Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-Of-Hospital Cardiac Arrest – A TTM-Trial Substudy
Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker ne...
Saved in:
| Published in | PloS one Vol. 12; no. 1; p. e0168894 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
18.01.2017
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0168894 |
Cover
| Abstract | Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population.
This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5.
A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58-0.84 versus 0.83).
NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort.
NCT01020916. |
|---|---|
| AbstractList | Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population.
This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5.
A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58-0.84 versus 0.83).
NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort.
NCT01020916. Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population.BACKGROUNDPrediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population.This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5.METHODSThis study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5.A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58-0.84 versus 0.83).RESULTSA total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58-0.84 versus 0.83).NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort.CONCLUSIONNSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort.NCT01020916.TRIAL REGISTRATIONNCT01020916. Background Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population. Methods This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5. Results A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58–0.84 versus 0.83). Conclusion NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort. Trial registration NCT01020916 Background Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population. Methods This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33 degree C or 36 degree C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5. Results A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58-0.84 versus 0.83). Conclusion NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort. Trial registration NCT01020916 Background Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population. Methods This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5. Results A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58–0.84 versus 0.83). Conclusion NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort. Trial registration NCT01020916 Background: Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population. Methods: This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTMPLOS trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and followup was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5. Results: A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58-0.84 versus 0.83). Conclusion: NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort. BACKGROUND:Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population. METHODS:This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5. RESULTS:A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58-0.84 versus 0.83). CONCLUSION:NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort. TRIAL REGISTRATION:NCT01020916. Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA. In addition, this study sought to investigate if serial NSE measurements add incremental prognostic information compared to a single NSE measurement at 48 hours in this population. This study is a post-hoc sub-study of the TTM trial, randomizing OHCA patients to a course of TTM at either 33°C or 36°C. Patients were included from sites participating in the TTM-trial biobank sub study. NSE was measured at 24, 48 and 72 hours after ROSC and follow-up was concluded after 180 days. The primary end point was poor neurological function or death defined by a cerebral performance category score (CPC-score) of 3 to 5. A total of 685 (73%) patients participated in the study. At day three after OHCA 63 (9%) patients had died and 473 (69%) patients were not awake. In these patients, a single NSE measurement at 48 hours predicted poor outcome with an area under the receiver operating characteristics curve (AUC) of 0.83. A combination of all three NSE measurements yielded the highest discovered AUC (0.88, p = .0002). Easily applicable combinations of serial NSE measurements did not significantly improve prediction over a single measurement at 48 hours (AUC 0.58-0.84 versus 0.83). NSE is a strong predictor of poor outcome after OHCA in persistently unconscious patients undergoing TTM, and NSE is a promising surrogate marker of outcome in clinical trials. While combinations of serial NSE measurements may provide an increase in overall prognostic information, it is unclear whether actual clinical prognostication with low false-positive rates is improved by application of serial measurements in persistently unconscious patients. The findings of this study should be confirmed in another prospective cohort. |
