Patterns of Individual Variation in Visual Pathway Structure and Function in the Sighted and Blind

• Published in: PloS one Vol. 11; no. 11; p. e0164677
• Main Authors: Aguirre, Geoffrey K., Datta, Ritobrato, Benson, Noah C., Prasad, Sashank, Jacobson, Samuel G., Cideciyan, Artur V., Bridge, Holly, Watkins, Kate E., Butt, Omar H., Dain, Aleksandra S., Brandes, Lauren, Gennatas, Efstathios D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.11.2016; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Age; Alterations; Anatomy; Anisotropy; Biology and Life Sciences; Blind people; Blindness; Blindness - pathology; Blindness - physiopathology; Brain; Brain research; Clusters; Corpus callosum; Cross-modal; Female; Functional magnetic resonance imaging; Glaucoma; Humans; Lateral geniculate nucleus; Male; Medicine; Medicine and Health Sciences; Middle Aged; Neuroimaging; Neurology; Neurosciences; NMR; Nuclear magnetic resonance; Optic chiasm; Physical Sciences; Research and Analysis Methods; Sensory integration; Social Sciences; Structure-function relationships; Surface area; Variation; Visual cortex; Visual Pathways - pathology; Visual Pathways - physiopathology; Visual perception; White Matter - pathology; White Matter - physiopathology; Young Adult; United Kingdom > UK; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0164677

Many structural and functional brain alterations accompany blindness, with substantial individual variation in these effects. In normally sighted people, there is correlated individual variation in some visual pathway structures. Here we examined if the changes in brain anatomy produced by blindness alter the patterns of anatomical variation found in the sighted. We derived eight measures of central visual pathway anatomy from a structural image of the brain from 59 sighted and 53 blind people. These measures showed highly significant differences in mean size between the sighted and blind cohorts. When we examined the measurements across individuals within each group we found three clusters of correlated variation, with V1 surface area and pericalcarine volume linked, and independent of the thickness of V1 cortex. These two clusters were in turn relatively independent of the volumes of the optic chiasm and lateral geniculate nucleus. This same pattern of variation in visual pathway anatomy was found in the sighted and the blind. Anatomical changes within these clusters were graded by the timing of onset of blindness, with those subjects with a post-natal onset of blindness having alterations in brain anatomy that were intermediate to those seen in the sighted and congenitally blind. Many of the blind and sighted subjects also contributed functional MRI measures of cross-modal responses within visual cortex, and a diffusion tensor imaging measure of fractional anisotropy within the optic radiations and the splenium of the corpus callosum. We again found group differences between the blind and sighted in these measures. The previously identified clusters of anatomical variation were also found to be differentially related to these additional measures: across subjects, V1 cortical thickness was related to cross-modal activation, and the volume of the optic chiasm and lateral geniculate was related to fractional anisotropy in the visual pathway. Our findings show that several of the structural and functional effects of blindness may be reduced to a smaller set of dimensions. It also seems that the changes in the brain that accompany blindness are on a continuum with normal variation found in the sighted.