Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter - Cronin, Therese; Vandenberghe, Luk H; Hantz, Péter; Juttner, Josephine; Reimann, Andreas; Kacsó, Ágota–Enikő; Huckfeldt, Rachel M; Busskamp, Volker; Kohler, Hubertus; Lagali, Pamela S; Roska, Botond; Bennett, Jean (EMBO molecular medicine, 2014)
Keywords: adeno‐associated virus; Animals; Binding sites; Bioengineering; Bipolar cells; Blindness; capsid library; Clinical trials; Dependovirus - genetics; EMBO16; EMBO27; Experiments; Ganglion cells; Gene expression; Gene therapy; Genetic Vectors; HEK293 Cells; Heparan sulfate; Humans; Imaging; Libraries; Life Sciences; Light; Mice; Mice, Inbred C57BL; multi‐electrode array; Mutagenesis; Mutagenesis, Site-Directed; Neurobiology; Neurons and Cognition; optogenetics; Photoreceptors; promoter optimization; Promoter Regions, Genetic; Research Article; Retina; Retinal Bipolar Cells - virology; Transduction, Genetic - methods; Vectors (Biology); capsid library; adeno‐associated virus; promoter optimization; multi‐electrode array; optogenetics; Neuroscience; adeno-associated virus; promoter optimization Subject Categories Genetics; Gene Therapy & Genetic Disease; multi-electrode array