Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling - Adhikari, Deepak; Risal, Sanjiv; Liu, Kui; Shen, Yan (PloS one, 2013)
Keywords: 1-Phosphatidylinositol 3-kinase; Activation; AKT protein; Animals; Biology; Cell cycle; Cell growth; Chemotherapy; Female; Follicles; Gametes; Gene Expression Regulation, Developmental; Germ Cells - growth & development; Germ Cells - metabolism; growth; Homology; Kinases; Life span; Mammals; Mechanistic Target of Rapamycin Complex 1; Medicine; Mice; Molecular Biology; Molekylärbiologi; mouse ovary; Multiprotein Complexes; Mutation; Oocytes; Oocytes - drug effects; Oocytes - growth & development; Oocytes - metabolism; Ovarian Follicle - drug effects; Ovarian Follicle - growth & development; Ovarian Follicle - metabolism; ovarian toxicity; ovotoxicity; pathway; Pharmacology; Phosphatases; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Preservation; Primary Ovarian Insufficiency - genetics; Primary Ovarian Insufficiency - metabolism; Primary Ovarian Insufficiency - physiopathology; Proteins - antagonists & inhibitors; Proteins - genetics; Proteins - metabolism; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - deficiency; PTEN Phosphohydrolase - genetics; PTEN protein; Rapamycin; Reproductive status; Rodents; Signal Transduction - drug effects; Signaling; Sirolimus - administration & dosage; survival; Tensin; TOR protein; TOR Serine-Threonine Kinases