Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M
A mutation conferring resistance to novel irreversible EGFR inhibitors is identified in cell-free plasma DNA from lung cancer patients. Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor...
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| Published in | Nature medicine Vol. 21; no. 6; pp. 560 - 562 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.06.2015
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1078-8956 1546-170X |
| DOI | 10.1038/nm.3854 |
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| Abstract | A mutation conferring resistance to novel irreversible EGFR inhibitors is identified in cell-free plasma DNA from lung cancer patients.
Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) AZD9291. We first performed next-generation sequencing of cfDNA from seven subjects and detected an acquired
EGFR
C797S mutation in one; expression of this mutant
EGFR
construct in a cell line rendered it resistant to AZD9291. We then performed droplet digital PCR on serial cfDNA specimens collected from 15 AZD9291-treated subjects. All were positive for the T790M mutation before treatment, but upon developing AZD9291 resistance three molecular subtypes emerged: six cases acquired the C797S mutation, five cases maintained the T790M mutation but did not acquire the C797S mutation and four cases lost the T790M mutation despite the presence of the underlying
EGFR
activating mutation. Our findings provide insight into the diversity of mechanisms through which tumors acquire resistance to AZD9291 and highlight the need for therapies that are able to overcome resistance mediated by the
EGFR
C797S mutation. |
|---|---|
| AbstractList | Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) AZD9291. We first performed next-generation sequencing of cfDNA from seven subjects and detected an acquired EGFR C797S mutation in one; expression of this mutant EGFR construct in a cell line rendered it resistant to AZD9291. We then performed droplet digital PCR on serial cfDNA specimens collected from 15 AZD9291-treated subjects. All were positive for the T790M mutation before treatment, but upon developing AZD9291 resistance three molecular subtypes emerged: six cases acquired the C797S mutation, five cases maintained the T790M mutation but did not acquire the C797S mutation and four cases lost the T790M mutation despite the presence of the underlying EGFR activating mutation. Our findings provide insight into the diversity of mechanisms through which tumors acquire resistance to AZD9291 and highlight the need for therapies that are able to overcome resistance mediated by the EGFR C797S mutation. A mutation conferring resistance to novel irreversible EGFR inhibitors is identified in cell-free plasma DNA from lung cancer patients. Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) AZD9291. We first performed next-generation sequencing of cfDNA from seven subjects and detected an acquired EGFR C797S mutation in one; expression of this mutant EGFR construct in a cell line rendered it resistant to AZD9291. We then performed droplet digital PCR on serial cfDNA specimens collected from 15 AZD9291-treated subjects. All were positive for the T790M mutation before treatment, but upon developing AZD9291 resistance three molecular subtypes emerged: six cases acquired the C797S mutation, five cases maintained the T790M mutation but did not acquire the C797S mutation and four cases lost the T790M mutation despite the presence of the underlying EGFR activating mutation. Our findings provide insight into the diversity of mechanisms through which tumors acquire resistance to AZD9291 and highlight the need for therapies that are able to overcome resistance mediated by the EGFR C797S mutation. |
| Audience | Academic |
| Author | Matthews, Sarah E Cho, Byoung Chul Kuang, Yanan Felip, Enriqueta Stetson, Daniel Paweletz, Cloud P Vivancos, Ana Oxnard, Geoffrey R Barrett, J Carl Thress, Kenneth S Markovets, Aleksandra Jänne, Pasi A Dougherty, Brian Cantarini, Mireille Lai, Zhongwu Ercan, Dalia |
| Author_xml | – sequence: 1 givenname: Kenneth S surname: Thress fullname: Thress, Kenneth S organization: AstraZeneca, Gatehouse Park – sequence: 2 givenname: Cloud P surname: Paweletz fullname: Paweletz, Cloud P organization: Department of Medical Oncology, Dana-Farber Cancer Institute, Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute – sequence: 3 givenname: Enriqueta surname: Felip fullname: Felip, Enriqueta organization: Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital – sequence: 4 givenname: Byoung Chul surname: Cho fullname: Cho, Byoung Chul organization: Yonsei Cancer Center, Yonsei University College of Medicine – sequence: 5 givenname: Daniel surname: Stetson fullname: Stetson, Daniel organization: AstraZeneca, Gatehouse Park – sequence: 6 givenname: Brian surname: Dougherty fullname: Dougherty, Brian organization: AstraZeneca, Gatehouse Park – sequence: 7 givenname: Zhongwu surname: Lai fullname: Lai, Zhongwu organization: AstraZeneca, Gatehouse Park – sequence: 8 givenname: Aleksandra surname: Markovets fullname: Markovets, Aleksandra organization: AstraZeneca, Gatehouse Park – sequence: 9 givenname: Ana surname: Vivancos fullname: Vivancos, Ana organization: Vall d'Hebron Institute of Oncology – sequence: 10 givenname: Yanan surname: Kuang fullname: Kuang, Yanan organization: Department of Medical Oncology, Dana-Farber Cancer Institute, Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute – sequence: 11 givenname: Dalia surname: Ercan fullname: Ercan, Dalia organization: Department of Medical Oncology, Dana-Farber Cancer Institute – sequence: 12 givenname: Sarah E surname: Matthews fullname: Matthews, Sarah E organization: Department of Medical Oncology, Dana-Farber Cancer Institute – sequence: 13 givenname: Mireille surname: Cantarini fullname: Cantarini, Mireille organization: AstraZeneca, Alderley Park – sequence: 14 givenname: J Carl surname: Barrett fullname: Barrett, J Carl organization: AstraZeneca, Gatehouse Park – sequence: 15 givenname: Pasi A surname: Jänne fullname: Jänne, Pasi A organization: Department of Medical Oncology, Dana-Farber Cancer Institute, Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute – sequence: 16 givenname: Geoffrey R surname: Oxnard fullname: Oxnard, Geoffrey R email: geoffrey_oxnard@DFCI.Harvard.edu organization: Department of Medical Oncology, Dana-Farber Cancer Institute |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25939061$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1056/NEJMoa0904554 10.1016/j.ejca.2008.10.026 10.1158/0008-5472.CAN-07-1248 10.1158/1078-0432.CCR-10-2277 10.1038/nature08622 10.1158/1535-7163.MCT-07-2387 10.1158/0008-5472.CAN-07-1885 10.1056/NEJMoa1400029 10.1126/scitranslmed.3002003 10.1021/jm400822z 10.1158/1078-0432.CCR-13-2482 10.1056/NEJMoa0810699 10.1158/2159-8290.CD-14-0337 10.1042/BJ20080728 |
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| References | ArcilaMEClin. Cancer Res.201117116911801:CAS:528:DC%2BC3MXis1eitrc%3D10.1158/1078-0432.CCR-10-2277 OxnardGRClin. Cancer Res.201420169817051:CAS:528:DC%2BC2cXks1OjtLo%3D10.1158/1078-0432.CCR-13-2482 EngelmanJACancer Res.20076711924119321:CAS:528:DC%2BD2sXhsVCjs7nL10.1158/0008-5472.CAN-07-1885 Jänne, P.A. et al. N. Engl. J. Med. (in the press, 2015). MokTSN. Engl. J. Med.20093619479571:CAS:528:DC%2BD1MXhtVygsbfK10.1056/NEJMoa0810699 EisenhauerEAEur. J. Cancer2009452282471:STN:280:DC%2BD1M%2Fgs12rug%3D%3D10.1016/j.ejca.2008.10.026 ZhouWNature2009462107010741:CAS:528:DC%2BD1MXhs1SktbvI10.1038/nature08622 CrossDAECancer Discov.20144104601611:CAS:528:DC%2BC2cXhsVykur%2FP10.1158/2159-8290.CD-14-0337 YuZCancer Res.20076710417104271:CAS:528:DC%2BD2sXht1erur3L10.1158/0008-5472.CAN-07-1248 AvizienyteEWardRAGarnerAPBiochem. J.20084151972061:CAS:528:DC%2BD1cXhtFKhsbnL10.1042/BJ20080728 Godin-HeymannNMol. Cancer Ther.200878748791:CAS:528:DC%2BD1cXks1GmsLo%3D10.1158/1535-7163.MCT-07-2387 SequistLVSci. Transl. Med.2011375ra2610.1126/scitranslmed.3002003 Sequist, L.V. et al. N. Engl. J. Med. (in the press, 2015). WoyachJAN. Engl. J. Med.20143702286229410.1056/NEJMoa1400029 RosellRN. Engl. J. Med.20093619589671:CAS:528:DC%2BD1MXhtVOqsL7M10.1056/NEJMoa0904554 WardRAJ. Med. Chem.201356702570481:CAS:528:DC%2BC3sXht1CltL%2FN10.1021/jm400822z Z Yu (BFnm3854_CR9) 2007; 67 BFnm3854_CR12 R Rosell (BFnm3854_CR2) 2009; 361 TS Mok (BFnm3854_CR1) 2009; 361 N Godin-Heymann (BFnm3854_CR10) 2008; 7 W Zhou (BFnm3854_CR5) 2009; 462 BFnm3854_CR8 GR Oxnard (BFnm3854_CR13) 2014; 20 EA Eisenhauer (BFnm3854_CR15) 2009; 45 JA Woyach (BFnm3854_CR14) 2014; 370 JA Engelman (BFnm3854_CR16) 2007; 67 DAE Cross (BFnm3854_CR7) 2014; 4 ME Arcila (BFnm3854_CR3) 2011; 17 RA Ward (BFnm3854_CR6) 2013; 56 E Avizienyte (BFnm3854_CR11) 2008; 415 LV Sequist (BFnm3854_CR4) 2011; 3 |
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| Snippet | A mutation conferring resistance to novel irreversible EGFR inhibitors is identified in cell-free plasma DNA from lung cancer patients.
Here we studied... Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth... |
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| SubjectTerms | 45/23 45/77 692/308/575 692/699/67/1612/1350 Acrylamides - administration & dosage Adult Aged Aniline Compounds - administration & dosage Biomedicine brief-communication Cancer Research Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Deoxyribonucleic acid DNA Drug resistance Drug Resistance, Neoplasm Drug therapy ErbB Receptors - genetics Female Genetic aspects High-Throughput Nucleotide Sequencing Humans Infectious Diseases Lung cancer Lung cancer, Non-small cell Male Metabolic Diseases Middle Aged Molecular Medicine Mutation Neurosciences Plasma Risk factors Tumors |
| Title | Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M |
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