Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice

Astaxanthin, a carotenoid found mainly in seafood, has potential clinical applications due to its antioxidant activity. In this study, we evaluated the effect of dietary astaxanthin derived from Haematococcus pluvialis on skin photoaging in UVA-irradiated hairless mice by assessing various parameter...

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Published inPloS one Vol. 12; no. 2; p. e0171178
Main Authors Komatsu, Toshiyuki, Sasaki, Suguru, Manabe, Yuki, Hirata, Takashi, Sugawara, Tatsuya
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 07.02.2017
Public Library of Science (PLoS)
Subjects
Animals
Antioxidants
Aquaporin 3
Aquaporins
Astaxanthin
Biology and Life Sciences
Biomarkers
Collagen
Dermis
Diet
Dietary Supplements
Epidermis
Extracellular matrix
Female
Fibroblasts
Filaggrin
Gene Expression
Haematococcus pluvialis
Hairless
Health aspects
High-performance liquid chromatography
Irradiation
Laboratory animals
Liquid chromatography
Matrix metalloproteinase
Medicine and Health Sciences
Metabolism
Metalloproteinase
Mice
Mice, Hairless
Physical sciences
Prevention
Research and Analysis Methods
RNA, Messenger - genetics
RNA, Messenger - metabolism
Rodents
Seafood
Skin
Skin - drug effects
Skin - metabolism
Skin - pathology
Skin - radiation effects
Skin aging
Skin Aging - drug effects
Skin Aging - genetics
Skin Aging - pathology
Skin Aging - radiation effects
Steroid sulfatase
Therapeutic applications
U.V. radiation
Ultraviolet radiation
Ultraviolet Rays - adverse effects
Water loss
Xanthophylls - pharmacokinetics
Xanthophylls - pharmacology
Japan
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0171178

