P2X7 Receptor and Caspase 1 Activation Are Central to Airway Inflammation Observed after Exposure to Tobacco Smoke - Eltom, Suffwan; Stevenson, Christopher S.; Rastrick, Joseph; Dale, Nicole; Raemdonck, Kristof; Wong, Sissie; Catley, Matthew C.; Belvisi, Maria G.; Birrell, Mark A. (PloS one, 2011)
Keywords: Activation; Adenosine; Animals; Biology; Caspase; Caspase 1 - metabolism; Caspase-1; Cell activation; Chronic exposure; Chronic obstructive pulmonary disease; Cigarette smoke; Cigarettes; Conditioned stimulus; Cytokines; Development and progression; Developmental stages; Drugs; Emphysema; Exposure; Genetic modification; Genetically modified organisms; Heart; Humans; Hypotheses; In Vitro Techniques; Inflammasomes; Inflammation; Inflammation - chemically induced; Inflammation - metabolism; Interleukin 18; Interleukin-18 - metabolism; Interleukin-1beta - metabolism; Laboratories; Lipopolysaccharides - toxicity; Lung diseases; Lungs; Male; Medical research; Medicine; Mice; Neutrophilia; Neutrophils; Obstructive lung disease; Pathogenesis; Patients; Pharmacology; Physiology; Receptors; Receptors, Purinergic P2X7 - metabolism; Respiratory System - drug effects; Respiratory System - metabolism; Respiratory tract diseases; Rodents; Smoke; Smoking; Smoking - adverse effects; Tobacco; Tobacco smoke; Tumor necrosis factor-TNF; United Kingdom--UK