Mitochondrial-Associated Cell Death Mechanisms Are Reset to an Embryonic-Like State in Aged Donor-Derived iPS Cells Harboring Chromosomal Aberrations - Prigione, Alessandro; Hossini, Amir M.; Lichtner, Björn; Serin, Akdes; Fauler, Beatrix; Megges, Matthias; Lurz, Rudi; Lehrach, Hans; Makrantonaki, Eugenia; Zouboulis, Christos C.; Adjaye, James (PloS one, 2011)
Keywords: Aberration; Abnormalities; Age; Aged, 80 and over; Aging; Aging - genetics; Aging - pathology; Apoptosis; Biochemistry; Biology; Cancer; Cell death; Cell Death - genetics; Cellular Reprogramming; Chromosome Aberrations; Chromosomes; Deoxyribonucleic acid; Disorders; DNA; DNA damage; Embryo cells; Embryonic stem cells; Female; Fibroblasts; Fibroblasts - cytology; Genetic aspects; Genetic transformation; Genomes; Genomic instability; Genomic Instability - genetics; Genomics; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - pathology; Inhibitory postsynaptic potentials; Integrity; Karyotype; Karyotypes; Medicine; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial DNA; Mortality; Oxidation resistance; Oxidative stress; Oxidative Stress - genetics; Pluripotency; Signal Transduction - genetics; Skin; Somatic cells; Stability; Stem cell transplantation; Stem cells; Telomerase; Therapy; Tissue Donors; Transformation; Germany