Influence of oxytocin administration on somatosensory evoked magnetic fields induced by median nerve stimulation during hand action observation in healthy male volunteers

Watching another person’s hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this phenomenon, oxytocin should enhance these effects. This single-blinded, placebo-controlled, crossover study therefore used magnetoencephalogra...

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Published inPloS one Vol. 16; no. 3; p. e0249167
Main Authors Ono, Yasuki, Hirosawa, Tetsu, Hasegawa, Chiaki, Ikeda, Takashi, Kudo, Kiwamu, Naito, Nobushige, Yoshimura, Yuko, Kikuchi, Mitsuru
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 31.03.2021
Public Library of Science (PLoS)
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ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0249167

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Abstract Watching another person’s hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this phenomenon, oxytocin should enhance these effects. This single-blinded, placebo-controlled, crossover study therefore used magnetoencephalography (MEG) to investigate SEFs following electrical stimulation of the right median nerve in 20 healthy male participants during hand movement observation, which were initially presented as static images followed by moving images. The participants were randomly assigned to receive either oxytocin or saline during the first trial, with the treatment being reversed during a second trial. Log-transformed ratios of the N20 and N30 amplitudes were calculated and compared between moving and static images observations. Phase locking (calculated using intertrial phase coherence) of brain oscillations was also analyzed to evaluate alpha, beta and gamma rhythm changes after oxytocin administration. Log N30 ratios showed no significant changes after placebo administration but showed a decreasing tendency (albeit not significant) after placebo administration, which may suggest mirror neuron system involvement. In contrast, log N20 ratios were increased after placebo administration, but showed no significant change after oxytocin administration. Interestingly, the gamma band activity around N20 increased after placebo administration, suggesting that oxytocin exerted an analgesic effect on median nerve stimulation, and inhibited the gamma band increase. Oxytocin might therefore modulate not only the mirror neuron system, but also the sensory processing associated with median nerve stimulation.
AbstractList About the Authors: Yasuki Ono Roles Data curation, Formal analysis, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing * E-mail: spfy7ff9@wish.ocn.ne.jp Affiliations Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan, Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan ORCID logo https://orcid.org/0000-0002-3374-4407 Tetsu Hirosawa Roles Data curation Affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan Chiaki Hasegawa Roles Data curation, Formal analysis Affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan Takashi Ikeda Roles Formal analysis, Methodology Affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan Kiwamu Kudo Roles Formal analysis Affiliation: Ricoh Company, Ltd, Kanazawa, Japan Nobushige Naito Roles Data curation Affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan Yuko Yoshimura Roles Data curation Affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan Mitsuru Kikuchi Roles Conceptualization, Supervision Affiliation: Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan Introduction Somatosensory inputs from the periphery reach the contralateral primary somatosensory cortex (SI), which subsequently activates the ipsilateral SI and bilateral secondary somatosensory cortex (SII) [1,2]. A recent study with a sequential EEG-functional magnetic resonance imaging (fMRI) design showed similar patterns of mirror neuron activity and mu suppression; however, mu suppression was not confined to the mirror neuron areas, but involved a range of subcortical areas related to motor preparation and visual sensitivity [10]. [...]they also found that the increase in N30 amplitude correlated with central and precentral alpha and parietal beta phase locking of ongoing electroencephalography (EEG) signals. [9] suggested that mu and beta suppression over the sensory-motor regions reflected a resonance system in the human brain analogous to mirror neuron activity. [...]we hypothesized that oxytocin would increase the N30 amplitude during hand movement observation, and enhance alpha and beta suppression during hand movement.
Watching another person’s hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this phenomenon, oxytocin should enhance these effects. This single-blinded, placebo-controlled, crossover study therefore used magnetoencephalography (MEG) to investigate SEFs following electrical stimulation of the right median nerve in 20 healthy male participants during hand movement observation, which were initially presented as static images followed by moving images. The participants were randomly assigned to receive either oxytocin or saline during the first trial, with the treatment being reversed during a second trial. Log-transformed ratios of the N20 and N30 amplitudes were calculated and compared between moving and static images observations. Phase locking (calculated using intertrial phase coherence) of brain oscillations was also analyzed to evaluate alpha, beta and gamma rhythm changes after oxytocin administration. Log N30 ratios showed no significant changes after placebo administration but showed a decreasing tendency (albeit not significant) after placebo administration, which may suggest mirror neuron system involvement. In contrast, log N20 ratios were increased after placebo administration, but showed no significant change after oxytocin administration. Interestingly, the gamma band activity around N20 increased after placebo administration, suggesting that oxytocin exerted an analgesic effect on median nerve stimulation, and inhibited the gamma band increase. Oxytocin might therefore modulate not only the mirror neuron system, but also the sensory processing associated with median nerve stimulation.
Watching another person's hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this phenomenon, oxytocin should enhance these effects. This single-blinded, placebo-controlled, crossover study therefore used magnetoencephalography (MEG) to investigate SEFs following electrical stimulation of the right median nerve in 20 healthy male participants during hand movement observation, which were initially presented as static images followed by moving images. The participants were randomly assigned to receive either oxytocin or saline during the first trial, with the treatment being reversed during a second trial. Log-transformed ratios of the N20 and N30 amplitudes were calculated and compared between moving and static images observations. Phase locking (calculated using intertrial phase coherence) of brain oscillations was also analyzed to evaluate alpha, beta and gamma rhythm changes after oxytocin administration. Log N30 ratios showed no significant changes after placebo administration but showed a decreasing tendency (albeit not significant) after placebo administration, which may suggest mirror neuron system involvement. In contrast, log N20 ratios were increased after placebo administration, but showed no significant change after oxytocin administration. Interestingly, the gamma band activity around N20 increased after placebo administration, suggesting that oxytocin exerted an analgesic effect on median nerve stimulation, and inhibited the gamma band increase. Oxytocin might therefore modulate not only the mirror neuron system, but also the sensory processing associated with median nerve stimulation.Watching another person's hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this phenomenon, oxytocin should enhance these effects. This single-blinded, placebo-controlled, crossover study therefore used magnetoencephalography (MEG) to investigate SEFs following electrical stimulation of the right median nerve in 20 healthy male participants during hand movement observation, which were initially presented as static images followed by moving images. The participants were randomly assigned to receive either oxytocin or saline during the first trial, with the treatment being reversed during a second trial. Log-transformed ratios of the N20 and N30 amplitudes were calculated and compared between moving and static images observations. Phase locking (calculated using intertrial phase coherence) of brain oscillations was also analyzed to evaluate alpha, beta and gamma rhythm changes after oxytocin administration. Log N30 ratios showed no significant changes after placebo administration but showed a decreasing tendency (albeit not significant) after placebo administration, which may suggest mirror neuron system involvement. In contrast, log N20 ratios were increased after placebo administration, but showed no significant change after oxytocin administration. Interestingly, the gamma band activity around N20 increased after placebo administration, suggesting that oxytocin exerted an analgesic effect on median nerve stimulation, and inhibited the gamma band increase. Oxytocin might therefore modulate not only the mirror neuron system, but also the sensory processing associated with median nerve stimulation.
Audience Academic
Author Hirosawa, Tetsu
Ikeda, Takashi
Naito, Nobushige
Hasegawa, Chiaki
Kikuchi, Mitsuru
Ono, Yasuki
Kudo, Kiwamu
Yoshimura, Yuko
AuthorAffiliation 4 Ricoh Company, Ltd, Kanazawa, Japan
1 Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
3 Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan
2 Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
Chiba Daigaku, JAPAN
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CitedBy_id crossref_primary_10_1089_cyber_2023_0040
crossref_primary_10_3389_fnins_2022_858070
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SSID ssj0053866
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Snippet Watching another person’s hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this...
Watching another person's hand movement modulates somatosensory evoked magnetic fields (SEFs). Assuming that the mirror neuron system may have a role in this...
About the Authors: Yasuki Ono Roles Data curation, Formal analysis, Project administration, Supervision, Validation, Visualization, Writing – original draft,...
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StartPage e0249167
SubjectTerms Amplitudes
Autism
Beta phase
Biology and Life Sciences
Biomagnetism
Brain mapping
Children
Cortex (parietal)
Cortex (somatosensory)
Data analysis
EEG
Electroencephalography
Frequency dependence
Functional magnetic resonance imaging
Genetic aspects
Graduate schools
Graduate studies
Keyboards
Locking
Magnetic fields
Magnetic resonance
Magnetic resonance imaging
Median nerve
Medical science
Medicine and Health Sciences
Mental development
Nervous system
Neurobiology
Neuroimaging
Neuropsychiatry
Neurosciences
Oxytocin
Physiological aspects
Psychiatry
Research and Analysis Methods
Research facilities
Resonance
Schizophrenia
Sensorimotor integration
Social Sciences
Somatosensory cortex
Somatosensory evoked magnetic fields
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Title Influence of oxytocin administration on somatosensory evoked magnetic fields induced by median nerve stimulation during hand action observation in healthy male volunteers
URI https://www.ncbi.nlm.nih.gov/pubmed/33788881
https://www.proquest.com/docview/2507667996
https://www.proquest.com/docview/2507729997
https://pubmed.ncbi.nlm.nih.gov/PMC8011787
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0249167&type=printable
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http://dx.doi.org/10.1371/journal.pone.0249167
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