Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model - Takakura, Kazuki; Shibazaki, Yuichiro; Yoneyama, Hiroyuki; Fujii, Masato; Hashiguchi, Taishi; Ito, Zensho; Kajihara, Mikio; Misawa, Takeyuki; Homma, Sadamu; Ohkusa, Toshifumi; Koido, Shigeo (PloS one, 2015)
Keywords: Adenocarcinoma; Adenocarcinoma - genetics; Animals; Antibiotics; Biosynthesis; Cancer; Carbohydrates; Carcinoma, Pancreatic Ductal - genetics; Care and treatment; Cell cycle; Cell Cycle - genetics; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; Chondroitin sulfate; Complications and side effects; Cyclin-dependent kinase inhibitor p21; Development and progression; Disease Progression; Endoscopy; Gastroenterology; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene Silencing - physiology; Genetic aspects; Hepatology; Humans; Internal medicine; Kinases; Medical prognosis; Medicine; Membrane Glycoproteins - genetics; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Motility; mRNA; Mucopolysaccharides; Pancreatic cancer; Pancreatic Neoplasms - genetics; RNA, Messenger - genetics; RNA, Small Interfering - genetics; siRNA; Stromal cells; Sulfates; Sulfotransferase; Sulfotransferases - genetics; Therapeutic applications; Tumor cell lines; Tumor cells; Tumors; Ultrasonic imaging; Up-Regulation - genetics; Xenograft Model Antitumor Assays - methods; Xenografts; Xenotransplantation; United States; United States--US; Japan; Germany