Protective Effect of Fucoxanthin against UVB-Induced Skin Photoaging in Hairless Mice
Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiati...
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| Published in | Bioscience, biotechnology, and biochemistry Vol. 75; no. 4; pp. 757 - 760 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
Japan Society for Bioscience, Biotechnology, and Agrochemistry
2011
Japan Society for Bioscience Biotechnology and Agrochemistry Oxford University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0916-8451 1347-6947 1347-6947 |
| DOI | 10.1271/bbb.110040 |
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| Abstract | Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects. |
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| AbstractList | Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects. Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects.Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects. |
| Author | SUGAWARA, Tatsuya HIRATA, Takashi URIKURA, Itaru |
| Author_xml | – sequence: 1 givenname: Itaru surname: URIKURA fullname: URIKURA, Itaru organization: Graduate School of Agriculture, Kyoto University – sequence: 2 givenname: Tatsuya surname: SUGAWARA fullname: SUGAWARA, Tatsuya organization: Graduate School of Agriculture, Kyoto University – sequence: 3 givenname: Takashi surname: HIRATA fullname: HIRATA, Takashi organization: Graduate School of Agriculture, Kyoto University |
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| Keywords | Angiogenesis Vertebrata Mammalia Ultraviolet irradiation Mouse UV-irradiation Rodentia Skin fucoxanthin Protection wrinkling photoaging |
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| SubjectTerms | Administration, Topical angiogenesis Animals antioxidants Biological and medical sciences biotechnology carotenoids Female fucoxanthin Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - radiation effects hypertrophy irradiation Mice Mice, Hairless photoaging protective effect Skin Aging - drug effects Skin Aging - genetics Skin Aging - radiation effects Ultraviolet Rays - adverse effects UV-irradiation wrinkling Xanthophylls - administration & dosage Xanthophylls - pharmacology |
| Title | Protective Effect of Fucoxanthin against UVB-Induced Skin Photoaging in Hairless Mice |
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