Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping - Zhao, Quanyi; Dacre, Michael; Nguyen, Trieu; Pjanic, Milos; Liu, Boxiang; Iyer, Dharini; Cheng, Paul; Wirka, Robert; Kim, Juyong Brian; Fraser, Hunter B.; Quertermous, Thomas (Genome Biology, 2020)
Keywords: Animal Genetics and Genomics; Atherosclerosis; Basic Helix-Loop-Helix Transcription Factors - metabolism; Binding sites; Bioinformatics; Biomedical and Life Sciences; Blood pressure; Breast cancer; Calcification; Cardiovascular disease; Chromatin; Chromatin accessibility; Chromosomal looping; Coronary artery; Coronary artery disease; Coronary Disease - genetics; Coronary Disease - metabolism; Coronary vessels; Coronary Vessels - cytology; cultured cells; Epigenesis, Genetic; epigenetics; Evolutionary Biology; Fibronectins - genetics; Gene expression; Gene mapping; Gene regulation; genes; Genetic diversity; Genome editing; Genomes; genomics; Heart attacks; Heart diseases; Human Genetics; Humans; Kawasaki disease; Life Sciences; Microbial Genetics and Genomics; Molecular modelling; Muscle, Smooth, Vascular - cytology; Myocytes, Smooth Muscle - metabolism; Plant Genetics and Genomics; Primary Cell Culture; Quantitative Trait Loci; Quantitative trait locus; quantitative traits; risk; Single-nucleotide polymorphism; Smad3 protein; Smad3 Protein - metabolism; Smooth muscle; Smooth muscle cells; Structure-function relationships; TCF21; transcription (genetics); Transcription factors; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b1; TCF21; Chromatin accessibility; Chromosomal looping; Quantitative trait locus; Smooth muscle cells; Coronary artery disease