Melanoma addiction to the long non-coding RNA SAMMSON
A known oncogene, MITF , resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene, SAMMSON , is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic targ...
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| Published in | Nature (London) Vol. 531; no. 7595; pp. 518 - 522 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
24.03.2016
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0028-0836 1476-4687 |
| DOI | 10.1038/nature17161 |
Cover
| Abstract | A known oncogene,
MITF
, resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene,
SAMMSON
, is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic target for anti-melanoma therapy.
An oncogenic non-coding RNA
The known oncogene
MITF
is found in the 3p13–3p14 region of chromosome 3 that is amplified in melanomas and associated with poor prognosis. This study shows that a long non-coding RNA,
SAMMSON
, also lies in this region and is co-gained with
MITF
.
SAMMSON
interacts with p32 and thereby affects mitochondrial function in a pro-oncogenic manner.
SAMMSON
depletion sensitizes melanoma cells to MAPK-targeting therapeutics
in vivo
and in patient-derived xenograft models. These results point to
SAMMSON
as a potentially useful biomarker for malignancy and as an anti-melanoma therapeutic target.
Focal amplifications of chromosome 3p13–3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene
MITF
resides at the epicentre of this amplicon
1
. However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA (lncRNA) gene
SAMMSON
is consistently co-gained with
MITF
. In addition,
SAMMSON
is a target of the lineage-specific transcription factor SOX10 and its expression is detectable in more than 90% of human melanomas. Whereas exogenous
SAMMSON
increases the clonogenic potential in
trans
,
SAMMSON
knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and
BRAF
,
NRAS
or
TP53
mutational status. Moreover,
SAMMSON
targeting sensitizes melanoma to MAPK-targeting therapeutics both
in vitro
and in patient-derived xenograft models. Mechanistically,
SAMMSON
interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function. Our results indicate that silencing of the lineage addiction oncogene
SAMMSON
disrupts vital mitochondrial functions in a cancer-cell-specific manner; this silencing is therefore expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses. |
|---|---|
| AbstractList | A known oncogene, MITF, resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene, SAMMSON, is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic target for anti-melanoma therapy. Focal amplifications of chromosome 3p13-3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the epicentre of this amplicon1. However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA (lncRNA) gene SAMMSON is consistently co-gained with MITF. In addition, SAMMSON is a target of the lineage-specific transcription factor SOX10 and its expression is detectable in more than 90% of human melanomas. Whereas exogenous SAMMSON increases the clonogenic potential in trans, SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Moreover, SAMMSON targeting sensitizes melanoma to MAPK-targeting therapeutics both in vitro and in patient-derived xenograft models. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function. Our results indicate that silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner; this silencing is therefore expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses. Focal amplifications of chromosome 3p13-3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the epicentre of this amplicon. However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA (lncRNA) gene SAMMSON is consistently co-gained with MITF. In addition, SAMMSON is a target of the lineage-specific transcription factor SOX10 and its expression is detectable in more than 90% of human melanomas. Whereas exogenous SAMMSON increases the clonogenic potential in trans, SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Moreover, SAMMSON targeting sensitizes melanoma to MAPK-targeting therapeutics both in vitro and in patient-derived xenograft models. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function. Our results indicate that silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner; this silencing is therefore expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses. A known oncogene, MITF , resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene, SAMMSON , is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic target for anti-melanoma therapy. An oncogenic non-coding RNA The known oncogene MITF is found in the 3p13–3p14 region of chromosome 3 that is amplified in melanomas and associated with poor prognosis. This study shows that a long non-coding RNA, SAMMSON , also lies in this region and is co-gained with MITF . SAMMSON interacts with p32 and thereby affects mitochondrial function in a pro-oncogenic manner. SAMMSON depletion sensitizes melanoma cells to MAPK-targeting therapeutics in vivo and in patient-derived xenograft models. These results point to SAMMSON as a potentially useful biomarker for malignancy and as an anti-melanoma therapeutic target. Focal amplifications of chromosome 3p13–3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the epicentre of this amplicon 1 . However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA (lncRNA) gene SAMMSON is consistently co-gained with MITF . In addition, SAMMSON is a target of the lineage-specific transcription factor SOX10 and its expression is detectable in more than 90% of human melanomas. Whereas exogenous SAMMSON increases the clonogenic potential in trans , SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF , NRAS or TP53 mutational status. Moreover, SAMMSON targeting sensitizes melanoma to MAPK-targeting therapeutics both in vitro and in patient-derived xenograft models. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function. Our results indicate that silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner; this silencing is therefore expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses. A known oncogene, MITF, resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene, SAMMSON, is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic target for anti-melanoma therapy. An oncogenic non-coding RNA The known oncogene MITF is found in the 3p13-3p14 region of chromosome 3 that is amplified in melanomas and associated with poor prognosis. This study shows that a long non-coding RNA, SAMMSON, also lies in this region and is co-gained with MITF. SAMMSON interacts with p32 and thereby affects mitochondrial function in a pro-oncogenic manner. SAMMSON depletion sensitizes melanoma cells to MAPK-targeting therapeutics in vivo and in patient-derived xenograft models. These results point to SAMMSON as a potentially useful biomarker for malignancy and as an anti-melanoma therapeutic target. Focal amplifications of chromosome 3p13-3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the epicentre of this amplicon.sup.1. However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA (lncRNA) gene SAMMSON is consistently co-gained with MITF. In addition, SAMMSON is a target of the lineage-specific transcription factor SOX10 and its expression is detectable in more than 90% of human melanomas. Whereas exogenous SAMMSON increases the clonogenic potential in trans, SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Moreover, SAMMSON targeting sensitizes melanoma to MAPK-targeting therapeutics both in vitro and in patient-derived xenograft models. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function. Our results indicate that silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner; this silencing is therefore expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses. Focal amplifications of chromosome 3p13-3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the epicentre of this amplicon (1). However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA (lncRNA) gene SAMMSON is consistently co-gained with MITF. In addition, SAMMSON is a target of the lineage-specific transcription factor SOX10 and its expression is detectable in more than 90% of human melanomas. Whereas exogenous SAMMSON increases the clonogenic potential in trans, SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Moreover, SAMMSON targeting sensitizes melanoma to MAPK-targeting therapeutics both in vitro and in patient-derived xenograft models. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function. Our results indicate that silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner; this silencing is therefore expected to deliver highly effective and tissue-restricted antimelanoma therapeutic responses. |
| Audience | Academic |
