Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation

Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiologica...

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Published inPloS one Vol. 12; no. 1; p. e0170842
Main Authors Sukma Dewi, Ihdina, Hollander, Zsuzsanna, Lam, Karen K., McManus, Janet-Wilson, Tebbutt, Scott J., Ng, Raymond T., Keown, Paul A., McMaster, Robert W., McManus, Bruce M., Gidlöf, Olof, Öhman, Jenny
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 26.01.2017
Public Library of Science (PLoS)
Subjects
Adaptor Proteins, Signal Transducing - blood
Adaptor Proteins, Signal Transducing - genetics
Adult
Bioindicators
Biology and life sciences
Biomarkers
Biomarkers - blood
Biopsy
Blood
C-Reactive Protein - metabolism
Calcineurin
Cardiology
Case-Control Studies
Clinical Laboratory Medicine
Clinical Medicine
Creatinine
Creatinine - blood
Cyclosporine - blood
Development and progression
Diagnostic software
Diagnostic systems
Female
Gene expression
Gene Expression Regulation
Genetic aspects
Graft rejection
Graft Rejection - blood
Graft Rejection - diagnosis
Graft Rejection - immunology
Graft Rejection - pathology
Heart
Heart Transplantation
Hospitals
Humans
Klinisk laboratoriemedicin
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Medicine and Health Sciences
MicroRNA
MicroRNAs
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
miRNA
Pathology
Patients
Physiological aspects
Prevention
Rejection
Research and Analysis Methods
Serum levels
Signal Transduction
Tacrolimus
Tacrolimus - blood
Transplantation
Transplants & implants
Canada
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0170842

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Abstract Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiological and underlying pathological conditions in human. We compared a group of heart transplant recipients with histologically-verified acute cellular rejection (ACR, n = 26) with a control group of heart transplant recipients without allograft rejection (NR, n = 37) by assessing the levels of a select set of microRNAs in serum specimens. The levels of seven microRNAs, miR-142-3p, miR-101-3p, miR-424-5p, miR-27a-3p, miR-144-3p, miR-339-3p and miR-326 were significantly higher in ACR group compared to the control group and could discriminate between patients with and without allograft rejection. MiR-142-3p and miR-101-3p had the best diagnostic test performance among the microRNAs tested. Serum levels of miR-142-3p and miR-101-3p were independent of calcineurin inhibitor levels, as measured by tacrolimus and cyclosporin; kidney function, as measured by creatinine level, and general inflammation state, as measured by CRP level. This study demonstrated two microRNAs, miR-142-3p and miR-101-3p, that could be relevant as non-invasive diagnostic tools for identifying heart transplant patients with acute cellular rejection.
AbstractList Background Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiological and underlying pathological conditions in human. Methods We compared a group of heart transplant recipients with histologically-verified acute cellular rejection (ACR, n = 26) with a control group of heart transplant recipients without allograft rejection (NR, n = 37) by assessing the levels of a select set of microRNAs in serum specimens. Results The levels of seven microRNAs, miR-142-3p, miR-101-3p, miR-424-5p, miR-27a-3p, miR-144-3p, miR-339-3p and miR-326 were significantly higher in ACR group compared to the control group and could discriminate between patients with and without allograft rejection. MiR-142-3p and miR-101-3p had the best diagnostic test performance among the microRNAs tested. Serum levels of miR-142-3p and miR-101-3p were independent of calcineurin inhibitor levels, as measured by tacrolimus and cyclosporin; kidney function, as measured by creatinine level, and general inflammation state, as measured by CRP level. Conclusion This study demonstrated two microRNAs, miR-142-3p and miR-101-3p, that could be relevant as non-invasive diagnostic tools for identifying heart transplant patients with acute cellular rejection.
Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiological and underlying pathological conditions in human. We compared a group of heart transplant recipients with histologically-verified acute cellular rejection (ACR, n = 26) with a control group of heart transplant recipients without allograft rejection (NR, n = 37) by assessing the levels of a select set of microRNAs in serum specimens. The levels of seven microRNAs, miR-142-3p, miR-101-3p, miR-424-5p, miR-27a-3p, miR-144-3p, miR-339-3p and miR-326 were significantly higher in ACR group compared to the control group and could discriminate between patients with and without allograft rejection. MiR-142-3p and miR-101-3p had the best diagnostic test performance among the microRNAs tested. Serum levels of miR-142-3p and miR-101-3p were independent of calcineurin inhibitor levels, as measured by tacrolimus and cyclosporin; kidney function, as measured by creatinine level, and general inflammation state, as measured by CRP level. This study demonstrated two microRNAs, miR-142-3p and miR-101-3p, that could be relevant as non-invasive diagnostic tools for identifying heart transplant patients with acute cellular rejection.
Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiological and underlying pathological conditions in human.BACKGROUNDIdentifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiological and underlying pathological conditions in human.We compared a group of heart transplant recipients with histologically-verified acute cellular rejection (ACR, n = 26) with a control group of heart transplant recipients without allograft rejection (NR, n = 37) by assessing the levels of a select set of microRNAs in serum specimens.METHODSWe compared a group of heart transplant recipients with histologically-verified acute cellular rejection (ACR, n = 26) with a control group of heart transplant recipients without allograft rejection (NR, n = 37) by assessing the levels of a select set of microRNAs in serum specimens.The levels of seven microRNAs, miR-142-3p, miR-101-3p, miR-424-5p, miR-27a-3p, miR-144-3p, miR-339-3p and miR-326 were significantly higher in ACR group compared to the control group and could discriminate between patients with and without allograft rejection. MiR-142-3p and miR-101-3p had the best diagnostic test performance among the microRNAs tested. Serum levels of miR-142-3p and miR-101-3p were independent of calcineurin inhibitor levels, as measured by tacrolimus and cyclosporin; kidney function, as measured by creatinine level, and general inflammation state, as measured by CRP level.RESULTSThe levels of seven microRNAs, miR-142-3p, miR-101-3p, miR-424-5p, miR-27a-3p, miR-144-3p, miR-339-3p and miR-326 were significantly higher in ACR group compared to the control group and could discriminate between patients with and without allograft rejection. MiR-142-3p and miR-101-3p had the best diagnostic test performance among the microRNAs tested. Serum levels of miR-142-3p and miR-101-3p were independent of calcineurin inhibitor levels, as measured by tacrolimus and cyclosporin; kidney function, as measured by creatinine level, and general inflammation state, as measured by CRP level.This study demonstrated two microRNAs, miR-142-3p and miR-101-3p, that could be relevant as non-invasive diagnostic tools for identifying heart transplant patients with acute cellular rejection.CONCLUSIONThis study demonstrated two microRNAs, miR-142-3p and miR-101-3p, that could be relevant as non-invasive diagnostic tools for identifying heart transplant patients with acute cellular rejection.
Background Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiological and underlying pathological conditions in human. Methods We compared a group of heart transplant recipients with histologically-verified acute cellular rejection (ACR, n = 26) with a control group of heart transplant recipients without allograft rejection (NR, n = 37) by assessing the levels of a select set of microRNAs in serum specimens. Results The levels of seven microRNAs, miR-142-3p, miR-101-3p, miR-424-5p, miR-27a-3p, miR-144-3p, miR-339-3p and miR-326 were significantly higher in ACR group compared to the control group and could discriminate between patients with and without allograft rejection. MiR-142-3p and miR-101-3p had the best diagnostic test performance among the microRNAs tested. Serum levels of miR-142-3p and miR-101-3p were independent of calcineurin inhibitor levels, as measured by tacrolimus and cyclosporin; kidney function, as measured by creatinine level, and general inflammation state, as measured by CRP level. Conclusion This study demonstrated two microRNAs, miR-142-3p and miR-101-3p, that could be relevant as non-invasive diagnostic tools for identifying heart transplant patients with acute cellular rejection.
Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiological and underlying pathological conditions in human. We compared a group of heart transplant recipients with histologically-verified acute cellular rejection (ACR, n = 26) with a control group of heart transplant recipients without allograft rejection (NR, n = 37) by assessing the levels of a select set of microRNAs in serum specimens. The levels of seven microRNAs, miR-142-3p, miR-101-3p, miR-424-5p, miR-27a-3p, miR-144-3p, miR-339-3p and miR-326 were significantly higher in ACR group compared to the control group and could discriminate between patients with and without allograft rejection. MiR-142-3p and miR-101-3p had the best diagnostic test performance among the microRNAs tested. Serum levels of miR-142-3p and miR-101-3p were independent of calcineurin inhibitor levels, as measured by tacrolimus and cyclosporin; kidney function, as measured by creatinine level, and general inflammation state, as measured by CRP level. This study demonstrated two microRNAs, miR-142-3p and miR-101-3p, that could be relevant as non-invasive diagnostic tools for identifying heart transplant patients with acute cellular rejection.
Audience Academic
Author Hollander, Zsuzsanna
Sukma Dewi, Ihdina
McManus, Janet-Wilson
Keown, Paul A.
Tebbutt, Scott J.
Gidlöf, Olof
Lam, Karen K.
Ng, Raymond T.
McManus, Bruce M.
Öhman, Jenny
McMaster, Robert W.
AuthorAffiliation 1 Department of Cardiology, Skåne University Hospital, Lund University, Lund, Sweden
5 Department of Medicine, University of British Columbia, Vancouver, Canada
9 Vancouver Coastal Health Research Institute, Vancouver, Canada
10 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
7 Department of Computer Science, University of British Columbia, Vancouver, Canada
2 Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, Canada
4 netCAD, Canadian Blood Services, Vancouver, Canada
Institut de Pharmacologie Moleculaire et Cellulaire, FRANCE
6 Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada
3 UBC James Hogg Research Centre, Vancouver, Canada
8 Vancouver General Hospital, Vancouver, Canada
AuthorAffiliation_xml – name: Institut de Pharmacologie Moleculaire et Cellulaire, FRANCE
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/28125729$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1097/TP.0b013e318218e978
10.1073/pnas.1019055108
10.1038/embor.2008.224
10.1016/j.healun.2010.05.034
10.1161/CIRCHEARTFAILURE.114.001658
10.1016/j.healun.2006.10.002
10.1016/j.healun.2012.11.008
10.1056/NEJMoa0912965
10.1093/eurheartj/ehu346
10.1161/CIRCULATIONAHA.106.683110
10.1158/1055-9965.EPI-15-0289
10.1111/j.1600-6143.2012.04313.x
10.1038/nri2708
10.1016/j.ymeth.2012.09.015
10.1017/S1462399411002080
10.1016/j.trim.2013.08.005
10.1016/j.healun.2006.10.003
10.1371/journal.pone.0003148
10.1681/ASN.2011060543
10.1111/j.1600-6143.2010.03032.x
10.1186/gm253
10.1016/j.healun.2012.12.007
10.1073/pnas.0804549105
10.1056/NEJMp038136
10.1111/j.1600-6143.2011.03807.x
10.1016/j.mrfmmm.2011.03.004
10.1111/j.1600-6143.2006.01305.x
10.1016/j.healun.2013.08.006
10.1172/JCI70013
ContentType Journal Article
Copyright COPYRIGHT 2017 Public Library of Science
2017 Sukma Dewi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2017 Sukma Dewi et al 2017 Sukma Dewi et al
Copyright_xml – notice: COPYRIGHT 2017 Public Library of Science
– notice: 2017 Sukma Dewi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2017 Sukma Dewi et al 2017 Sukma Dewi et al
CorporateAuthor Kardiologi
Department of Clinical Sciences, Lund
Faculty of Medicine
Institutionen för kliniska vetenskaper, Lund
Sektion II
Section II
Lunds universitet
Medicinska fakulteten
Lund University
Cardiology
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DocumentTitleAlternate MicroRNA Biomarker for Acute Cardiac Allograft Rejection
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Competing Interests: The authors have declared that no competing interests exist.
