Peripheral blood metabolic and inflammatory factors as biomarkers to ocular findings in diabetic macular edema
To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included...
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| Published in | PloS one Vol. 12; no. 3; p. e0173865 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
22.03.2017
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0173865 |
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| Abstract | To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients.
Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal thickness, diffuse retinal thickness (DRT), cystoid macular edema (CME), serous retinal detachment and epirretinal membrane. UWFA items included pattern of DME, presence of peripheral retinal ischemia and enlarged foveal avascular zone (FAZ).
Metabolic and inflammatory factors did not statistically differ between groups. However, several inflammatory mediators did associate to certain ocular items of DME cases: IL-6 was significantly higher in patients with DRT (p = 0.044), IL-10 was decreased in patients with CME (p = 0.012), and higher IL-8 (p = 0.031) and VEGF levels (p = 0.031) were observed in patients with enlarged FAZ.
Inflammatory and metabolic peripheral blood factors in T2DM may not be differentially associated to DME when compared to non-DME cases. However, some OCT and UWFA features of DME such as DRT, CME and enlarged FAZ may be associated to certain systemic inflammatory mediators. |
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| AbstractList | Aims To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. Material and methods Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal thickness, diffuse retinal thickness (DRT), cystoid macular edema (CME), serous retinal detachment and epirretinal membrane. UWFA items included pattern of DME, presence of peripheral retinal ischemia and enlarged foveal avascular zone (FAZ). Results Metabolic and inflammatory factors did not statistically differ between groups. However, several inflammatory mediators did associate to certain ocular items of DME cases: IL-6 was significantly higher in patients with DRT (p = 0.044), IL-10 was decreased in patients with CME (p = 0.012), and higher IL-8 (p = 0.031) and VEGF levels (p = 0.031) were observed in patients with enlarged FAZ. Conclusion Inflammatory and metabolic peripheral blood factors in T2DM may not be differentially associated to DME when compared to non-DME cases. However, some OCT and UWFA features of DME such as DRT, CME and enlarged FAZ may be associated to certain systemic inflammatory mediators. To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal thickness, diffuse retinal thickness (DRT), cystoid macular edema (CME), serous retinal detachment and epirretinal membrane. UWFA items included pattern of DME, presence of peripheral retinal ischemia and enlarged foveal avascular zone (FAZ). Metabolic and inflammatory factors did not statistically differ between groups. However, several inflammatory mediators did associate to certain ocular items of DME cases: IL-6 was significantly higher in patients with DRT (p = 0.044), IL-10 was decreased in patients with CME (p = 0.012), and higher IL-8 (p = 0.031) and VEGF levels (p = 0.031) were observed in patients with enlarged FAZ. Inflammatory and metabolic peripheral blood factors in T2DM may not be differentially associated to DME when compared to non-DME cases. However, some OCT and UWFA features of DME such as DRT, CME and enlarged FAZ may be associated to certain systemic inflammatory mediators. To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal thickness, diffuse retinal thickness (DRT), cystoid macular edema (CME), serous retinal detachment and epirretinal membrane. UWFA items included pattern of DME, presence of peripheral retinal ischemia and enlarged foveal avascular zone (FAZ). Metabolic and inflammatory factors did not statistically differ between groups. However, several inflammatory mediators did associate to certain ocular items of DME cases: IL-6 was significantly higher in patients with DRT (p = 0.044), IL-10 was decreased in patients with CME (p = 0.012), and higher IL-8 (p = 0.031) and VEGF levels (p = 0.031) were observed in patients with enlarged FAZ. Inflammatory and metabolic peripheral blood factors in T2DM may not be differentially associated to DME when compared to non-DME cases. However, some OCT and UWFA features of DME such as DRT, CME and enlarged FAZ may be associated to certain systemic inflammatory mediators. To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients.AIMSTo study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients.Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal thickness, diffuse retinal thickness (DRT), cystoid macular edema (CME), serous retinal detachment and epirretinal membrane. UWFA items included pattern of DME, presence of peripheral retinal ischemia and enlarged foveal avascular zone (FAZ).MATERIAL AND METHODSObservational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal thickness, diffuse retinal thickness (DRT), cystoid macular edema (CME), serous retinal detachment and epirretinal membrane. UWFA items included pattern of DME, presence of peripheral retinal ischemia and enlarged foveal avascular zone (FAZ).Metabolic and inflammatory factors did not statistically differ between groups. However, several inflammatory mediators did associate to certain ocular items of DME cases: IL-6 was significantly higher in patients with DRT (p = 0.044), IL-10 was decreased in patients with CME (p = 0.012), and higher IL-8 (p = 0.031) and VEGF levels (p = 0.031) were observed in patients with enlarged FAZ.RESULTSMetabolic and inflammatory factors did not statistically differ between groups. However, several inflammatory mediators did associate to certain ocular items of DME cases: IL-6 was significantly higher in patients with DRT (p = 0.044), IL-10 was decreased in patients with CME (p = 0.012), and higher IL-8 (p = 0.031) and VEGF levels (p = 0.031) were observed in patients with enlarged FAZ.Inflammatory and metabolic peripheral blood factors in T2DM may not be differentially associated to DME when compared to non-DME cases. However, some OCT and UWFA features of DME such as DRT, CME and enlarged FAZ may be associated to certain systemic inflammatory mediators.CONCLUSIONInflammatory and metabolic peripheral blood factors in T2DM may not be differentially associated to DME when compared to non-DME cases. However, some OCT and UWFA features of DME such as DRT, CME and enlarged FAZ may be associated to certain systemic inflammatory mediators. Aims To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. Material and methods Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal thickness, diffuse retinal thickness (DRT), cystoid macular edema (CME), serous retinal detachment and epirretinal membrane. UWFA items included pattern of DME, presence of peripheral retinal ischemia and enlarged foveal avascular zone (FAZ). Results Metabolic and inflammatory factors did not statistically differ between groups. However, several inflammatory mediators did associate to certain ocular items of DME cases: IL-6 was significantly higher in patients with DRT (p = 0.044), IL-10 was decreased in patients with CME (p = 0.012), and higher IL-8 (p = 0.031) and VEGF levels (p = 0.031) were observed in patients with enlarged FAZ. Conclusion Inflammatory and metabolic peripheral blood factors in T2DM may not be differentially associated to DME when compared to non-DME cases. However, some OCT and UWFA features of DME such as DRT, CME and enlarged FAZ may be associated to certain systemic inflammatory mediators. |
| Audience | Academic |
| Author | Adán, Alfredo Ríos, José Molins, Blanca Figueras-Roca, Marc Sala-Puigdollers, Anna Vinagre, Irene Matas, Jessica |
| AuthorAffiliation | 3 Department of Endocrinology, Hospital Clínic, Barcelona, Spain 5 Biostatistics Unit, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain 1 Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain Massachusetts Eye & Ear Infirmary, Harvard Medical School, UNITED STATES 2 August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain 4 Medical Statistics Core Facility, IDIBAPS, Barcelona, Spain |
| AuthorAffiliation_xml | – name: 2 August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain – name: 4 Medical Statistics Core Facility, IDIBAPS, Barcelona, Spain – name: 5 Biostatistics Unit, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain – name: 1 Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain – name: 3 Department of Endocrinology, Hospital Clínic, Barcelona, Spain – name: Massachusetts Eye & Ear Infirmary, Harvard Medical School, UNITED STATES |
| Author_xml | – sequence: 1 givenname: Marc surname: Figueras-Roca fullname: Figueras-Roca, Marc – sequence: 2 givenname: Blanca surname: Molins fullname: Molins, Blanca – sequence: 3 givenname: Anna surname: Sala-Puigdollers fullname: Sala-Puigdollers, Anna – sequence: 4 givenname: Jessica surname: Matas fullname: Matas, Jessica – sequence: 5 givenname: Irene surname: Vinagre fullname: Vinagre, Irene – sequence: 6 givenname: José surname: Ríos fullname: Ríos, José – sequence: 7 givenname: Alfredo surname: Adán fullname: Adán, Alfredo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28328965$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Figueras-Roca et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. cc-by (c) Figueras Roca, Marc et al., 2017 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es 2017 Figueras-Roca et al 2017 Figueras-Roca et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Competing Interests: The authors have declared that no competing interests exist. These authors also contributed equally to this work. Conceptualization: MF BM IV AA.Data curation: MF AS JM.Formal analysis: BM JR.Funding acquisition: JM AA.Investigation: MF JM IV.Methodology: MF BM.Project administration: MF.Resources: BM.Supervision: MF.Validation: BM.Visualization: BM.Writing – original draft: MF BM.Writing – review & editing: MF BM. |
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publication-title: Current Diabetes Reviews doi: 10.2174/157339906776818532 – volume: 30 year: 2012 ident: ref17 article-title: The effect of glycemic control on visual and anatomic outcomes in response to therapy for diabetic macular edema publication-title: Eur J Ophthalmol – volume: 91 start-page: 1 issue: 1 year: 1984 ident: ref2 article-title: Visual impairment in diabetes publication-title: Ophthalmology doi: 10.1016/S0161-6420(84)34337-8 – volume: 158 start-page: 144 issue: 1 year: 2014 ident: ref25 article-title: Patterns of peripheral retinal and central macula ischemia in diabetic retinopathy as evaluated by ultra-widefield fluorescein angiography publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2014.03.009 – volume: 122 start-page: 1820 issue: 9 year: 2015 ident: ref19 article-title: Dyslipidemia and Diabetic Macular Edema: A Systematic Review and Meta-Analysis publication-title: Ophthalmology doi: 10.1016/j.ophtha.2015.05.011 – volume: 35 start-page: 556 issue: 3 year: 2012 ident: ref4 article-title: Global prevalence and major risk factors of diabetic retinopathy publication-title: Diabetes Care doi: 10.2337/dc11-1909 – volume: 344 start-page: 163 year: 2010 ident: ref31 article-title: Recombinant adenoviral expression of IL-10 protects beta cell from impairment induced by pro-inflammatory cytokine publication-title: Mol Cell Biochem doi: 10.1007/s11010-010-0539-x – volume: 23 start-page: 1 year: 2015 ident: ref26 article-title: Serum and Aqueous Concentrations of Inflammatory Markers in Diabetic Macular Edema publication-title: Ocul Immunol Inflamm – volume: 22 start-page: 151 issue: 2 year: 2015 ident: ref11 article-title: Diabetic Retinopathy and Systemic Factors publication-title: Middle East Afr J Ophthalmol doi: 10.4103/0974-9233.154388 – volume: 96 start-page: 694 issue: 5 year: 2012 ident: ref33 article-title: Peripheral retinal ischaemia, as evaluated by ultra-widefield fluorescein angiography, is associated with diabetic macular oedema publication-title: Br J Ophthalmol doi: 10.1136/bjophthalmol-2011-300774 – volume: 38 start-page: 361 issue: 4 year: 2008 ident: ref21 article-title: Cytokine Profile of Peripheral Blood in Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy publication-title: Annals of Clinical and Laboratory Science – volume: 110 start-page: 1677 issue: 9 year: 2003 ident: ref22 article-title: Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales publication-title: Ophthalmology doi: 10.1016/S0161-6420(03)00475-5 – volume: 22 start-page: 309 year: 2008 ident: ref15 article-title: TNF-α is an independent serum marker for proliferative retinopathy in type 1 diabetic patients publication-title: Journal of Diabetes and Its Complications doi: 10.1016/j.jdiacomp.2007.03.001 – volume: 13 issue: 34 year: 2014 ident: ref10 article-title: Inflammatory biomarkers in type 2 diabetic patients: effect of glycemic control and impact of Idl subfraction phenotype publication-title: Cardiovascular Diabetology – volume: 146 start-page: 649 issue: 5 year: 2008 ident: ref24 article-title: Diabetic macular edema: what is focal and what is diffuse? publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2008.07.013 – year: 2015 ident: ref12 article-title: Diabetic Retinopathy: Vascular and Inflammatory Disease publication-title: Journal of Diabetes Research – volume: 19 start-page: 52 issue: 1 year: 2012 ident: ref13 article-title: Diabetic retinopathy and inflammation: novel therapeutic targets publication-title: Middle East Afr J Ophthalmol doi: 10.4103/0974-9233.92116 |
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| Snippet | To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic... Aims To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic... AIMS: To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related... AIMS:To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic... Aims To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic... |
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| SubjectTerms | Aged Angiography Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Biomedical research Blood Blood cells Blood glucose Complicacions de la diabetis Cross-Sectional Studies Cytokines Cytokines - blood Diabetes Diabetes complications Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetic retinopathy Diabetic Retinopathy - blood Diabetic Retinopathy - diagnostic imaging Diabetis Edema Expansion Female Fluorescein Fluorescein Angiography Health aspects Hemoglobin Hospitals Humans Inflammation Inflammation Mediators - blood Interleukin 10 Interleukin 6 Interleukin 8 Ischemia Macular Edema - blood Macular Edema - complications Macular Edema - diagnostic imaging Male Medical imaging Medicine and Health Sciences Metabolism Middle Aged Oftalmologia Ophthalmology Optical Coherence Tomography Patients Peripheral blood Permeability Research and Analysis Methods Retina Risk factors Serum levels Studies Systematic review Tomography, Optical Coherence Tumor necrosis factor-TNF Type 2 diabetes Vascular endothelial growth factor |
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| Title | Peripheral blood metabolic and inflammatory factors as biomarkers to ocular findings in diabetic macular edema |
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