| Author | Aerts, Stein Baatsen, Pieter Vandesompele, Jo Vendramin, Roberto Eyckerman, Sven Leonelli, Carina Rogiers, Aljosja Hermans, Els Lafontaine, Denis L. J. Mestdagh, Pieter Radaelli, Enrico Vanderheyden, Katrien Amant, Frederic Leucci, Eleonora Fiers, Mark Wouters, Jasper Van Aelst, Stefan Spinazzi, Marco Marine, Jean-Christophe van den Oord, Joost Gevaert, Kris Davidson, Irwin Laurette, Patrick de Strooper, Bart |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27008969$$D View this record in MEDLINE/PubMed https://hal.science/hal-02086933$$DView record in HAL |
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| Cites_doi | 10.1038/cdd.2015.34 10.1038/sj.onc.1209599 10.1038/nrm4051 10.1101/gad.189365.112 10.1016/j.cub.2013.02.019 10.7554/eLife.06857 10.1074/jbc.272.39.24363 10.1093/molehr/gau039 10.1128/MCB.01101-09 10.1042/BJ20121829 10.1016/j.neuroscience.2011.10.003 10.1186/gb-2009-10-6-r64 10.1038/ncomms7683 10.1016/j.tibs.2010.05.003 10.1158/0008-5472.CAN-07-6752 10.1093/nar/gks774 10.1016/j.ccr.2012.11.020 10.1111/j.1349-7006.2010.01828.x 10.1038/nature03664 10.1038/nature14443 10.1016/j.cell.2009.08.005 10.1056/NEJMoa1002011 10.1016/j.ccr.2013.02.003 10.1111/j.1755-148X.2010.00711.x 10.1038/nature14859 10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2 10.1038/nature14951 10.18632/oncotarget.2708 10.1038/nm.2863 10.1016/j.cell.2015.03.025 |
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| Keywords | Long Noncoding Pair 3 Cell Proliferation RNA Humans Molecular Targeted Therapy Mitochondrial Proteins Carcinogenesis Gene Knockdown Techniques SOXE Transcription Factors Female Clone Cells Chromosomes Oncogenes Mitogen-Activated Protein Kinases Human Cell Survival mitochondria melanoma Xenograft Model Antitumor Assays Microphthalmia-Associated Transcription Factor Cell Lineage Gene Amplification Animals Mice |
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| References | Fantin, Leder (CR24) 2006; 25 Vazquez (CR25) 2013; 23 Fogal (CR11) 2015; 6 McHugh (CR7) 2015; 521 Yagi (CR14) 2012; 40 Gembarska (CR2) 2012; 18 Richter (CR23) 2013; 23 Amamoto (CR9) 2011; 102 Muta, Kang, Kitajima, Fujiwara, Hamasaki (CR13) 1997; 272 Fogal (CR10) 2010; 30 Matos (CR16) 2014; 20 Haq (CR26) 2013; 23 Dang (CR28) 2012; 26 Harris, Baxter, Loftus, Pavan (CR4) 2010; 23 Li, Wan, Xie, Chung (CR17) 2011; 199 Verfaillie (CR3) 2015; 6 Mestdagh (CR30) 2009; 10 Wang, Chen (CR21) 2015; 524 Flaherty (CR6) 2010; 363 Wrobel (CR22) 2015; 524 Richter-Dennerlein, Dennerlein, Rehling (CR19) 2015; 16 Chu (CR8) 2015; 161 Wise, Thompson (CR27) 2010; 35 Jiao (CR18) 2015; 22 Chacinska, Koehler, Milenkovic, Lithgow, Pfanner (CR20) 2009; 138 Hu (CR15) 2013; 453 Garraway (CR1) 2005; 436 Fogal, Zhang, Krajewski, Ruoslahti (CR12) 2008; 68 Laurette (CR5) 2015; 4 Perkins, Pappin, Creasy, Cottrell (CR29) 1999; 20 X Wang (BFnature17161_CR21) 2015; 524 P Matos (BFnature17161_CR16) 2014; 20 DN Perkins (BFnature17161_CR29) 1999; 20 VR Fantin (BFnature17161_CR24) 2006; 25 L Wrobel (BFnature17161_CR22) 2015; 524 P Mestdagh (BFnature17161_CR30) 2009; 10 CA McHugh (BFnature17161_CR7) 2015; 521 F Vazquez (BFnature17161_CR25) 2013; 23 DR Wise (BFnature17161_CR27) 2010; 35 C Chu (BFnature17161_CR8) 2015; 161 U Richter (BFnature17161_CR23) 2013; 23 Y Li (BFnature17161_CR17) 2011; 199 LA Garraway (BFnature17161_CR1) 2005; 436 KT Flaherty (BFnature17161_CR6) 2010; 363 A Gembarska (BFnature17161_CR2) 2012; 18 CV Dang (BFnature17161_CR28) 2012; 26 ML Harris (BFnature17161_CR4) 2010; 23 R Amamoto (BFnature17161_CR9) 2011; 102 V Fogal (BFnature17161_CR12) 2008; 68 R Richter-Dennerlein (BFnature17161_CR19) 2015; 16 A Chacinska (BFnature17161_CR20) 2009; 138 A Verfaillie (BFnature17161_CR3) 2015; 6 V Fogal (BFnature17161_CR11) 2015; 6 M Yagi (BFnature17161_CR14) 2012; 40 R Haq (BFnature17161_CR26) 2013; 23 T Muta (BFnature17161_CR13) 1997; 272 H Jiao (BFnature17161_CR18) 2015; 22 V Fogal (BFnature17161_CR10) 2010; 30 P Laurette (BFnature17161_CR5) 2015; 4 M Hu (BFnature17161_CR15) 2013; 453 27377824 - Sci Data. 2016;3:160052 27056832 - Cancer Discov. 2016 May;6(5):470 27165740 - Cancer Cell. 2016 May 9;29(5):619-21 |