| Audience | Academic |
| Author | Cronberg, Tobias Thomsen, Jakob Hartvig Bro-Jeppesen, John Devaux, Yvan Pellis, Tommaso Hassager, Christian Åneman, Anders Wiberg, Sebastian Wise, Matthew P. Kjaergaard, Jesper Winther-Jensen, Matilde Wanscher, Michael Horn, Janneke Kuiper, Michael Gasche, Yvan Erlinge, David Friberg, Hans Stammet, Pascal Wetterslev, Jørn Hovdenes, Jan Nielsen, Niklas |
| AuthorAffiliation | 2 Department of Anaesthesia and Intensive Care, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg 6 Department of Intensive Care, Liverpool hospital, Sydney, New South Wales, Australia 7 Department of Anaesthesia and Intensive Care, Skåne University Hospital, Lund, Sweden 13 Lund University, Skane University Hospital, Department of Clinical Sciences, Neurology, Lund, Sweden 5 Department of Intensive Care, Santa Maria degli Angeli, Pordenone, Italy 15 Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg 3 Department of Cardiology, Skåne University Hospital, Lund, Sweden 10 Copenhagen Trial Unit, Centre of Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark 11 Department of Intensive Care, University Hospital of Wales, Cardiff, United Kingdom 1 Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark 4 Department of Anaesthesia and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden 9 |
| AuthorAffiliation_xml | – name: 15 Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg – name: 3 Department of Cardiology, Skåne University Hospital, Lund, Sweden – name: 9 Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands – name: 2 Department of Anaesthesia and Intensive Care, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg – name: 8 Department of Anaesthesia and Intensive Care, Oslo University Hospital, Rikshospitalet, Oslo, Norway – name: 1 Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark – name: 11 Department of Intensive Care, University Hospital of Wales, Cardiff, United Kingdom – name: 5 Department of Intensive Care, Santa Maria degli Angeli, Pordenone, Italy – name: 10 Copenhagen Trial Unit, Centre of Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark – name: Versailles Hospital – site André Mignot, FRANCE – name: 7 Department of Anaesthesia and Intensive Care, Skåne University Hospital, Lund, Sweden – name: 14 Department of Intensive Care, Geneva University Hospital, Geneva, Switzerland – name: 13 Lund University, Skane University Hospital, Department of Clinical Sciences, Neurology, Lund, Sweden – name: 12 Department of Intensive Care, Leeuwarden Medical Center, Leeuwarden, The Netherlands – name: 4 Department of Anaesthesia and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden – name: 6 Department of Intensive Care, Liverpool hospital, Sydney, New South Wales, Australia |
| Author_xml | – sequence: 1 givenname: Sebastian surname: Wiberg fullname: Wiberg, Sebastian – sequence: 2 givenname: Christian surname: Hassager fullname: Hassager, Christian – sequence: 3 givenname: Pascal surname: Stammet fullname: Stammet, Pascal – sequence: 4 givenname: Matilde surname: Winther-Jensen fullname: Winther-Jensen, Matilde – sequence: 5 givenname: Jakob Hartvig surname: Thomsen fullname: Thomsen, Jakob Hartvig – sequence: 6 givenname: David surname: Erlinge fullname: Erlinge, David – sequence: 7 givenname: Michael surname: Wanscher fullname: Wanscher, Michael – sequence: 8 givenname: Niklas surname: Nielsen fullname: Nielsen, Niklas – sequence: 9 givenname: Tommaso surname: Pellis fullname: Pellis, Tommaso – sequence: 10 givenname: Anders surname: Åneman fullname: Åneman, Anders – sequence: 11 givenname: Hans surname: Friberg fullname: Friberg, Hans – sequence: 12 givenname: Jan surname: Hovdenes fullname: Hovdenes, Jan – sequence: 13 givenname: Janneke surname: Horn fullname: Horn, Janneke – sequence: 14 givenname: Jørn surname: Wetterslev fullname: Wetterslev, Jørn – sequence: 15 givenname: John surname: Bro-Jeppesen fullname: Bro-Jeppesen, John – sequence: 16 givenname: Matthew P. surname: Wise fullname: Wise, Matthew P. – sequence: 17 givenname: Michael surname: Kuiper fullname: Kuiper, Michael – sequence: 18 givenname: Tobias surname: Cronberg fullname: Cronberg, Tobias – sequence: 19 givenname: Yvan surname: Gasche fullname: Gasche, Yvan – sequence: 20 givenname: Yvan surname: Devaux fullname: Devaux, Yvan – sequence: 21 givenname: Jesper surname: Kjaergaard fullname: Kjaergaard, Jesper |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28099439$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk9tu1DAQhiNURA_wBggiISG4yBIfcjAXSKuq0Eotu2K33FqO7ey68trBTlr2jnfgsXgLngSn2VbdqhJVLmJNvvlnMv94P9ox1sgoegnSEUAF-HBhO2eYHjUhPEpBXpYEP4n2AEEwyWGKdu6cd6N97y_SNENlnj-LdmGZEoIR2Yv-zJRZaBlfSuc7H8-kU0zHZ5L5zsmVNK2PbR1_lZ2zJpk1kqta8fjIWM28jJkR8dRJoXirrOnJqbVuwLVdKB60Jl3L7UrGysTTUET5NqjqdXxuuDWeKxvKTlmrrmuxupWuT0kmdXJsfaPaIHHInFCMx2PnpG_jv79-x-N4Pj9L5tfdzrrKt51YP4-e1kx7-WLzPojOPx_ND4-T08mXk8PxacJLkLWJEDXOMEsl5xjXFSdMZFnOIMZFWrIcYlITUImyQijPBa8QLitGCkFgJRGBOTqIXg-6jbaebnzwFJQZKcoSYhiIk4EQll3QxqkVc2tqmaLXAesWlLlWcS2pyHiegaogqRAY5YzkGQk2IVBCKGA4HkTZoNWZhq2vmNa3giCl_SrctED7VaCbVQh5bMjzV7Lpqq0uGuvCXGmYpmSOL6nuqJc0UDpY1lvpKWEVImkmKBQipxgQTkkOappmsIBSsKoq-t4-bSbRVSspePDQMb1dauuLUUu6sJc0C1MKmkHg3UbA2R9dMJeulOdSa2ZkWIww07xECCMIHoOCrChSXAb0zT30YZM21IIFH5SpbWiR96J0jIsSIARgT40eoMIj5EqFDZa1CvGthPdbCYFp5c92wTrv6cns2-PZyfdt9u0ddimZbpfe6m6wawt8ddeUWzduLn0APg4Ad9Z7J2vKwzXrdcKvKf2_tcL3kh-1jf8AGPGD2w |
| CitedBy_id | crossref_primary_10_1016_j_resplu_2021_100133 crossref_primary_10_1097_MCC_0000000000000500 crossref_primary_10_15360_1813_9779_2018_3_68_81 crossref_primary_10_1177_2048872619860804 crossref_primary_10_1016_j_resuscitation_2017_09_001 crossref_primary_10_1016_j_resuscitation_2019_12_031 crossref_primary_10_1186_s13613_024_01406_y crossref_primary_10_1007_s00246_022_02899_9 crossref_primary_10_1080_00365513_2024_2359091 crossref_primary_10_1371_journal_pone_0210666 crossref_primary_10_1007_s00134_020_06218_9 crossref_primary_10_1080_1354750X_2020_1754465 crossref_primary_10_1097_CCE_0000000000000321 crossref_primary_10_1016_j_resuscitation_2021_01_041 crossref_primary_10_1161_CIR_0000000000000916 crossref_primary_10_1007_s10049_021_00892_y crossref_primary_10_1016_j_resuscitation_2020_08_010 crossref_primary_10_1007_s00134_021_06368_4 crossref_primary_10_3390_ncrna4040042 crossref_primary_10_1007_s00134_020_06198_w crossref_primary_10_1016_j_heliyon_2024_e34618 crossref_primary_10_1016_j_resuscitation_2021_09_033 crossref_primary_10_1016_j_resuscitation_2019_01_011 crossref_primary_10_1016_j_recesp_2019_01_014 crossref_primary_10_1016_j_recesp_2019_01_015 crossref_primary_10_1016_j_rec_2019_01_007 crossref_primary_10_1016_j_rec_2019_01_008 crossref_primary_10_1016_j_ajem_2023_03_047 crossref_primary_10_1080_14017431_2022_2074093 crossref_primary_10_1097_MCC_0000000000000406 crossref_primary_10_1016_j_resuscitation_2021_02_012 crossref_primary_10_1007_s11940_021_00682_4 crossref_primary_10_1016_j_resuscitation_2017_10_006 crossref_primary_10_1186_s13049_018_0558_2 crossref_primary_10_1002_ana_25067 crossref_primary_10_1016_j_ahj_2019_10_002 crossref_primary_10_1016_j_cnp_2017_08_001 crossref_primary_10_3390_brainsci8020033 crossref_primary_10_1007_s00134_020_06309_7 crossref_primary_10_1002_jcb_27281 crossref_primary_10_1186_s12877_023_03986_z crossref_primary_10_1097_CCM_0000000000004107 crossref_primary_10_21292_2078_5658_2021_18_3_72_78 crossref_primary_10_1007_s13311_020_00856_z crossref_primary_10_3390_jcm8091480 crossref_primary_10_1097_MCC_0000000000001194 crossref_primary_10_1186_s10020_021_00397_x crossref_primary_10_1007_s12028_024_02055_6 crossref_primary_10_1186_s13054_018_2060_7 crossref_primary_10_1016_j_resuscitation_2021_07_026 crossref_primary_10_4266_acc_2024_00570 crossref_primary_10_1016_j_biopha_2018_01_058 crossref_primary_10_1177_09603271211043475 crossref_primary_10_1080_15563650_2017_1415347 |
| Cites_doi | 10.1016/j.resuscitation.2011.12.026 10.1016/j.resuscitation.2013.06.020 10.1016/j.ahj.2012.01.013 10.1016/j.resuscitation.2012.09.015 10.1016/j.resuscitation.2009.03.025 10.1161/01.STR.0000103320.90706.35 10.1016/j.jacc.2015.03.538 10.1161/01.STR.25.3.558 10.1097/TA.0b013e318246887e 10.7326/M14-0697 10.1056/NEJMoa1310519 10.1186/1757-7241-20-6 10.1016/j.resuscitation.2013.05.026 10.1186/1745-6215-14-300 10.1016/j.resuscitation.2005.06.005 10.1186/1471-2261-11-48 10.1161/CIR.0000000000000273 10.1186/1757-7241-21-45 10.1007/s00134-013-3043-4 10.3233/RNN-2003-00229 10.1080/00365510701666031 10.1161/01.STR.18.5.911 10.1186/cc8975 10.1002/ana.22632 10.1016/j.resuscitation.2013.03.021 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Wiberg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017 Wiberg et al 2017 Wiberg et al |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Wiberg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2017 Wiberg et al 2017 Wiberg et al |
