Comparative Study of the Usefulness of the Drug-Induced Lymphocyte Stimulation Test and the Leukocyte Migration Test in Drug Allergies

In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identif...

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Published in	Biological & Pharmaceutical Bulletin Vol. 31; no. 2; pp. 299 - 304
Main Authors	Uno, Katsuji, