Vaccinia virus strain LC16m8 defective in the B5R gene keeps strong protection comparable to its parental strain Lister in immunodeficient mice

Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties. The protective activity of LC16m8 vaccine against cha...

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Published in	Vaccine Vol. 33; no. 45; pp. 6112 - 6119
Main Authors	Yokote, Hiroyuki, Shinmura, Yasuhiko, Kanehara, Tomomi, Maruno, Shinichi, Kuranaga, Masahiko, Matsui, Hajime, Hashizume, So
Format	Journal Article
Language	English
Published	Netherlands Elsevier Ltd 09.11.2015 Elsevier Limited
Subjects	Allergy and Immunology Animals Antibodies, Viral - blood Antigens Biological & chemical terrorism Bioterrorism Cloning Conflicts of interest Efficacy evaluation study genes Good Manufacturing Practice humoral immunity Immunization Immunocompromised Host Immunodeficient subject Immunology innate immunity Japan LC16m8 lethal dose Membrane Glycoproteins - genetics Mice parental behavior Proteins Smallpox Smallpox - immunology Smallpox - prevention & control Smallpox - virology Smallpox vaccine Smallpox Vaccine - administration & dosage Smallpox Vaccine - immunology Strategic Stockpile vaccination Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Vaccinia virus Vaccinia virus - genetics Vaccinia virus - immunology Variola virus Viral Envelope Proteins - genetics Viruses WHO stockpile vaccine Japan New York United States > US LC16m8 Immunodeficient subject WHO stockpile vaccine Bioterrorism Efficacy evaluation study Smallpox vaccine
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ISSN	0264-410X 1873-2518 1873-2518
DOI	10.1016/j.vaccine.2015.07.076

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Abstract	Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties. The protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens. The immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in the B5R gene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients. LC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister.
AbstractList	Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties. The protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens. The immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in the B5R gene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients. LC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister. Abstract Background Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties. Methods The protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens. Results The immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in the B5R gene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients. Conclusion LC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister. Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties.The protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens.The immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in the B5R gene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients.LC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister. Background Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties. Methods The protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens. Results The immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in the B5R gene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients. Conclusion LC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister. Background Attenuated vaccinia virus strain, LC16m8, defective in theB5Renvelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in theB5Rgene mainly contributes to its highly attenuated properties. Methods The protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens. Results The immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in theB5Rgene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients. Conclusion LC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister. Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties.BACKGROUNDAttenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties.The protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens.METHODSThe protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens.The immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in the B5R gene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients.RESULTSThe immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in the B5R gene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients.LC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister.CONCLUSIONLC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister.