Conceptualization: JÖ.Data curation: OG ISD.Formal analysis: ZH KKL JM SJT RTN PAK RM BM.Funding acquisition: JÖ.Investigation: OG ISD ZH KL JM SJT RTN PAK RM BM.Methodology: OG ISD.Project administration: OG.Resources: ZH KL JM SJT RTN PAK RM BM.Software: ISD.Supervision: JÖ OG.Validation: OG ISD.Visualization: ISD.Writing – original draft: ISD.Writing – review & editing: OG ISD ZH KL JM SJT RTN PAK RM BM JÖ.
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References Z Hollander (ref27) 2013; 32
J Kobashigawa (ref26) 2015; 8
JP Duong Van Huyen (ref32) 2014; 35
A Harris (ref15) 2010; 10
MX Pham (ref5) 2010; 362
S Roedder (ref7) 2011; 3
H Nielsen (ref4) 1993; 12
TB Rounge (ref22) 2015; 24
MR Costanzo (ref25) 2010; 29
Y Sun (ref16) 2013; 123
DA Morrow (ref20) 2007; 115
R Danger (ref29) 2012; 23
S Gilad (ref9) 2008; 3
A Etheridge (ref8) 2011; 717
MC Deng (ref23) 2006; 6
J Stehlik (ref1) 2006; 25
I Sukma Dewi (ref11) 2013; 32
L Wei (ref33) 2013; 29
B Huang (ref28) 2009; 10
GL Winters (ref3) 1996; 15
LN Van Aelst (ref30) 2015
S Heidt (ref6) 2011; 92
RM O'Connell (ref13) 2010; 10
T Manolio (ref19) 2003; 349
PS Mitchell (ref17) 2008; 105
JC Spiegel (ref14) 2011; 13
LH Lund (ref2) 2013; 32
VR Mas (ref10) 2013; 13
A Gautam (ref21) 2016
T Blondal (ref12) 2013; 59
T Asaoka (ref31) 2012; 12
JD Arroyo (ref18) 2011; 108
RC Starling (ref24) 2006; 25
21494177 - Transplantation. 2011 Jul 15;92(1):1-9
23384889 - J Heart Lung Transplant. 2013 Apr;32(4):463-6
21658299 - Genome Med. 2011 Jun 08;3(6):37
17325253 - Circulation. 2007 Feb 27;115(8):949-52
26249758 - Am J Transplant. 2016 Jan;16(1):99-110
19098714 - EMBO Rep. 2009 Feb;10(2):180-5
20098459 - Nat Rev Immunol. 2010 Feb;10(2):111-22
20199506 - Am J Transplant. 2010 Apr;10(4):713-9
24054804 - J Heart Lung Transplant. 2013 Oct;32(10):951-64
25176944 - Eur Heart J. 2014 Dec 1;35(45):3194-202
20413602 - N Engl J Med. 2010 May 20;362(20):1890-900
27510798 - Mol Biol Rep. 2016 Oct;43(10 ):1165-78
24216511 - J Clin Invest. 2013 Nov;123(11):4739-54
8820790 - J Heart Lung Transplant. 1996 Jul;15(7):728-35
23036329 - Methods. 2013 Jan;59(1):S1-6
18663219 - Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
25697852 - Circ Heart Fail. 2015 May;8(3):557-64
22026534 - Am J Transplant. 2012 Feb;12(2):458-68
22152163 - Expert Rev Mol Med. 2011 Dec 08;13:e37
26108462 - Cancer Epidemiol Biomarkers Prev. 2015 Sep;24(9):1381-7
23136949 - Am J Transplant. 2013 Jan;13(1):11-9
16611349 - Am J Transplant. 2006 May;6(5 Pt 1):1086-7
17178332 - J Heart Lung Transplant. 2006 Dec;25(12):1402-9
20643330 - J Heart Lung Transplant. 2010 Aug;29(8):914-56
24001411 - Transpl Immunol. 2013 Dec;29(1-4):123-9
18773077 - PLoS One. 2008 Sep 05;3(9):e3148
21383194 - Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5003-8
17178330 - J Heart Lung Transplant. 2006 Dec;25(12):1389-95
21402084 - Mutat Res. 2011 Dec 1;717(1-2):85-90
14573728 - N Engl J Med. 2003 Oct 23;349(17):1587-9
22282590 - J Am Soc Nephrol. 2012 Apr;23 (4):597-606
8476896 - J Heart Lung Transplant. 1993 Mar-Apr;12(2):239-43
23265908 - J Heart Lung Transplant. 2013 Feb;32(2):259-65
References_xml – volume: 15
  start-page: 728
  year: 1996
  ident: ref3
  article-title: Consistencies and controversies in the application of the International Society for Heart and Lung Transplantation working formulation for heart transplant biopsy specimens. Rapamycin Cardiac Rejection Treatment Trial Pathologists
  publication-title: J Heart Lung Transplant
– volume: 92
  start-page: 1
  year: 2011
  ident: ref6
  article-title: Peripheral blood sampling for the detection of allograft rejection: biomarker identification and validation
