Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
Alopecia areata genetics The genetic basis of alopecia areata, a common autoimmune disease that causes disfiguring hair loss due to the collapse of immune privilege of the hair follicle, is largely unknown. A genome-wide association study has now identified several susceptibility loci for alopecia a...
Saved in:
| Published in | Nature (London) Vol. 466; no. 7302; pp. 113 - 117 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.07.2010
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0028-0836 1476-4687 1476-4687 |
| DOI | 10.1038/nature09114 |
Cover
| Abstract | Alopecia areata genetics
The genetic basis of alopecia areata, a common autoimmune disease that causes disfiguring hair loss due to the collapse of immune privilege of the hair follicle, is largely unknown. A genome-wide association study has now identified several susceptibility loci for alopecia areata, most of them clustered into eight genomic regions. The spectrum of gene activities affected implies the involvement of both acquired and innate immunity in the condition. Among significant associations are the
ULBP
genes that encode activating ligands for the natural killer cell receptor NKG2D, which have not been previously linked to autoimmune disease.
The genetic basis of alopecia areata, one of the most common human autoimmune diseases, is largely unknown. This study reports a genome-wide association for this trait that implies the involvement of acquired and innate immunity. Among significant associations are the cytomegalovirus UL16-binding protein genes, which encode activating ligands for the natural killer cell receptor, NKG2D, here implicated for the first time in any autoimmune disease.
Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack
1
,
2
. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (
P
≤ 5 × 10
−7
). Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T
reg
cells), cytotoxic T lymphocyte-associated antigen 4 (
CTLA4
), interleukin (
IL
)
-2/IL-21
, IL-2 receptor A (
IL-2RA; CD25
) and
Eos
(also known as Ikaros family zinc finger 4;
IKZF4
), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself (
PRDX5
and
STX17
). A region of strong association resides within the
ULBP
(cytomegalovirus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. |
|---|---|
| AbstractList | Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P ≤ 5 × 10^sup -7^). Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T^sub reg^ cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself (PRDX5 and STX17). A region of strong association resides within the ULBP (cytomegalo-virus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. [PUBLICATION ABSTRACT] Alopecia areata genetics The genetic basis of alopecia areata, a common autoimmune disease that causes disfiguring hair loss due to the collapse of immune privilege of the hair follicle, is largely unknown. A genome-wide association study has now identified several susceptibility loci for alopecia areata, most of them clustered into eight genomic regions. The spectrum of gene activities affected implies the involvement of both acquired and innate immunity in the condition. Among significant associations are the ULBP genes that encode activating ligands for the natural killer cell receptor NKG2D, which have not been previously linked to autoimmune disease. The genetic basis of alopecia areata, one of the most common human autoimmune diseases, is largely unknown. This study reports a genome-wide association for this trait that implies the involvement of acquired and innate immunity. Among significant associations are the cytomegalovirus UL16-binding protein genes, which encode activating ligands for the natural killer cell receptor, NKG2D, here implicated for the first time in any autoimmune disease. Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack 1 , 2 . The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA ( P ≤ 5 × 10 −7 ). Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T reg cells), cytotoxic T lymphocyte-associated antigen 4 ( CTLA4 ), interleukin ( IL ) -2/IL-21 , IL-2 receptor A ( IL-2RA; CD25 ) and Eos (also known as Ikaros family zinc finger 4; IKZF4 ), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself ( PRDX5 and STX17 ). A region of strong association resides within the ULBP (cytomegalovirus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack 1 , 2 . The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA ( P ≤ 5 × 10 −7 ). Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T reg cells), cytotoxic T lymphocyte-associated antigen 4 ( CTLA4 ), interleukin ( IL ) -2/IL-21 , IL-2 receptor A ( IL-2RA; CD25 ) and Eos (also known as Ikaros family zinc finger 4; IKZF4 ), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself ( PRDX5 and STX17 ). A region of strong association resides within the ULBP (cytomegalovirus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P <or= 5 x 10(-7)). Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T(reg) cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself (PRDX5 and STX17). A region of strong association resides within the ULBP (cytomegalovirus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity.Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P <or= 5 x 10(-7)). Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T(reg) cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself (PRDX5 and STX17). A region of strong association resides within the ULBP (cytomegalovirus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P,510 super(& #x2212; 7)). Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T sub(reg) cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself (PRDX5 and STX17). A region of strong association resides within the ULBP (cytomegalovirus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack (1,2). The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P ≤ 5 X [10.sup.-7]).Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells ([T.sub.reg] cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21,IL-2 receptor A (IL-2RA; CD25)and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself (PRDX5 and STX17). A region of strong association resides within the ULBP (cytomegalovirus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P <or= 5 x 10(-7)). Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T(reg) cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region. We also find association evidence for regions containing genes expressed in the hair follicle itself (PRDX5 and STX17). A region of strong association resides within the ULBP (cytomegalovirus UL16-binding protein) gene cluster on chromosome 6q25.1, encoding activating ligands of the natural killer cell receptor NKG2D that have not previously been implicated in an autoimmune disease. By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly upregulated in the hair follicle dermal sheath during active disease. This study provides evidence for the involvement of both innate and acquired immunity in the pathogenesis of AA. We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. |
| Audience | Academic |
| Author | Lee, Annette Christiano, Angela M. Hordinsky, Maria Gregersen, Peter K. Norris, David Chen, Wei V. Meyer, Katja C. Amos, Christopher I. Singh, Pallavi Kim, Hyunmi Price, Vera Petukhova, Lynn Jahoda, Colin A. B. Paus, Ralf Duvic, Madeleine Shimomura, Yutaka |
| AuthorAffiliation | 4 Department of Dermatology, University of Colorado, Denver, Colorado 80010, USA 6 The Feinstein Institute for Medical Research, North Shore LIJHS, Manhasset, New York 11030, USA 11 Department of Genetics and Development, Columbia University, New York, New York 10032, USA 1 Department of Dermatology, Columbia University, New York, New York 10032, USA 2 Department of Dermatology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA 5 Department of Dermatology, UCSF, San Francisco, California 94115, USA 8 Department of Dermatology, University of Lübeck, 23538 Lübeck, Germany 7 Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA 9 School of Translational Medicine, University of Manchester, Manchester M13 9PT, UK 10 Department of Biological Sciences, University of Durham, Durham DH1 3LE, UK 3 Department of Dermatology, University of Minnesota, Minneapolis, Minnesota 55455, USA |
| AuthorAffiliation_xml | – name: 1 Department of Dermatology, Columbia University, New York, New York 10032, USA – name: 6 The Feinstein Institute for Medical Research, North Shore LIJHS, Manhasset, New York 11030, USA – name: 10 Department of Biological Sciences, University of Durham, Durham DH1 3LE, UK – name: 9 School of Translational Medicine, University of Manchester, Manchester M13 9PT, UK – name: 4 Department of Dermatology, University of Colorado, Denver, Colorado 80010, USA – name: 7 Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA – name: 11 Department of Genetics and Development, Columbia University, New York, New York 10032, USA – name: 3 Department of Dermatology, University of Minnesota, Minneapolis, Minnesota 55455, USA – name: 2 Department of Dermatology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA – name: 5 Department of Dermatology, UCSF, San Francisco, California 94115, USA – name: 8 Department of Dermatology, University of Lübeck, 23538 Lübeck, Germany |
| Author_xml | – sequence: 1 givenname: Lynn surname: Petukhova fullname: Petukhova, Lynn organization: Department of Dermatology, Columbia University, New York, New York 10032, USA – sequence: 2 givenname: Madeleine surname: Duvic fullname: Duvic, Madeleine organization: Department of Dermatology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA – sequence: 3 givenname: Maria surname: Hordinsky fullname: Hordinsky, Maria organization: Department of Dermatology, University of Minnesota, Minneapolis, Minnesota 55455, USA – sequence: 4 givenname: David surname: Norris fullname: Norris, David organization: Department of Dermatology, University of Colorado, Denver, Colorado 80010, USA – sequence: 5 givenname: Vera surname: Price fullname: Price, Vera organization: Department of Dermatology, UCSF, San Francisco, California 94115, USA – sequence: 6 givenname: Yutaka surname: Shimomura fullname: Shimomura, Yutaka organization: Department of Dermatology, Columbia University, New York, New York 10032, USA – sequence: 7 givenname: Hyunmi surname: Kim fullname: Kim, Hyunmi organization: Department of Dermatology, Columbia University, New York, New York 10032, USA – sequence: 8 givenname: Pallavi surname: Singh fullname: Singh, Pallavi organization: Department of Dermatology, Columbia University, New York, New York 10032, USA – sequence: 9 givenname: Annette surname: Lee fullname: Lee, Annette organization: The Feinstein Institute for Medical Research, North Shore LIJHS, Manhasset, New York 11030, USA – sequence: 10 givenname: Wei V. surname: Chen fullname: Chen, Wei V. organization: Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA – sequence: 11 givenname: Katja C. surname: Meyer fullname: Meyer, Katja C. organization: Department of Dermatology, University of Lübeck – sequence: 12 givenname: Ralf surname: Paus fullname: Paus, Ralf organization: Department of Dermatology, University of Lübeck, School of Translational Medicine, University of Manchester – sequence: 13 givenname: Colin A. B. surname: Jahoda fullname: Jahoda, Colin A. B. organization: Department of Biological Sciences, University of Durham – sequence: 14 givenname: Christopher I. surname: Amos fullname: Amos, Christopher I. organization: Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA – sequence: 15 givenname: Peter K. surname: Gregersen fullname: Gregersen, Peter K. organization: The Feinstein Institute for Medical Research, North Shore LIJHS, Manhasset, New York 11030, USA – sequence: 16 givenname: Angela M. surname: Christiano fullname: Christiano, Angela M. email: amc65@columbia.edu organization: Department of Dermatology, Columbia University, New York, New York 10032, USA, Department of Genetics and Development, Columbia University, New York, New York 10032, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20596022$$D View this record in MEDLINE/PubMed |
| BookMark | eNqF09tv0zAUB-AIDbFu8MQ7isYDQ5BhO_ElL0hVBWPSBBIM8YQs1znpPCV2Fjtj_e9x111aFEB5iGR__ukcX_aSHessJMlzjI4wysU7q8LQAyoxLh4lE1xwlhVM8J1kghARGRI52032vL9ACFHMiyfJLkG0ZIiQSfLzGKxrIftlKkiV904bFYyzqQ9DtUyNTVXjOoijqepBBZWatmuMVgF8OnfhPJJYQFxrq1RVqgvmCqJpB2vC8mnyuFaNh2e3__3k-8cPZ7NP2emX45PZ9DTTnPOQ8dgHaCZKXjKhFRJ8XoECWhQqB46QLoioFaF1ndN5jXNK52VFNGcE4lwN-X7yfp3bDfMWKg029KqRXW9a1S-lU0Zuz1hzLhfuSpKSYMxJDHh1G9C7ywF8kK3xGppGWXCDl7xgmFFByv_LPGdEiAJHefhPiTmNnVCEVqEHf9ALN_Q2bplkGBWIUL7Ke7lGC9WANLZ2sRW9ypRTkiPOGLpR2YhagIXYd7w4tYnDW_5gxOvOXMpNdDSC4ldBa_Ro6uutBdEEuA4LNXgvT7593bZv_m6nZz9mn7f1i82jvj_juysdAV4D3Tvve6ilNuHmTseaTSMxkqtnIzeezUMJ92vuYsf127X2UdkF9A-nNcZ_A5lUJJs |
| CODEN | NATUAS |
| CitedBy_id | crossref_primary_10_1038_gene_2017_4 crossref_primary_10_2217_rme_13_87 crossref_primary_10_1016_j_autrev_2021_102761 crossref_primary_10_1159_000468991 crossref_primary_10_1093_imammb_dqx009 crossref_primary_10_1038_jid_2011_395 crossref_primary_10_2147_CCID_S496720 crossref_primary_10_3389_fimmu_2024_1347311 crossref_primary_10_1016_j_cell_2018_08_071 crossref_primary_10_1111_1346_8138_14648 crossref_primary_10_1038_jid_2011_393 crossref_primary_10_1111_j_1365_2133_2011_10646_x crossref_primary_10_3109_08916934_2016_1166214 crossref_primary_10_1038_jidsymp_2013_6 crossref_primary_10_1111_j_1365_2567_2011_03427_x crossref_primary_10_3109_08820139_2013_857351 crossref_primary_10_1038_jidsymp_2013_7 crossref_primary_10_1038_jidsymp_2013_4 crossref_primary_10_1016_S1776_0313_15_70734_3 crossref_primary_10_1038_jidsymp_2013_5 crossref_primary_10_1038_jidsymp_2013_2 crossref_primary_10_1038_jidsymp_2013_3 crossref_primary_10_1007_s40265_023_01873_w crossref_primary_10_1111_jdv_15701 crossref_primary_10_1007_s00403_018_1853_5 crossref_primary_10_1038_s41536_020_0095_2 crossref_primary_10_1016_j_biomaterials_2018_03_019 crossref_primary_10_1093_cei_uxac088 crossref_primary_10_1038_srep44127 crossref_primary_10_1111_bjd_19664 crossref_primary_10_1111_exd_12209 crossref_primary_10_1189_jlb_0413196 crossref_primary_10_1007_s12016_021_08883_0 crossref_primary_10_1177_03009858231170329 crossref_primary_10_1038_s41588_020_0684_4 crossref_primary_10_1001_jamadermatol_2018_4398 crossref_primary_10_1016_j_bbrc_2017_07_164 crossref_primary_10_1111_ced_14208 crossref_primary_10_3389_fimmu_2023_1148359 crossref_primary_10_1159_000441250 crossref_primary_10_1016_j_humimm_2013_09_003 crossref_primary_10_1016_j_jid_2020_06_010 crossref_primary_10_1111_ajd_12065 crossref_primary_10_1111_jdv_15937 crossref_primary_10_1111_exd_13535 crossref_primary_10_1186_bcr3475 crossref_primary_10_3390_biom13091285 crossref_primary_10_1111_exd_12318 crossref_primary_10_4110_in_2022_22_e7 crossref_primary_10_1126_scisignal_aai8904 crossref_primary_10_1038_ng_3963 crossref_primary_10_2336_nishinihonhifu_84_491 crossref_primary_10_1007_s00105_018_4278_3 crossref_primary_10_1007_s00105_013_2576_3 crossref_primary_10_1007_s00403_016_1687_y crossref_primary_10_1111_1346_8138_14986 crossref_primary_10_1016_j_molmed_2018_03_007 crossref_primary_10_1111_j_1365_2133_2011_10482_x crossref_primary_10_1016_j_jdermsci_2016_10_004 crossref_primary_10_1007_s11295_013_0594_z crossref_primary_10_1111_all_13346 crossref_primary_10_1097_MED_0b013e32836285b6 crossref_primary_10_3109_08916934_2011_606446 crossref_primary_10_1186_s12929_020_0624_8 crossref_primary_10_1111_jdv_13879 crossref_primary_10_1016_j_jaci_2016_10_055 crossref_primary_10_1007_s13555_023_00991_3 crossref_primary_10_1016_j_jid_2022_11_009 crossref_primary_10_1136_bmjopen_2021_053137 crossref_primary_10_3109_08916934_2014_910769 crossref_primary_10_1111_dth_13053 crossref_primary_10_1111_j_1600_0625_2011_01427_x crossref_primary_10_1111_exd_12264 crossref_primary_10_3389_fimmu_2023_1147447 crossref_primary_10_1134_S1022795416070073 