Author	Matsui, Hajime Yokote, Hiroyuki Kuranaga, Masahiko Kanehara, Tomomi Hashizume, So Shinmura, Yasuhiko Maruno, Shinichi
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Cites_doi	10.1128/JVI.02061-06 10.1006/viro.1998.9516 10.4049/jimmunol.178.11.6814 10.1038/nature02331 10.1016/j.cell.2006.02.015 10.1093/infdis/jir527 10.1093/infdis/jiq162 10.1073/pnas.0406671102 10.4049/jimmunol.134.1.598 10.1099/vir.0.055921-0 10.1001/jama.2009.289 10.1099/0022-1317-83-12-2915 10.1073/pnas.0506768102 10.2217/fmb.09.110 10.1128/JVI.79.18.11873-11891.2005 10.1126/science.304.5672.809a 10.1128/CVI.00040-09 10.1111/j.1600-065X.2010.00975.x 10.1099/vir.0.034207-0 10.2217/17460913.2.1.17 10.1016/0042-6822(91)90480-Y 10.1016/S0140-6736(03)14674-0 10.1128/CVI.00199-14 10.1073/pnas.1233578100 10.1128/JVI.02642-05
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References	Parker, Nuara, Buller, Schultz (bib0225) 2007; 2 Hashizume, Morita, Yoshikawa, Suzuki, Arita, Komatsu (bib0165) 1973; 19 Belyakov, Earl, Dzutsev, Kuznetsov, Lemon, Wyatt (bib0155) 2003; 100 Kidokoro, Tashiro, Shida (bib0215) 2005; 102 Kennedy, Gurwith, Dekker, Frey, Edwards, Kenner (bib0255) 2011; 204 Enserink, Biodefense (bib0150) 2004; 304 Stitz, Althage, Hengartner, Zinkernagel (bib0265) 1985; 134 Takahashi-Nishimaki, Funahashi, Miki, Hashizume, Sugimoto (bib0180) 1991; 181 Earl, Americo, Wyatt, Eller, Whitbeck, Cohen (bib0160) 2004; 428 Saito, Fujii, Kanatani, Saijo, Morikawa, Yokote (bib0250) 2009; 301 Saijo, Ami, Suzaki, Nagata, Iwata, Hasegawa (bib0210) 2006; 80 Moss (bib0230) 2011; 239 Gordon, Cecchinato, Andresen, Heraud, Hryniewicz, Parks (bib0260) 2011; 203 Moutaftsi, Bui, Peters, Sidney, Salek-Ardakani, Oseroff (bib0245) 2007; 178 Smith, Benfield, Maluquer de Motes, Mazzon, Ember, Ferguson (bib0280) 2013; 94 Galmiche, Goenaga, Wittek, Rindisbacher (bib0200) 1999; 254 Oseroff, Kos, Bui, Peters, Pasquetto, Glenn (bib0240) 2005; 102 WHO (bib0175) 2014; 89 Yokote, Shinmura, Kanehara, Maruno, Kuranaga, Matsui (bib0220) 2014; 21 Moutaftsi, Tscharke, Vaughan, Koelle, Stern, Calvo-Calle (bib0235) 2010; 5 Meseda, Mayer, Kumar, Garcia, Campbell, Listrani (bib0195) 2009; 16 Parker, Parker, Yokoyama, Corbett, Buller (bib0275) 2007; 81 Akira, Uematsu, Takeuchi (bib0270) 2006; 124 Morikawa, Sakiyama, Hasegawa, Saijo, Maeda, Kurane (bib0190) 2005; 79 Johnson, Kanatani, Fujii, Saito, Yokote, Smith (bib0205) 2011; 92 Chen, Lane (bib0145) 2003; 362 Hashizume, Yoshikawa, Morita, Suzuki (bib0170) 1985 Smith, Vanderplasschen, Law (bib0185) 2002; 83 Earl (10.1016/j.vaccine.2015.07.076_bib0160) 2004; 428 Akira (10.1016/j.vaccine.2015.07.076_bib0270) 2006; 124 Saito (10.1016/j.vaccine.2015.07.076_bib0250) 2009; 301 Belyakov (10.1016/j.vaccine.2015.07.076_bib0155) 2003; 100 Moutaftsi (10.1016/j.vaccine.2015.07.076_bib0245) 2007; 178 Gordon (10.1016/j.vaccine.2015.07.076_bib0260) 2011; 203 WHO (10.1016/j.vaccine.2015.07.076_bib0175) 2014; 89 Galmiche (10.1016/j.vaccine.2015.07.076_bib0200) 1999; 254 Hashizume (10.1016/j.vaccine.2015.07.076_bib0170) 1985 Kennedy (10.1016/j.vaccine.2015.07.076_bib0255) 2011; 204 Stitz (10.1016/j.vaccine.2015.07.076_bib0265) 1985; 134 Hashizume (10.1016/j.vaccine.2015.07.076_bib0165) 1973; 19 Kidokoro (10.1016/j.vaccine.2015.07.076_bib0215) 2005; 102 Yokote (10.1016/j.vaccine.2015.07.076_bib0220) 2014; 21 Takahashi-Nishimaki (10.1016/j.vaccine.2015.07.076_bib0180) 1991; 181 Meseda (10.1016/j.vaccine.2015.07.076_bib0195) 2009; 16 Chen (10.1016/j.vaccine.2015.07.076_bib0145) 2003; 362 Enserink (10.1016/j.vaccine.2015.07.076_bib0150) 2004; 304 Morikawa (10.1016/j.vaccine.2015.07.076_bib0190) 2005; 79 Parker (10.1016/j.vaccine.2015.07.076_bib0275) 2007; 81 Saijo (10.1016/j.vaccine.2015.07.076_bib0210) 2006; 80 Johnson (10.1016/j.vaccine.2015.07.076_bib0205) 2011; 92 Moss (10.1016/j.vaccine.2015.07.076_bib0230) 2011; 239 Oseroff (10.1016/j.vaccine.2015.07.076_bib0240) 2005; 102 Parker (10.1016/j.vaccine.2015.07.076_bib0225) 2007; 2 Moutaftsi (10.1016/j.vaccine.2015.07.076_bib0235) 2010; 5 Smith (10.1016/j.vaccine.2015.07.076_bib0280) 2013; 94 Smith (10.1016/j.vaccine.2015.07.076_bib0185) 2002; 83
References_xml	– volume: 79 start-page: 11873 year: 2005 end-page: 11891 ident: bib0190 article-title: An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection publication-title: J Virol – volume: 428 start-page: 182 year: 2004 end-page: 185 ident: bib0160 article-title: Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox publication-title: Nature – volume: 81 start-page: 4070 year: 2007 end-page: 4079 ident: bib0275 article-title: Induction of natural killer cell responses by ectromelia virus controls infection publication-title: J Virol – volume: 124 start-page: 783 year: 2006 end-page: 801 ident: bib0270 article-title: Pathogen recognition and innate immunity publication-title: Cell – volume: 204 start-page: 1395 year: 2011 end-page: 1402 ident: bib0255 article-title: Safety and immunogenicity of LC16m8, an attenuated smallpox vaccine in vaccinia-naive adults publication-title: J Infect Dis – volume: 83 start-page: 2915 year: 2002 end-page: 2931 ident: bib0185 article-title: The formation and function of extracellular enveloped vaccinia virus publication-title: J Gen Virol – volume: 304 start-page: 809 year: 2004 ident: bib0150 article-title: Smallpox vaccines: looking beyond the next generation publication-title: Science – volume: 100 start-page: 9458 year: 2003 end-page: 9463 ident: bib0155 article-title: Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses publication-title: Proc Natl Acad Sci USA – volume: 5 start-page: 221 year: 2010 end-page: 239 ident: bib0235 article-title: Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens publication-title: Future Microbiol – start-page: 421 year: 1985 end-page: 428 ident: bib0170 article-title: Properties of attenuated mutant of vaccinia virus, LC16m8, derived from Lister strain publication-title: Vaccinia virus as vectors for vaccine antigens – volume: 203 start-page: 1043 year: 2011 end-page: 1053 ident: bib0260 article-title: Smallpox vaccine safety is dependent on T cells and not B cells publication-title: J Infect Dis – volume: 92 start-page: 2405 year: 2011 end-page: 2410 ident: bib0205 article-title: Serological responses in humans to the smallpox vaccine LC16m8 publication-title: J Gen Virol – volume: 94 start-page: 2367 year: 2013 end-page: 2392 ident: bib0280 article-title: Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity publication-title: J Gen Virol – volume: 301 start-page: 1025 year: 2009 end-page: 1033 ident: bib0250 article-title: Clinical and immunological response to attenuated tissue-cultured smallpox vaccine LC16m8 publication-title: JAMA – volume: 2 start-page: 17 year: 2007 end-page: 34 ident: bib0225 article-title: Human monkeypox: an emerging zoonotic disease publication-title: Future Microbiol – volume: 254 start-page: 71 year: 1999 end-page: 80 ident: bib0200 article-title: Neutralizing and protective antibodies directed against vaccinia virus envelope antigens publication-title: Virology – volume: 134 start-page: 598 year: 1985 end-page: 602 ident: bib0265 article-title: Natural killer cells vs cytotoxic T cells in the peripheral blood of virus-infected mice publication-title: J Immunol – volume: 362 start-page: 1345 year: 2003 end-page: 1346 ident: bib0145 article-title: Myocarditis: the unexpected return of smallpox vaccine adverse events publication-title: Lancet – volume: 19 start-page: 325 year: 1973 end-page: 331 ident: bib0165 article-title: Internal symposium on smallpox vaccines publication-title: Bilthoven Symp Ser Immunobiol Stand – volume: 178 start-page: 6814 year: 2007 end-page: 6820 ident: bib0245 article-title: Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses publication-title: J Immunol – volume: 102 start-page: 4152 year: 2005 end-page: 4157 ident: bib0215 article-title: Genetically stable and fully effective smallpox vaccine strain constructed from highly attenuated vaccinia LC16m8 publication-title: Proc Natl Acad Sci USA – volume: 21 start-page: 1261 year: 2014 end-page: 1266 ident: bib0220 article-title: Safety of attenuated smallpox vaccine LC16m8 in immunodeficient mice publication-title: Clin Vaccine Immunol – volume: 239 start-page: 8 year: 2011 end-page: 26 ident: bib0230 article-title: Smallpox vaccines: targets of protective immunity publication-title: Immunol Rev – volume: 89 start-page: 1 year: 2014 end-page: 20 ident: bib0175 article-title: Meeting of the Strategic Advisory Group of Experts on immunization, November 2013—conclusions and recommendations publication-title: WHO Wkly Epidemiol Rec – volume: 102 start-page: 13980 year: 2005 end-page: 13985 ident: bib0240 article-title: HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation publication-title: Proc Natl Acad Sci USA – volume: 181 start-page: 158 year: 1991 end-page: 164 ident: bib0180 article-title: Regulation of plaque size and host range by a vaccinia virus gene related to complement system proteins publication-title: Virology – volume: 80 start-page: 5179 year: 2006 end-page: 5188 ident: bib0210 article-title: LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox publication-title: J Virol – volume: 16 start-page: 1261 year: 2009 end-page: 1271 ident: bib0195 article-title: Comparative evaluation of the immune responses and protection engendered by LC16m8 and Dryvax smallpox vaccines in a mouse model publication-title: Clin Vaccine Immunol – volume: 81 start-page: 4070 year: 2007 ident: 10.1016/j.vaccine.2015.07.076_bib0275 article-title: Induction of natural killer cell responses by ectromelia virus controls infection publication-title: J Virol doi: 10.1128/JVI.02061-06 – volume: 89 start-page: 1 year: 2014 ident: 10.1016/j.vaccine.2015.07.076_bib0175 article-title: Meeting of the Strategic Advisory Group of Experts on immunization, November 2013—conclusions and recommendations publication-title: WHO Wkly Epidemiol Rec – volume: 254 start-page: 71 year: 1999 ident: 10.1016/j.vaccine.2015.07.076_bib0200 article-title: Neutralizing and protective antibodies directed against vaccinia virus envelope antigens publication-title: Virology doi: 10.1006/viro.1998.9516 – volume: 178 start-page: 6814 year: 2007 ident: 10.1016/j.vaccine.2015.07.076_bib0245 article-title: Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses publication-title: J Immunol doi: 10.4049/jimmunol.178.11.6814 – volume: 428 start-page: 182 year: 2004 ident: 10.1016/j.vaccine.2015.07.076_bib0160 article-title: Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox publication-title: Nature doi: 10.1038/nature02331 – volume: 124 start-page: 783 year: 2006 ident: 10.1016/j.vaccine.2015.07.076_bib0270 article-title: Pathogen recognition and innate immunity publication-title: Cell doi: 10.1016/j.cell.2006.02.015 – volume: 204 start-page: 1395 year: 2011 ident: 10.1016/j.vaccine.2015.07.076_bib0255 article-title: Safety and immunogenicity of LC16m8, an attenuated smallpox vaccine in vaccinia-naive adults publication-title: J Infect Dis doi: 10.1093/infdis/jir527 – volume: 19 start-page: 325 year: 1973 ident: 10.1016/j.vaccine.2015.07.076_bib0165 article-title: Internal symposium on smallpox vaccines publication-title: Bilthoven Symp Ser Immunobiol Stand – volume: 203 start-page: 1043 year: 2011 ident: 10.1016/j.vaccine.2015.07.076_bib0260 article-title: Smallpox vaccine safety is dependent on T cells and not B cells publication-title: J Infect Dis doi: 10.1093/infdis/jiq162 – volume: 102 start-page: 4152 year: 2005 ident: 10.1016/j.vaccine.2015.07.076_bib0215 article-title: Genetically stable and fully effective smallpox vaccine strain constructed from highly attenuated vaccinia LC16m8 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0406671102 – volume: 134 start-page: 598 year: 1985 ident: 10.1016/j.vaccine.2015.07.076_bib0265 article-title: Natural killer cells vs cytotoxic T cells in the peripheral blood of virus-infected mice publication-title: J Immunol doi: 10.4049/jimmunol.134.1.598 – volume: 94 start-page: 2367 year: 2013 ident: 10.1016/j.vaccine.2015.07.076_bib0280 article-title: Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity publication-title: J Gen Virol doi: 10.1099/vir.0.055921-0 – volume: 301 start-page: 1025 year: 2009 ident: 10.1016/j.vaccine.2015.07.076_bib0250 article-title: Clinical and immunological response to attenuated tissue-cultured smallpox vaccine LC16m8 publication-title: JAMA doi: 10.1001/jama.2009.289 – volume: 83 start-page: 2915 year: 2002 ident: 10.1016/j.vaccine.2015.07.076_bib0185 article-title: The formation and function of extracellular enveloped vaccinia virus publication-title: J Gen Virol doi: 10.1099/0022-1317-83-12-2915 – volume: 102 start-page: 13980 year: 2005 ident: 10.1016/j.vaccine.2015.07.076_bib0240 article-title: HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0506768102 – volume: 5 start-page: 221 year: 2010 ident: 10.1016/j.vaccine.2015.07.076_bib0235 article-title: Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens publication-title: Future Microbiol doi: 10.2217/fmb.09.110 – volume: 79 start-page: 11873 year: 2005 ident: 10.1016/j.vaccine.2015.07.076_bib0190 article-title: An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection publication-title: J Virol doi: 10.1128/JVI.79.18.11873-11891.2005 – volume: 304 start-page: 809 year: 2004 ident: 10.1016/j.vaccine.2015.07.076_bib0150 article-title: Smallpox vaccines: looking beyond the next generation publication-title: Science doi: 10.1126/science.304.5672.809a – start-page: 421 year: 1985 ident: 10.1016/j.vaccine.2015.07.076_bib0170 article-title: Properties of attenuated mutant of vaccinia virus, LC16m8, derived from Lister strain – volume: 16 start-page: 1261 year: 2009 ident: 10.1016/j.vaccine.2015.07.076_bib0195 article-title: Comparative evaluation of the immune responses and protection engendered by LC16m8 and Dryvax smallpox vaccines in a mouse model publication-title: Clin Vaccine Immunol doi: 10.1128/CVI.00040-09 – volume: 239 start-page: 8 year: 2011 ident: 10.1016/j.vaccine.2015.07.076_bib0230 article-title: Smallpox vaccines: targets of protective immunity publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2010.00975.x – volume: 92 start-page: 2405 year: 2011 ident: 10.1016/j.vaccine.2015.07.076_bib0205 article-title: Serological responses in humans to the smallpox vaccine LC16m8 publication-title: J Gen Virol doi: 10.1099/vir.0.034207-0 – volume: 2 start-page: 17 year: 2007 ident: 10.1016/j.vaccine.2015.07.076_bib0225 article-title: Human monkeypox: an emerging zoonotic disease publication-title: Future Microbiol doi: 10.2217/17460913.2.1.17 – volume: 181 start-page: 158 year: 1991 ident: 10.1016/j.vaccine.2015.07.076_bib0180 article-title: Regulation of plaque size and host range by a vaccinia virus gene related to complement system proteins publication-title: Virology doi: 10.1016/0042-6822(91)90480-Y – volume: 362 start-page: 1345 year: 2003 ident: 10.1016/j.vaccine.2015.07.076_bib0145 article-title: Myocarditis: the unexpected return of smallpox vaccine adverse events publication-title: Lancet doi: 10.1016/S0140-6736(03)14674-0 – volume: 21 start-page: 1261 year: 2014 ident: 10.1016/j.vaccine.2015.07.076_bib0220 article-title: Safety of attenuated smallpox vaccine LC16m8 in immunodeficient mice publication-title: Clin Vaccine Immunol doi: 10.1128/CVI.00199-14 – volume: 100 start-page: 9458 year: 2003 ident: 10.1016/j.vaccine.2015.07.076_bib0155 article-title: Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1233578100 – volume: 80 start-page: 5179 year: 2006 ident: 10.1016/j.vaccine.2015.07.076_bib0210 article-title: LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox publication-title: J Virol doi: 10.1128/JVI.02642-05
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Snippet	Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against... Abstract Background Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in... Background Attenuated vaccinia virus strain, LC16m8, defective in theB5Renvelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against... Background Attenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan...
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SubjectTerms	Allergy and Immunology Animals Antibodies, Viral - blood Antigens Biological & chemical terrorism Bioterrorism Cloning Conflicts of interest Efficacy evaluation study genes Good Manufacturing Practice humoral immunity Immunization Immunocompromised Host Immunodeficient subject Immunology innate immunity Japan LC16m8 lethal dose Membrane Glycoproteins - genetics Mice parental behavior Proteins Smallpox Smallpox - immunology Smallpox - prevention & control Smallpox - virology Smallpox vaccine Smallpox Vaccine - administration & dosage Smallpox Vaccine - immunology Strategic Stockpile vaccination Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Vaccinia virus Vaccinia virus - genetics Vaccinia virus - immunology Variola virus Viral Envelope Proteins - genetics Viruses WHO stockpile vaccine
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Title	Vaccinia virus strain LC16m8 defective in the B5R gene keeps strong protection comparable to its parental strain Lister in immunodeficient mice
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