Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain
Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and v...
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| Published in | Neurobiology of aging Vol. 36; no. 7; pp. 2296 - 2303 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.07.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0197-4580 1558-1497 1558-1497 |
| DOI | 10.1016/j.neurobiolaging.2015.03.012 |
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| Abstract | Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging. |
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| AbstractList | Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging. Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging.Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging. Abstract Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging. Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging. |
| Author | Gao, Xiaoli Zhang, Wei Lin, Ai-Ling Watts, Lora |
| AuthorAffiliation | e Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA c Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA b Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA d Institutional Mass Spectrometry Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA a Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA f Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA |
| AuthorAffiliation_xml | – name: c Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA – name: f Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA – name: b Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA – name: a Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA – name: d Institutional Mass Spectrometry Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA – name: e Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA |
| Author_xml | – sequence: 1 givenname: Ai-Ling surname: Lin fullname: Lin, Ai-Ling email: ailing.lin@uky.edu organization: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA – sequence: 2 givenname: Wei surname: Zhang fullname: Zhang, Wei organization: Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA – sequence: 3 givenname: Xiaoli surname: Gao fullname: Gao, Xiaoli organization: Institutional Mass Spectrometry Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA – sequence: 4 givenname: Lora surname: Watts fullname: Watts, Lora organization: Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25896951$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/00004647-200105000-00013 10.2217/fnl.14.13 10.1016/S1043-2760(00)00370-2 10.1155/2012/907409 10.1016/j.neuroscience.2006.11.065 10.1016/j.neuint.2013.08.006 10.1111/j.1471-4159.2012.07670.x 10.1073/pnas.0808587106 10.1056/NEJM200008173430701 10.1038/jcbfm.2013.82 10.1016/j.plefa.2003.09.007 10.1073/pnas.061509598 10.1126/science.1173635 10.1016/j.neulet.2009.08.038 10.1111/j.1749-6632.1991.tb00190.x 10.1016/j.nut.2010.07.021 10.1016/S0197-4580(01)00249-4 10.1093/gerona/glq165 10.1016/S0022-510X(00)00396-8 10.1073/pnas.83.4.1140 10.1038/jcbfm.2014.77 10.1038/nature13264 10.1073/pnas.91.22.10625 10.1002/hipo.20577 10.1089/jmf.2012.2592 10.1073/pnas.0909711107 10.1523/JNEUROSCI.0671-06.2006 10.1016/j.bbrc.2011.05.008 10.1046/j.1471-4159.1999.731674.x 10.1093/gerona/glp060 10.1016/j.cmet.2012.11.003 10.1016/j.brainresrev.2008.09.002 10.1016/j.cell.2011.02.018 10.3233/JAD-2011-110899 10.1098/rstb.2005.1763 10.1007/s12035-008-8040-1 10.1111/j.1474-9726.2009.00533.x 10.1038/jcbfm.2013.87 10.1111/j.1749-6632.1997.tb48479.x 10.1371/journal.pone.0028427 10.1073/pnas.0510452103 10.1093/gerona/glq113 10.1016/j.neuint.2003.11.005 10.1038/nature09584 10.1126/science.3260686 10.1111/j.1528-1157.1992.tb01770.x 10.1111/j.1474-9726.2011.00702.x 10.1038/sj.jcbfm.9600177 10.1111/nyas.12222 10.1016/j.neurobiolaging.2012.11.023 10.1194/jlr.R046706 10.1002/ana.20062 10.1002/mrm.22667 10.1146/annurev.genet.39.110304.095751 10.1016/S0197-4580(99)00032-9 10.1093/gerona/54.11.B492 10.18632/aging.100569 10.1038/jcbfm.2014.114 10.1371/journal.pone.0046585 10.1073/pnas.1002220107 |
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| Keywords | Neuroimaging Brain metabolism Cerebral blood flow Mammalian target of rapamycin Aging Ketone bodies α-ketoglutarate |
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| References | Veech (bib58) 2004; 70 Colman, Anderson, Johnson, Kastman, Kosmatka, Beasley, Allison, Cruzen, Simmons, Kemnitz, Weindruch (bib11) 2009; 325 Reiman, Caselli, Chen, Alexander, Bandy, Frost (bib46) 2001; 98 Kida, Hyder, Behar (bib22) 2001; 21 Uh, Lin, Lee, Liu, Fox, Lu (bib64) 2011; 65 Nagata, Buchan, Yokoyama, Kondoh, Sato, Terashi, Satoh, Watahiki, Senova, Hirata, Hatazawa (bib41) 1997; 826 Lin, Fox, Hardies, Duong, Gao (bib28) 2010; 107 Stranahan, Lee, Martin, Maudsley, Golden, Cutler, Mattson (bib51) 2009; 19 Kashiwaya, Bergman, Lee, Wan, King, Mughal, Okun, Clarke, Mattson, Veech (bib21) 2013; 34 Burdakov, Luckman, Verkhratsky (bib6) 2005; 360 Lin, Coman, Jiang, Rothman, Hyder (bib27) 2014; 34 Lynch, Cooney, Bennett, Thornton, Khan, Ingram, Sonntag (bib34) 1999; 20 Lin, Zheng, Halloran, Burbank, Hussong, Hart, Javors, Shih, Muir, Solano Fonseca, Strong, Richardson, Lechleiter, Fox, Galvan (bib31) 2013; 33 Hertz (bib19) 2013; 4 Blazquez, Woods, de Ceballos, Carling, Guzman (bib3) 1999; 73 Cunnane, Nugent, Roy, Courchesne-Loyer, Croteau, Tremblay, Castellano, Pifferi, Bocti, Paquet, Begdouri, Bentourkia, Turcotte, Allard, Barberger-Gateau, Fulop, Rapoport (bib12) 2011; 27 Fox, Raichle, Mintun, Dence (bib16) 1988; 241 Lanza, Zabielski, Klaus, Morse, Heppelmann, Bergen, Dasari, Walrand, Short, Johnson, Robinson, Schimke, Jakaitis, Asmann, Sun, Nair (bib24) 2012; 16 Maalouf, Sullivan, Davis, Kim, Rho (bib36) 2007; 145 Bookheimer, Strojwas, Cohen, Saunders, Pericak-Vance, Mazziotta, Small (bib4) 2000; 343 Witte, Fobker, Gellner, Knecht, Floel (bib61) 2009; 106 McNally, Hartman (bib39) 2012; 121 Sengupta, Peterson, Laplante, Oh, Sabatini (bib49) 2010; 468 Mouton, Chachich, Quigley, Spangler, Ingram (bib40) 2009; 464 Akram (bib1) 2013; 16 Roy, Hennebelle, St-Pierre, Courchesne-Loyer, Fortier, Bouzier-Sore, Gallis, Beauvieux, Cunnane (bib48) 2013; 63 Markowska, Savonenko (bib37) 2002; 23 Maalouf, Rho, Mattson (bib35) 2009; 59 Fox, Raichle (bib15) 1986; 83 Lin, Poteet, Du, Gourav, Liu, Wen, Bresnen, Huang, Fox, Yang, Duong (bib29) 2012; 7 Lin, A.L., Laird, A.R., Fox, P.T., Gao, J.H., 2012a. Multimodal MRI neuroimaging biomarkers for cognitive normal adults, amnestic mild cognitive impairment, and Alzheimer's disease, Neurol. Res. Int. 2012, 907409. Rahat, Maoz, Cohen (bib45) 2011; 66 Brown, Baltan Tekkok, Ransom (bib5) 2004; 45 Chowdhury, Jiang, Rothman, Behar (bib10) 2014; 34 Lin, Rothman (bib30) 2014; 9 Veech (bib59) 2013; 1302 Richardson, Galvan, Lin, Oddo (bib47) 2014 Valdez, Tapia, Kang, Clemenson, Gage, Lichtman, Sanes (bib57) 2010; 107 Chin, Fu, Pai, Vergnes, Hwang, Deng, Diep, Lomenick, Meli, Monsalve, Hu, Whelan, Wang, Jung, Solis, Fazlollahi, Kaweeteerawat, Quach, Nili, Krall, Godwin, Chang, Faull, Guo, Jiang, Trauger, Saghatelian, Braas, Christofk, Clarke, Teitell, Petrascheck, Reue, Jung, Frand, Huang (bib8) 2014; 510 Kinsman, Vining, Quaskey, Mellits, Freeman (bib23) 1992; 33 Mattson (bib38) 2010; 2 Hasselbalch, Madsen, Hageman, Olsen, Justesen, Holm, Paulson (bib18) 1996; 270 Pellerin, Magistretti (bib43) 1994; 91 Suzuki, Stern, Bozdagi, Huntley, Walker, Magistretti, Alberini (bib54) 2011; 144 Wallace (bib60) 2005; 39 Zhang, Kuang, Xu, Harris, Lee, LaManna, Puchowicz (bib62) 2013; 33 Carter, Leeuwenburgh, Daniels, Foster (bib7) 2009; 64 Stranahan, Mattson (bib52) 2012; 30 Newman, Korol, Gold (bib42) 2011; 6 Fontan-Lozano, Lopez-Lluch, Delgado-Garcia, Navas, Carrion (bib14) 2008; 38 Lopez-Lluch, Hunt, Jones, Zhu, Jamieson, Hilmer, Cascajo, Allard, Ingram, Navas, de Cabo (bib33) 2006; 103 Sullivan, Rippy, Dorenbos, Concepcion, Agarwal, Rho (bib53) 2004; 55 Dash, Orsi, Moore (bib13) 2006; 26 Linde, Hasselbalch, Topp, Paulson, Madsen (bib32) 2006; 26 Shafique, Choy, Liu, Feng, Cordeiro, Lyra, Arafah, Yassin-Kassab, Zanetti, Clements, Bianchi, Benjamin, Sellke, Abid (bib50) 2013; 5 Turturro, Witt, Lewis, Hass, Lipman, Hart (bib55) 1999; 54 Guzman, Blazquez (bib17) 2001; 12 Liao, Rikke, Johnson, Diaz, Nelson (bib25) 2010; 9 Prins, Matsumoto (bib44) 2014; 55 Ungvari, Kaley, de Cabo, Sonntag, Csiszar (bib56) 2010; 65 Choi, Choi, Lee (bib9) 2011; 409 Bentourkia, Bol, Ivanoiu, Labar, Sibomana, Coppens, Michel, Cosnard, De Volder (bib2) 2000; 181 Hoyer (bib20) 1991; 640 Liao, Rikke, Johnson, Gelfond, Diaz, Nelson (bib26) 2011; 10 Mattson (10.1016/j.neurobiolaging.2015.03.012_bib38) 2010; 2 Lanza (10.1016/j.neurobiolaging.2015.03.012_bib24) 2012; 16 Veech (10.1016/j.neurobiolaging.2015.03.012_bib59) 2013; 1302 Fontan-Lozano (10.1016/j.neurobiolaging.2015.03.012_bib14) 2008; 38 Witte (10.1016/j.neurobiolaging.2015.03.012_bib61) 2009; 106 Sullivan (10.1016/j.neurobiolaging.2015.03.012_bib53) 2004; 55 Bentourkia (10.1016/j.neurobiolaging.2015.03.012_bib2) 2000; 181 Chin (10.1016/j.neurobiolaging.2015.03.012_bib8) 2014; 510 Lynch (10.1016/j.neurobiolaging.2015.03.012_bib34) 1999; 20 Lin (10.1016/j.neurobiolaging.2015.03.012_bib30) 2014; 9 Stranahan (10.1016/j.neurobiolaging.2015.03.012_bib52) 2012; 30 Fox (10.1016/j.neurobiolaging.2015.03.012_bib16) 1988; 241 10.1016/j.neurobiolaging.2015.03.012_bib63 Lopez-Lluch (10.1016/j.neurobiolaging.2015.03.012_bib33) 2006; 103 Stranahan (10.1016/j.neurobiolaging.2015.03.012_bib51) 2009; 19 Choi (10.1016/j.neurobiolaging.2015.03.012_bib9) 2011; 409 Roy (10.1016/j.neurobiolaging.2015.03.012_bib48) 2013; 63 Sengupta (10.1016/j.neurobiolaging.2015.03.012_bib49) 2010; 468 Nagata (10.1016/j.neurobiolaging.2015.03.012_bib41) 1997; 826 Hoyer (10.1016/j.neurobiolaging.2015.03.012_bib20) 1991; 640 Turturro (10.1016/j.neurobiolaging.2015.03.012_bib55) 1999; 54 Maalouf (10.1016/j.neurobiolaging.2015.03.012_bib35) 2009; 59 Carter (10.1016/j.neurobiolaging.2015.03.012_bib7) 2009; 64 McNally (10.1016/j.neurobiolaging.2015.03.012_bib39) 2012; 121 Wallace (10.1016/j.neurobiolaging.2015.03.012_bib60) 2005; 39 Valdez (10.1016/j.neurobiolaging.2015.03.012_bib57) 2010; 107 Cunnane (10.1016/j.neurobiolaging.2015.03.012_bib12) 2011; 27 Kashiwaya (10.1016/j.neurobiolaging.2015.03.012_bib21) 2013; 34 Linde (10.1016/j.neurobiolaging.2015.03.012_bib32) 2006; 26 Bookheimer (10.1016/j.neurobiolaging.2015.03.012_bib4) 2000; 343 Hertz (10.1016/j.neurobiolaging.2015.03.012_bib19) 2013; 4 Lin (10.1016/j.neurobiolaging.2015.03.012_bib28) 2010; 107 Pellerin (10.1016/j.neurobiolaging.2015.03.012_bib43) 1994; 91 Kinsman (10.1016/j.neurobiolaging.2015.03.012_bib23) 1992; 33 Zhang (10.1016/j.neurobiolaging.2015.03.012_bib62) 2013; 33 Ungvari (10.1016/j.neurobiolaging.2015.03.012_bib56) 2010; 65 Liao (10.1016/j.neurobiolaging.2015.03.012_bib26) 2011; 10 Maalouf (10.1016/j.neurobiolaging.2015.03.012_bib36) 2007; 145 Akram (10.1016/j.neurobiolaging.2015.03.012_bib1) 2013; 16 Lin (10.1016/j.neurobiolaging.2015.03.012_bib29) 2012; 7 Dash (10.1016/j.neurobiolaging.2015.03.012_bib13) 2006; 26 Kida (10.1016/j.neurobiolaging.2015.03.012_bib22) 2001; 21 Reiman (10.1016/j.neurobiolaging.2015.03.012_bib46) 2001; 98 Burdakov (10.1016/j.neurobiolaging.2015.03.012_bib6) 2005; 360 Rahat (10.1016/j.neurobiolaging.2015.03.012_bib45) 2011; 66 Lin (10.1016/j.neurobiolaging.2015.03.012_bib27) 2014; 34 Shafique (10.1016/j.neurobiolaging.2015.03.012_bib50) 2013; 5 Blazquez (10.1016/j.neurobiolaging.2015.03.012_bib3) 1999; 73 Guzman (10.1016/j.neurobiolaging.2015.03.012_bib17) 2001; 12 Veech (10.1016/j.neurobiolaging.2015.03.012_bib58) 2004; 70 Colman (10.1016/j.neurobiolaging.2015.03.012_bib11) 2009; 325 Richardson (10.1016/j.neurobiolaging.2015.03.012_bib47) 2014 Uh (10.1016/j.neurobiolaging.2015.03.012_bib64) 2011; 65 Suzuki (10.1016/j.neurobiolaging.2015.03.012_bib54) 2011; 144 Newman (10.1016/j.neurobiolaging.2015.03.012_bib42) 2011; 6 Fox (10.1016/j.neurobiolaging.2015.03.012_bib15) 1986; 83 Brown (10.1016/j.neurobiolaging.2015.03.012_bib5) 2004; 45 Markowska (10.1016/j.neurobiolaging.2015.03.012_bib37) 2002; 23 Liao (10.1016/j.neurobiolaging.2015.03.012_bib25) 2010; 9 Mouton (10.1016/j.neurobiolaging.2015.03.012_bib40) 2009; 464 Prins (10.1016/j.neurobiolaging.2015.03.012_bib44) 2014; 55 Chowdhury (10.1016/j.neurobiolaging.2015.03.012_bib10) 2014; 34 Lin (10.1016/j.neurobiolaging.2015.03.012_bib31) 2013; 33 Hasselbalch (10.1016/j.neurobiolaging.2015.03.012_bib18) 1996; 270 16001018 - J Cereb Blood Flow Metab. 2006 Feb;26(2):170-80 11755022 - Neurobiol Aging. 2002 Jan-Feb;23(1):75-86 3260686 - Science. 1988 Jul 22;241(4864):462-4 24018842 - Aging (Albany NY). 2013 Jul;5(7):515-30 23217257 - Cell Metab. 2012 Dec 5;16(6):777-88 21337407 - Magn Reson Med. 2011 Mar;65(3):744-9 20679195 - Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14863-8 23736643 - J Cereb Blood Flow Metab. 2013 Aug;33(8):1307-11 24828042 - Nature. 2014 Jun 19;510(7505):397-401 22045480 - J Alzheimers Dis. 2012;30 Suppl 2:S5-13 25481271 - Exp Gerontol. 2015 Aug;68:51-8 11333369 - J Cereb Blood Flow Metab. 2001 May;21(5):585-91 21179166 - Nature. 2010 Dec 23;468(7327):1100-4 18759009 - Mol Neurobiol. 2008 Oct;38(2):167-77 21575595 - Biochem Biophys Res Commun. 2011 Jun 3;409(2):308-14 10619312 - J Gerontol A Biol Sci Med Sci. 1999 Nov;54(11):B492-501 23909803 - Ann N Y Acad Sci. 2013 Oct;1302:42-8 10501215 - J Neurochem. 1999 Oct;73(4):1674-82 15186919 - Neurochem Int. 2004 Sep;45(4):529-36 16885218 - J Neurosci. 2006 Aug 2;26(31):8048-56 22268909 - J Neurochem. 2012 Apr;121(1):28-35 24721741 - J Lipid Res. 2014 Dec;55(12):2450-7 20552045 - Front Aging Neurosci. 2010 Mar 08;2:5 19280661 - Hippocampus. 2009 Oct;19(10):951-61 21949904 - Neurol Res Int. 2012;2012:907409 16446459 - Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1768-73 19878144 - Aging Cell. 2010 Feb;9(1):92-5 24138078 - J Med Food. 2013 Nov;16(11):965-7 10537028 - Neurobiol Aging. 1999 Mar-Apr;20(2):191-200 23801246 - J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21 17240074 - Neuroscience. 2007 Mar 2;145(1):256-64 10944562 - N Engl J Med. 2000 Aug 17;343(7):450-6 21388497 - Aging Cell. 2011 Aug;10(4):629-39 11099707 - J Neurol Sci. 2000 Dec 1;181(1-2):19-28 1776759 - Ann N Y Acad Sci. 1991;640:53-8 19699265 - Neurosci Lett. 2009 Oct 30;464(3):184-7 24780902 - J Cereb Blood Flow Metab. 2014 Jul;34(7):1233-42 25214817 - Future Neurol. 2014 May 1;9(3):341-354 24984898 - J Cereb Blood Flow Metab. 2014 Sep;34(9):1440-3 11295573 - Trends Endocrinol Metab. 2001 May-Jun;12(4):169-73 9329699 - Ann N Y Acad Sci. 1997 Sep 26;826:272-81 21376239 - Cell. 2011 Mar 4;144(5):810-23 14769489 - Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):309-19 23750153 - Front Endocrinol (Lausanne). 2013 May 27;4:59 1464275 - Epilepsia. 1992 Nov-Dec;33(6):1132-6 16285865 - Annu Rev Genet. 2005;39:359-407 11248079 - Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3334-9 19420296 - J Gerontol A Biol Sci Med Sci. 2009 Aug;64(8):850-9 19590001 - Science. 2009 Jul 10;325(5937):201-4 21035308 - Nutrition. 2011 Jan;27(1):3-20 7938003 - Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10625-9 22180782 - PLoS One. 2011;6(12):e28427 15048898 - Ann Neurol. 2004 Apr;55(4):576-80 20576649 - J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1028-41 23276384 - Neurobiol Aging. 2013 Jun;34(6):1530-9 19171901 - Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1255-60 21081478 - J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):163-9 20404151 - Proc Natl Acad Sci U S A. 2010 May 4;107(18):8446-51 16321792 - Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2227-35 23974047 - Neurochem Int. 2013 Nov;63(5):450-7 8967461 - Am J Physiol. 1996 May;270(5 Pt 1):E746-51 18845187 - Brain Res Rev. 2009 Mar;59(2):293-315 23056355 - PLoS One. 2012;7(10):e46585 3485282 - Proc Natl Acad Sci U S A. 1986 Feb;83(4):1140-4 |
| References_xml | – volume: 98 start-page: 3334 year: 2001 end-page: 3339 ident: bib46 article-title: Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 409 start-page: 308 year: 2011 end-page: 314 ident: bib9 article-title: Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae publication-title: Biochem. Biophys. Res. Commun. – volume: 464 start-page: 184 year: 2009 end-page: 187 ident: bib40 article-title: Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice publication-title: Neurosci. Lett. – volume: 20 start-page: 191 year: 1999 end-page: 200 ident: bib34 article-title: Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats publication-title: Neurobiol. Aging – volume: 26 start-page: 170 year: 2006 end-page: 180 ident: bib32 article-title: Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat publication-title: J. Cereb. Blood Flow Metab. – volume: 468 start-page: 1100 year: 2010 end-page: 1104 ident: bib49 article-title: mTORC1 controls fasting-induced ketogenesis and its modulation by ageing publication-title: Nature – volume: 12 start-page: 169 year: 2001 end-page: 173 ident: bib17 article-title: Is there an astrocyte-neuron ketone body shuttle? publication-title: Trends Endocrinol. Metab. – volume: 33 start-page: 1132 year: 1992 end-page: 1136 ident: bib23 article-title: Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases publication-title: Epilepsia – volume: 19 start-page: 951 year: 2009 end-page: 961 ident: bib51 article-title: Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice publication-title: Hippocampus – volume: 65 start-page: 744 year: 2011 end-page: 749 ident: bib64 article-title: Validation of VASO cerebral blood volume measurement with positron emission tomography publication-title: Magn. Reson. Med. – volume: 107 start-page: 14863 year: 2010 end-page: 14868 ident: bib57 article-title: Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 91 start-page: 10625 year: 1994 end-page: 10629 ident: bib43 article-title: Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 33 start-page: 1412 year: 2013 end-page: 1421 ident: bib31 article-title: Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease publication-title: J. Cereb. Blood Flow Metab. – volume: 241 start-page: 462 year: 1988 end-page: 464 ident: bib16 article-title: Nonoxidative glucose consumption during focal physiologic neural activity publication-title: Science – volume: 325 start-page: 201 year: 2009 end-page: 204 ident: bib11 article-title: Caloric restriction delays disease onset and mortality in rhesus monkeys publication-title: Science – volume: 1302 start-page: 42 year: 2013 end-page: 48 ident: bib59 article-title: Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the rat publication-title: Ann. N. Y. Acad. Sci. – volume: 45 start-page: 529 year: 2004 end-page: 536 ident: bib5 article-title: Energy transfer from astrocytes to axons: the role of CNS glycogen publication-title: Neurochem. Int. – volume: 121 start-page: 28 year: 2012 end-page: 35 ident: bib39 article-title: Ketone bodies in epilepsy publication-title: J. Neurochem. – volume: 510 start-page: 397 year: 2014 end-page: 401 ident: bib8 article-title: The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR publication-title: Nature – volume: 70 start-page: 309 year: 2004 end-page: 319 ident: bib58 article-title: The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism publication-title: Prostaglandins Leukot. Essent. Fatty Acids – volume: 73 start-page: 1674 year: 1999 end-page: 1682 ident: bib3 article-title: The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes publication-title: J. Neurochem. – volume: 343 start-page: 450 year: 2000 end-page: 456 ident: bib4 article-title: Patterns of brain activation in people at risk for Alzheimer's disease publication-title: N. Engl. J. Med. – volume: 640 start-page: 53 year: 1991 end-page: 58 ident: bib20 article-title: Abnormalities of glucose metabolism in Alzheimer's disease publication-title: Ann. N. Y. Acad. Sci. – volume: 55 start-page: 2450 year: 2014 end-page: 2457 ident: bib44 article-title: The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury publication-title: J. Lipid Res. – volume: 66 start-page: 163 year: 2011 end-page: 169 ident: bib45 article-title: Multiple pathways regulating the calorie restriction response in yeast publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 34 start-page: 1233 year: 2014 end-page: 1242 ident: bib10 article-title: The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo publication-title: J. Cereb. Blood Flow Metab. – volume: 9 start-page: 341 year: 2014 end-page: 354 ident: bib30 article-title: What have novel imaging techniques revealed about metabolism in the aging brain? publication-title: Future Neurol. – volume: 144 start-page: 810 year: 2011 end-page: 823 ident: bib54 article-title: Astrocyte-neuron lactate transport is required for long-term memory formation publication-title: Cell – volume: 360 start-page: 2227 year: 2005 end-page: 2235 ident: bib6 article-title: Glucose-sensing neurons of the hypothalamus publication-title: Philosophical Trans. R. Soc. Lond. B Biol. Sci. – volume: 2 start-page: 5 year: 2010 ident: bib38 article-title: The impact of dietary energy intake on cognitive aging publication-title: Front. Aging Neurosci. – volume: 65 start-page: 1028 year: 2010 end-page: 1041 ident: bib56 article-title: Mechanisms of vascular aging: new perspectives publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 181 start-page: 19 year: 2000 end-page: 28 ident: bib2 article-title: Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging publication-title: J. Neurol. Sci. – volume: 107 start-page: 8446 year: 2010 end-page: 8451 ident: bib28 article-title: Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 145 start-page: 256 year: 2007 end-page: 264 ident: bib36 article-title: Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation publication-title: Neuroscience – volume: 55 start-page: 576 year: 2004 end-page: 580 ident: bib53 article-title: The ketogenic diet increases mitochondrial uncoupling protein levels and activity publication-title: Ann. Neurol. – year: 2014 ident: bib47 article-title: How longevity research can lead to therapies for Alzheimer's disease: the rapamycin story publication-title: Exp. Gerontol. – volume: 83 start-page: 1140 year: 1986 end-page: 1144 ident: bib15 article-title: Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 63 start-page: 450 year: 2013 end-page: 457 ident: bib48 article-title: Long-term calorie restriction has minimal impact on brain metabolite and fatty acid profiles in aged rats on a Western-style diet publication-title: Neurochem. Int. – volume: 10 start-page: 629 year: 2011 end-page: 639 ident: bib26 article-title: Fat maintenance is a predictor of the murine lifespan response to dietary restriction publication-title: Aging Cell – volume: 4 start-page: 59 year: 2013 ident: bib19 article-title: The glutamate-glutamine (GABA) Cycle: Importance of late postnatal development and potential reciprocal interactions between biosynthesis and degradation publication-title: Front. Endocrinol. – volume: 7 start-page: e46585 year: 2012 ident: bib29 article-title: Methylene blue as a cerebral metabolic and hemodynamic enhancer publication-title: PLoS One – volume: 26 start-page: 8048 year: 2006 end-page: 8056 ident: bib13 article-title: Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway publication-title: J. Neurosci. – volume: 826 start-page: 272 year: 1997 end-page: 281 ident: bib41 article-title: Misery perfusion with preserved vascular reactivity in Alzheimer's disease publication-title: Ann. N. Y. Acad. Sci. – volume: 33 start-page: 1307 year: 2013 end-page: 1311 ident: bib62 article-title: Ketosis proportionately spares glucose utilization in brain publication-title: J. Cereb. Blood Flow Metab. – volume: 9 start-page: 92 year: 2010 end-page: 95 ident: bib25 article-title: Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening publication-title: Aging Cell – volume: 54 start-page: B492 year: 1999 end-page: B501 ident: bib55 article-title: Growth curves and survival characteristics of the animals used in the biomarkers of aging Program publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 16 start-page: 777 year: 2012 end-page: 788 ident: bib24 article-title: Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis publication-title: Cell Metab. – volume: 106 start-page: 1255 year: 2009 end-page: 1260 ident: bib61 article-title: Caloric restriction improves memory in elderly humans publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 39 start-page: 359 year: 2005 end-page: 407 ident: bib60 article-title: A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine publication-title: Annu. Rev. Genet. – volume: 59 start-page: 293 year: 2009 end-page: 315 ident: bib35 article-title: The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies publication-title: Brain Res. Rev. – volume: 27 start-page: 3 year: 2011 end-page: 20 ident: bib12 article-title: Brain fuel metabolism, aging, and Alzheimer's disease publication-title: Nutrition – volume: 16 start-page: 965 year: 2013 end-page: 967 ident: bib1 article-title: A focused review of the role of ketone bodies in health and disease publication-title: J. Med. Food – volume: 34 start-page: 1440 year: 2014 end-page: 1443 ident: bib27 article-title: Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity publication-title: J. Cereb. Blood Flow Metab. – volume: 34 start-page: 1530 year: 2013 end-page: 1539 ident: bib21 article-title: A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease publication-title: Neurobiol. Aging – reference: Lin, A.L., Laird, A.R., Fox, P.T., Gao, J.H., 2012a. Multimodal MRI neuroimaging biomarkers for cognitive normal adults, amnestic mild cognitive impairment, and Alzheimer's disease, Neurol. Res. Int. 2012, 907409. – volume: 103 start-page: 1768 year: 2006 end-page: 1773 ident: bib33 article-title: Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 30 start-page: S5 year: 2012 end-page: S13 ident: bib52 article-title: Metabolic reserve as a determinant of cognitive aging publication-title: J. Alzheimers Dis. – volume: 6 start-page: e28427 year: 2011 ident: bib42 article-title: Lactate produced by glycogenolysis in astrocytes regulates memory processing publication-title: PLoS One – volume: 64 start-page: 850 year: 2009 end-page: 859 ident: bib7 article-title: Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 5 start-page: 515 year: 2013 end-page: 530 ident: bib50 article-title: Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK publication-title: Aging – volume: 270 start-page: E746 year: 1996 end-page: E751 ident: bib18 article-title: Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia publication-title: Am. J. Physiol. – volume: 38 start-page: 167 year: 2008 end-page: 177 ident: bib14 article-title: Molecular bases of caloric restriction regulation of neuronal synaptic plasticity publication-title: Mol. Neurobiol. – volume: 21 start-page: 585 year: 2001 end-page: 591 ident: bib22 article-title: Inhibition of voltage-dependent sodium channels suppresses the functional magnetic resonance imaging response to forepaw somatosensory activation in the rodent publication-title: J. Cereb. Blood Flow Metab. – volume: 23 start-page: 75 year: 2002 end-page: 86 ident: bib37 article-title: Retardation of cognitive aging by life-long diet restriction: implications for genetic variance publication-title: Neurobiol. Aging – volume: 21 start-page: 585 year: 2001 ident: 10.1016/j.neurobiolaging.2015.03.012_bib22 article-title: Inhibition of voltage-dependent sodium channels suppresses the functional magnetic resonance imaging response to forepaw somatosensory activation in the rodent publication-title: J. Cereb. Blood Flow Metab. doi: 10.1097/00004647-200105000-00013 – volume: 9 start-page: 341 year: 2014 ident: 10.1016/j.neurobiolaging.2015.03.012_bib30 article-title: What have novel imaging techniques revealed about metabolism in the aging brain? publication-title: Future Neurol. doi: 10.2217/fnl.14.13 – volume: 12 start-page: 169 year: 2001 ident: 10.1016/j.neurobiolaging.2015.03.012_bib17 article-title: Is there an astrocyte-neuron ketone body shuttle? publication-title: Trends Endocrinol. Metab. doi: 10.1016/S1043-2760(00)00370-2 – ident: 10.1016/j.neurobiolaging.2015.03.012_bib63 doi: 10.1155/2012/907409 – volume: 145 start-page: 256 year: 2007 ident: 10.1016/j.neurobiolaging.2015.03.012_bib36 article-title: Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation publication-title: Neuroscience doi: 10.1016/j.neuroscience.2006.11.065 – volume: 63 start-page: 450 year: 2013 ident: 10.1016/j.neurobiolaging.2015.03.012_bib48 article-title: Long-term calorie restriction has minimal impact on brain metabolite and fatty acid profiles in aged rats on a Western-style diet publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2013.08.006 – volume: 121 start-page: 28 year: 2012 ident: 10.1016/j.neurobiolaging.2015.03.012_bib39 article-title: Ketone bodies in epilepsy publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2012.07670.x – volume: 106 start-page: 1255 year: 2009 ident: 10.1016/j.neurobiolaging.2015.03.012_bib61 article-title: Caloric restriction improves memory in elderly humans publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0808587106 – volume: 343 start-page: 450 year: 2000 ident: 10.1016/j.neurobiolaging.2015.03.012_bib4 article-title: Patterns of brain activation in people at risk for Alzheimer's disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJM200008173430701 – volume: 33 start-page: 1412 year: 2013 ident: 10.1016/j.neurobiolaging.2015.03.012_bib31 article-title: Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2013.82 – volume: 70 start-page: 309 year: 2004 ident: 10.1016/j.neurobiolaging.2015.03.012_bib58 article-title: The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism publication-title: Prostaglandins Leukot. Essent. Fatty Acids doi: 10.1016/j.plefa.2003.09.007 – volume: 98 start-page: 3334 year: 2001 ident: 10.1016/j.neurobiolaging.2015.03.012_bib46 article-title: Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.061509598 – volume: 325 start-page: 201 year: 2009 ident: 10.1016/j.neurobiolaging.2015.03.012_bib11 article-title: Caloric restriction delays disease onset and mortality in rhesus monkeys publication-title: Science doi: 10.1126/science.1173635 – volume: 464 start-page: 184 year: 2009 ident: 10.1016/j.neurobiolaging.2015.03.012_bib40 article-title: Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2009.08.038 – volume: 270 start-page: E746 year: 1996 ident: 10.1016/j.neurobiolaging.2015.03.012_bib18 article-title: Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia publication-title: Am. J. Physiol. – volume: 640 start-page: 53 year: 1991 ident: 10.1016/j.neurobiolaging.2015.03.012_bib20 article-title: Abnormalities of glucose metabolism in Alzheimer's disease publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1991.tb00190.x – year: 2014 ident: 10.1016/j.neurobiolaging.2015.03.012_bib47 article-title: How longevity research can lead to therapies for Alzheimer's disease: the rapamycin story publication-title: Exp. Gerontol. – volume: 27 start-page: 3 year: 2011 ident: 10.1016/j.neurobiolaging.2015.03.012_bib12 article-title: Brain fuel metabolism, aging, and Alzheimer's disease publication-title: Nutrition doi: 10.1016/j.nut.2010.07.021 – volume: 23 start-page: 75 year: 2002 ident: 10.1016/j.neurobiolaging.2015.03.012_bib37 article-title: Retardation of cognitive aging by life-long diet restriction: implications for genetic variance publication-title: Neurobiol. Aging doi: 10.1016/S0197-4580(01)00249-4 – volume: 66 start-page: 163 year: 2011 ident: 10.1016/j.neurobiolaging.2015.03.012_bib45 article-title: Multiple pathways regulating the calorie restriction response in yeast publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glq165 – volume: 181 start-page: 19 year: 2000 ident: 10.1016/j.neurobiolaging.2015.03.012_bib2 article-title: Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging publication-title: J. Neurol. Sci. doi: 10.1016/S0022-510X(00)00396-8 – volume: 83 start-page: 1140 year: 1986 ident: 10.1016/j.neurobiolaging.2015.03.012_bib15 article-title: Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.83.4.1140 – volume: 34 start-page: 1233 year: 2014 ident: 10.1016/j.neurobiolaging.2015.03.012_bib10 article-title: The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2014.77 – volume: 510 start-page: 397 year: 2014 ident: 10.1016/j.neurobiolaging.2015.03.012_bib8 article-title: The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR publication-title: Nature doi: 10.1038/nature13264 – volume: 91 start-page: 10625 year: 1994 ident: 10.1016/j.neurobiolaging.2015.03.012_bib43 article-title: Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.91.22.10625 – volume: 19 start-page: 951 year: 2009 ident: 10.1016/j.neurobiolaging.2015.03.012_bib51 article-title: Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice publication-title: Hippocampus doi: 10.1002/hipo.20577 – volume: 16 start-page: 965 year: 2013 ident: 10.1016/j.neurobiolaging.2015.03.012_bib1 article-title: A focused review of the role of ketone bodies in health and disease publication-title: J. Med. Food doi: 10.1089/jmf.2012.2592 – volume: 107 start-page: 8446 year: 2010 ident: 10.1016/j.neurobiolaging.2015.03.012_bib28 article-title: Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0909711107 – volume: 26 start-page: 8048 year: 2006 ident: 10.1016/j.neurobiolaging.2015.03.012_bib13 article-title: Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0671-06.2006 – volume: 409 start-page: 308 year: 2011 ident: 10.1016/j.neurobiolaging.2015.03.012_bib9 article-title: Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2011.05.008 – volume: 73 start-page: 1674 year: 1999 ident: 10.1016/j.neurobiolaging.2015.03.012_bib3 article-title: The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.1999.731674.x – volume: 64 start-page: 850 year: 2009 ident: 10.1016/j.neurobiolaging.2015.03.012_bib7 article-title: Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glp060 – volume: 16 start-page: 777 year: 2012 ident: 10.1016/j.neurobiolaging.2015.03.012_bib24 article-title: Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis publication-title: Cell Metab. doi: 10.1016/j.cmet.2012.11.003 – volume: 59 start-page: 293 year: 2009 ident: 10.1016/j.neurobiolaging.2015.03.012_bib35 article-title: The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies publication-title: Brain Res. Rev. doi: 10.1016/j.brainresrev.2008.09.002 – volume: 144 start-page: 810 year: 2011 ident: 10.1016/j.neurobiolaging.2015.03.012_bib54 article-title: Astrocyte-neuron lactate transport is required for long-term memory formation publication-title: Cell doi: 