Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer - Heo, Jeong; Reid, Tony; Ruo, Leyo; Breitbach, Caroline J; Rose, Steven; Bloomston, Mark; Cho, Mong; Lim, Ho Yeong; Chung, Hyun Cheol; Kim, Chang Won; Burke, James; Lencioni, Riccardo; et al. (Nature medicine, 2013)
Keywords: 631/67/1059/2325; 631/67/1504/1610; 692/308/153; 692/308/2779/109/1942; 692/308/575; 692/700/565/1331; Aged; Antitumor activity; Biomedicine; Cancer Research; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - therapy; Care and treatment; Chemotherapy; Clinical trials; Colony-stimulating factor; Disease control; Dosage; Dose-Response Relationship, Immunologic; Female; Genomes; Granulocyte-macrophage colony stimulating factor; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis; Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Health aspects; Hepatocellular carcinoma; Humans; Immunity; Immunotherapy; Infectious Diseases; Liver cancer; Liver Neoplasms - immunology; Liver Neoplasms - mortality; Liver Neoplasms - therapy; Male; Metabolic Diseases; Middle Aged; Molecular Medicine; Neurosciences; Oncolysis; Oncolytic Virotherapy; Oncolytic Viruses - metabolism; Pharmacology; Prevention; Solid tumors; Survival; Survival Rate; Tumors; Vaccinia virus; Vaccinia virus - genetics; Vaccinia virus - physiology; Viral vaccines; Virus Replication; Viruses; United States