A New Safety Concern for Glaucoma Treatment Demonstrated by Mass Spectrometry Imaging of Benzalkonium Chloride Distribution in the Eye, an Experimental Study in Rabbits - Brignole-Baudouin, Françoise; Desbenoit, Nicolas; Hamm, Gregory; Liang, Hong; Both, Jean-Pierre; Brunelle, Alain; Fournier, Isabelle; Guerineau, Vincent; Legouffe, Raphael; Stauber, Jonathan; Touboul, David; Wisztorski, Maxence; et al. (PloS one, 2012)
Keywords: Animals; Anti-Infective Agents, Local - adverse effects; Apoptosis; Benzalkonium chloride; Benzalkonium Compounds - adverse effects; Biology; CD45 antigen; Cell activation; Cellular stress response; Chemical Sciences; Chlorides; Data analysis; Data processing; Desorption; Eye; Eye (anatomy); Eye - drug effects; Eye - pathology; Glaucoma; Glaucoma - drug therapy; Glaucoma - metabolism; Immunohistochemistry - methods; Infiltration; Inflammation; Information management; Intermediate filament proteins; Ionization; Ions; Lasers; Leukocyte Common Antigens - biosynthesis; Lipids; Mass spectrometers; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Medicine; Neuroglia - cytology; Ophthalmic agents; Ophthalmic Solutions - adverse effects; Ophthalmology; Optic nerve; Optic Nerve - drug effects; Organic chemistry; Preservatives; Rabbits; Retina; Retina - drug effects; Safety; Sample preparation; Scientific imaging; Spectrometers; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy; Stainless steel; Steel plates; Surface active agents; Time Factors; Tissues; Toxicity testing; Tragacanth; Vimentin; Vimentin - biosynthesis; France