmus Medical Center, Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) – sequence: 111 givenname: Tony surname: Kwan fullname: Kwan, Tony organization: Department of Human Genetics, McGill University, McGill University and Genome Québec Innovation Centre – sequence: 112 givenname: Rui surname: Li fullname: Li, Rui organization: Department of Epidemiology and Biostatistics, Lady Davis Institute, McGill University – sequence: 113 givenname: Robert surname: Luben fullname: Luben, Robert organization: Department of Public Health and Primary Care, University of Cambridge – sequence: 114 givenname: Carolina surname: Medina-Gómez fullname: Medina-Gómez, Carolina organization: Department of Internal Medicine, Erasmus Medical Center, Department of Epidemiology, Erasmus Medical Center – sequence: 115 givenname: Stefan surname: Th Palsson fullname: Th Palsson, Stefan organization: deCODE Genetics – sequence: 117 givenname: Jerome I surname: Rotter fullname: Rotter, Jerome I organization: Medical Genetics Institute, Cedars-Sinai Medical Center – sequence: 118 givenname: Gunnar surname: Sigurdsson fullname: Sigurdsson, Gunnar organization: Faculty of Medicine, University of Iceland, Department of Endocrinology and Metabolism, University Hospital – sequence: 119 givenname: Joyce B J surname: van Meurs fullname: van Meurs, Joyce B J organization: Department of Internal Medicine, Erasmus Medical Center, Department of Epidemiology, Erasmus Medical Center, Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) – sequence: 121 givenname: Frances M K surname: Williams fullname: Williams, Frances M K organization: Department of Twin Research and Genetic Epidemiology, King's College London – sequence: 123 givenname: Yanhua surname: Zhou fullname: Zhou, Yanhua organization: Department of Biostatistics, Boston University School of Public Health – sequence: 125 givenname: Tomi surname: Pastinen fullname: Pastinen, Tomi organization: Department of Human Genetics, McGill University, McGill University and Genome Québec Innovation Centre, Department of Medical Genetics, McGill University Health Centre – sequence: 127 givenname: Jane A surname: Cauley fullname: Cauley, Jane A organization: Department of Epidemiology, University of Pittsburgh – sequence: 128 givenname: Daniel I surname: Chasman fullname: Chasman, Daniel I organization: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School – sequence: 129 givenname: Graeme R surname: Clark fullname: Clark, Graeme R organization: Human Genetics Group, University of Queensland Diamantina Institute – sequence: 130 givenname: Steven R surname: Cummings fullname: Cummings, Steven R organization: California Pacific Medical Center – sequence: 133 givenname: Richard surname: Eastell fullname: Eastell, Richard organization: National Institute for Health and Research (NIHR), Musculoskeletal Biomedical Research Unit, University of Sheffield – sequence: 134 givenname: John A surname: Eisman fullname: Eisman, John A organization: Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Department of Medicine, University of New South Wales, Department of Endocrinology, St. Vincent's Hospital – sequence: 136 givenname: Albert surname: Hofman fullname: Hofman, Albert organization: Department of Epidemiology, Erasmus Medical Center, Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) – sequence: 139 givenname: J Wouter surname: Jukema fullname: Jukema, J Wouter organization: Department of Cardiology, Leiden University Medical Center, Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute of the Netherlands – sequence: 140 givenname: Kay-Tee surname: Khaw fullname: Khaw, Kay-Tee organization: Department of Public Health and Primary Care, University of Cambridge – sequence: 141 givenname: Terho surname: Lehtimäki fullname: Lehtimäki, Terho organization: Department of Clinical Chemistry, Tampere University Hospital, Department of Clinical Chemistry, University of Tampere School of Medicine, Fimlab – sequence: 142 givenname: Yongmei surname: Liu fullname: Liu, Yongmei organization: Center for Human Genomics, Wake Forest University School of Medicine – sequence: 148 givenname: Ben A surname: Oostra fullname: Oostra, Ben A organization: Department of Clinical Genetics, Erasmus Medical Center – sequence: 150 givenname: Huibert A P surname: Pols fullname: Pols, Huibert A P organization: Department of Internal Medicine, Erasmus Medical Center, Department of Epidemiology, Erasmus Medical Center – sequence: 153 givenname: Ian R surname: Reid fullname: Reid, Ian R organization: Department of Medicine, University of Auckland – sequence: 154 givenname: John surname: Robbins fullname: Robbins, John organization: Department of Medicine, University of California, Davis, Sacramento, California, USA – sequence: 155 givenname: Philip N surname: Sambrook fullname: Sambrook, Philip N organization: Kolling Institute, Royal North Shore Hospital, University of Sydney – sequence: 156 givenname: Pak Chung surname: Sham fullname: Sham, Pak Chung organization: Department of Psychiatry, The University of Hong Kong, Centre for Reproduction, Development and Growth, The University of Hong Kong – sequence: 157 givenname: Alan R surname: Shuldiner fullname: Shuldiner, Alan R organization: Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Geriatric Research and Education Clinical Center (GRECC), Veterans Administration Medical Center – sequence: 159 givenname: Cornelia M surname: van Duijn fullname: van Duijn, Cornelia M organization: Department of Epidemiology, Erasmus Medical Center – sequence: 160 givenname: Nick J surname: Wareham fullname: Wareham, Nick J organization: MRC Epidemiology Unit Box 285, MRC – sequence: 162 givenname: Michael J surname: Econs fullname: Econs, Michael J organization: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Department of Medicine, Indiana University School of Medicine – sequence: 164 givenname: Tamara B surname: Harris fullname: Harris, Tamara B organization: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging – sequence: 165 givenname: Annie Wai Chee surname: Kung fullname: Kung, Annie Wai Chee organization: Department of Medicine, The University of Hong Kong, Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong – sequence: 169 givenname: Elizabeth A surname: Streeten fullname: Streeten, Elizabeth A organization: Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Geriatric Research and Education Clinical Center (GRECC), Veterans Administration Medical Center – sequence: 171 givenname: Unnur surname: Thorsteinsdottir fullname: Thorsteinsdottir, Unnur organization: deCODE Genetics, Faculty of Medicine, University of Iceland – sequence: 173 givenname: David surname: Karasik fullname: Karasik, David organization: Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Harvard Medical School – sequence: 174 givenname: J Brent surname: Richards fullname: Richards, J Brent organization: Department of Twin Research and Genetic Epidemiology, King's College London, Department of Human Genetics, Lady Davis Institute, McGill University, Department of Epidemiology and Biostatistics, Lady Davis Institute, McGill University, Department of Medicine, Lady Davis Institute, McGill University – sequence: 175 givenname: Matthew A surname: Brown fullname: Brown, Matthew A organization: Human Genetics Group, University of Queensland Diamantina Institute – sequence: 178 givenname: Stuart H surname: Ralston fullname: Ralston, Stuart H organization: Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh – sequence: 179 givenname: John P A surname: Ioannidis fullname: Ioannidis, John P A organization: Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Stanford Prevention Research Center, Stanford University – sequence: 180 givenname: Douglas P surname: Kiel fullname: Kiel, Douglas P organization: Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Harvard Medical School |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25876526$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22504420$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54103$$DView record from Swedish Publication Index https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-176250$$DView record from Swedish Publication Index https://gup.ub.gu.se/publication/161420$$DView record from Swedish Publication Index |
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Contributor | Universitat de Barcelona |
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CorporateAuthor | Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Lund University Strategiska forskningsområden (SFO) EpiHealth: Epidemiology for Health Orthopedics Faculty of Medicine Strategic research areas (SRA) Medicinska fakulteten Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö Ortopedi |
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Keywords | Osteoarticular system Diseases of the osteoarticular system Risk Fracture Identification Bone Locus Trauma Density Metaanalysis |
Language | English |
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Snippet | Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with... Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck... Bone mineral density (BMD) is the most important predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck... |
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SubjectTerms | 631/208/205/2138 631/208/2489/144 631/208/480 Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Bone Bone densitometry Bone Density Bone Density - genetics Bone mineral density Bones Cancer Research Cell differentiation Clinical Medicine Computational Biology Densitometria òssia Density Endocrinology and Diabetes Endokrinologi och diabetes European Continental Ancestry Group Extracellular Matrix Proteins Extracellular Matrix Proteins - genetics Female Femur Femur Neck Femur Neck - physiopathology Fractures Fractures, Bone - genetics Fundamental and applied biological sciences. Psychology Fèmur Gene Expression Profiling Gene Function Gene loci Genes Genetic aspects Genetic Predisposition to Disease Genetics Genetics of eukaryotes. Biological and molecular evolution genetik Genome-Wide Association Study Genomics Genotype Gens Glycoproteins Glycoproteins - genetics Human Genetics Humans Identification and classification Intercellular Signaling Peptides and Proteins Intercellular Signaling Peptides and Proteins - genetics Klinisk medicin Low Density Lipoprotein Receptor-Related Protein-5 Low Density Lipoprotein Receptor-Related Protein-5 - genetics Lumbar Vertebrae Lumbar Vertebrae - physiopathology Male Medical and Health Sciences Medical research Medicin och hälsovetenskap Mitochondrial Membrane Transport Proteins Mitochondrial Membrane Transport Proteins - genetics Orthopaedics Ortopedi Osteoporosis Osteoporosis - genetics Phosphoproteins Phosphoproteins - genetics physiopathology Polymorphism Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci Risk Factors Single Nucleotide Spectrin Spectrin - genetics Spine Stem cells Vèrtebres lumbars White People |
Title | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture |
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