| CorporateAuthor | Institutionen för kliniska vetenskaper, Lund Sektion II Section II Lunds universitet Lund University Kardiologi Department of Clinical Sciences, Lund Neurology, Lund Anesthesiology and Intensive Care Faculty of Medicine Section IV Medicinska fakulteten Sektion IV Cardiology Anestesiologi och intensivvård Neurologi, Lund |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Sektion II – name: Kardiologi – name: Section II – name: Anesthesiology and Intensive Care – name: Cardiology – name: Institutionen för kliniska vetenskaper, Lund – name: Lunds universitet – name: Neurology, Lund – name: Department of Clinical Sciences, Lund – name: Anestesiologi och intensivvård – name: Sektion IV – name: Lund University – name: Section IV – name: Neurologi, Lund |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC ADTOC UNPAY DOA |
| DOI | 10.1371/journal.pone.0168894 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni Edition) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium ProQuest advanced technologies & aerospace journals ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SWEPUB Lunds universitet full text SwePub Articles SWEPUB Freely available online SWEPUB Lunds universitet SwePub Articles full text Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Engineering Research Database Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 5 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Single versus Serial Measurements of Neuron-Specific Enolase in Unconscious Patients after OHCA |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1859788242 oai_doaj_org_article_d5c651b790dd436a965953831822d295 10.1371/journal.pone.0168894 oai_portal_research_lu_se_publications_9ab3905d_2dd6_419c_961f_05272edabb75 PMC5242419 4304192391 A478133122 28099439 10_1371_journal_pone_0168894 |
| Genre | Randomized Controlled Trial Multicenter Study Journal Article |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PUEGO PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG PMFND 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC ADTOC UNPAY AAPBV ABPTK |
| ID | FETCH-LOGICAL-c815t-ddf454a0ecc44fbc9ad556a244708a6249f91bd8b3366dcb348ba97d92be39263 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Sun Nov 05 00:20:40 EDT 2023 Wed Aug 27 01:19:00 EDT 2025 Tue Aug 19 09:21:33 EDT 2025 Tue Sep 09 22:26:33 EDT 2025 Tue Sep 30 15:58:13 EDT 2025 Sun Sep 28 08:23:57 EDT 2025 Wed Oct 01 14:29:17 EDT 2025 Fri Jul 25 10:32:04 EDT 2025 Tue Jun 17 21:29:31 EDT 2025 Tue Jun 10 20:09:52 EDT 2025 Fri Jun 27 03:33:12 EDT 2025 Fri Jun 27 05:06:06 EDT 2025 Thu May 22 21:17:33 EDT 2025 Wed Feb 19 02:08:35 EST 2025 Thu Apr 24 22:51:39 EDT 2025 Wed Oct 01 05:53:35 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. cc-by Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c815t-ddf454a0ecc44fbc9ad556a244708a6249f91bd8b3366dcb348ba97d92be39263 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: SW CH PS DE NN J. Hovdenes J. Horn MK TC YG YD JK.Formal analysis: SW CH PS MW-J JHT JK.Methodology: SW CH JK.Project administration: JK.Supervision: CH JK.Writing – original draft: SW CH JK.Writing – review & editing: SW CH PS MW-J JHT DE MW NN TP AÅ HF J. Hovdenes J. Horn JW JB-J MPW MK TC YG YD JK. |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0168894 |
| PMID | 28099439 |
| PQID | 1859788242 |
| PQPubID | 1436336 |
| PageCount | e0168894 |
| ParticipantIDs | plos_journals_1859788242 doaj_primary_oai_doaj_org_article_d5c651b790dd436a965953831822d295 unpaywall_primary_10_1371_journal_pone_0168894 swepub_primary_oai_portal_research_lu_se_publications_9ab3905d_2dd6_419c_961f_05272edabb75 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5242419 proquest_miscellaneous_1868334321 proquest_miscellaneous_1861577048 proquest_journals_1859788242 gale_infotracmisc_A478133122 gale_infotracacademiconefile_A478133122 gale_incontextgauss_ISR_A478133122 gale_incontextgauss_IOV_A478133122 gale_healthsolutions_A478133122 pubmed_primary_28099439 crossref_citationtrail_10_1371_journal_pone_0168894 crossref_primary_10_1371_journal_pone_0168894 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2017-01-18 |
| PublicationDateYYYYMMDD | 2017-01-18 |
