Comparative study of lipid profile anomalies in thyroid dysfunction

• Published in: National journal of physiology, pharmacy and pharmacology Vol. 12; no. 9; pp. 1 - 1370
• Main Authors: Gopalakrishnan, Meenu, P, Ramidha, V, Vinitha
• Format: Journal Article
• Language: English
• Published: Surat Association of Physiologists, Pharmacists & Pharmacologists 2022
• Subjects: Age groups; Cardiovascular disease; Cholesterol; Coronary vessels; Gene expression; High density lipoprotein; Hormones; Hyperthyroidism; Hypothyroidism; Lipids; Lipoproteins; Low density lipoprotein receptors; Metabolism; Population; Thyroid gland; Triglycerides; Vein & artery diseases
• ISSN: 2320-4672; 2231-3206
• DOI: 10.5455/njppp.2022.12.01014202213012022

Conclusion: Hypothyroidism demonstrates an atherogenic lipid profile with a positive correlation with serum TSH values and lipid profile. Since altered lipid profile can predispose to cardiovascular diseases, screening for these in individuals with thyroid dysfunction especially hypothyroidism needs to made mandatory. [10] The study found that there is a significant difference in the serum cholesterol, serum LDL, serum triglyceride, serum HDL, serum VLDL and the thyroid status of the study subjects. [11-14] Similarly, the study showed a significant difference in the mean values of serum LDL, serum triglyceride, and serum VLDL between the hypothyroid group and euthyroid group, but the difference was not significant between hyperthyroid and the control group. [22] This occurs partly because of the regulation of CETP (Cholesteryl Ester Transfer Protein) and Hepatic lipase activity by thyroid hormone.