A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population - Cabeza Barrera, José; Dávila-Fajardo, Cristina Lucía; Tong, Hoi Y; Perea León, Laura María; Martínez-González, Luis Javier; Blanco Bañares, María J; Fernández-Capitán, Carmen; Borobia, Alberto M; Lubomirov, Rubin; Díaz-Villamarín, Xando; Carcas, Antonio J (PLOS ONE, 2016)
Keywords: A new algorithm; Acenocoumarol; Acenocoumarol - administration & dosage; Acenocoumarol - pharmacology; Acenocoumarol dosage; Aged; Algorithms; Amiodarone; Analysis; Anticoagulants; Anticoagulants - administration & dosage; Anticoagulants - pharmacology; Appropriate acenocoumarol dosag; Biology and Life Sciences; Biomedical research; Cardiac arrhythmia; Dependent variables; Dosage; Drug dosages; Embolisms; Farmacia; Female; Fibrillation; Genetic algorithms; Genetic polymorphisms; Genomics; Genotypes; Genotyping; Health care; Humans; Independent variables; Male; Medical Subject Headings::Check Tags::Female; Medical Subject Headings::Check Tags::Male; Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Hematologic Agents::Anticoagulants; Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Benzopyrans::Coumarins::4-Hydroxycoumarins::Acenocoumarol; Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Pharmacology::Pharmacogenetics; Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain; Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged; Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged; Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans; Medical Subject Headings::Phenomena and Processes::Mathematical Concepts::Algorithms; Medicina; Medicine; Medicine and Health Sciences; Middle Aged; Patients; Pharmacodynamics; Pharmacogenetic; Pharmacogenetics; Pharmacokinetics; Pharmacology; Pharmacy; Physical Sciences; Q; Quality of life; R; Research and Analysis Methods; Research Article; Science; Spain; Stable anticoagulation; Thromboembolism; Spain