| PublicationDate_xml | – month: 01 year: 2017 text: 2017-01-18 day: 18 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2017 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | ref13 I Dragancea (ref3) 2013; 84 SY Chabok (ref10) 2012; 72 S Påhlman (ref6) 1985 H Reiber (ref4) 2003; 21 M Rundgren (ref24) 2009; 80 T Notomi (ref5) 1985 N Nielsen (ref14) 2013; 369 L Persson (ref9) 1987; 18 C Sandroni (ref11) 2013; 84 IG Steffen (ref26) 2010; 14 N Nielsen (ref19) 2012; 163 V Lemiale (ref2) 2013; 39 C Storm (ref28) 2012; 20 GS Collins (ref30) 2015; 162 A Trajman (ref21) 2009; 68 CW Callaway (ref12) 2015; 132 N Nielsen (ref16) 2013; 14 H Schaarschmidt (ref8) 1994; 25 T Cronberg (ref17) 2013; 21 A Langhelle (ref15) 2005; 66 A Bouwes (ref25) 2012; 71 M Tiainen (ref27) 2003; 34 C Daubin (ref29) 2011; 11 ref7 T Zellner (ref23) 2013; 84 S Sendelbach (ref1) 2012; 83 B Jennett (ref20) 1975 BK Lee (ref22) 2013; 84 E Westhall (ref18) 2016 |
| References_xml | – volume: 83 start-page: 829 issue: 7 year: 2012 ident: ref1 article-title: Effects of variation in temperature management on cerebral performance category scores in patients who received therapeutic hypothermia post cardiac arrest publication-title: Resuscitation doi: 10.1016/j.resuscitation.2011.12.026 – year: 1985 ident: ref6 article-title: Purification and characterization of human neuron-specific enolase: radioimmunoassay development publication-title: Tumour Biol – volume: 84 start-page: 1324 issue: 10 year: 2013 ident: ref11 article-title: Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: A systematic review and meta-analysis. Part 2: Patients treated with therapeutic hypothermia publication-title: Resuscitation doi: 10.1016/j.resuscitation.2013.06.020 – volume: 163 start-page: 541 issue: 4 year: 2012 ident: ref19 article-title: Target temperature management after out-of-hospital cardiac arrest—a randomized, parallel-group, assessor-blinded clinical trial—rationale and design publication-title: American Heart Journal doi: 10.1016/j.ahj.2012.01.013 – volume: 84 start-page: 337 issue: 3 year: 2013 ident: ref3 article-title: The influence of induced hypothermia and delayed prognostication on the mode of death after cardiac arrest publication-title: Resuscitation doi: 10.1016/j.resuscitation.2012.09.015 – ident: ref7 – volume: 80 start-page: 784 issue: 7 year: 2009 ident: ref24 article-title: Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia publication-title: Resuscitation doi: 10.1016/j.resuscitation.2009.03.025 – start-page: 1 year: 2016 ident: ref18 article-title: Standardized EEG interpretation accurately predicts prognosis after cardiac arrest publication-title: Neurology – volume: 34 start-page: 2881 issue: 12 year: 2003 ident: ref27 article-title: Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia publication-title: Stroke doi: 10.1161/01.STR.0000103320.90706.35 – year: 1985 ident: ref5 article-title: Radioimmunoassay development for human neuron-specific enolase: with some clinical results in lung cancers and neuroblastoma publication-title: Tumour Biol – ident: ref13 doi: 10.1016/j.jacc.2015.03.538 – volume: 25 start-page: 558 year: 1994 ident: ref8 article-title: Neuron-Specific Enolase Concentrations publication-title: Stroke doi: 10.1161/01.STR.25.3.558 – volume: 72 start-page: 1654 issue: 6 year: 2012 ident: ref10 article-title: Neuron-specific enolase and S100BB as outcome predictors in severe diffuse axonal injury publication-title: Journal of Trauma and Acute Care Surgery doi: 10.1097/TA.0b013e318246887e – volume: 162 start-page: 55 issue: 1 year: 2015 ident: ref30 article-title: Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): The TRIPOD Statement publication-title: Ann Intern Med doi: 10.7326/M14-0697 – volume: 369 start-page: 2197 issue: 23 year: 2013 ident: ref14 article-title: Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest publication-title: N Engl J Med doi: 10.1056/NEJMoa1310519 – volume: 20 start-page: 6 issue: 1 year: 2012 ident: ref28 article-title: Serial measurement of neuron specific enolase improves prognostication in cardiac arrest patients treated with hypothermia: A prospective study publication-title: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine doi: 10.1186/1757-7241-20-6 – volume: 84 start-page: 1387 issue: 10 year: 2013 ident: ref22 article-title: Combining brain computed tomography and serum neuron specific enolase improves the prognostic performance compared to either alone in comatose cardiac arrest survivors treated with therapeutic hypothermia publication-title: Resuscitation doi: 10.1016/j.resuscitation.2013.05.026 – volume: 14 start-page: 1 issue: 1 year: 2013 ident: ref16 article-title: Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial publication-title: Trials doi: 10.1186/1745-6215-14-300 – volume: 66 start-page: 271 issue: 3 year: 2005 ident: ref15 article-title: Recommended guidelines for reviewing, reporting, and conducting research on post-resuscitation care: The Utstein style publication-title: Resuscitation