| References_xml | – volume: 22 start-page: 1812 year: 2015 end-page: 1823 ident: CR18 article-title: Chaperone-like protein p32 regulates ULK1 stability and autophagy publication-title: Cell Death Differ. doi: 10.1038/cdd.2015.34 – volume: 25 start-page: 4787 year: 2006 end-page: 4797 ident: CR24 article-title: Mitochondriotoxic compounds for cancer therapy publication-title: Oncogene doi: 10.1038/sj.onc.1209599 – volume: 16 start-page: 586 year: 2015 end-page: 592 ident: CR19 article-title: Integrating mitochondrial translation into the cellular context publication-title: Nature Rev. Mol. Cell Biol. doi: 10.1038/nrm4051 – volume: 26 start-page: 877 year: 2012 end-page: 890 ident: CR28 article-title: Links between metabolism and cancer publication-title: Genes Dev. doi: 10.1101/gad.189365.112 – volume: 23 start-page: 535 year: 2013 end-page: 541 ident: CR23 article-title: A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation publication-title: Curr. Biol. doi: 10.1016/j.cub.2013.02.019 – volume: 4 start-page: 06857 year: 2015 ident: CR5 article-title: Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells publication-title: eLife doi: 10.7554/eLife.06857 – volume: 272 start-page: 24363 year: 1997 end-page: 24370 ident: CR13 article-title: p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.39.24363 – volume: 20 start-page: 745 year: 2014 end-page: 755 ident: CR16 article-title: A role for the mitochondrial-associated protein p32 in regulation of trophoblast proliferation publication-title: Mol. Hum. Reprod. doi: 10.1093/molehr/gau039 – volume: 30 start-page: 1303 year: 2010 end-page: 1318 ident: CR10 article-title: Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01101-09 – volume: 453 start-page: 381 year: 2013 end-page: 391 ident: CR15 article-title: p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival publication-title: Biochem. J. doi: 10.1042/BJ20121829 – volume: 199 start-page: 346 year: 2011 end-page: 358 ident: CR17 article-title: p32 regulates mitochondrial morphology and dynamics through parkin publication-title: Neuroscience doi: 10.1016/j.neuroscience.2011.10.003 – volume: 10 start-page: R64 year: 2009 ident: CR30 article-title: A novel and universal method for microRNA RT–qPCR data normalization publication-title: Genome Biol. doi: 10.1186/gb-2009-10-6-r64 – volume: 6 start-page: 6683 year: 2015 ident: CR3 article-title: Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state publication-title: Nature Commun doi: 10.1038/ncomms7683 – volume: 35 start-page: 427 year: 2010 end-page: 433 ident: CR27 article-title: Glutamine addiction: a new therapeutic target in cancer publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2010.05.003 – volume: 68 start-page: 7210 year: 2008 end-page: 7218 ident: CR12 article-title: Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-6752 – volume: 40 start-page: 9717 year: 2012 end-page: 9737 ident: CR14 article-title: p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks774 – volume: 23 start-page: 287 year: 2013 end-page: 301 ident: CR25 article-title: PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.11.020 – volume: 102 start-page: 639 year: 2011 end-page: 647 ident: CR9 article-title: Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2010.01828.x – volume: 436 start-page: 117 year: 2005 end-page: 122 ident: CR1 article-title: Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma publication-title: Nature doi: 10.1038/nature03664 – volume: 521 start-page: 232 year: 2015 end-page: 236 ident: CR7 article-title: The lncRNA interacts directly with SHARP to silence transcription through HDAC3 publication-title: Nature doi: 10.1038/nature14443 – volume: 138 start-page: 628 year: 2009 end-page: 644 ident: CR20 article-title: Importing mitochondrial proteins: machineries and mechanisms publication-title: Cell doi: 10.1016/j.cell.2009.08.005 – volume: 363 start-page: 809 year: 2010 end-page: 819 ident: CR6 article-title: Inhibition of mutated, activated BRAF in metastatic melanoma publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1002011 – volume: 23 start-page: 302 year: 2013 end-page: 315 ident: CR26 article-title: Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.02.003 – volume: 23 start-page: 496 year: 2010 end-page: 513 ident: CR4 article-title: Sox proteins in melanocyte development and melanoma publication-title: Pigment Cell Melanoma Res. doi: 10.1111/j.1755-148X.2010.00711.x – volume: 524 start-page: 481 year: 2015 end-page: 484 ident: CR21 article-title: A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death publication-title: Nature doi: 10.1038/nature14859 – volume: 20 start-page: 3551 year: 1999 end-page: 3567 ident: CR29 article-title: Probability-based protein identification by searching sequence databases using mass spectrometry data publication-title: Electrophoresis doi: 