crossref_primary_10_1016_j_omtn_2023_03_002 crossref_primary_10_1111_bjd_18248 crossref_primary_10_1038_s41598_019_48226_w crossref_primary_10_1056_NEJMoa1009742 crossref_primary_10_1007_s13555_021_00614_9 crossref_primary_10_1016_j_jaut_2018_12_001 crossref_primary_10_1016_j_jid_2016_04_004 crossref_primary_10_1111_jdv_13325 crossref_primary_10_1159_000500364 crossref_primary_10_1007_s00251_012_0638_9 crossref_primary_10_1111_ced_14224 crossref_primary_10_3389_fimmu_2023_1207544 crossref_primary_10_3390_ijms23031038 crossref_primary_10_1038_jidsymp_2015_42 crossref_primary_10_1016_j_coi_2015_09_001 crossref_primary_10_1371_journal_pgen_1002178 crossref_primary_10_1038_jidsymp_2015_44 crossref_primary_10_1371_journal_pone_0023089 crossref_primary_10_1159_000354767 crossref_primary_10_1007_s12016_017_8620_9 crossref_primary_10_1111_exd_13217 crossref_primary_10_1007_s12026_019_09104_9 crossref_primary_10_1371_journal_pone_0180958 crossref_primary_10_4049_jimmunol_2100758 crossref_primary_10_3389_fmed_2023_1181572 crossref_primary_10_1126_sciimmunol_adh0152 crossref_primary_10_1038_jid_2010_427 crossref_primary_10_11622_smedj_2017039 crossref_primary_10_1042_BSR20210609 crossref_primary_10_1038_jidsymp_2015_31 crossref_primary_10_3389_fimmu_2024_1393799 crossref_primary_10_1038_jidsymp_2015_36 crossref_primary_10_1111_bjd_17142 crossref_primary_10_1016_j_jdermsci_2015_01_004 crossref_primary_10_2147_CCID_S280855 crossref_primary_10_1038_jidsymp_2015_38 crossref_primary_10_1111_exd_13337 crossref_primary_10_1371_journal_pgen_1006643 crossref_primary_10_1038_ncomms3260 crossref_primary_10_1111_dth_14171 crossref_primary_10_1080_17425255_2025_2461483 crossref_primary_10_1111_1346_8138_14940 crossref_primary_10_1007_s11538_020_00707_0 crossref_primary_10_1080_1354750X_2022_2046855 crossref_primary_10_1038_cmi_2017_161 crossref_primary_10_1038_s41467_021_27936_8 crossref_primary_10_1038_s41467_017_01381_y crossref_primary_10_1016_j_sjbs_2022_103460 crossref_primary_10_1111_exd_12233 crossref_primary_10_1016_j_jaci_2013_10_030 crossref_primary_10_1517_17460441_2015_1009892 crossref_primary_10_1146_annurev_genom_021610_131501 crossref_primary_10_1016_j_jid_2015_12_003 crossref_primary_10_1016_j_jdermsci_2020_09_001 crossref_primary_10_1097_MPA_0b013e31823a0d4c crossref_primary_10_1016_j_pharmthera_2017_05_008 crossref_primary_10_1159_000494613 crossref_primary_10_1049_syb2_12048 crossref_primary_10_1016_j_gene_2016_11_032 crossref_primary_10_1038_s41577_019_0162_3 crossref_primary_10_1002_JLB_3A0420_386R crossref_primary_10_4049_jimmunol_1500636 crossref_primary_10_6000_1927_7229_2014_03_04_3 crossref_primary_10_3390_genes13030505 crossref_primary_10_1159_000533779 crossref_primary_10_1016_j_jaci_2019_08_014 crossref_primary_10_1038_jid_2012_365 crossref_primary_10_1016_j_jid_2017_05_023 crossref_primary_10_1038_jid_2012_129 crossref_primary_10_1111_ddg_14689 crossref_primary_10_3389_fendo_2024_1356832 crossref_primary_10_1186_s13619_022_00122_x crossref_primary_10_2336_nishinihonhifu_75_528 crossref_primary_10_1016_j_genrep_2022_101657 crossref_primary_10_1016_j_xjidi_2021_100051 crossref_primary_10_1038_s41588_023_01445_4 crossref_primary_10_1016_j_jid_2020_08_015 crossref_primary_10_1186_s13287_021_02614_0 crossref_primary_10_2147_CCID_S376096 crossref_primary_10_1016_j_autrev_2022_103061 crossref_primary_10_1093_cei_uxac123 crossref_primary_10_1016_j_humimm_2016_06_002 crossref_primary_10_1056_NEJMra1100030 crossref_primary_10_1007_s12325_022_02241_y crossref_primary_10_36691_RJA16904 crossref_primary_10_1111_jdv_16082 crossref_primary_10_1111_j_1399_0039_2011_01791_x crossref_primary_10_2147_JIR_S331579 crossref_primary_10_1016_j_det_2012_08_006 crossref_primary_10_1016_j_heliyon_2022_e09184 crossref_primary_10_1016_j_pcl_2013_12_002 crossref_primary_10_2147_ITT_S266409 crossref_primary_10_1111_j_1755_148X_2010_00808_x crossref_primary_10_1038_ncomms6966 crossref_primary_10_1016_j_ejmg_2021_104292 crossref_primary_10_1111_imr_12328 crossref_primary_10_1111_jdv_12932 crossref_primary_10_1038_jid_2013_141 crossref_primary_10_1007_s40257_017_0285_x crossref_primary_10_1016_j_imlet_2011_01_002 crossref_primary_10_1038_ng_887 crossref_primary_10_1016_j_humimm_2016_10_019 crossref_primary_10_1016_j_jdcr_2020_10_027 crossref_primary_10_1016_j_devcel_2017_05_020 crossref_primary_10_1038_jid_2012_344 crossref_primary_10_1016_j_jaci_2019_08_035 crossref_primary_10_1016_j_celrep_2019_05_070 crossref_primary_10_1016_j_jisp_2017_10_006 crossref_primary_10_1016_j_jaad_2020_09_028 crossref_primary_10_1016_j_jisp_2017_10_001 crossref_primary_10_1038_nm_3685 crossref_primary_10_1080_24750573_2017_1338821 crossref_primary_10_1111_jdv_20311 crossref_primary_10_1016_j_smim_2014_02_003 crossref_primary_10_1016_j_det_2012_08_014 crossref_primary_10_1016_j_cels_2015_11_001 crossref_primary_10_1016_j_jtbi_2015_05_033 crossref_primary_10_1038_jid_2011_203 crossref_primary_10_1016_j_annder_2022_03_006 crossref_primary_10_1016_j_clim_2013_09_003 crossref_primary_10_1111_1346_8138_12978 crossref_primary_10_1097_MD_0000000000037300 crossref_primary_10_1038_s41573_022_00561_w crossref_primary_10_1056_NEJMra1103442 crossref_primary_10_1007_s13555_024_01218_9 crossref_primary_10_1007_s10238_020_00673_w crossref_primary_10_1016_j_jaut_2012_09_002 crossref_primary_10_1002_ajmg_a_35367 crossref_primary_10_3389_fimmu_2023_1243556 crossref_primary_10_1016_j_jisp_2017_10_014 crossref_primary_10_3389_fimmu_2023_1152513 crossref_primary_10_3389_fimmu_2023_1274270 crossref_primary_10_1038_ng_980 crossref_primary_10_1038_jid_2012_320 crossref_primary_10_1038_jid_2012_441 crossref_primary_10_1016_j_jid_2016_03_047 crossref_primary_10_1111_j_1529_8019_2011_01415_x crossref_primary_10_3389_fimmu_2018_01304 crossref_primary_10_1172_jci_insight_121949 crossref_primary_10_1111_exd_14844 crossref_primary_10_3389_fimmu_2021_652191 crossref_primary_10_1016_j_annder_2010_09_011 crossref_primary_10_3812_jocd_36_505 crossref_primary_10_3389_fgene_2016_00003 crossref_primary_10_4161_mabs_4_1_18713 crossref_primary_10_1089_scd_2022_29011_wwu crossref_primary_10_1002_eji_201646680 crossref_primary_10_1007_s00018_011_0799_y crossref_primary_10_1016_j_jaci_2017_10_028 crossref_primary_10_1073_pnas_2305764120 crossref_primary_10_1002_jvc2_392 crossref_primary_10_1038_s41577_023_00877_7 crossref_primary_10_1007_s00403_013_1348_3 crossref_primary_10_1159_000353159 crossref_primary_10_7554_eLife_80768 crossref_primary_10_1111_exd_13986 crossref_primary_10_3389_fmicb_2024_1431646 crossref_primary_10_1016_j_gpb_2021_10_003 crossref_primary_10_2147_CCID_S428788 crossref_primary_10_3390_medicina60101611 crossref_primary_10_1016_j_jid_2022_09_656 crossref_primary_10_3389_fimmu_2019_02847 crossref_primary_10_1038_ng_732 crossref_primary_10_1172_JCI74475 crossref_primary_10_1038_nrg_2015_33 crossref_primary_10_1159_000512747 crossref_primary_10_1542_pir_2019_0009 crossref_primary_10_3389_fphar_2022_950450 crossref_primary_10_1007_s12016_022_08954_w crossref_primary_10_1111_bjd_14709 crossref_primary_10_1371_journal_pone_0083811 crossref_primary_10_1007_s40005_020_00501_z crossref_primary_10_1111_ajd_12941 crossref_primary_10_1007_s10103_011_0953_7 crossref_primary_10_1111_j_1529_8019_2011_01416_x crossref_primary_10_1111_bjd_19040 crossref_primary_10_18553_jmcp_2023_22371 crossref_primary_10_1016_j_jaad_2017_10_048 crossref_primary_10_1016_j_det_2021_03_005 crossref_primary_10_1016_j_autrev_2016_03_008 crossref_primary_10_1038_s41598_017_01379_y crossref_primary_10_1016_j_ygeno_2011_08_009 crossref_primary_10_3389_fcell_2021_789676 crossref_primary_10_1080_1744666X_2022_2096590 crossref_primary_10_5021_ad_2017_29_6_755 crossref_primary_10_1038_nm_3645 crossref_primary_10_1136_esmoopen_2018_000472 crossref_primary_10_1016_j_jaad_2023_04_039 crossref_primary_10_1111_bjd_14703 crossref_primary_10_1016_j_freeradbiomed_2015_09_008 crossref_primary_10_1038_jid_2011_407 crossref_primary_10_1016_j_jid_2019_03_1142 crossref_primary_10_1016_j_jaad_2015_01_057 