doi: 10.1016/j.resuscitation.2005.06.005 – volume: 11 start-page: 48 issue: 1 year: 2011 ident: ref29 article-title: Serum neuron-specific enolase as predictor of outcome in comatose cardiac-arrest survivors: a prospective cohort study publication-title: BMC Cardiovascular Disorders doi: 10.1186/1471-2261-11-48 – volume: 132 start-page: 84 year: 2015 ident: ref12 article-title: Part 4: Advanced Life Support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations publication-title: Circulation doi: 10.1161/CIR.0000000000000273 – volume: 21 start-page: 1 issue: 1 year: 2013 ident: ref17 article-title: A structured approach to neurologic prognostication in clinical cardiac arrest trials publication-title: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine doi: 10.1186/1757-7241-21-45 – start-page: 1 year: 1975 ident: ref20 article-title: Assessment of outcome after severe brain damage publication-title: The Lancet – volume: 39 start-page: 1972 issue: 11 year: 2013 ident: ref2 article-title: Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort publication-title: Intensive Care Med doi: 10.1007/s00134-013-3043-4 – volume: 21 start-page: 1 year: 2003 ident: ref4 article-title: Proteins in cerebrospinal fluid and blood: Barriers, CSF flow rate and source-related dynamics publication-title: Restorative Neurology and Neuroscience doi: 10.3233/RNN-2003-00229 – volume: 68 start-page: 77 issue: 1 year: 2009 ident: ref21 article-title: McNemar χ 2test revisited: comparing sensitivity and specificity of diagnostic examinations publication-title: Scandinavian Journal of Clinical and Laboratory Investigation doi: 10.1080/00365510701666031 – volume: 18 start-page: 1 year: 1987 ident: ref9 article-title: S-100 Protein and Neuron-Specific Enolase in Cerebrospinal Fluid and Serum: Markers of Cell Damage in Human Central Nervous System publication-title: Stroke doi: 10.1161/01.STR.18.5.911 – volume: 14 start-page: R69 issue: 2 year: 2010 ident: ref26 article-title: Mild therapeutic hypothermia alters neuron specific enolase as an outcome predictor after resuscitation: 97 prospective hypothermia patients compared to 133 historical non-hypothermia patients publication-title: Crit Care doi: 10.1186/cc8975 – volume: 71 start-page: 206 issue: 2 year: 2012 ident: ref25 article-title: Prognosis of coma after therapeutic hypothermia: A prospective cohort study publication-title: Ann Neurol doi: 10.1002/ana.22632 – volume: 84 start-page: 1382 issue: 10 year: 2013 ident: ref23 article-title: NSE and S-100B are not sufficiently predictive of neurologic outcome after therapeutic hypothermia for cardiac arrest publication-title: Resuscitation doi: 10.1016/j.resuscitation.2013.03.021 |
| SSID | ssj0053866 |
| Score | 2.446182 |
| Snippet | Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after... Background Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated... Background: Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated... BACKGROUND:Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated... Background Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated... |
| SourceID | plos doaj unpaywall swepub pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0168894 |
| SubjectTerms | Anestesi och intensivvård Anesthesiology and Intensive Care Biology and Life Sciences Biomarkers Biomarkers - blood Brain damage Brain research Cardiac arrest Cardiology Cardiopulmonary resuscitation Causes of Clinical Medicine Clinical trials Comparative analysis CPR Emergency medical care Heart Heart diseases Humans Hypothermia, Induced Intensive care Klinisk medicin Measurement Medical and Health Sciences Medical research Medicin och hälsovetenskap Medicine and Health Sciences Nervous system diseases Out-of-Hospital Cardiac Arrest - mortality Out-of-Hospital Cardiac Arrest - pathology Patient outcomes Patients People and Places Phosphopyruvate hydratase Phosphopyruvate Hydratase - blood Population studies Predictions Prognosis Prospective Studies Rewarming Studies Trauma Treatment Outcome Unconsciousness - pathology |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELVQL8ABUb66UMAgJODgNo4TxzmWqlVBKq3oFlVcLMdO2kpRsmp2hfoT-VfMON7QiIr2wG21HmfXnufxjON5Q8i7sooc50XKZFRBgJJYy0wuOKukcNAFHFSBicL7X-XecfLlJD25UuoL74T19MD9xG261MqUF1keOZcIaTwBHoRV4BfHLs49eylsY8tgqrfBICBlSJQTGd8MetmYtU25AU6OUnky2og8X_9glVdmddtd53L-fXMy8IveJ3cXzcxc_jR1fWV_2n1IHgTHkm71A1old8rmEVkNS7ejHwK_9MfH5NcRbFd1SfFCxqKj_fkY3f9zWNjRtqKetaNhvj59dW7pTgNBcFdS0zh6eIGvd1ClKHnYthe9eLCj9GAxByCX9LyheMMekdTM60t63ED0DXtuCz972BO6dtRXKccu7KBiyzImdNsj18J4sHgIZXSLTqf7bOr_K1o7pMV9Qo53d6bbeyxUdGBW8XTOnKuSNDER4CZJqsLmxqWpNOBiZJEyEkLBKueFU4UQUjpbiEQVJs9cHhclOHJSPCUrDehwjVALnp6rlJOpMUkeW6Wkgk8lGKGIKysmRCzVq22gO8eqG7X27_AyCHt6xWgEhQ6gmBA29Jr1dB83yH9C5AyySNbtvwAI6wBhfROEJ-Q14k73ma-DydFbmAYsBI_jCXnrJZCwo8EbQadm0XX688H3WwgdfRsJvQ9CVQvTYU3IwoAxIRHYSHJ9JAlmx46a13CVLGel0-D45RnEawn2XK6c65vfDM34ULzl15SAPJAB_zrLYFP5p4wSmA3NJ-RZvxiH2Y8VxDvgYU9INlqmI_WMW5rzM8-pnmKaFIeeP_oFPe7iI2Ed6LfOdL3QXalnV87VdW4KkUep07FzUsOTrM4lr3SUxllcOlMUGeh5YzASt0LX8_-BrhfkXoyuaMQZV-tkZX6xKF-CIz0vXnmb-RvtTcpL priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3NbtQwELagHIADovx1oYBBSMAh2zhOHOeEStVSkEorukUVF8uxk7ZSlCybXaHeeAcei7fgSZhxvNtGVKW31Xqc3Xj-bc83hLwqytAylieBCEtIUGJjAp1xFpSCW5gCASrHQuGdz2L7IP50mBz6DbfWX6uc20RnqG1jcI98DfwKJDwSPMq78fcAu0bh6apvoXGd3GARSBJWim99mFti0GUhfLkcT9ma585w3NTFEEIdKbO4544cav_CNi-Nq6a9KPD89_6kRxm9TW7O6rE-_aGr6pyX2rpL7vjwkq538rBMrhX1PbLsFbilbzzK9Nv75Pc-OK2qoHgtY9bSbpeM7pxtGba0KanD7qgD16W-PDF0s4ZUuC2ori3dm-AhDzIWKfeaZtKRe2tKd2dTWNqCntQU79mjPNXT6pQe1JCDg-dt4Gf3OljXlrpe5Tgl2C2DeTMTuuHk18D7YAsR-ufnL7pOR6OdYOT-LVo9hMd9QA62Nkcb24Hv7BAYyZJpYG0ZJ7EOQX7iuMxNpm2SCA2hRhpKLSAlLDOWW5lzLoQ1OY9lrrPUZlFeQEAn-EOyVAMXVwg1EPHZUlqRaB1nkZFSSPhUgDEKmTR8QPicwcp42HPsvlEpd5aXQvrTsUahWCgvFgMSLGaNO9iP_9C_R9lZ0CJot_uimRwpbwOUTYxIWJ5mobUxF9phOXIJVjWKbJQlA_IcJU91FbAL06PWsRyYcxZFA_LSUSBwR403g470rG3Vx92vVyDa_9Ijeu2JygaWw2hfjQHvhIBgPcrVHiWYH9MbXkE9ma9Kq84UFWbOdefi4ReLYXwo3varC5A9oIE4O03BuVxKIzlWRbMBedSp42L1Iwl5D0TaA5L2FLXHnv5IfXLssNUTLJdiMPNbp9L9KS4jVh6G61hVM9UWanxuf11lOudZmFgVWSsUPMmoTLBShUmURoXVeZ4Cn4cLM3El6Xp8-UI-IbciDDZDFjC5Spamk1nxFELlaf7M2cO_YuXFVA priority: 102 providerName: ProQuest – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELdG9wA8AOPfCgMMQvx5SBfHieM8lmnTQNpWsRYNJGQ5dsImqrRqWqHxgPgOfCy-BZ-Eu8QtCwwYD7xF9Z3VnM_nu9zdz4Q8zHLfMpZGnvBzCFBCYzydcOblgltgAQeVY6Pwzq7YHoQvDqKDJfJ23gvjJAgx4nBUVpl8fBgV2bqT5DriFdXZ0w7jMZtzdMZA1AEHRsokfFQhDuGXsSk2IJ0jywLzTy2yPNjtdV_XmebAE4HPXTvd72ZqHFcVqv_Cdrfwn53mmP5aX-lQSC-S87NirI8_6OHwxCm2dZl8mr9_XbzyvjObph3z8SdoyP8moCvkkvN_abeeZYUsZcVVsuIsTEmfOBjsp9fI1304VYcZxbqRWUnrz3h058c3zZKOclqBixTe_jirigvpZgGxeplRXVjam2AWCjUPKXuj0aQmd-ae7s2msN8yelRQbARAhS-mw2M6KAzsRYPVwbRX486WtLpMHVm8vdyb37ZCN6oNZuB98I4T-u3zF9ql_f6O16_-LZplxO-9TgZbm_2Nbc9dPeEZyaKpZ20eRqH2QcHDME9Nom0UCQ2-UOxLLSBmzROWWplyLoQ1KQ9lqpPYJkGagccp-A3SKkDeq4QacEltLq2ItA6TwEgpJDxlYC19Jg1vEz7XMGUcLjteDzJUVbIxhvisXhqFC6jcAraJt-Aa17gkf6F_hsq7oEVU8eoH0CDlNEfZyIiIpXHiWxtyoSuwSS7B7AeBDZKoTe6h6qu6RXdhG1UX-5U5Z0HQJg8qCkQWKbB06Z2elaV6vvfqDET7LxtEjx1RPgJxGO3aReCdUMEblGsNSrCPpjG8ijtkLpVSgYeaxBBYhsg537ynD99fDOOkWI5YZKB7QAOBQBzD6fdHGsmxbZu1yc3aHiykH0gIzCAUaJO4YSkay9McKY4OK_D3CPu5GHC-qW1Kk6UK2ZXDCTtUw5kqMzU-kQBQiU554kdWBdYKBTMZlQiWKz8K4iCzOk1jWOfOwk6dSbtu_SvDbXIhQP_YZx6Ta6Q1ncyyO-DdT9O7zkZ_BwHsBSI priority: 102 providerName: Unpaywall |
| Title | Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-Of-Hospital Cardiac Arrest – A TTM-Trial Substudy |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28099439 https://www.proquest.com/docview/1859788242 https://www.proquest.com/docview/1861577048 https://www.proquest.com/docview/1868334321 https://pubmed.ncbi.nlm.nih.gov/PMC5242419 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0168894&type=printable https://doaj.org/article/d5c651b790dd436a965953831822d295 http://dx.doi.org/10.1371/journal.pone.0168894 |
| UnpaywallVersion | publishedVersion |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry (Selected full-text) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: HH5 dateStart: 20060101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20060101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20061001 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: ABDBF dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DIK dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: GX1 dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central (Free e-resource, activated by CARLI) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: RPM dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Technology Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8FG dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/technologycollection1 providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1932-6203 dateEnd: 20250930 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M48 dateStart: 20061201 