Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.] - Um, S.H; Frigerio, F; Watanabe, M; Picard, F; Joaquin, M; Sticker, M; Fumagalli, S; Allegrini, P.R; Kozma, S.C; Auwerx, J (Nature (London), 2004)
Keywords: Adipocytes - metabolism; adipose tissue; age; Aging - physiology; animal proteins; Animals; Biochemistry, Molecular Biology; Biological and medical sciences; blood glucose; Blood Glucose - analysis; blood lipids; Diabetes; Diet; Dietary Fats - pharmacology; Enzyme Activation; enzyme activity; enzyme deficiencies; Fasting - blood; Fasting - physiology; Fatty Acids, Nonesterified - blood; free fatty acids; Gene Deletion; high fat diet; hormonal regulation; Humanities and Social Sciences; Hypersensitivity; Insulin; Insulin - pharmacology; insulin receptor substrate 1; Insulin Receptor Substrate Proteins; Insulin Resistance - genetics; Insulin Resistance - physiology; letter; Life Sciences; Lipolysis; Male; Medical sciences; Medical treatment; Metabolic diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; multidisciplinary; Nutrients; Obesity; Obesity - blood; Obesity - chemically induced; Obesity - genetics; Obesity - metabolism; overeating; Oxidation-Reduction; Phosphoproteins - metabolism; Phosphorylation; Receptor, Insulin - metabolism; Ribosomal Protein S6 Kinases, 70-kDa - deficiency; Ribosomal Protein S6 Kinases, 70-kDa - genetics; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Science; Science (multidisciplinary); Signal Transduction - drug effects; Endocrinopathy; Animal model; Obesity; Pancreatic hormone; Enzyme; Transferases; Diabetes mellitus; Deficiency; Rodentia; Insulin; Metabolic disorder; Vertebrata; Mammalia; Sensitivity resistance; Mouse; Protein kinase; Animal