10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2 – volume: 524 start-page: 485 year: 2015 end-page: 488 ident: CR22 article-title: Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol publication-title: Nature doi: 10.1038/nature14951 – volume: 6 start-page: 1157 year: 2015 end-page: 1170 ident: CR11 article-title: Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction publication-title: Oncotarget doi: 10.18632/oncotarget.2708 – volume: 18 start-page: 1239 year: 2012 end-page: 1247 ident: CR2 article-title: MDM4 is a key therapeutic target in cutaneous melanoma publication-title: Nature Med. doi: 10.1038/nm.2863 – volume: 161 start-page: 404 year: 2015 end-page: 416 ident: CR8 article-title: Systematic discovery of Xist RNA binding proteins publication-title: Cell doi: 10.1016/j.cell.2015.03.025 – volume: 23 start-page: 535 year: 2013 ident: BFnature17161_CR23 publication-title: Curr. Biol. doi: 10.1016/j.cub.2013.02.019 – volume: 16 start-page: 586 year: 2015 ident: BFnature17161_CR19 publication-title: Nature Rev. Mol. Cell Biol. doi: 10.1038/nrm4051 – volume: 524 start-page: 485 year: 2015 ident: BFnature17161_CR22 publication-title: Nature doi: 10.1038/nature14951 – volume: 20 start-page: 3551 year: 1999 ident: BFnature17161_CR29 publication-title: Electrophoresis doi: 10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2 – volume: 23 start-page: 287 year: 2013 ident: BFnature17161_CR25 publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.11.020 – volume: 26 start-page: 877 year: 2012 ident: BFnature17161_CR28 publication-title: Genes Dev. doi: 10.1101/gad.189365.112 – volume: 199 start-page: 346 year: 2011 ident: BFnature17161_CR17 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2011.10.003 – volume: 35 start-page: 427 year: 2010 ident: BFnature17161_CR27 publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2010.05.003 – volume: 363 start-page: 809 year: 2010 ident: BFnature17161_CR6 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1002011 – volume: 30 start-page: 1303 year: 2010 ident: BFnature17161_CR10 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01101-09 – volume: 4 start-page: 06857 year: 2015 ident: BFnature17161_CR5 publication-title: eLife doi: 10.7554/eLife.06857 – volume: 161 start-page: 404 year: 2015 ident: BFnature17161_CR8 publication-title: Cell doi: 10.1016/j.cell.2015.03.025 – volume: 453 start-page: 381 year: 2013 ident: BFnature17161_CR15 publication-title: Biochem. J. doi: 10.1042/BJ20121829 – volume: 138 start-page: 628 year: 2009 ident: BFnature17161_CR20 publication-title: Cell doi: 10.1016/j.cell.2009.08.005 – volume: 436 start-page: 117 year: 2005 ident: BFnature17161_CR1 publication-title: Nature doi: 10.1038/nature03664 – volume: 6 start-page: 6683 year: 2015 ident: BFnature17161_CR3 publication-title: Nature Commun doi: 10.1038/ncomms7683 – volume: 272 start-page: 24363 year: 1997 ident: BFnature17161_CR13 publication-title: J. Biol. 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| Snippet | A known oncogene,
MITF
, resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA... Focal amplifications of chromosome 3p13-3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF... A known oncogene, MITF, resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene,... |
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| SubjectTerms | 631/337/384/2568 631/67/1059/602 631/67/1813/1634 Animals Binding sites Cancer Carcinogenesis - genetics Carcinogenesis - pathology Cell Lineage Cell Proliferation Cell Survival Chromosomes, Human, Pair 3 - genetics Clone Cells - metabolism Clone Cells - pathology Female Gene amplification Gene Amplification - genetics Gene Knockdown Techniques Genetic aspects Genomes Health aspects Human health and pathology Humanities and Social Sciences Humans Kinases letter Life Sciences Melanoma Melanoma - genetics Melanoma - pathology Melanoma - therapy Metabolism Mice Microphthalmia-Associated Transcription Factor - genetics Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Mitochondrial Proteins - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Molecular Targeted Therapy multidisciplinary Oncogenes - genetics Oncology, Experimental Proteins Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - therapeutic use Science SOXE Transcription Factors - metabolism Xenograft Model Antitumor Assays |
| Title | Melanoma addiction to the long non-coding RNA SAMMSON |
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