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELb6OAAHRHl1oSwGIQGHrJI4D-eA0LZqKUgtVdtFhYvl2ElbKSRhsyvoT-RfMeN4QyPK48IlWq1nol17Zvz5Md8Q8izLXe15aehEbg4LlEApRybMc_KIaVABgMowUXhvP9qdBO9OwpMlsqjZajuwuXJph_WkJtNi9O3LxWtw-FemakPsLZRGdVVmI4AwnCfBMlmFuclHO98LunMF8G5zeomoxYl8l9lkut-9pTdZGU7_LnKv1EXVXAVLf71daTlIb5Br87KWF19lUVyaw3ZukZsWfNJxay1rZCkrb5M1694NfWE5qF_eId-PYEorMoqXNuYNbe2Ufv65odjQKqeGDLN0MFsTbxzRrITebDIqS03rKR4B4bCjZF1V01bcxlpazWdg7Bk9L2mNe3ZgbeWsuKAwz4IjKLyaSy3pa0NNJXNUcarcObOlTqgy1q2oNAVGqEPH9Ph4zzGFSGgDERGpc--Syc728dauY6s-OIp74czROg_CQLpgW0GQpyqROgwjCTAkdrmMYLmYJ16qecpYFGmVsoCnMol14qcZgL2I3SMrJYzhOqEK0KDOuY5CKYPEV5xHHD5lEKhcjys2IGwxvEJZSnSszFEIc84Xw9KoHRiBRiGsUQyI02nVLSXIX-Q30XI6WST0Nl9U01Nh44PQoYpCL40TV-uARdLwPDIOEdf3tZ-EA_IY7U602bFdWBJjTBVmzPP9AXlqJJDUo8RbQ6dy3jTi7fsP_yB0dNgTem6F8gq6Q0mbqQH_CcnCepIbPUkITarXvI5esuiVRgA4TGJY0wWoufCcq5ufdM34UrwJWGZgeSADGDyOYeL5owxnmDHtDcj91hm73vc5rIkAhQ9I3HPT3vD0W8rzM8O7HmIqlQean1qH7quYQCUsRdeZKOaiyUR9ae9dJDJliRtq4WsdCXiTEknk5cIN_djPtEzTGMZ51AWJf7KuB__z1zwk132Esa7neHyDrMym8-wRgPBZOiTL8UkMT77l4XPnzZCsbm7vHxwOzbbW0MRd-G6yfzD--AMtnOuY |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fT9RAEN8gPqAPRvzHKcpqNOpDoe222-2DMYgQEA6IHIb4sm53WyBp2nq9C-HN7-D38Iv4LfwkzrS9QiNBXni7dGd77c7sb2a284eQl3FiG8eJfIvbCTgontaWCpljJZwZmAIGKsNE4f42X9_3Ph34B1Pk1yQXBsMqJ5hYAbXJNZ6RL4FeAYdHgEZ5X3y3sGsUfl2dtNCoxWIzPj0Bl618t_ER-PvKdddWByvrVtNVwNLC8UeWMYnne8qGZ_e8JNKhMr7PFai5wBaKgzuShE5kRMQY50ZHzBORCgMTulEMxgRncN8b5KbHbA9r9QcHrYMH2MF5k57HAmepkYbFIs_iRTCthAi9jvqrugS0umC6SPPyIkP333jNpqrpbTIzzgp1eqLS9JxWXLtL7jTmLF2u5W-WTMXZPTLbAEZJ3zRVrd_eJ7_3QEmmMcUwkHFJ61M52j87oixpntCqVkhm7RVxFStIVzNwvcuYqszQ3SF-VEJBQsrdPB_W5A16053xCFgZ0-OMYlw_ym82Sk_pfgY-P2j6HP52ty4jW9KqNzpOsXYSa9I8ha5U-0XD-2DLEvrnx0-6TAeDvjWonhZRFsvxPiD718Lzh2Q6Ay7OEarBwjSJMNxXygtdLQQX8CsG8LMdoVmPsAmDpW7KrGO3j1RW3w4DcLdq1kgUC9mIRY9Y7ayiLjPyH_oPKDstLRYJry7kw0PZYI40vua-EwWhbYzHuKpqRzIBKO66xg39HllAyZN1xm0LdXIZ048Zc1y3R15UFFgoJMNIpEM1Lku5sfPlCkR7nztErxuiJIfl0KrJ_oB3wgJkHcr5DiXAne4Mz-E-maxKKc-AAWZO9s7Fw8_bYbwpRhdmMcge0IBdHwSgzC6lEQyzsJ0eeVRvx3b1XQF-Flj2PRJ0NmqHPd2R7PioquXuY3qWAzO_1lu6O6XywGVT9utIpmNZxrI4d54vQxWx0PaNdI3hEu6kZcidRNq-G7ixUVEUAJ8XW5i4knQ9vnwhF8jM-qC_Jbc2tjefkFsuGrq2YzlinkyPhuP4KZjpo-hZhY2UfLtuMP4LC1EC4Q |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwELZKkfg5IMpfFwo1CAQc0iZx4jgHhEp_1FLarugWVVyMYydtpVWybHZV9cY78Da8Am_BkzCTeNNGVKWX3lbrcXbjGX8zY88PIS_TzDWel4QOdzNwUAKtHRUzz8k4MzAFDFSGicJb23x9L_i4H-5PkV-TXBgMq5xgYgXUptB4Rr4IegUcHgEaZTGzYRHdlbX3g-8OdpDCm9ZJO41aRDbTk2Nw38p3GyvA61e-v7baW153bIcBRwsvHDnGZEEYKBfeIwiyRMfKhCFXoPIiVygOrkkWe4kRCWOcG52wQCQqjkzsJykYFpzBc6-R6xELGIaTRfuNswc4wrlN1WORt2glY2FQ5OkCmFlCxEFLFVYdAxq9MD3oF-V5Ru-_sZu2wultcnOcD9TJser3z2jItbvkjjVt6VItizNkKs3vkRkLHiV9Yytcv71Pfu-CwuynFENCxiWtT-jo1ulxZUmLjFZ1Q3Jnd5BWcYN0NQc3vEypyg3tDvGCCYUKKbtFMazJLZLTnfEI2JrSo5xijD_Kcj7qn9C9HPx_0PoF_Gy3Lilb0qpPOk5xdjJn0kiFLld7R8P7YPsS-ufHT7pEe70tp1f9W0RcLM37gOxdCc8fkukcuDhLqAZr02TC8FCpIPa1EFzApxSA0PWEZh3CJgyW2pZcx84ffVndI0bgetWskSgW0opFhzjNrEFdcuQ_9B9QdhpaLBhefVEMD6TFH2lCzUMviWLXmIBxVdWRZAIQ3feNH4cdMo-SJ-vs2wb25BKmIjPm-X6HvKgosGhIjtvvQI3LUm7sfLkE0e7nFtFrS5QVsBxa2UwQeCcsRtainGtRAvTp1vAs7pPJqpTyFCRg5mTvnD_8vBnGh2KkYZ6C7AEN2PhRBIrtQhrBMCPb65BH9XZsVt8X4HOBld8hUWujttjTHsmPDqu67iGmankw82u9pdtTKm9c2hJgh7I_lmUqB2fO9mWsEha7oZG-MVzCk7SMuZdJN_QjPzUqSSLg80IDE5eSrscXL-Q8uQEwLD9tbG8-Ibd8tHldz_HEHJkeDcfpU7DYR8mzChop-XbVWPwXN2kHHA |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELdG9wA8AOPfCgMMQvx5SBfHieM8lmnTQNpWsRYNJGQ5dsImqrRqWqHxgPgOfCy-BZ-Eu8QtCwwYD7xF9Z3VnM_nu9zdz4Q8zHLfMpZGnvBzCFBCYzydcOblgltgAQeVY6Pwzq7YHoQvDqKDJfJ23gvjJAgx4nBUVpl8fBgV2bqT5DriFdXZ0w7jMZtzdMZA1AEHRsokfFQhDuGXsSk2IJ0jywLzTy2yPNjtdV_XmebAE4HPXTvd72ZqHFcVqv_Cdrfwn53mmP5aX-lQSC-S87NirI8_6OHwxCm2dZl8mr9_XbzyvjObph3z8SdoyP8moCvkkvN_abeeZYUsZcVVsuIsTEmfOBjsp9fI1304VYcZxbqRWUnrz3h058c3zZKOclqBixTe_jirigvpZgGxeplRXVjam2AWCjUPKXuj0aQmd-ae7s2msN8yelRQbARAhS-mw2M6KAzsRYPVwbRX486WtLpMHVm8vdyb37ZCN6oNZuB98I4T-u3zF9ql_f6O16_-LZplxO-9TgZbm_2Nbc9dPeEZyaKpZ20eRqH2QcHDME9Nom0UCQ2-UOxLLSBmzROWWplyLoQ1KQ9lqpPYJkGagccp-A3SKkDeq4QacEltLq2ItA6TwEgpJDxlYC19Jg1vEz7XMGUcLjteDzJUVbIxhvisXhqFC6jcAraJt-Aa17gkf6F_hsq7oEVU8eoH0CDlNEfZyIiIpXHiWxtyoSuwSS7B7AeBDZKoTe6h6qu6RXdhG1UX-5U5Z0HQJg8qCkQWKbB06Z2elaV6vvfqDET7LxtEjx1RPgJxGO3aReCdUMEblGsNSrCPpjG8ijtkLpVSgYeaxBBYhsg537ynD99fDOOkWI5YZKB7QAOBQBzD6fdHGsmxbZu1yc3aHiykH0gIzCAUaJO4YSkay9McKY4OK_D3CPu5GHC-qW1Kk6UK2ZXDCTtUw5kqMzU-kQBQiU554kdWBdYKBTMZlQiWKz8K4iCzOk1jWOfOwk6dSbtu_SvDbXIhQP_YZx6Ta6Q1ncyyO-DdT9O7zkZ_BwHsBSI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Single+versus+serial+measurements+of+neuron-specific+enolase+and+prediction+of+poor+neurological+outcome+in+persistently+unconscious+patients+after+out-of-hospital+cardiac+arrest+-+A+TTM-trial+substudy&rft.jtitle=PloS+one&rft.au=Wiberg%2C+Sebastian&rft.au=Hassager%2C+Christian&rft.au=Stammet%2C+Pascal&rft.au=Winther-Jensen%2C+Matilde&rft.date=2017-01-18&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=12&rft.issue=1&rft_id=info:doi/10.1371%2Fjournal.pone.0168894&rft.externalDocID=oai_portal_research_lu_se_publications_9ab3905d_2dd6_419c_961f_05272edabb75 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |