Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies

Saved in:
Bibliographic Details
Published ineLife Vol. 13
Main Authors Fawaz, Sami, Marti, Severine, Dufossee, Melody, Pucheu, Yann, Gaufroy, Astrid, Broitman, Jean, Bidet, Audrey, Soumare, Aicha, Munsch, Gaëlle, Tzourio, Christophe, Debette, Stephanie, Trégouët, David-Alexandre, James, Chloe, Mansier, Olivier, Couffinhal, Thierry
Format Journal Article
LanguageEnglish
Published 12.12.2024
Online AccessGet full text
ISSN2050-084X
2050-084X
DOI10.7554/eLife.96150.3

Cover

Author Debette, Stephanie
Marti, Severine
Fawaz, Sami
Dufossee, Melody
Bidet, Audrey
Broitman, Jean
Couffinhal, Thierry
Mansier, Olivier
Tzourio, Christophe
Gaufroy, Astrid
Pucheu, Yann
Munsch, Gaëlle
Trégouët, David-Alexandre
James, Chloe
Soumare, Aicha
Author_xml – sequence: 1
  givenname: Sami
  surname: Fawaz
  fullname: Fawaz, Sami
– sequence: 2
  givenname: Severine
  surname: Marti
  fullname: Marti, Severine
– sequence: 3
  givenname: Melody
  surname: Dufossee
  fullname: Dufossee, Melody
– sequence: 4
  givenname: Yann
  surname: Pucheu
  fullname: Pucheu, Yann
– sequence: 5
  givenname: Astrid
  surname: Gaufroy
  fullname: Gaufroy, Astrid
– sequence: 6
  givenname: Jean
  surname: Broitman
  fullname: Broitman, Jean
– sequence: 7
  givenname: Audrey
  surname: Bidet
  fullname: Bidet, Audrey
– sequence: 8
  givenname: Aicha
  surname: Soumare
  fullname: Soumare, Aicha
– sequence: 9
  givenname: Gaëlle
  orcidid: 0000-0003-1564-9825
  surname: Munsch
  fullname: Munsch, Gaëlle
– sequence: 10
  givenname: Christophe
  orcidid: 0000-0002-6517-2984
  surname: Tzourio
  fullname: Tzourio, Christophe
– sequence: 11
  givenname: Stephanie
  surname: Debette
  fullname: Debette, Stephanie
– sequence: 12
  givenname: David-Alexandre
  orcidid: 0000-0001-9084-7800
  surname: Trégouët
  fullname: Trégouët, David-Alexandre
– sequence: 13
  givenname: Chloe
  surname: James
  fullname: James, Chloe
– sequence: 14
  givenname: Olivier
  orcidid: 0000-0002-7943-8800
  surname: Mansier
  fullname: Mansier, Olivier
– sequence: 15
  givenname: Thierry
  surname: Couffinhal
  fullname: Couffinhal, Thierry
BookMark eNpNkE9LAzEQxYNUsNYevecLbE1M9p-3UqoVCl560NMym0xodDdZkm2hB7-7afXgXGZ4vPkx827JxHmHhNxztijzXD7g1hpc1AXP2UJckekjy1nGKvk--TffkHmMnyxVKauK11PyvT5Cd4DReke9oarzDjq6xx5GP3iL0UYKTtPeR7CKdj7Gs--Dqn3wSfQ9UuuogqCtP0JUhw4CDTZ-PdGlS6vQnc6M5BmCjwOq0R6RxvGgE_yOXBvoIs7_-ozsnte71Sbbvr28rpbbTJWlyAwHXRtZycII3homcg28glYiojGiLVquTZl-lKgMryRnbZ0zSCpirQsUM5L9YlU6IQY0zRBsD-HUcNac02su6TWX9BohfgC7s2lM
Cites_doi 10.1016/j.jacc.2022.08.740
10.1182/bloodadvances.2020004062
10.1182/blood-2017-02-769869
10.1182/blood-2015-03-631747
10.1038/s41586-020-2819-2
10.1038/ng.3821
10.1182/bloodadvances.2018024729
10.1016/j.jmoldx.2016.10.002
10.1038/s41598-018-30759-1
10.1016/j.jacc.2018.08.1038
10.1038/s41375-021-01456-2
10.1182/bloodadvances.2020001582
10.1038/s41588-022-01121-z
10.1182/bloodadvances.2019000770
10.2337/dc19-S002
10.1161/CIR.0000000000000678
10.1056/NEJMoa1701719
10.1038/s41375-022-01613-1
10.1182/bloodadvances.2020003444
10.1093/rheumatology/keac108
10.1126/science.aag1381
10.1159/000072920
10.1038/ng.2966
10.1038/s41586-022-05448-9
10.1182/blood.2022018825
10.1093/eurheartj/ehad093
10.1038/s44161-022-00206-6
10.1016/j.ebiom.2022.103964
10.1161/CIRCULATIONAHA.122.062126
10.1161/STROKEAHA.122.041416
10.1056/NEJMoa1012848
10.1177/2047487311434107
10.1161/CIRCRESAHA.120.317104
10.1016/j.jacc.2021.02.028
10.1038/s41591-021-01411-9
10.1093/eurheartj/ehw128
10.1093/eurheartj/ehz591
10.1182/blood.2022017661
10.1038/ng.3545
10.1161/CIRCGEN.123.004415
10.1001/jamacardio.2023.5095
10.1056/NEJMoa1409405
10.1056/NEJMoa1408617
10.1126/science.abn3100
ContentType Journal Article
DBID AAYXX
CITATION
DOI 10.7554/eLife.96150.3
DatabaseName CrossRef
DatabaseTitle CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2050-084X
ExternalDocumentID 10_7554_eLife_96150_3
GroupedDBID 53G
5VS
7X7
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAKDD
AAYXX
ABUWG
ACGFO
ACGOD
ACPRK
ADBBV
ADRAZ
AENEX
AFKRA
AFPKN
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CITATION
DIK
DWQXO
EMOBN
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IEA
IHR
INH
INR
ISR
ITC
KQ8
LK8
M1P
M2P
M48
M7P
M~E
NQS
OK1
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RHI
RNS
RPM
UKHRP
ID FETCH-LOGICAL-c773-f1ad9f4846f31bf035da18ab4eeeff3b6b1df70504ecf18410b950ab1dee9d6e3
IEDL.DBID M48
ISSN 2050-084X
IngestDate Tue Jul 01 01:34:15 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c773-f1ad9f4846f31bf035da18ab4eeeff3b6b1df70504ecf18410b950ab1dee9d6e3
ORCID 0000-0003-1564-9825
0000-0002-6517-2984
0000-0002-7943-8800
0000-0001-9084-7800
OpenAccessLink https://doi.org/10.7554/elife.96150.3
ParticipantIDs crossref_primary_10_7554_eLife_96150_3
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-12-12
PublicationDateYYYYMMDD 2024-12-12
PublicationDate_xml – month: 12
  year: 2024
  text: 2024-12-12
  day: 12
PublicationDecade 2020
PublicationTitle eLife
PublicationYear 2024
References Ponikowski (bib31) 2016; 37
Arends (bib4) 2023; 141
Genovese (bib14) 2014; 371
Zhou (bib43) 2016; 48
Luque Paz (bib26) 2021; 5
Wright (bib40) 2017; 49
Steensma (bib34) 2015; 126
Pascual-Figal (bib30) 2021; 77
Thygesen (bib35) 2018; 72
Sano (bib33) 2022; 377
Forsberg (bib12) 2014; 46
Zink (bib44) 2017; 130
Zekavat (bib41) 2023; 2
Fuster (bib13) 2017; 355
Vlasschaert (bib38) 2023; 141
David (bib11) 2022; 61
Li (bib23) 2017; 19
Bick (bib7) 2020; 586
Mas-Peiro (bib28) 2023; 44
Lafitte (bib22) 2013; 20
Wang (bib39) 2022; 78
Zhao (bib42) 2024; 9
Böhme (bib8) 2022; 80
Busque (bib9) 2020; 4
American Diabetes Association (bib3) 2019; 42
Jaiswal (bib18) 2017; 377
van Zeventer (bib36) 2021; 5
Ljungström (bib24) 2022; 36
Guermouche (bib15) 2020; 4
Heimlich (bib16) 2024; 17
Loftfield (bib25) 2018; 8
3C Study Group (bib1) 2003; 22
Kessler (bib20) 2022; 612
Vlasschaert (bib37) 2023; 147
Mayerhofer (bib29) 2023; 54
Jaiswal (bib17) 2014; 371
Berry (bib6) 2012; 366
Abplanalp (bib2) 2021; 128
Mas-Peiro (bib27) 2020; 41
Cook (bib10) 2019; 3
Arnett (bib5) 2019; 140
Kar (bib19) 2022; 54
Khoury (bib21) 2022; 36
Saiki (bib32) 2021; 27
References_xml – volume: 80
  start-page: 1545
  year: 2022
  ident: bib8
  article-title: Impact of clonal hematopoiesis in patients with cardiogenic shock complicating acute myocardial infarction
  publication-title: Journal of the American College of Cardiology
  doi: 10.1016/j.jacc.2022.08.740
– volume: 5
  start-page: 2115
  year: 2021
  ident: bib36
  article-title: Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years
  publication-title: Blood Advances
  doi: 10.1182/bloodadvances.2020004062
– volume: 130
  start-page: 742
  year: 2017
  ident: bib44
  article-title: Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
  publication-title: Blood
  doi: 10.1182/blood-2017-02-769869
– volume: 126
  start-page: 9
  year: 2015
  ident: bib34
  article-title: Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
  publication-title: Blood
  doi: 10.1182/blood-2015-03-631747
– volume: 586
  start-page: 763
  year: 2020
  ident: bib7
  article-title: Inherited causes of clonal haematopoiesis in 97,691 whole genomes
  publication-title: Nature
  doi: 10.1038/s41586-020-2819-2
– volume: 49
  start-page: 674
  year: 2017
  ident: bib40
  article-title: Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility
  publication-title: Nature Genetics
  doi: 10.1038/ng.3821
– volume: 3
  start-page: 2482
  year: 2019
  ident: bib10
  article-title: Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis
  publication-title: Blood Advances
  doi: 10.1182/bloodadvances.2018024729
– volume: 19
  start-page: 4
  year: 2017
  ident: bib23
  article-title: Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists
  publication-title: The Journal of Molecular Diagnostics
  doi: 10.1016/j.jmoldx.2016.10.002
– volume: 8
  year: 2018
  ident: bib25
  article-title: Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank
  publication-title: Scientific Reports
  doi: 10.1038/s41598-018-30759-1
– volume: 72
  start-page: 2231
  year: 2018
  ident: bib35
  article-title: Fourth Universal Definition of Myocardial Infarction (2018)
  publication-title: Journal of the American College of Cardiology
  doi: 10.1016/j.jacc.2018.08.1038
– volume: 36
  start-page: 889
  year: 2022
  ident: bib24
  article-title: Loss of Y and clonal hematopoiesis in blood-two sides of the same coin?
  publication-title: Leukemia
  doi: 10.1038/s41375-021-01456-2
– volume: 4
  start-page: 3550
  year: 2020
  ident: bib15
  article-title: High prevalence of clonal hematopoiesis in the blood and bone marrow of healthy volunteers
  publication-title: Blood Advances
  doi: 10.1182/bloodadvances.2020001582
– volume: 54
  start-page: 1155
  year: 2022
  ident: bib19
  article-title: Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis
  publication-title: Nature Genetics
  doi: 10.1038/s41588-022-01121-z
– volume: 4
  start-page: 2430
  year: 2020
  ident: bib9
  article-title: High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential
  publication-title: Blood Advances
  doi: 10.1182/bloodadvances.2019000770
– volume: 42
  start-page: S13
  year: 2019
  ident: bib3
  article-title: 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019
  publication-title: Diabetes Care
  doi: 10.2337/dc19-S002
– volume: 140
  start-page: e596
  year: 2019
  ident: bib5
  article-title: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000678
– volume: 377
  start-page: 111
  year: 2017
  ident: bib18
  article-title: Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
  publication-title: The New England Journal of Medicine
  doi: 10.1056/NEJMoa1701719
– volume: 36
  start-page: 1703
  year: 2022
  ident: bib21
  article-title: The 5th edition of the world health organization classification of haematolymphoid tumours: Myeloid and histiocytic/dendritic neoplasms
  publication-title: Leukemia
  doi: 10.1038/s41375-022-01613-1
– volume: 5
  start-page: 1442
  year: 2021
  ident: bib26
  article-title: Genomic analysis of primary and secondary myelofibrosis redefines the prognostic impact of ASXL1 mutations: a FIM study
  publication-title: Blood Advances
  doi: 10.1182/bloodadvances.2020003444
– volume: 61
  start-page: 4355
  year: 2022
  ident: bib11
  article-title: Clonal haematopoiesis of indeterminate potential and cardiovascular events in systemic lupus erythematosus (HEMATOPLUS study)
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/keac108
– volume: 355
  start-page: 842
  year: 2017
  ident: bib13
  article-title: Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
  publication-title: Science
  doi: 10.1126/science.aag1381
– volume: 22
  start-page: 316
  year: 2003
  ident: bib1
  article-title: Vascular factors and risk of dementia: Design of the three-city study and baseline characteristics of the study population
  publication-title: Neuroepidemiology
  doi: 10.1159/000072920
– volume: 46
  start-page: 624
  year: 2014
  ident: bib12
  article-title: Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer
  publication-title: Nature Genetics
  doi: 10.1038/ng.2966
– volume: 612
  start-page: 301
  year: 2022
  ident: bib20
  article-title: Common and rare variant associations with clonal haematopoiesis phenotypes
  publication-title: Nature
  doi: 10.1038/s41586-022-05448-9
– volume: 141
  start-page: 2214
  year: 2023
  ident: bib38
  article-title: A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets
  publication-title: Blood
  doi: 10.1182/blood.2022018825
– volume: 44
  start-page: 1943
  year: 2023
  ident: bib28
  article-title: Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement
  publication-title: European Heart Journal
  doi: 10.1093/eurheartj/ehad093
– volume: 2
  start-page: 144
  year: 2023
  ident: bib41
  article-title: TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease
  publication-title: Nature Cardiovascular Research
  doi: 10.1038/s44161-022-00206-6
– volume: 78
  year: 2022
  ident: bib39
  article-title: Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2022.103964
– volume: 147
  start-page: 358
  year: 2023
  ident: bib37
  article-title: Interleukin-6 receptor polymorphism attenuates clonal hematopoiesis-mediated coronary artery disease risk among 451 180 individuals in the UK Biobank
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.122.062126
– volume: 54
  start-page: 938
  year: 2023
  ident: bib29
  article-title: Prevalence and therapeutic implications of clonal hematopoiesis of indeterminate potential in young patients with stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.122.041416
– volume: 366
  start-page: 321
  year: 2012
  ident: bib6
  article-title: Lifetime risks of cardiovascular disease
  publication-title: The New England Journal of Medicine
  doi: 10.1056/NEJMoa1012848
– volume: 20
  start-page: 283
  year: 2013
  ident: bib22
  article-title: Predictors of cardiovascular prognosis in patients receiving optimized secondary prevention measures after acute coronary syndrome
  publication-title: European Journal of Preventive Cardiology
  doi: 10.1177/2047487311434107
– volume: 128
  start-page: 216
  year: 2021
  ident: bib2
  article-title: Clonal hematopoiesis-driver DNMT3A mutations alter immune cells in heart failure
  publication-title: Circulation Research
  doi: 10.1161/CIRCRESAHA.120.317104
– volume: 77
  start-page: 1747
  year: 2021
  ident: bib30
  article-title: Clonal hematopoiesis and risk of progression of heart failure with reduced left ventricular ejection fraction
  publication-title: Journal of the American College of Cardiology
  doi: 10.1016/j.jacc.2021.02.028
– volume: 27
  start-page: 1239
  year: 2021
  ident: bib32
  article-title: Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis
  publication-title: Nature Medicine
  doi: 10.1038/s41591-021-01411-9
– volume: 37
  start-page: 2129
  year: 2016
  ident: bib31
  article-title: 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC
  publication-title: European Heart Journal
  doi: 10.1093/eurheartj/ehw128
– volume: 41
  start-page: 933
  year: 2020
  ident: bib27
  article-title: Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation
  publication-title: European Heart Journal
  doi: 10.1093/eurheartj/ehz591
– volume: 141
  start-page: 787
  year: 2023
  ident: bib4
  article-title: Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke
  publication-title: Blood
  doi: 10.1182/blood.2022017661
– volume: 48
  start-page: 563
  year: 2016
  ident: bib43
  article-title: Mosaic loss of chromosome Y is associated with common variation near TCL1A
  publication-title: Nature Genetics
  doi: 10.1038/ng.3545
– volume: 17
  year: 2024
  ident: bib16
  article-title: Invasive assessment of coronary artery disease in clonal hematopoiesis of indeterminate potential
  publication-title: Circulation. Genomic and Precision Medicine
  doi: 10.1161/CIRCGEN.123.004415
– volume: 9
  start-page: 233
  year: 2024
  ident: bib42
  article-title: Somatic and germline variants and coronary heart disease in a chinese population
  publication-title: JAMA Cardiology
  doi: 10.1001/jamacardio.2023.5095
– volume: 371
  start-page: 2477
  year: 2014
  ident: bib14
  article-title: Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
  publication-title: The New England Journal of Medicine
  doi: 10.1056/NEJMoa1409405
– volume: 371
  start-page: 2488
  year: 2014
  ident: bib17
  article-title: Age-related clonal hematopoiesis associated with adverse outcomes
  publication-title: The New England Journal of Medicine
  doi: 10.1056/NEJMoa1408617
– volume: 377
  start-page: 292
  year: 2022
  ident: bib33
  article-title: Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
  publication-title: Science
  doi: 10.1126/science.abn3100
SSID ssj0000748819
Score 2.3974783
SourceID crossref
SourceType Index Database
Title Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: KQ8
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: KQ8
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: DOA
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: DIK
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: GX1
  dateStart: 0
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: M~E
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: RPM
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: 7X7
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 2050-084X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: BENPR
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 2050-084X
  dateEnd: 20250131
  omitProxy: true
  ssIdentifier: ssj0000748819
  issn: 2050-084X
  databaseCode: M48
  dateStart: 20121201
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3PS8MwFA66IXgRf-LPkYN460ybtF28yJQNETdENpinkrQJFrZ2rhPcwf_dl7TTiR68ltcEvpeX9z14-R5C5yERoQ6075BACYd5Wjmi5Rt5vJhBbDHpWnX9Xj-4G7L7kT_6lhSqACz-LO3MPKnhbNx8f11cQ8ADf22GkA0v1UOqVZMbafMmXUd1SEqeOeC9iunbSzmEk2rHfHjEt2qmo1Jx8_cKKxlqJdV0t9FWxRFxu3TqDlpT2S7aKKdGLvbQR-dLoRvnGsdjQ6axFV_NpzlUvmmBRZbgSV6INMZj2MTYPeP4xfTeFflE4TTD8Y9OVGx6zK9wO4NfS5kSYwPX6_IpJi7KjsN9NOh2Brd3TjVFwYnDkDraFQnXDGiGpq7UhPqJcFtCMqWU1lQG0k10CJgwFWso91wiuU8EfFWKJ4GiB6iW5Zk6RBjczRNOBSGaM8kZFyRoCQoMiiUBRNsRulgCF01LrYwIagyDcGQRjizCET3-r-EJ2vSARJj2Edc7RbX57E2dAQmYywaq33T6j08NW0Q3rLM_AS3jtWY
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+clonal+hematopoiesis+and+mosaic+loss+of+Y+chromosome+in+cardiovascular+risk%3A+An+analysis+in+prospective+studies&rft.jtitle=eLife&rft.au=Fawaz%2C+Sami&rft.au=Marti%2C+Severine&rft.au=Dufossee%2C+Melody&rft.au=Pucheu%2C+Yann&rft.date=2024-12-12&rft.issn=2050-084X&rft.eissn=2050-084X&rft.volume=13&rft_id=info:doi/10.7554%2FeLife.96150.3&rft.externalDBID=n%2Fa&rft.externalDocID=10_7554_eLife_96150_3
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-084X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-084X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-084X&client=summon