Ancient Pathways Programmed by Small RNAs
Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression...
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| Published in | Science (American Association for the Advancement of Science) Vol. 296; no. 5571; pp. 1265 - 1269 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for the Advancement of Science
17.05.2002
American Association for the Advancement of Science The American Association for the Advancement of Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0036-8075 1095-9203 1095-9203 |
| DOI | 10.1126/science.1072457 |
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| Abstract | Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. Current evidence suggests that RNA interference and other "RNA silencing" phenomena reflect an elaborate cellular apparatus that eliminates abundant but defective messenger RNAs and defends against molecular parasites such as transposons and viruses. |
|---|---|
| AbstractList | Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. Current evidence suggests that RNA interference and other "RNA silencing" phenomena reflect an elaborate cellular apparatus that eliminates abundant but defective messenger RNAs and defends against molecular parasites such as transposons and viruses.Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. Current evidence suggests that RNA interference and other "RNA silencing" phenomena reflect an elaborate cellular apparatus that eliminates abundant but defective messenger RNAs and defends against molecular parasites such as transposons and viruses. Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. Current evidence suggests that RNA interference and other "RNA silencing" phenomena reflect an elaborate cellular apparatus that eliminates abundant but defective messenger RNAs and defends against molecular parasites such as transposons and viruses. Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. Current evidence suggests that RNA interference and other "RNA silencing" phenomena reflect an elaborate cellular apparatus that eliminates abundant but defective messenger RNAs Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. |
| Audience | Academic |
| Author | Zamore, Phillip D. |
| Author_xml | – sequence: 1 givenname: Phillip D. surname: Zamore fullname: Zamore, Phillip D. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12016303$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Cellular biology Cultured cells DNA Transposable Elements Double stranded RNA Drosophila Endoribonucleases Endoribonucleases - metabolism Fungi gene expression Gene Silencing Genes Genetics Humans mechanism of action Messenger RNA metabolism Plant Diseases Plants Plants - genetics prevention & control Proteins Ribonuclease III Ribonucleic acid Ribonucleoproteins Ribonucleoproteins - metabolism RNA RNA interference RNA Replicase - metabolism RNA, Antisense RNA, Antisense - genetics RNA, Antisense - metabolism RNA, Double-Stranded RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Plant RNA, Plant - genetics RNA, Plant - metabolism RNA, Small Interfering RNA, Untranslated RNA, Untranslated - genetics RNA, Untranslated - metabolism RNA-Dependent RNA Polymerase Small interfering RNA small nuclear RNA Transcription, Genetic Transcripts (Written Records) Transgenes Viewpoints Virus Diseases Virus Diseases - prevention & control Virus Physiological Phenomena |
| Title | Ancient Pathways Programmed by Small RNAs |
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