Application of Ancestry Informative Markers to Association Studies in European Americans
[...]depending on the number of case and control samples and the cost of prescreening with AIM panels, it may be advantageous to first match cases and controls for ancestry. [...]if a variant is more polymorphic or has higher relative risk in samples of a particular ancestry, then a more genetically...
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Published in | PLoS genetics Vol. 4; no. 1; p. e5 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
2008
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
ISSN | 1553-7390 1553-7404 1553-7404 |
DOI | 10.1371/journal.pgen.0040005 |
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Abstract | [...]depending on the number of case and control samples and the cost of prescreening with AIM panels, it may be advantageous to first match cases and controls for ancestry. [...]if a variant is more polymorphic or has higher relative risk in samples of a particular ancestry, then a more genetically homogeneous group of subjects (for example, focusing on Ashkenazi Jewish ancestry [14]) may be more likely to reveal that variant. |
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AbstractList | [...]depending on the number of case and control samples and the cost of prescreening with AIM panels, it may be advantageous to first match cases and controls for ancestry. [...]if a variant is more polymorphic or has higher relative risk in samples of a particular ancestry, then a more genetically homogeneous group of subjects (for example, focusing on Ashkenazi Jewish ancestry [14]) may be more likely to reveal that variant. [...]depending on the number of case and control samples and the cost of prescreening with AIM panels, it may be advantageous to first match cases and controls for ancestry. [...]if a variant is more polymorphic or has higher relative risk in samples of a particular ancestry, then a more genetically homogeneous group of subjects (for example, focusing on Ashkenazi Jewish ancestry [14]) may be more likely to reveal that variant. |
Audience | Academic |
Author | Price, Alkes L. Seldin, Michael F. |
AuthorAffiliation | University of Chicago, United States of America |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18208330$$D View this record in MEDLINE/PubMed |
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Cites_doi | 1553-7404(2008)004[e4.:AAAOEG]2.0.CO;2 1553-7404(2006)002[1339:EPSCON]2.0.CO;2 1061-4036(2005)037[0868:DSIAEA]2.0.CO;2 1079-5642(1997)017[2548:COFVGT]2.0.CO;2 1553-7404(2008)004[e236.:DTAOEA]2.0.CO;2 0193-4511(2006)314[1461:AGASII]2.0.CO;2 1061-4036(2006)038[0904:PCACFS]2.0.CO;2 0002-9297(2007)081[0559:PATFWA]2.0.CO;2 0002-9297(2003)072[1492:COCOGA]2.0.CO;2 0017-5749(1993)034[0517:FERFIB]2.0.CO;2 0002-9297(2007)080[0948:MEPSWM]2.0.CO;2 1061-4036(2005)037[0090:AIEOTI]2.0.CO;2 0022-3050(2003)074[1159:SIAICE]2.0.CO;2 1355-6037(2000)084[0238:CHDIIN]2.0.CO;2 1061-4036(2005)037[1243:PSDBAG]2.0.CO;2 |
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Copyright | COPYRIGHT 2008 Public Library of Science 2008 Seldin and Price. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Seldin MF, Price AL (2008) Application of Ancestry Informative Markers to Association Studies in European Americans. PLoS Genet 4(1): e5. doi:10.1371/journal.pgen.0040005 2008 Seldin and Price. 2008 |
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SubjectTerms | Alleles Associations Chromosomes, Human European Continental Ancestry Group - genetics Gene Frequency Genealogy Genetic Markers Genetics Genetics and Genomics Genetics, Population Geography Health risk assessment Humans Ireland - ethnology Jews - ethnology Methods Oligonucleotide Array Sequence Analysis Physical Chromosome Mapping Population Principal components analysis Studies United States |
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Title | Application of Ancestry Informative Markers to Association Studies in European Americans |
URI | https://www.ncbi.nlm.nih.gov/pubmed/18208330 https://www.proquest.com/docview/1313475109 https://www.proquest.com/docview/70246343 https://pubmed.ncbi.nlm.nih.gov/PMC2211545 https://doaj.org/article/2af83bfa7bff460aaf0a91e519c97c3e http://dx.doi.org/10.1371/journal.pgen.0040005 |
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