  publication-title: Transplantation
  doi: 10.1097/TP.0b013e318218e978
– volume: 108
  start-page: 5003
  year: 2011
  ident: ref18
  article-title: Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1019055108
– volume: 10
  start-page: 180
  year: 2009
  ident: ref28
  article-title: miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA
  publication-title: EMBO Rep
  doi: 10.1038/embor.2008.224
– volume: 29
  start-page: 914
  year: 2010
  ident: ref25
  article-title: The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients
  publication-title: J Heart Lung Transplant
  doi: 10.1016/j.healun.2010.05.034
– volume: 8
  start-page: 557
  year: 2015
  ident: ref26
  article-title: Randomized pilot trial of gene expression profiling versus heart biopsy in the first year after heart transplant: early invasive monitoring attenuation through gene expression trial
  publication-title: Circ Heart Fail
  doi: 10.1161/CIRCHEARTFAILURE.114.001658
– volume: 25
  start-page: 1389
  year: 2006
  ident: ref24
  article-title: Molecular testing in the management of cardiac transplant recipients: initial clinical experience
  publication-title: J Heart Lung Transplant
  doi: 10.1016/j.healun.2006.10.002
– volume: 12
  start-page: 239
  year: 1993
  ident: ref4
  article-title: Reproducibility of the acute rejection diagnosis in human cardiac allografts. The Stanford Classification and the International Grading System
  publication-title: J Heart Lung Transplant
– volume: 32
  start-page: 259
  year: 2013
  ident: ref27
  article-title: Predicting acute cardiac rejection from donor heart and pre-transplant recipient blood gene expression
  publication-title: J Heart Lung Transplant
  doi: 10.1016/j.healun.2012.11.008
– volume: 362
  start-page: 1890
  year: 2010
  ident: ref5
  article-title: Gene-expression profiling for rejection surveillance after cardiac transplantation
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa0912965
– volume: 35
  start-page: 3194
  year: 2014
  ident: ref32
  article-title: MicroRNAs as non-invasive biomarkers of heart transplant rejection
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehu346
– volume: 115
  start-page: 949
  year: 2007
  ident: ref20
  article-title: Benchmarks for the assessment of novel cardiovascular biomarkers
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.683110
– volume: 24
  start-page: 1381
  year: 2015
  ident: ref22
  article-title: microRNA Biomarker Discovery and High-Throughput DNA Sequencing Are Possible Using Long-term Archived Serum Samples
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-15-0289
– volume: 13
  start-page: 11
  year: 2013
  ident: ref10
  article-title: MicroRNAs as biomarkers in solid organ transplantation
  publication-title: Am J Transplant
  doi: 10.1111/j.1600-6143.2012.04313.x
– volume: 10
  start-page: 111
  year: 2010
  ident: ref13
  article-title: Physiological and pathological roles for microRNAs in the immune system
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2708
– volume: 59
  start-page: S1
  year: 2013
  ident: ref12
  article-title: Assessing sample and miRNA profile quality in serum and plasma or other biofluids
  publication-title: Methods
  doi: 10.1016/j.ymeth.2012.09.015
– volume: 13
  start-page: e37
  year: 2011
  ident: ref14
  article-title: Role of microRNAs in immunity and organ transplantation
  publication-title: Expert Rev Mol Med
  doi: 10.1017/S1462399411002080
– volume: 29
  start-page: 123
  year: 2013
  ident: ref33
  article-title: Differential expression and functions of microRNAs in liver transplantation and potential use as non-invasive biomarkers