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Abstract Astaxanthin, a carotenoid found mainly in seafood, has potential clinical applications due to its antioxidant activity. In this study, we evaluated the effect of dietary astaxanthin derived from Haematococcus pluvialis on skin photoaging in UVA-irradiated hairless mice by assessing various parameters of photoaging. After chronic ultraviolet A (UVA) exposure, a significant increase in transepidermal water loss (TEWL) and wrinkle formation in the dorsal skin caused by UVA was observed, and dietary astaxanthin significantly suppressed these photoaging features. We found that the mRNA expression of lympho-epithelial Kazal-type-related inhibitor, steroid sulfatase, and aquaporin 3 in the epidermis was significantly increased by UVA irradiation for 70 days, and dietary astaxanthin significantly suppressed these increases in mRNA expression to be comparable to control levels. In the dermis, the mRNA expression of matrix metalloprotease 13 was increased by UVA irradiation and significantly suppressed by dietary astaxanthin. In addition, HPLC-PDA analysis confirmed that dietary astaxanthin reached not only the dermis but also the epidermis. Our results indicate that dietary astaxanthin accumulates in the skin and appears to prevent the effects of UVA irradiation on filaggrin metabolism and desquamation in the epidermis and the extracellular matrix in the dermis.
AbstractList Astaxanthin, a carotenoid found mainly in seafood, has potential clinical applications due to its antioxidant activity. In this study, we evaluated the effect of dietary astaxanthin derived from Haematococcus pluvialis on skin photoaging in UVA-irradiated hairless mice by assessing various parameters of photoaging. After chronic ultraviolet A (UVA) exposure, a significant increase in transepidermal water loss (TEWL) and wrinkle formation in the dorsal skin caused by UVA was observed, and dietary astaxanthin significantly suppressed these photoaging features. We found that the mRNA expression of lympho-epithelial Kazal-type-related inhibitor, steroid sulfatase, and aquaporin 3 in the epidermis was significantly increased by UVA irradiation for 70 days, and dietary astaxanthin significantly suppressed these increases in mRNA expression to be comparable to control levels. In the dermis, the mRNA expression of matrix metalloprotease 13 was increased by UVA irradiation and significantly suppressed by dietary astaxanthin. In addition, HPLC-PDA analysis confirmed that dietary astaxanthin reached not only the dermis but also the epidermis. Our results indicate that dietary astaxanthin accumulates in the skin and appears to prevent the effects of UVA irradiation on filaggrin metabolism and desquamation in the epidermis and the extracellular matrix in the dermis.
Astaxanthin, a carotenoid found mainly in seafood, has potential clinical applications due to its antioxidant activity. In this study, we evaluated the effect of dietary astaxanthin derived from Haematococcus pluvialis on skin photoaging in UVA-irradiated hairless mice by assessing various parameters of photoaging. After chronic ultraviolet A (UVA) exposure, a significant increase in transepidermal water loss (TEWL) and wrinkle formation in the dorsal skin caused by UVA was observed, and dietary astaxanthin significantly suppressed these photoaging features. We found that the mRNA expression of lympho-epithelial Kazal-type-related inhibitor, steroid sulfatase, and aquaporin 3 in the epidermis was significantly increased by UVA irradiation for 70 days, and dietary astaxanthin significantly suppressed these increases in mRNA expression to be comparable to control levels. In the dermis, the mRNA expression of matrix metalloprotease 13 was increased by UVA irradiation and significantly suppressed by dietary astaxanthin. In addition, HPLC-PDA analysis confirmed that dietary astaxanthin reached not only the dermis but also the epidermis. Our results indicate that dietary astaxanthin accumulates in the skin and appears to prevent the effects of UVA irradiation on filaggrin metabolism and desquamation in the epidermis and the extracellular matrix in the dermis.Astaxanthin, a carotenoid found mainly in seafood, has potential clinical applications due to its antioxidant activity. In this study, we evaluated the effect of dietary astaxanthin derived from Haematococcus pluvialis on skin photoaging in UVA-irradiated hairless mice by assessing various parameters of photoaging. After chronic ultraviolet A (UVA) exposure, a significant increase in transepidermal water loss (TEWL) and wrinkle formation in the dorsal skin caused by UVA was observed, and dietary astaxanthin significantly suppressed these photoaging features. We found that the mRNA expression of lympho-epithelial Kazal-type-related inhibitor, steroid sulfatase, and aquaporin 3 in the epidermis was significantly increased by UVA irradiation for 70 days, and dietary astaxanthin significantly suppressed these increases in mRNA expression to be comparable to control levels. In the dermis, the mRNA expression of matrix metalloprotease 13 was increased by UVA irradiation and significantly suppressed by dietary astaxanthin. In addition, HPLC-PDA analysis confirmed that dietary astaxanthin reached not only the dermis but also the epidermis. Our results indicate that dietary astaxanthin accumulates in the skin and appears to prevent the effects of UVA irradiation on filaggrin metabolism and desquamation in the epidermis and the extracellular matrix in the dermis.
Audience Academic
Author Sasaki, Suguru
Sugawara, Tatsuya
Komatsu, Toshiyuki
Manabe, Yuki
Hirata, Takashi
AuthorAffiliation University of Alabama at Birmingham, UNITED STATES
Graduate School of Agriculture, Kyoto University, Kyoto, Japan
AuthorAffiliation_xml – name: Graduate School of Agriculture, Kyoto University, Kyoto, Japan
– name: University of Alabama at Birmingham, UNITED STATES
Author_xml – sequence: 1
  givenname: Toshiyuki
  surname: Komatsu
  fullname: Komatsu, Toshiyuki
– sequence: 2
  givenname: Suguru
  surname: Sasaki
  fullname: Sasaki, Suguru
– sequence: 3
  givenname: Yuki
  surname: Manabe
  fullname: Manabe, Yuki
– sequence: 4
  givenname: Takashi
  surname: Hirata
  fullname: Hirata, Takashi
– sequence: 5
  givenname: Tatsuya
  orcidid: 0000-0002-1203-5521
  surname: Sugawara
  fullname: Sugawara, Tatsuya
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28170435$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright COPYRIGHT 2017 Public Library of Science
2017 Komatsu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2017 Komatsu et al 2017 Komatsu et al
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– notice: 2017 Komatsu et al 2017 Komatsu et al
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DocumentTitleAlternate Preventive effect of dietary astaxanthin on skin photoaging
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Conceptualization: TS TH.Formal analysis: TK SS TS.Funding acquisition: TS.Investigation: TK SS YM.Project administration: TH TS.Writing – original draft: TS.Writing – review & editing: TK SS YM TH TS.
Current address: Shijonawate Gakuen University, Daito, Osaka, Japan
Competing Interests: FUJIFILM Corporation funded this study and provided support for the author TS. The other authors state no conflict of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
ORCID 0000-0002-1203-5521
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0171178
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Snippet Astaxanthin, a carotenoid found mainly in seafood, has potential clinical applications due to its antioxidant activity. In this study, we evaluated the effect...
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SubjectTerms Animals
Antioxidants
Aquaporin 3
Aquaporins
Astaxanthin
Biology and Life Sciences
Biomarkers
Collagen
Dermis
Diet
Dietary Supplements
Epidermis
Extracellular matrix
Female
Fibroblasts
Filaggrin
Gene Expression
Haematococcus pluvialis
Hairless
Health aspects
High-performance liquid chromatography
Irradiation
Laboratory animals
Liquid chromatography
Matrix metalloproteinase
Medicine and Health Sciences
Metabolism
Metalloproteinase
Mice
Mice, Hairless
Physical sciences
Prevention
Research and Analysis Methods
RNA, Messenger - genetics
RNA, Messenger - metabolism
Rodents
Seafood
Skin
Skin - drug effects
Skin - metabolism
Skin - pathology
Skin - radiation effects
Skin aging
Skin Aging - drug effects
Skin Aging - genetics
Skin Aging - pathology
Skin Aging - radiation effects
Steroid sulfatase
Therapeutic applications
U.V. radiation
Ultraviolet radiation
Ultraviolet Rays - adverse effects
Water loss
Xanthophylls - pharmacokinetics
Xanthophylls - pharmacology
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Title Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice
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