10.1016/j.cell.2011.02.018 – volume: 30 start-page: S5 issue: Suppl 2 year: 2012 ident: 10.1016/j.neurobiolaging.2015.03.012_bib52 article-title: Metabolic reserve as a determinant of cognitive aging publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-2011-110899 – volume: 360 start-page: 2227 year: 2005 ident: 10.1016/j.neurobiolaging.2015.03.012_bib6 article-title: Glucose-sensing neurons of the hypothalamus publication-title: Philosophical Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2005.1763 – volume: 38 start-page: 167 year: 2008 ident: 10.1016/j.neurobiolaging.2015.03.012_bib14 article-title: Molecular bases of caloric restriction regulation of neuronal synaptic plasticity publication-title: Mol. Neurobiol. doi: 10.1007/s12035-008-8040-1 – volume: 9 start-page: 92 year: 2010 ident: 10.1016/j.neurobiolaging.2015.03.012_bib25 article-title: Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening publication-title: Aging Cell doi: 10.1111/j.1474-9726.2009.00533.x – volume: 33 start-page: 1307 year: 2013 ident: 10.1016/j.neurobiolaging.2015.03.012_bib62 article-title: Ketosis proportionately spares glucose utilization in brain publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2013.87 – volume: 826 start-page: 272 year: 1997 ident: 10.1016/j.neurobiolaging.2015.03.012_bib41 article-title: Misery perfusion with preserved vascular reactivity in Alzheimer's disease publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1997.tb48479.x – volume: 6 start-page: e28427 year: 2011 ident: 10.1016/j.neurobiolaging.2015.03.012_bib42 article-title: Lactate produced by glycogenolysis in astrocytes regulates memory processing publication-title: PLoS One doi: 10.1371/journal.pone.0028427 – volume: 103 start-page: 1768 year: 2006 ident: 10.1016/j.neurobiolaging.2015.03.012_bib33 article-title: Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0510452103 – volume: 4 start-page: 59 issue: 5 Pt 1 year: 2013 ident: 10.1016/j.neurobiolaging.2015.03.012_bib19 article-title: The glutamate-glutamine (GABA) Cycle: Importance of late postnatal development and potential reciprocal interactions between biosynthesis and degradation publication-title: Front. Endocrinol. – volume: 65 start-page: 1028 year: 2010 ident: 10.1016/j.neurobiolaging.2015.03.012_bib56 article-title: Mechanisms of vascular aging: new perspectives publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glq113 – volume: 45 start-page: 529 year: 2004 ident: 10.1016/j.neurobiolaging.2015.03.012_bib5 article-title: Energy transfer from astrocytes to axons: the role of CNS glycogen publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2003.11.005 – volume: 468 start-page: 1100 year: 2010 ident: 10.1016/j.neurobiolaging.2015.03.012_bib49 article-title: mTORC1 controls fasting-induced ketogenesis and its modulation by ageing publication-title: Nature doi: 10.1038/nature09584 – volume: 241 start-page: 462 year: 1988 ident: 10.1016/j.neurobiolaging.2015.03.012_bib16 article-title: Nonoxidative glucose consumption during focal physiologic neural activity publication-title: Science doi: 10.1126/science.3260686 – volume: 33 start-page: 1132 year: 1992 ident: 10.1016/j.neurobiolaging.2015.03.012_bib23 article-title: Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases publication-title: Epilepsia doi: 10.1111/j.1528-1157.1992.tb01770.x – volume: 10 start-page: 629 year: 2011 ident: 10.1016/j.neurobiolaging.2015.03.012_bib26 article-title: Fat maintenance is a predictor of the murine lifespan response to dietary restriction publication-title: Aging Cell doi: 10.1111/j.1474-9726.2011.00702.x – volume: 26 start-page: 170 year: 2006 ident: 10.1016/j.neurobiolaging.2015.03.012_bib32 article-title: Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/sj.jcbfm.9600177 – volume: 1302 start-page: 42 year: 2013 ident: 10.1016/j.neurobiolaging.2015.03.012_bib59 article-title: Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the rat publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.12222 – volume: 34 start-page: 1530 year: 2013 ident: 10.1016/j.neurobiolaging.2015.03.012_bib21 article-title: A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2012.11.023 – volume: 55 start-page: 2450 year: 2014 ident: 10.1016/j.neurobiolaging.2015.03.012_bib44 article-title: The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury publication-title: J. Lipid Res. doi: 10.1194/jlr.R046706 – volume: 2 start-page: 5 year: 2010 ident: 10.1016/j.neurobiolaging.2015.03.012_bib38 article-title: The impact of dietary energy intake on cognitive aging publication-title: Front. Aging Neurosci. – volume: 55 start-page: 576 year: 2004 ident: 10.1016/j.neurobiolaging.2015.03.012_bib53 article-title: The ketogenic diet increases mitochondrial uncoupling protein levels and activity publication-title: Ann. Neurol. doi: 10.1002/ana.20062 – volume: 65 start-page: 744 year: 2011 ident: 10.1016/j.neurobiolaging.2015.03.012_bib64 article-title: Validation of VASO cerebral blood volume measurement with positron emission tomography publication-title: Magn. Reson. Med. doi: 10.1002/mrm.22667 – volume: 39 start-page: 359 year: 2005 ident: 10.1016/j.neurobiolaging.2015.03.012_bib60 article-title: A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine publication-title: Annu. Rev. Genet. doi: 10.1146/annurev.genet.39.110304.095751 – volume: 20 start-page: 191 year: 1999 ident: 10.1016/j.neurobiolaging.2015.03.012_bib34 article-title: Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats publication-title: Neurobiol. Aging doi: 10.1016/S0197-4580(99)00032-9 – volume: 54 start-page: B492 year: 1999 ident: 10.1016/j.neurobiolaging.2015.03.012_bib55 article-title: Growth curves and survival characteristics of the animals used in the biomarkers of aging Program publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/54.11.B492 – volume: 5 start-page: 515 year: 2013 ident: 10.1016/j.neurobiolaging.2015.03.012_bib50 article-title: Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK publication-title: Aging doi: 10.18632/aging.100569 – volume: 34 start-page: 1440 year: 2014 ident: 10.1016/j.neurobiolaging.2015.03.012_bib27 article-title: Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2014.114 – volume: 7 start-page: e46585 year: 2012 ident: 10.1016/j.neurobiolaging.2015.03.012_bib29 article-title: Methylene blue as a cerebral metabolic and hemodynamic enhancer publication-title: PLoS One doi: 10.1371/journal.pone.0046585 – volume: 107 start-page: 14863 year: 2010 ident: 10.1016/j.neurobiolaging.2015.03.012_bib57 article-title: Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1002220107 – reference: 20576649 - J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1028-41 – reference: 20679195 - Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14863-8 – reference: 21179166 - Nature. 2010 Dec 23;468(7327):1100-4 – reference: 10537028 - Neurobiol Aging. 1999 Mar-Apr;20(2):191-200 – reference: 21035308 - Nutrition. 2011 Jan;27(1):3-20 – reference: 10501215 - J Neurochem. 1999 Oct;73(4):1674-82 – reference: 23276384 - Neurobiol Aging. 2013 Jun;34(6):1530-9 – reference: 18845187 - Brain Res Rev. 2009 Mar;59(2):293-315 – reference: 14769489 - Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):309-19 – reference: 23750153 - Front Endocrinol (Lausanne). 2013 May 27;4:59 – reference: 17240074 - Neuroscience. 2007 Mar 2;145(1):256-64 – reference: 24780902 - J Cereb Blood Flow Metab. 2014 Jul;34(7):1233-42 – reference: 11295573 - Trends Endocrinol Metab. 2001 May-Jun;12(4):169-73 – reference: 10619312 - J Gerontol A Biol Sci Med Sci. 1999 Nov;54(11):B492-501 – reference: 24138078 - J Med Food. 2013 Nov;16(11):965-7 – reference: 24018842 - Aging (Albany NY). 2013 Jul;5(7):515-30 – reference: 11099707 - J Neurol Sci. 2000 Dec 1;181(1-2):19-28 – reference: 22180782 - PLoS One. 2011;6(12):e28427 – reference: 19699265 - Neurosci Lett. 2009 Oct 30;464(3):184-7 – reference: 21575595 - Biochem Biophys Res Commun. 2011 Jun 3;409(2):308-14 – reference: 16446459 - Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1768-73 – reference: 18759009 - Mol Neurobiol. 2008 Oct;38(2):167-77 – reference: 23974047 - Neurochem Int. 2013 Nov;63(5):450-7 – reference: 1464275 - Epilepsia. 1992 Nov-Dec;33(6):1132-6 – reference: 23736643 - J Cereb Blood Flow Metab. 2013 Aug;33(8):1307-11 – reference: 21337407 - Magn Reson Med. 2011 Mar;65(3):744-9 – reference: 23056355 - PLoS One. 2012;7(10):e46585 – reference: 20552045 - Front Aging Neurosci. 2010 Mar 08;2:5 – reference: 19420296 - J Gerontol A Biol Sci Med Sci. 2009 Aug;64(8):850-9 – reference: 22268909 - J Neurochem. 2012 Apr;121(1):28-35 – reference: 11333369 - J Cereb Blood Flow Metab. 2001 May;21(5):585-91 – reference: 21949904 - Neurol Res Int. 2012;2012:907409 – reference: 24984898 - J Cereb Blood Flow Metab. 2014 Sep;34(9):1440-3 – reference: 23909803 - Ann N Y Acad Sci. 2013 Oct;1302:42-8 – reference: 25481271 - Exp Gerontol. 2015 Aug;68:51-8 – reference: 16001018 - J Cereb Blood Flow Metab. 2006 Feb;26(2):170-80 – reference: 19878144 - Aging Cell. 2010 Feb;9(1):92-5 – reference: 15186919 - Neurochem Int. 2004 Sep;45(4):529-36 – reference: 9329699 - Ann N Y Acad Sci. 1997 Sep 26;826:272-81 – reference: 10944562 - N Engl J Med. 2000 Aug 17;343(7):450-6 – reference: 11248079 - Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3334-9 – reference: 19590001 - Science. 2009 Jul 10;325(5937):201-4 – reference: 19280661 - Hippocampus. 2009 Oct;19(10):951-61 – reference: 21081478 - J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):163-9 – reference: 21388497 - Aging Cell. 2011 Aug;10(4):629-39 – reference: 1776759 - Ann N Y Acad Sci. 1991;640:53-8 – reference: 24721741 - J Lipid Res. 2014 Dec;55(12):2450-7 – reference: 24828042 - Nature. 2014 Jun 19;510(7505):397-401 – reference: 8967461 - Am J Physiol. 1996 May;270(5 Pt 1):E746-51 – reference: 16321792 - Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2227-35 – reference: 22045480 - J Alzheimers Dis. 2012;30 Suppl 2:S5-13 – reference: 25214817 - Future Neurol. 2014 May 1;9(3):341-354 – reference: 19171901 - Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1255-60 – reference: 3485282 - Proc Natl Acad Sci U S A. 1986 Feb;83(4):1140-4 – reference: 20404151 - Proc Natl Acad Sci U S A. 2010 May 4;107(18):8446-51 – reference: 16885218 - J Neurosci. 2006 Aug 2;26(31):8048-56 – reference: 3260686 - Science. 1988 Jul 22;241(4864):462-4 – reference: 15048898 - Ann Neurol. 2004 Apr;55(4):576-80 – reference: 16285865 - Annu Rev Genet. 2005;39:359-407 – reference: 11755022 - Neurobiol Aging. 2002 Jan-Feb;23(1):75-86 – reference: 23801246 - J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21 – reference: 21376239 - Cell. 2011 Mar 4;144(5):810-23 – reference: 7938003 - Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10625-9 – reference: 23217257 - Cell Metab. 2012 Dec 5;16(6):777-88 |
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| Snippet | Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions... Abstract Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain... Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions... |
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| SubjectTerms | Aging Aging - physiology Animals Brain - blood supply Brain - metabolism Caloric Restriction Cerebral blood flow Cerebrovascular Circulation Internal Medicine Ketone bodies Ketone Bodies - metabolism Male Mammalian target of rapamycin Neuroimaging Neurology Rats, Inbred F344 α-ketoglutarate |
| Title | Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain |
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