  publication-title: Transpl Immunol
  doi: 10.1016/j.trim.2013.08.005
– volume: 25
  start-page: 1402
  year: 2006
  ident: ref1
  article-title: Utility of long-term surveillance endomyocardial biopsy: a multi-institutional analysis
  publication-title: J Heart Lung Transplant
  doi: 10.1016/j.healun.2006.10.003
– volume: 3
  start-page: e3148
  year: 2008
  ident: ref9
  article-title: Serum microRNAs are promising novel biomarkers
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0003148
– volume: 23
  start-page: 597
  year: 2012
  ident: ref29
  article-title: Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2011060543
– volume: 10
  start-page: 713
  year: 2010
  ident: ref15
  article-title: MicroRNAs as immune regulators: implications for transplantation
  publication-title: Am J Transplant
  doi: 10.1111/j.1600-6143.2010.03032.x
– volume: 3
  start-page: 37
  year: 2011
  ident: ref7
  article-title: Biomarkers in solid organ transplantation: establishing personalized transplantation medicine
  publication-title: Genome Med
  doi: 10.1186/gm253
– volume: 32
  start-page: 463
  year: 2013
  ident: ref11
  article-title: Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance
  publication-title: J Heart Lung Transplant
  doi: 10.1016/j.healun.2012.12.007
– volume: 105
  start-page: 10513
  year: 2008
  ident: ref17
  article-title: Circulating microRNAs as stable blood-based markers for cancer detection
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0804549105
– year: 2016
  ident: ref21
  article-title: Identification of extracellular miRNA in archived serum samples by next-generation sequencing from RNA extracted using multiple methods
  publication-title: Mol Biol Rep
– volume: 349
  start-page: 1587
  year: 2003
  ident: ref19
  article-title: Novel risk markers and clinical practice
  publication-title: N Engl J Med
  doi: 10.1056/NEJMp038136
– volume: 12
  start-page: 458
  year: 2012
  ident: ref31
  article-title: MicroRNA signature of intestinal acute cellular rejection in formalin-fixed paraffin-embedded mucosal biopsies
  publication-title: Am J Transplant
  doi: 10.1111/j.1600-6143.2011.03807.x
– volume: 717
  start-page: 85
  year: 2011
  ident: ref8
  article-title: Extracellular microRNA: a new source of biomarkers
  publication-title: Mutat Res
  doi: 10.1016/j.mrfmmm.2011.03.004
– volume: 6
  start-page: 1086
  year: 2006
  ident: ref23
  article-title: Methodological challenges of genomic research—the CARGO study
  publication-title: Am J Transplant
  doi: 10.1111/j.1600-6143.2006.01305.x
– year: 2015
  ident: ref30
  article-title: RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection
  publication-title: Am J Transplant
– volume: 32
  start-page: 951
  year: 2013
  ident: ref2
  article-title: The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report—2013; focus theme: age
  publication-title: J Heart Lung Transplant
  doi: 10.1016/j.healun.2013.08.006
– volume: 123
  start-page: 4739
  year: 2013
  ident: ref16
  article-title: Allogeneic T cell responses are regulated by a specific miRNA-mRNA network
  publication-title: J Clin Invest
  doi: 10.1172/JCI70013
– reference: 23384889 - J Heart Lung Transplant. 2013 Apr;32(4):463-6
– reference: 22152163 - Expert Rev Mol Med. 2011 Dec 08;13:e37
– reference: 27510798 - Mol Biol Rep. 2016 Oct;43(10 ):1165-78
– reference: 18773077 - PLoS One. 2008 Sep 05;3(9):e3148
– reference: 20098459 - Nat Rev Immunol. 2010 Feb;10(2):111-22
– reference: 16611349 - Am J Transplant. 2006 May;6(5 Pt 1):1086-7
– reference: 21494177 - Transplantation. 2011 Jul 15;92(1):1-9