crossref_primary_10_1016_j_jid_2018_05_027 crossref_primary_10_1002_adbi_202400769 crossref_primary_10_1016_j_jaad_2017_04_1141 crossref_primary_10_1111_jocd_16049 crossref_primary_10_14442_general_16_47 crossref_primary_10_12677_acm_2024_1441049 crossref_primary_10_1016_j_intimp_2022_108517 crossref_primary_10_1111_bph_16046 crossref_primary_10_3389_fimmu_2018_00585 crossref_primary_10_1007_s00403_020_02109_7 crossref_primary_10_5694_mja13_10895 crossref_primary_10_1007_s00403_016_1617_z crossref_primary_10_1111_dth_15310 crossref_primary_10_1016_j_isci_2023_107162 crossref_primary_10_1016_j_autrev_2014_10_014 crossref_primary_10_1515_medgen_2023_2004 crossref_primary_10_1016_j_jaad_2021_10_045 crossref_primary_10_1056_NEJMoa2110343 crossref_primary_10_1016_j_jisp_2020_04_002 crossref_primary_10_1016_j_jisp_2020_04_003 crossref_primary_10_1016_S1773_035X_13_72132_4 crossref_primary_10_3390_genes13101860 crossref_primary_10_1093_intimm_dxz039 crossref_primary_10_1111_exd_14070 crossref_primary_10_1111_exd_14073 crossref_primary_10_1111_j_1468_3083_2010_03912_x crossref_primary_10_1159_000530432 crossref_primary_10_1159_000445182 crossref_primary_10_1111_j_1365_2133_2011_10466_x crossref_primary_10_4103_jdds_jdds_77_19 crossref_primary_10_1021_acsami_4c20709 crossref_primary_10_5021_ad_2019_31_4_387 crossref_primary_10_3389_fimmu_2022_955035 crossref_primary_10_1590_1678_9199_jvatitd_1481_18 crossref_primary_10_4049_jimmunol_1501798 crossref_primary_10_1080_15321819_2024_2371590 crossref_primary_10_1002_hsr2_602 crossref_primary_10_2147_JIR_S356316 crossref_primary_10_1080_17512433_2020_1702878 crossref_primary_10_1111_bjd_16808 crossref_primary_10_1111_j_1529_8019_2011_01414_x crossref_primary_10_1111_j_1365_2133_2012_10955_x crossref_primary_10_3390_ijerph15122882 crossref_primary_10_1186_1471_2164_12_610 crossref_primary_10_1093_ced_llad084 crossref_primary_10_1038_s41590_023_01547_5 crossref_primary_10_1016_j_immuni_2019_02_023 crossref_primary_10_1093_intimm_dxz031 crossref_primary_10_1164_rccm_201204_0708OC crossref_primary_10_1016_j_ebiom_2015_03_022 crossref_primary_10_1016_j_jaad_2020_09_091 crossref_primary_10_1177_0960327115626579 crossref_primary_10_1002_eji_201141696 crossref_primary_10_1111_exd_14293 crossref_primary_10_3389_fimmu_2024_1343987 crossref_primary_10_1080_15548627_2022_2074104 crossref_primary_10_1111_jdv_15489 crossref_primary_10_58224_2658_3313_2024_7_6_27_37 crossref_primary_10_1111_jdv_18758 crossref_primary_10_1007_s00403_019_01934_9 crossref_primary_10_7759_cureus_78298 crossref_primary_10_1111_ddg_14689_g crossref_primary_10_1517_14656566_2012_685160 crossref_primary_10_1089_jir_2011_0103 crossref_primary_10_1093_intimm_dxz020 crossref_primary_10_1186_s40779_023_00484_6 crossref_primary_10_1016_j_gene_2013_05_086 crossref_primary_10_3390_ijms25084409 crossref_primary_10_1080_14728222_2018_1481504 crossref_primary_10_3389_fimmu_2024_1500284 crossref_primary_10_1016_j_jisp_2020_05_001 crossref_primary_10_1038_ng_2384 crossref_primary_10_1111_j_1529_8019_2011_01411_x crossref_primary_10_1155_2011_518090 crossref_primary_10_18632_oncotarget_22417 crossref_primary_10_1016_j_cdev_2022_203793 crossref_primary_10_1007_s00281_021_00885_6 crossref_primary_10_1111_pde_13387 crossref_primary_10_1172_jci_insight_87270 crossref_primary_10_3390_ijms25137100 crossref_primary_10_1097_JDN_0000000000000703 crossref_primary_10_3389_fimmu_2018_01820 crossref_primary_10_1007_s00105_017_4118_x crossref_primary_10_1016_j_cellsig_2023_110679 crossref_primary_10_1038_gene_2012_46 crossref_primary_10_1111_tan_13246 crossref_primary_10_1016_j_coi_2012_09_006 crossref_primary_10_1016_j_det_2018_11_002 crossref_primary_10_1038_jid_2014_459 crossref_primary_10_33589_21_1_0014 crossref_primary_10_3389_fimmu_2024_1469424 crossref_primary_10_1016_j_jid_2016_08_038 crossref_primary_10_1016_j_jaut_2017_12_004 crossref_primary_10_1016_j_jdermsci_2012_12_003 crossref_primary_10_1007_s40272_017_0239_z crossref_primary_10_1093_bjd_ljae385 crossref_primary_10_1007_s13671_017_0163_z crossref_primary_10_1016_j_heliyon_2024_e28583 crossref_primary_10_1007_s12325_017_0542_7 crossref_primary_10_1007_s00403_024_03203_w crossref_primary_10_1111_bjd_12396 crossref_primary_10_1016_j_jdermsci_2023_05_005 crossref_primary_10_1038_nrdp_2017_11 crossref_primary_10_1016_j_jaad_2010_08_032 crossref_primary_10_1016_j_clindermatol_2022_02_009 crossref_primary_10_1038_s41598_017_18282_1 crossref_primary_10_1111_exd_12914 crossref_primary_10_1016_j_ebiom_2020_102810 crossref_primary_10_1111_bjd_12004 crossref_primary_10_3390_biomedicines10071639 crossref_primary_10_1016_j_jaci_2020_05_009 crossref_primary_10_1111_1346_8138_16207 crossref_primary_10_33589_31_3_103 crossref_primary_10_1126_scitranslmed_3007579 crossref_primary_10_1038_ng_2272 crossref_primary_10_1002_cam4_1448 crossref_primary_10_1007_s12026_020_09115_x crossref_primary_10_1371_journal_pone_0188402 crossref_primary_10_1016_j_jdcr_2021_12_012 crossref_primary_10_1093_intimm_dxy088 crossref_primary_10_1016_j_jaad_2021_08_043 crossref_primary_10_1097_MD_0000000000015448 crossref_primary_10_3390_ijms21218196 crossref_primary_10_1126_scisignal_aad7279 crossref_primary_10_3389_fimmu_2019_02342 crossref_primary_10_1016_j_ebiom_2015_02_015 crossref_primary_10_2147_CCID_S462294 crossref_primary_10_1016_j_genrep_2021_101130 crossref_primary_10_1007_s00403_013_1354_5 crossref_primary_10_1007_s00105_020_04727_8 crossref_primary_10_2147_DDDT_S297858 crossref_primary_10_1007_s40257_023_00805_4 crossref_primary_10_1038_ng_3118 crossref_primary_10_1111_pde_12062 crossref_primary_10_1038_cmi_2015_23 crossref_primary_10_1126_sciimmunol_aat1482 crossref_primary_10_1007_s00403_024_03092_z crossref_primary_10_1016_j_compbiomed_2019_103354 crossref_primary_10_1186_1471_2156_14_40 crossref_primary_10_1007_s00251_015_0843_4 crossref_primary_10_1002_cpz1_1113 crossref_primary_10_1111_exd_14129 crossref_primary_10_1172_jci_insight_89776 crossref_primary_10_1016_j_jid_2020_01_017 crossref_primary_10_1111_ijd_14192 crossref_primary_10_1097_RHU_0b013e31824ea103 crossref_primary_10_3389_fimmu_2022_1082055 crossref_primary_10_1093_imammb_dqab008 crossref_primary_10_1016_j_abd_2021_03_006 crossref_primary_10_1016_j_jdcr_2024_10_009 crossref_primary_10_1111_exd_70074 crossref_primary_10_1038_s43587_023_00428_8 crossref_primary_10_5021_ad_22_227 crossref_primary_10_1016_j_jaad_2019_11_064 crossref_primary_10_1111_j_1529_8019_2011_01421_x crossref_primary_10_1055_s_0040_1715143 crossref_primary_10_1371_journal_pone_0094260 crossref_primary_10_1016_j_jdermsci_2014_11_009 crossref_primary_10_1016_j_regen_2020_100028 crossref_primary_10_1016_j_annder_2016_10_009 crossref_primary_10_1016_j_jaad_2019_10_016 crossref_primary_10_1016_j_jaut_2024_103217 crossref_primary_10_1146_annurev_immunol_051116_052442 crossref_primary_10_3389_fimmu_2021_624131 crossref_primary_10_1016_j_gendis_2025_101518 crossref_primary_10_1016_j_jaut_2012_05_006 crossref_primary_10_1172_JCI72932 crossref_primary_10_1016_j_jdcr_2018_04_006 crossref_primary_10_1093_molbev_msv256 crossref_primary_10_1007_s12325_017_0540_9 crossref_primary_10_3389_fneur_2017_00569 crossref_primary_10_1016_j_jdcr_2018_04_003 crossref_primary_10_1111_srt_70063 crossref_primary_10_1111_imm_12791 crossref_primary_10_1016_j_jaad_2020_04_105 crossref_primary_10_1016_j_sder_2012_08_003 crossref_primary_10_1159_000515764 crossref_primary_10_1038_ejhg_2011_185 crossref_primary_10_1111_jdv_18921 crossref_primary_10_1080_08820139_2020_1796700 crossref_primary_10_1371_journal_pgen_1004148 crossref_primary_10_1016_j_coi_2014_10_006 crossref_primary_10_1111_exd_13255 crossref_primary_10_1016_j_clindermatol_2016_07_004 crossref_primary_10_1016_j_gene_2013_02_048 crossref_primary_10_1038_s41598_021_84236_3 crossref_primary_10_1016_j_jaad_2020_10_063 crossref_primary_10_17816_dv112313 crossref_primary_10_1038_gene_2014_41 crossref_primary_10_52888_0514_2515_2022_352_1_108_115 crossref_primary_10_1016_j_jaad_2014_03_005 crossref_primary_10_1172_jci_insight_89790 crossref_primary_10_1016_j_jid_2017_09_046 crossref_primary_10_3389_fimmu_2023_1111547 crossref_primary_10_3390_jcm13144264 crossref_primary_10_1038_ng_3680 crossref_primary_10_1155_2024_5556012 crossref_primary_10_1016_j_cellimm_2015_06_005 crossref_primary_10_1586_1744666X_2015_1085306 crossref_primary_10_1111_exd_13123 crossref_primary_10_1016_j_jid_2022_08_033 crossref_primary_10_1016_S1761_2896_20_43361_8 crossref_primary_10_1002_ski2_209 crossref_primary_10_1002_iid3_564 crossref_primary_10_1111_jocd_15425 crossref_primary_10_25259_IJDVL_975_19 crossref_primary_10_1155_2013_348546 crossref_primary_10_3389_fmed_2024_1510363 crossref_primary_10_7861_clinmedicine_16_1_74 crossref_primary_10_1111_jdv_13598 crossref_primary_10_1016_j_bbamcr_2012_09_003 crossref_primary_10_1084_jem_20140455 crossref_primary_10_1016_j_jdermsci_2020_08_003 crossref_primary_10_3389_fimmu_2021_651751 crossref_primary_10_1016_j_ebiom_2016_03_036 crossref_primary_10_1016_j_jdermsci_2020_08_006 crossref_primary_10_15171_mejdd_2017_91 crossref_primary_10_1111_exd_13071 crossref_primary_10_1016_j_jdermsci_2010_08_016 crossref_primary_10_1007_s00403_016_1652_9 crossref_primary_10_1002_jgc4_1178 crossref_primary_10_3390_ijms19092703 crossref_primary_10_1038_JID_2015_402 crossref_primary_10_1111_pde_15842 crossref_primary_10_1111_jocd_15741 crossref_primary_10_3389_fmed_2020_00150 crossref_primary_10_1016_j_crimmu_2021_02_001 crossref_primary_10_1001_jamadermatol_2023_2205 crossref_primary_10_1371_journal_pone_0258499 crossref_primary_10_1111_j_1600_0625_2012_01566_x crossref_primary_10_3390_nu10020199 crossref_primary_10_1016_j_gene_2025_149343 crossref_primary_10_33589_28_1_0012 crossref_primary_10_1007_s13577_021_00540_0 crossref_primary_10_1038_jid_2010_260 crossref_primary_10_1371_journal_pone_0053613 crossref_primary_10_1038_s41467_022_28343_3 crossref_primary_10_3390_cosmetics9030055 crossref_primary_10_1111_exd_14155 crossref_primary_10_1038_jidsymp_2013_23 crossref_primary_10_2174_1872213X14999200728145822 crossref_primary_10_15690_vsp_v23i6_2825 crossref_primary_10_2340_actadv_v103_9604 crossref_primary_10_1016_j_jid_2021_04_017 crossref_primary_10_4049_jimmunol_1003342 crossref_primary_10_1007_s40257_023_00808_1 crossref_primary_10_1016_j_jdermsci_2024_04_005 crossref_primary_10_1111_j_1365_2133_2012_10889_x crossref_primary_10_1016_j_abb_2016_06_003 crossref_primary_10_1016_j_cell_2017_05_002 crossref_primary_10_3390_ijms25179236 crossref_primary_10_3389_fimmu_2022_890027 crossref_primary_10_1111_ajd_14325 crossref_primary_10_1001_jamadermatol_2023_1261 crossref_primary_10_1038_jidsymp_2013_12 crossref_primary_10_1038_jidsymp_2013_11 crossref_primary_10_1016_j_jaut_2021_102711 crossref_primary_10_1111_j_1600_0625_2011_01401_x crossref_primary_10_1038_jidsymp_2013_16 crossref_primary_10_5507_bp_2019_049 crossref_primary_10_3389_fimmu_2024_1486627 crossref_primary_10_1016_j_dsi_2014_09_004 crossref_primary_10_3389_fmed_2023_1131286 crossref_primary_10_1002_tkm2_1233 crossref_primary_10_1097_01_EPX_0000461326_05328_d3 crossref_primary_10_1007_s00105_013_2578_1 crossref_primary_10_1016_j_jid_2020_05_084 crossref_primary_10_1177_1203475417716363 crossref_primary_10_1093_bib_bbab181 crossref_primary_10_1111_j_1529_8019_2011_01420_x crossref_primary_10_1038_jid_2010_286 crossref_primary_10_1093_sleep_zsy111 crossref_primary_10_1007_s10238_012_0224_3 crossref_primary_10_1097_DAD_0000000000001929 crossref_primary_10_3390_ijms232113228 crossref_primary_10_1073_pnas_1901720117 crossref_primary_10_1111_exd_14254 crossref_primary_10_1159_000351555 crossref_primary_10_1093_bioinformatics_btu571 crossref_primary_10_2174_1573396316666200430084825 crossref_primary_10_1126_sciadv_abd1866 crossref_primary_10_4103_ijt_ijt_120_20 crossref_primary_10_1007_s00403_018_1823_y crossref_primary_10_2139_ssrn_3188356 crossref_primary_10_1089_jir_2013_0055 crossref_primary_10_3389_fmed_2017_00112 crossref_primary_10_4103_idoj_idoj_452_22 crossref_primary_10_1080_09546634_2022_2133956 |
| Cites_doi | 10.1126/science.1160062 10.1172/JCI34462 10.1369/jhc.4A6508.2005 10.1086/519795 10.1006/geno.2001.6673 10.1038/ng2022 10.1159/000131412 10.1046/j.1365-2230.2002.01077.x 10.1093/bioinformatics/bth457 10.1056/NEJMoa073491 10.1111/j.1432-0436.2006.00061.x 10.1016/S0190-9622(98)70499-2 10.1126/science.1176077 10.1146/annurev.immunol.021908.132653 10.1038/sj.jidsp.5640212 10.1016/j.tips.2009.05.006 10.1038/ni1556 10.1089/thy.2005.15.205 10.1016/j.jaut.2009.09.008 10.1126/science.1071059 10.1093/jurban/jth116 10.1177/1352458507078064 10.1038/ng2075 10.1038/ng.185 10.1172/JCI31942 10.4065/70.7.628 10.1086/511442 10.1016/j.humimm.2006.02.013 10.1046/j.1087-0024.2003.00814.x 10.2119/molmed.2009.00094 10.1016/S0014-5793(02)03511-1 10.1038/nri2144 10.1111/j.1348-0421.2005.tb03640.x 10.1016/S1521-6616(02)00042-6 10.1016/S0923-1811(02)00015-4 10.1038/sj.jid.5701183 10.2340/0001555572373375 10.1002/eji.200939502 |
| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2010 COPYRIGHT 2010 Nature Publishing Group Copyright Nature Publishing Group Jul 1, 2010 2010 Macmillan Publishers Limited. All rights reserved 2010 |
| Copyright_xml | – notice: Springer Nature Limited 2010 – notice: COPYRIGHT 2010 Nature Publishing Group – notice: Copyright Nature Publishing Group Jul 1, 2010 – notice: 2010 Macmillan Publishers Limited. All rights reserved 2010 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM ATWCN 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7SC 7SP 7SR 7TB 7U5 8BQ F28 JG9 JQ2 KR7 L7M L~C L~D 7X8 5PM |
| DOI | 10.1038/nature09114 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Middle School ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database (subscription) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts Computer and Information Systems Abstracts Electronics & Communications Abstracts Engineered Materials Abstracts Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts METADEX ANTE: Abstracts in New Technology & Engineering Materials Research Database ProQuest Computer Science Collection Civil Engineering Abstracts Advanced Technologies Database with Aerospace Computer and Information Systems Abstracts Academic Computer and Information Systems Abstracts Professional MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) Materials Research Database Civil Engineering Abstracts Computer and Information Systems Abstracts – Academic Mechanical & Transportation Engineering Abstracts Electronics & Communications Abstracts ProQuest Computer Science Collection Computer and Information Systems Abstracts METADEX Computer and Information Systems Abstracts Professional Engineered Materials Abstracts Solid State and Superconductivity Abstracts Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE - Academic AIDS and Cancer Research Abstracts MEDLINE Materials Research Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Physics |
| EISSN | 1476-4687 |
| EndPage | 117 |
| ExternalDocumentID | PMC2921172 2081401111 A230766071 20596022 10_1038_nature09114 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: N01 AR062279 – fundername: NIAMS NIH HHS grantid: R01 AR056016 – fundername: NIAMS NIH HHS grantid: R01 AR044422 – fundername: NCI NIH HHS grantid: P30CA016772 – fundername: NIAMS NIH HHS grantid: R01AR56016 – fundername: NCI NIH HHS grantid: R01 CA133996 – fundername: NIAMS NIH HHS grantid: R01AR44422 – fundername: NIAMS NIH HHS grantid: R01AR52579 – fundername: NIAMS NIH HHS grantid: R01 AR052579 – fundername: NCI NIH HHS grantid: R01CA133996 |
| GroupedDBID | --- --Z -DZ -ET -~X .-4 .55 .CO .HR .XZ 00M 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3O- 3V. 4.4 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAYZH ABAWZ ABDBF ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABNNU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACRPL ACUHS ACWUS ADBBV ADFRT ADNMO ADUKH ADYSU ADZCM AENEX AEUYN AFFDN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGCDD AGGDT AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B0M BBNVY BCR BCU BDKGC BEC BENPR BES BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L-9 L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OHT OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PEA PKN PM3 PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YNT YOC YQT YR2 YR5 YXB YYP YZZ Z5M ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~G0 ~KM .GJ 08P 1CY 1VW 354 3EH 41~ 42X 4R4 663 79B 9M8 AAJYS AARCD AAVBQ AAYOK AAYXX ABDPE ABEFU ABFSG ACBNA ACBTR ACMFV ACSTC ACTDY ADGHP ADRHT ADXHL AETEA AEZWR AFANA AFBBN AFHIU AFHKK AGQPQ AHWEU AIXLP AJUXI ALPWD ATHPR BKOMP CITATION DB5 FA8 FAC HG6 J5H LGEZI LOTEE MVM N4W NADUK NFIDA NXXTH ODYON PHGZM PHGZT PV9 QS- R4F RHI SKT TUD UBY UHB USG VOH X7L XOL YJ6 YQI YQJ YV5 YXA YYQ ZCG ZGI ZHY ZY4 CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB AEIIB PMFND 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7SC 7SP 7SR 7TB 7U5 8BQ F28 JG9 JQ2 KR7 L7M L~C L~D PUEGO 7X8 ESTFP 5PM |
| ID | FETCH-LOGICAL-c777t-7103ec6897968ca087bdeae544a3e700c428fa25ff35bf1355b9d2c762e0c4fe3 |
| IEDL.DBID | BENPR |
| ISSN | 0028-0836 1476-4687 |
| IngestDate | Thu Aug 21 18:15:57 EDT 2025 Mon Sep 08 02:48:16 EDT 2025 Mon Sep 08 07:26:30 EDT 2025 Fri Sep 05 02:43:06 EDT 2025 Fri Jul 25 09:06:06 EDT 2025 Tue Jun 17 22:06:48 EDT 2025 Fri Jun 13 00:04:44 EDT 2025 Tue Jun 10 15:39:55 EDT 2025 Tue Jun 10 21:00:13 EDT 2025 Fri Jun 27 05:29:19 EDT 2025 Fri Jun 27 05:47:49 EDT 2025 Mon Jul 21 05:16:31 EDT 2025 Thu Apr 24 22:53:16 EDT 2025 Tue Jul 01 02:00:21 EDT 2025 Fri Feb 21 02:37:27 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7302 |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c777t-7103ec6897968ca087bdeae544a3e700c428fa25ff35bf1355b9d2c762e0c4fe3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://durham-repository.worktribe.com/output/1476199 |
| PMID | 20596022 |
| PQID | 610402571 |
| PQPubID | 40569 |
| PageCount | 5 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2921172 proquest_miscellaneous_746165829 proquest_miscellaneous_733628841 proquest_miscellaneous_1753555009 proquest_journals_610402571 gale_infotracmisc_A230766071 gale_infotracgeneralonefile_A230766071 gale_infotraccpiq_230766071 gale_infotracacademiconefile_A230766071 gale_incontextgauss_ISR_A230766071 gale_incontextgauss_ATWCN_A230766071 pubmed_primary_20596022 crossref_citationtrail_10_1038_nature09114 crossref_primary_10_1038_nature09114 springer_journals_10_1038_nature09114 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20100701 2010-7-00 2010-Jul-01 |
| PublicationDateYYYYMMDD | 2010-07-01 |
| PublicationDate_xml | – month: 7 year: 2010 text: 20100701 day: 1 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationSubtitle | International weekly journal of science |
| PublicationTitle | Nature (London) |
| PublicationTitleAbbrev | Nature |
| PublicationTitleAlternate | Nature |
| PublicationYear | 2010 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Radosavljevic (CR12) 2002; 79 Plenge (CR33) 2007; 357 Barrett, Fry, Maller, Daly (CR38) 2005; 21 Caillat-Zucman (CR15) 2006; 67 Wing (CR28) 2008; 322 Ito, Meyer, Ito, Paus (CR7) 2008; 10 Jelinek (CR3) 1972; 48 Karasawa, Ozaki, Nishioka, Kato (CR26) 2005; 49 CR14 Akar (CR22) 2002; 29 Zhang, Li, Deavers, Abbruzzese, Ho (CR20) 2005; 53 McDonagh, Tazi-Ahnini (CR8) 2002; 27 Van der Steen (CR9) 1992; 72 Safavi, Muller, Suman, Moshell, Melton (CR2) 1995; 70 Rosengren Pielberg (CR21) 2008; 40 Mitchell, Gregersen, Johnson, Parsons, Vlahov (CR32) 2004; 81 Cooper, Bynum, Somers (CR1) 2009; 33 Holley, Newcombe, Winyard, Gutowski (CR23) 2007; 13 Eagle, Trowsdale (CR13) 2007; 7 Hunter (CR34) 2007; 39 Jackow (CR10) 1998; 38 Pan (CR27) 2009; 325 Purcell (CR36) 2007; 81 Gilhar, Paus, Kalish (CR4) 2007; 117 Yeager (CR35) 2007; 39 Martinez-Mir (CR11) 2007; 80 Monteleone, Pallone, Macdonald (CR29) 2009; 30 Gerard, Many, Daumerie, Knoops, Colin (CR24) 2005; 15 Bazzi (CR39) 2006; 74 Strid (CR17) 2008; 9 Borchers (CR18) 2009; 119 Gilhar (CR5) 2003; 106 Wang (CR25) 2002; 531 Duvic, Norris, Christiano, Hordinsky, Price (CR31) 2003; 8 Ito (CR19) 2008; 128 Tian, Kosoy, Nassir, Lee, Villoslada, Klareskog, Hammarström, Garchon, Pulver, Ransom, Gregersen, Seldin (CR37) 2009; 15 Gilhar, Shalaginov, Assy, Serafimovich, Kalish (CR6) 1999; 4 Matzinger (CR16) 2002; 296 Gregersen, Olsson (CR30) 2009; 27 AJ McDonagh (BFnature09114_CR8) 2002; 27 S Purcell (BFnature09114_CR36) 2007; 81 AC Gerard (BFnature09114_CR24) 2005; 15 H Bazzi (BFnature09114_CR39) 2006; 74 S Caillat-Zucman (BFnature09114_CR15) 2006; 67 MK Mitchell (BFnature09114_CR32) 2004; 81 R Karasawa (BFnature09114_CR26) 2005; 49 A Gilhar (BFnature09114_CR4) 2007; 117 M Radosavljevic (BFnature09114_CR12) 2002; 79 BFnature09114_CR14 A Martinez-Mir (BFnature09114_CR11) 2007; 80 RM Plenge (BFnature09114_CR33) 2007; 357 J Strid (BFnature09114_CR17) 2008; 9 T Ito (BFnature09114_CR19) 2008; 128 G Rosengren Pielberg (BFnature09114_CR21) 2008; 40 Chao Tian (BFnature09114_CR37) 2009; 15 JE Jelinek (BFnature09114_CR3) 1972; 48 A Akar (BFnature09114_CR22) 2002; 29 DJ Hunter (BFnature09114_CR34) 2007; 39 A Gilhar (BFnature09114_CR5) 2003; 106 M Yeager (BFnature09114_CR35) 2007; 39 A Gilhar (BFnature09114_CR6) 1999; 4 G Monteleone (BFnature09114_CR29) 2009; 30 RA Eagle (BFnature09114_CR13) 2007; 7 F Pan (BFnature09114_CR27) 2009; 325 T Ito (BFnature09114_CR7) 2008; 10 P Van der Steen (BFnature09114_CR9) 1992; 72 C Jackow (BFnature09114_CR10) 1998; 38 MT Borchers (BFnature09114_CR18) 2009; 119 PK Gregersen (BFnature09114_CR30) 2009; 27 JC Barrett (BFnature09114_CR38) 2005; 21 Q Zhang (BFnature09114_CR20) 2005; 53 MX Wang (BFnature09114_CR25) 2002; 531 K Wing (BFnature09114_CR28) 2008; 322 KH Safavi (BFnature09114_CR2) 1995; 70 GS Cooper (BFnature09114_CR1) 2009; 33 M Duvic (BFnature09114_CR31) 2003; 8 P Matzinger (BFnature09114_CR16) 2002; 296 JE Holley (BFnature09114_CR23) 2007; 13 |
| References_xml | – volume: 322 start-page: 271 year: 2008 end-page: 275 ident: CR28 article-title: CTLA-4 control over Foxp3 regulatory T cell function publication-title: Science doi: 10.1126/science.1160062 – ident: CR14 – volume: 119 start-page: 636 year: 2009 end-page: 649 ident: CR18 article-title: Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease publication-title: J. Clin. Invest. doi: 10.1172/JCI34462 – volume: 53 start-page: 1371 year: 2005 end-page: 1382 ident: CR20 article-title: The subcellular localization of syntaxin 17 varies among different cell types and is altered in some malignant cells publication-title: J. Histochem. Cytochem. doi: 10.1369/jhc.4A6508.2005 – volume: 81 start-page: 559 year: 2007 end-page: 575 ident: CR36 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 72 start-page: 373 year: 1992 end-page: 375 ident: CR9 article-title: The genetic risk for alopecia areata in first degree relatives of severely affected patients. An estimate publication-title: Acta Derm. Venereol. – volume: 79 start-page: 114 year: 2002 end-page: 123 ident: CR12 article-title: A cluster of ten novel MHC class I related genes on human chromosome 6q24.2–q25.3 publication-title: Genomics doi: 10.1006/geno.2001.6673 – volume: 39 start-page: 645 year: 2007 end-page: 649 ident: CR35 article-title: Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 publication-title: Nature Genet. doi: 10.1038/ng2022 – volume: 10 start-page: 27 year: 2008 end-page: 52 ident: CR7 article-title: Immune privilege and the skin publication-title: Curr. Dir. Autoimmun. doi: 10.1159/000131412 – volume: 27 start-page: 405 year: 2002 end-page: 409 ident: CR8 article-title: Epidemiology and genetics of alopecia areata publication-title: Clin. Exp. Dermatol. doi: 10.1046/j.1365-2230.2002.01077.x – volume: 21 start-page: 263 year: 2005 end-page: 265 ident: CR38 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 357 start-page: 1199 year: 2007 end-page: 1209 ident: CR33 article-title: TRAF1-C5 as a risk locus for rheumatoid arthritis—a genomewide study publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa073491 – volume: 74 start-page: 129 year: 2006 end-page: 140 ident: CR39 article-title: Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle publication-title: Differentiation doi: 10.1111/j.1432-0436.2006.00061.x – volume: 38 start-page: 418 year: 1998 end-page: 425 ident: CR10 article-title: Alopecia areata and cytomegalovirus infection in twins: genes versus environment? publication-title: J. Am. Acad. Dermatol. doi: 10.1016/S0190-9622(98)70499-2 – volume: 325 start-page: 1142 year: 2009 end-page: 1146 ident: CR27 article-title: Eos mediates Foxp3-dependent gene silencing in CD4 regulatory T cells publication-title: Science doi: 10.1126/science.1176077 – volume: 27 start-page: 363 year: 2009 end-page: 391 ident: CR30 article-title: Recent advances in the genetics of autoimmune disease publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.021908.132653 – volume: 4 start-page: 207 year: 1999 end-page: 210 ident: CR6 article-title: Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice publication-title: J. Investig. Dermatol. Symp. Proc. doi: 10.1038/sj.jidsp.5640212 – volume: 30 start-page: 441 year: 2009 end-page: 447 ident: CR29 article-title: Interleukin-21 as a new therapeutic target for immune-mediated diseases publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2009.05.006 – volume: 9 start-page: 146 year: 2008 end-page: 154 ident: CR17 article-title: Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis publication-title: Nature Immunol. doi: 10.1038/ni1556 – volume: 15 start-page: 205 year: 2005 end-page: 209 ident: CR24 article-title: Peroxiredoxin 5 expression in the human thyroid gland publication-title: Thyroid doi: 10.1089/thy.2005.15.205 – volume: 33 start-page: 197 year: 2009 end-page: 207 ident: CR1 article-title: Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases publication-title: J. Autoimmun. doi: 10.1016/j.jaut.2009.09.008 – volume: 296 start-page: 301 year: 2002 end-page: 305 ident: CR16 article-title: The danger model: a renewed sense of self publication-title: Science doi: 10.1126/science.1071059 – volume: 81 start-page: 301 year: 2004 end-page: 310 ident: CR32 article-title: The New York Cancer Project: rationale, organization, design, and baseline characteristics publication-title: J. Urban Health doi: 10.1093/jurban/jth116 – volume: 13 start-page: 955 year: 2007 end-page: 961 ident: CR23 article-title: Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes publication-title: Mult. Scler. doi: 10.1177/1352458507078064 – volume: 39 start-page: 870 year: 2007 end-page: 874 ident: CR34 article-title: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer publication-title: Nature Genet. doi: 10.1038/ng2075 – volume: 48 start-page: 1003 year: 1972 end-page: 1013 ident: CR3 article-title: Sudden whitening of the hair publication-title: Bull. N. Y. Acad. Med. – volume: 40 start-page: 1004 year: 2008 end-page: 1009 ident: CR21 article-title: A -acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse publication-title: Nature Genet. doi: 10.1038/ng.185 – volume: 117 start-page: 2019 year: 2007 end-page: 2027 ident: CR4 article-title: Lymphocytes, neuropeptides, and genes involved in alopecia areata publication-title: J. Clin. Invest. doi: 10.1172/JCI31942 – volume: 70 start-page: 628 year: 1995 end-page: 633 ident: CR2 article-title: Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989 publication-title: Mayo Clin. Proc. doi: 10.4065/70.7.628 – volume: 80 start-page: 316 year: 2007 end-page: 328 ident: CR11 article-title: Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata publication-title: Am. J. Hum. Genet. doi: 10.1086/511442 – volume: 67 start-page: 204 year: 2006 end-page: 207 ident: CR15 article-title: How NKG2D ligands trigger autoimmunity? publication-title: Hum. Immunol. doi: 10.1016/j.humimm.2006.02.013 – volume: 8 start-page: 219 year: 2003 end-page: 221 ident: CR31 article-title: Alopecia areata registry: an overview publication-title: J. Investig. Dermatol. Symp. Proc. doi: 10.1046/j.1087-0024.2003.00814.x – volume: 15 start-page: 371 issue: 11-12 year: 2009 end-page: 383 ident: CR37 article-title: European Population Genetic Substructure: Further Definition of Ancestry Informative Markers for Distinguishing among Diverse European Ethnic Groups publication-title: Molecular Medicine doi: 10.2119/molmed.2009.00094 – volume: 531 start-page: 359 year: 2002 end-page: 362 ident: CR25 article-title: Expression and regulation of peroxiredoxin 5 in human osteoarthritis publication-title: FEBS Lett. doi: 10.1016/S0014-5793(02)03511-1 – volume: 7 start-page: 737 year: 2007 end-page: 744 ident: CR13 article-title: Promiscuity and the single receptor: NKG2D publication-title: Nature Rev. Immunol. doi: 10.1038/nri2144 – volume: 49 start-page: 57 year: 2005 end-page: 65 ident: CR26 article-title: Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases publication-title: Microbiol. Immunol. doi: 10.1111/j.1348-0421.2005.tb03640.x – volume: 106 start-page: 181 year: 2003 end-page: 187 ident: CR5 article-title: Transfer of alopecia areata in the human scalp graft/Prkdc(scid) (SCID) mouse system is characterized by a TH1 response publication-title: Clin. Immunol. doi: 10.1016/S1521-6616(02)00042-6 – volume: 29 start-page: 85 year: 2002 end-page: 90 ident: CR22 article-title: Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata publication-title: J. Dermatol. Sci. doi: 10.1016/S0923-1811(02)00015-4 – volume: 128 start-page: 1196 year: 2008 end-page: 1206 ident: CR19 article-title: Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack publication-title: J. Invest. Dermatol. doi: 10.1038/sj.jid.5701183 – volume: 531 start-page: 359 year: 2002 ident: BFnature09114_CR25 publication-title: FEBS Lett. doi: 10.1016/S0014-5793(02)03511-1 – volume: 27 start-page: 363 year: 2009 ident: BFnature09114_CR30 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.021908.132653 – volume: 8 start-page: 219 year: 2003 ident: BFnature09114_CR31 publication-title: J. Investig. Dermatol. Symp. Proc. doi: 10.1046/j.1087-0024.2003.00814.x – volume: 39 start-page: 645 year: 2007 ident: BFnature09114_CR35 publication-title: Nature Genet. doi: 10.1038/ng2022 – volume: 106 start-page: 181 year: 2003 ident: BFnature09114_CR5 publication-title: Clin. Immunol. doi: 10.1016/S1521-6616(02)00042-6 – volume: 9 start-page: 146 year: 2008 ident: BFnature09114_CR17 publication-title: Nature Immunol. doi: 10.1038/ni1556 – volume: 80 start-page: 316 year: 2007 ident: BFnature09114_CR11 publication-title: Am. J. Hum. Genet. doi: 10.1086/511442 – volume: 39 start-page: 870 year: 2007 ident: BFnature09114_CR34 publication-title: Nature Genet. doi: 10.1038/ng2075 – volume: 21 start-page: 263 year: 2005 ident: BFnature09114_CR38 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 15 start-page: 205 year: 2005 ident: BFnature09114_CR24 publication-title: Thyroid doi: 10.1089/thy.2005.15.205 – volume: 38 start-page: 418 year: 1998 ident: BFnature09114_CR10 publication-title: J. Am. Acad. Dermatol. doi: 10.1016/S0190-9622(98)70499-2 – volume: 79 start-page: 114 year: 2002 ident: BFnature09114_CR12 publication-title: Genomics doi: 10.1006/geno.2001.6673 – volume: 13 start-page: 955 year: 2007 ident: BFnature09114_CR23 publication-title: Mult. Scler. doi: 10.1177/1352458507078064 – volume: 7 start-page: 737 year: 2007 ident: BFnature09114_CR13 publication-title: Nature Rev. Immunol. doi: 10.1038/nri2144 – volume: 40 start-page: 1004 year: 2008 ident: BFnature09114_CR21 publication-title: Nature Genet. doi: 10.1038/ng.185 – volume: 49 start-page: 57 year: 2005 ident: BFnature09114_CR26 publication-title: Microbiol. Immunol. doi: 10.1111/j.1348-0421.2005.tb03640.x – volume: 15 start-page: 371 issue: 11-12 year: 2009 ident: BFnature09114_CR37 publication-title: Molecular Medicine doi: 10.2119/molmed.2009.00094 – volume: 74 start-page: 129 year: 2006 ident: BFnature09114_CR39 publication-title: Differentiation doi: 10.1111/j.1432-0436.2006.00061.x – volume: 70 start-page: 628 year: 1995 ident: BFnature09114_CR2 publication-title: Mayo Clin. Proc. doi: 10.4065/70.7.628 – volume: 29 start-page: 85 year: 2002 ident: BFnature09114_CR22 publication-title: J. Dermatol. Sci. doi: 10.1016/S0923-1811(02)00015-4 – volume: 296 start-page: 301 year: 2002 ident: BFnature09114_CR16 publication-title: Science doi: 10.1126/science.1071059 – volume: 48 start-page: 1003 year: 1972 ident: BFnature09114_CR3 publication-title: Bull. N. Y. Acad. Med. – volume: 67 start-page: 204 year: 2006 ident: BFnature09114_CR15 publication-title: Hum. Immunol. doi: 10.1016/j.humimm.2006.02.013 – volume: 33 start-page: 197 year: 2009 ident: BFnature09114_CR1 publication-title: J. Autoimmun. doi: 10.1016/j.jaut.2009.09.008 – volume: 357 start-page: 1199 year: 2007 ident: BFnature09114_CR33 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa073491 – volume: 117 start-page: 2019 year: 2007 ident: BFnature09114_CR4 publication-title: J. Clin. Invest. doi: 10.1172/JCI31942 – volume: 53 start-page: 1371 year: 2005 ident: BFnature09114_CR20 publication-title: J. Histochem. Cytochem. doi: 10.1369/jhc.4A6508.2005 – volume: 81 start-page: 559 year: 2007 ident: BFnature09114_CR36 publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 10 start-page: 27 year: 2008 ident: BFnature09114_CR7 publication-title: Curr. Dir. Autoimmun. doi: 10.1159/000131412 – volume: 4 start-page: 207 year: 1999 ident: BFnature09114_CR6 publication-title: J. Investig. Dermatol. Symp. Proc. doi: 10.1038/sj.jidsp.5640212 – volume: 322 start-page: 271 year: 2008 ident: BFnature09114_CR28 publication-title: Science doi: 10.1126/science.1160062 – volume: 325 start-page: 1142 year: 2009 ident: BFnature09114_CR27 publication-title: Science doi: 10.1126/science.1176077 – volume: 72 start-page: 373 year: 1992 ident: BFnature09114_CR9 publication-title: Acta Derm. Venereol. doi: 10.2340/0001555572373375 – ident: BFnature09114_CR14 doi: 10.1002/eji.200939502 – volume: 30 start-page: 441 year: 2009 ident: BFnature09114_CR29 publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2009.05.006 – volume: 128 start-page: 1196 year: 2008 ident: BFnature09114_CR19 publication-title: J. Invest. Dermatol. doi: 10.1038/sj.jid.5701183 – volume: 81 start-page: 301 year: 2004 ident: BFnature09114_CR32 publication-title: J. Urban Health doi: 10.1093/jurban/jth116 – volume: 119 start-page: 636 year: 2009 ident: BFnature09114_CR18 publication-title: J. Clin. Invest. doi: 10.1172/JCI34462 – volume: 27 start-page: 405 year: 2002 ident: BFnature09114_CR8 publication-title: Clin. Exp. Dermatol. doi: 10.1046/j.1365-2230.2002.01077.x |
| SSID | ssj0005174 |
| Score | 2.5489383 |
| Snippet | Alopecia areata genetics
The genetic basis of alopecia areata, a common autoimmune disease that causes disfiguring hair loss due to the collapse of immune... Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of... |
| SourceID | pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 113 |
| SubjectTerms | 631/208/205/2138 631/80/304 692/420/2780 692/699/249/1313 Adaptive Immunity - genetics Adaptive Immunity - immunology Adult Aged Alleles Alopecia Alopecia Areata - genetics Alopecia Areata - immunology Antigens Antigens, CD - genetics Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - immunology Baldness Case-Control Studies Celiac disease Chromosomes CTLA-4 Antigen Cytomegalovirus Female Genes Genetic aspects Genetic Predisposition to Disease Genetics Genome-Wide Association Study GPI-Linked Proteins Hair Hair Follicle - cytology Hair Follicle - immunology Hair Follicle - metabolism Haplotypes Health aspects Health risk assessment Humanities and Social Sciences Humans Ikaros Transcription Factor - genetics Immune response Immune system Immunity, Innate - genetics Immunity, Innate - immunology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Interleukin-2 Receptor alpha Subunit - genetics letter Lymphocytes Male Middle Aged multidisciplinary NK Cell Lectin-Like Receptor Subfamily K - immunology Pathogenesis Peroxiredoxins - genetics Polymorphism, Single Nucleotide - genetics Principal components analysis Qa-SNARE Proteins - genetics Receptors Review boards Rheumatoid arthritis Risk factors Science Science (multidisciplinary) T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology Validation studies Zinc |
| Title | Genome-wide association study in alopecia areata implicates both innate and adaptive immunity |
| URI | https://link.springer.com/article/10.1038/nature09114 https://www.ncbi.nlm.nih.gov/pubmed/20596022 https://www.proquest.com/docview/610402571 https://www.proquest.com/docview/1753555009 https://www.proquest.com/docview/733628841 https://www.proquest.com/docview/746165829 https://pubmed.ncbi.nlm.nih.gov/PMC2921172 |
| Volume | 466 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ba9swFD60CYO9jLW7ee2CN7ormPoiW_bDGEnWrBu0jK6leRlGluUu0NnpnDD273eOLSdxSPtiDPosRz46F0VH3wE4SBLmKUcpS6ao5CwKfUugp7cyRCvHC2RaUeafnAbHF-zb2B9vwUlzFobSKhubWBnqtJD0H_khunlc6vjc-TS9sahoFG2uNhU0hK6skH6sGMa2oYsW2bc70B0cnX4_W-Z8rNEy6wN7thce1jya6D0d1nJR64Z6xVOtZ1GubaVWHmr0EB7o0NLs13NhB7ZUvgv3qhRPWe7Cjlbj0nynuabfP4KfeFv8VtbfSapMsRSVWdHOmpPcFNdFVaLeFBReCnOiU9CxnwSljBAcEz6bp6ZIxZSsJ2Lo0Mns32O4GB2dD48tXXHBkpzzGSVmekoGYcSjIJQoNJ6kSiifMeEpbtsSFyuZcP0s8_wkczBWSaLUlWhQFbZlynsCnbzI1TMwM6EYU1mEaArJRCS5SmSUSuyJudI24EPzkWOp6cipKsZ1XG2Le2G8IhEDDhbgac3CcQuMpBUTr0VOiTNXYl6Wcf_8cnga9ynlPSA6PQNebYJ9_XHWAr3VoKzA3yWFPq6AoyPGrBZyr4WU08lNvNL6ptV6VUt4Uzf7LSCquWy_pZmCsTYzZbxQCgNeLlrpQcqcy1UxL2NiYvVxGWpHBpi3YIgS0w1D5twBYYGDwaqLvTytp_1CEC5VcMJQ0ADeUogFgBjM2y355FfFZO5GroMRtAGvG9VZjm2DfJ_f-Q324H6d2kG51PvQmf2ZqxcYMc6SHmzzMcdrOHToOvrSg25_8Hkw6mkL8R-JqXEq |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9swED-xoml7mQb7ymCbN8G-pIgmcb4e0NQxUDugmljReJkyx3FYJZaUpRXij9v_trvEKU1VeOMtin9xYp99d47PvwPYiGPuKEspUyY4yXkYuKZAS2-miFaW48mkpMw_7HvdY_71xD1Zgn_1WRgKq6x1Yqmok1zSP_ItNPO41HF969Po3KSkUbS5WmfQEDqzQrJdMozpcx376vICV3DFdu8LinvTtvd2BztdUycZMKXv-2OKRXSU9ILQD71A4nf6caKEcjkXjvLbbYn-eSpsN00dN04tNM9xmNgSdYjCslQ5WO8dWOb0_6QFy593-9-OrmJM5mig9QHBthNsVbydaK0t3jCJ84ZhxjLOR23Obd2WFnHvITzQrizrVGNvBZZUtgp3y5BSWazCilYbBXuvua0_PIKfeJn_UebFMFFMXA0NVtLcsmHGxFk-UniXCXJnBRvqkHesJ8ZRhRBsEz6bJUwkYkTaGjF0yGV8-RiOb6Xzn0AryzP1DFgqFOcqDRFNLqAIpa9iGSYSa-K2bBvwse7kSGr6c8rCcRaV2_BOEM1IxICNKXhUsX5cAyNpRcSjkVGgzqmYFEXUGfzY6UcdCrH3iL7PgDeLYL3vRw3QOw1Kc_wuKfTxCGwdMXQ1kGsNpBwNz6OZ0reN0tNKwouqWW8AUa3I5lvqIRhptVZE00lowOtpKT1IkXqZyidFRMyvLi5726EB7BoMUXDaQcCtGyDcs9A5trGWp9WwnwrCpoxR6Hoa4DcmxBRAjOnNkmz4u2ROt0PbQo_dgM166ly1bYF8n9_YB6_gXndweBAd9Pr7a3C_CiuhOO51aI3_TtQL9FbH8UutExj8um019B_1EapN |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NIRAviI2vsAEGbXxJUfPhxMkDQtVGtTKoEGyiLyg4jjMqjaQjrab9afx33OWjbapub3ur6l_c2He-O9fn3wHsxDF3ta21qRJc5DwMPFOipzdTRGvb9VVSUuZ_GfgHx_zT0Buuwb_mLgylVTY2sTTUSa7oP_IOunnc6njC7qR1VsTX_d6H8ZlJBaTooLWpplFpyKG-OMfdW_G-v4-i3nWc3sejvQOzLjBgKiHEhPIQXa38IBShHyh8RxEnWmqPc-lqYVkKY_NUOl6aul6c2uia4zBxFNoPjW2pdrHfG3BTuJxT1QgxFPPskiUC6PpqoOUGnYqxE_20zVvOcNklLPjE5XzNpUPb0hf27sHdOohl3UrrNmBNZ5twq0wmVcUmbNQGo2Bvalbrt_fhJ37M_2jzfJRoJudKwUqCWzbKmDzNxxq_ZZICWclGdbI79hOjPiEEx4TPZgmTiRyTnUYMXW-ZXDyA42uZ-oewnuWZfgwslZpznYaIpuBPhkroWIWJwp64oywD3jWTHKma-Jzqb5xG5QG8G0QLEjFgZwYeV3wfl8BIWhExaGSkjCdyWhRR9-jH3iDqUnK9T8R9BrxcBet__9YCva5BaY7vpWR9MQJHR9xcLeRWC6nGo7NoofVVq_WkkvCqbrZbQDQoqv0rjQpGtUErotnyM-DFrJUepBy9TOfTIiLOVw83vFZoALsEQ-SbThBw-woI920Mix3s5VGl9jNBOFQrCoNOA0RrQcwAxJXebslGv0vOdCd0bIzVDdhtls58bCvk--TKOXgOt9H4RJ_7g8MtuFPlk1AC9zasT_5O9VMMUyfxs9IgMPh13RboP1pgp-k |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome-wide+association+study+in+alopecia+areata+implicates+both+innate+and+adaptive+immunity&rft.jtitle=Nature+%28London%29&rft.au=Petukhova%2C+Lynn&rft.au=Duvic%2C+Madeleine&rft.au=Hordinsky%2C+Maria&rft.au=Norris%2C+David&rft.date=2010-07-01&rft.pub=Nature+Publishing+Group+UK&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=466&rft.issue=7302&rft.spage=113&rft.epage=117&rft_id=info:doi/10.1038%2Fnature09114&rft.externalDocID=10_1038_nature09114 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |