Combined Functional Genomic Maps of the C. elegans DNA Damage Response
Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phenotyp...
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| Published in | Science (American Association for the Advancement of Science) Vol. 295; no. 5552; pp. 127 - 131 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Society for the Advancement of Science
04.01.2002
American Association for the Advancement of Science The American Association for the Advancement of Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0036-8075 1095-9203 |
| DOI | 10.1126/science.1065986 |
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| Abstract | Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phenotypic analysis in Caenorhabditis elegans. Together, these approaches identified 12 worm DDR orthologs and 11 novel DDR genes. One of these is the putative ortholog of hBCL3, a gene frequently altered in chronic lymphocytic leukemia. Thus, the combination of functional genomic mapping approaches in model organisms may facilitate the identification and characterization of genes involved in cancer and, perhaps, other human diseases. |
|---|---|
| AbstractList | Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phenotypic analysis in
Caenorhabditis elegans
. Together, these approaches identified 12 worm DDR orthologs and 11 novel DDR genes. One of these is the putative ortholog of hBCL3, a gene frequently altered in chronic lymphocytic leukemia. Thus, the combination of functional genomic mapping approaches in model organisms may facilitate the identification and characterization of genes involved in cancer and, perhaps, other human diseases. Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phenotypic analysis in Caenorhabditis elegans. Together, these approaches identified 12 worm DDR orthologs and 11 novel DDR genes. One of these is the putative ortholog of hBCL3, a gene frequently altered in chronic lymphocytic leukemia. Thus, the combination of functional genomic mapping approaches in model organisms may facilitate the identification and characterization of genes involved in cancer and, perhaps, other human diseases. Many human cancers originate from defects in the DNA damage response (DDR). To identify DDR genes, Boulton et al used a strategy that combines protein-protein interaction mapping and large-scale phenotypic analysis in Caenorhabditis elegans. Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phenotypic analysis in Caenorhabditis elegans. Together, these approaches identified 12 worm DDR orthologs and 11 novel DDR genes. One of these is the putative ortholog of hBCL3, a gene frequently altered in chronic lymphocytic leukemia. Thus, the combination of functional genomic mapping approaches in model organisms may facilitate the identification and characterization of genes involved in cancer and, perhaps, other human diseases.Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phenotypic analysis in Caenorhabditis elegans. Together, these approaches identified 12 worm DDR orthologs and 11 novel DDR genes. One of these is the putative ortholog of hBCL3, a gene frequently altered in chronic lymphocytic leukemia. Thus, the combination of functional genomic mapping approaches in model organisms may facilitate the identification and characterization of genes involved in cancer and, perhaps, other human diseases. |
| Audience | Academic |
| Author | Vaglio, Philippe Dyson, Nick Reboul, Jérôme Boulton, Simon J. Vidal, Marc Hill, David E. Gartner, Anton |
| Author_xml | – sequence: 1 givenname: Simon J. surname: Boulton fullname: Boulton, Simon J. – sequence: 2 givenname: Anton surname: Gartner fullname: Gartner, Anton – sequence: 3 givenname: Jérôme surname: Reboul fullname: Reboul, Jérôme – sequence: 4 givenname: Philippe surname: Vaglio fullname: Vaglio, Philippe – sequence: 5 givenname: Nick surname: Dyson fullname: Dyson, Nick – sequence: 6 givenname: David E. surname: Hill fullname: Hill, David E. – sequence: 7 givenname: Marc surname: Vidal fullname: Vidal, Marc |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13438835$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/11778048$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright 2002 American Association for the Advancement of Science 2002 INIST-CNRS COPYRIGHT 2002 American Association for the Advancement of Science Copyright American Association for the Advancement of Science Jan 4, 2002 |
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| Snippet | Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes... Many human cancers originate from defects in the DNA damage response (DDR). To identify DDR genes, Boulton et al used a strategy that combines protein-protein... |
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| SubjectTerms | Algorithms Animals Base Sequence BCL3 gene Biological and medical sciences Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - physiology Cancer Cancer research Chromosome Mapping Computational Biology Deoxyribonucleic acid DNA DNA damage DNA Damage - genetics DNA repair DNA Repair - genetics DNA Replication Evaluation Fundamental and applied biological sciences. Psychology Gamma Rays Gene Silencing Genes Genes, Helminth Genome Genomics Germ cells Human genome Humans Interaction Process Analysis Medical research Medicine, Experimental Molecular and cellular biology Oncology, Experimental Open Reading Frames Phenotype Phenotypes Protein interaction mapping Proteins Proteome Proto-Oncogene Proteins - genetics Recombination, Genetic Sertoli cells Transcription Factors Two-Hybrid System Techniques Worms Yeast Yeast (Food product) |
| Title | Combined Functional Genomic Maps of the C. elegans DNA Damage Response |
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