– reference: 20643330 - J Heart Lung Transplant. 2010 Aug;29(8):914-56
– reference: 17325253 - Circulation. 2007 Feb 27;115(8):949-52
– reference: 22026534 - Am J Transplant. 2012 Feb;12(2):458-68
– reference: 23265908 - J Heart Lung Transplant. 2013 Feb;32(2):259-65
– reference: 22282590 - J Am Soc Nephrol. 2012 Apr;23 (4):597-606
– reference: 8476896 - J Heart Lung Transplant. 1993 Mar-Apr;12(2):239-43
– reference: 25697852 - Circ Heart Fail. 2015 May;8(3):557-64
– reference: 14573728 - N Engl J Med. 2003 Oct 23;349(17):1587-9
– reference: 23136949 - Am J Transplant. 2013 Jan;13(1):11-9
– reference: 25176944 - Eur Heart J. 2014 Dec 1;35(45):3194-202
– reference: 18663219 - Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
– reference: 24001411 - Transpl Immunol. 2013 Dec;29(1-4):123-9
– reference: 17178330 - J Heart Lung Transplant. 2006 Dec;25(12):1389-95
– reference: 26249758 - Am J Transplant. 2016 Jan;16(1):99-110
– reference: 20413602 - N Engl J Med. 2010 May 20;362(20):1890-900
– reference: 21658299 - Genome Med. 2011 Jun 08;3(6):37
– reference: 19098714 - EMBO Rep. 2009 Feb;10(2):180-5
– reference: 21383194 - Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5003-8
– reference: 8820790 - J Heart Lung Transplant. 1996 Jul;15(7):728-35
– reference: 24216511 - J Clin Invest. 2013 Nov;123(11):4739-54
– reference: 17178332 - J Heart Lung Transplant. 2006 Dec;25(12):1402-9
– reference: 21402084 - Mutat Res. 2011 Dec 1;717(1-2):85-90
– reference: 24054804 - J Heart Lung Transplant. 2013 Oct;32(10):951-64
– reference: 20199506 - Am J Transplant. 2010 Apr;10(4):713-9
– reference: 26108462 - Cancer Epidemiol Biomarkers Prev. 2015 Sep;24(9):1381-7
– reference: 23036329 - Methods. 2013 Jan;59(1):S1-6
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Snippet Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great...
Background Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of...
Background: Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of...
Background Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of...
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SubjectTerms Adaptor Proteins, Signal Transducing - blood
Adaptor Proteins, Signal Transducing - genetics
Adult
Bioindicators
Biology and life sciences
Biomarkers
Biomarkers - blood
Biopsy
Blood
C-Reactive Protein - metabolism
Calcineurin
Cardiology
Case-Control Studies
Clinical Laboratory Medicine
Clinical Medicine
Creatinine
Creatinine - blood
Cyclosporine - blood
Development and progression
Diagnostic software
Diagnostic systems
Female
Gene expression
Gene Expression Regulation
Genetic aspects
Graft rejection
Graft Rejection - blood
Graft Rejection - diagnosis
Graft Rejection - immunology
Graft Rejection - pathology
Heart
Heart Transplantation
Hospitals
Humans
Klinisk laboratoriemedicin
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Medicine and Health Sciences
MicroRNA
MicroRNAs
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
miRNA
Pathology
Patients
Physiological aspects
Prevention
Rejection
Research and Analysis Methods
Serum levels
Signal Transduction
Tacrolimus
Tacrolimus - blood
Transplantation
Transplants & implants
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Title Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation
URI https://www.ncbi.nlm.nih.gov/pubmed/28125729
https://www.proquest.com/docview/1862131932
https://www.proquest.com/docview/1865557557
https://www.proquest.com/docview/1868325429
https://pubmed.ncbi.nlm.nih.gov/PMC5268768
https://doaj.org/article/58e3247693cc40abb5f0f41b72af42b0
http://dx.doi.org/10.1371/journal.pone.0170842
Volume 12
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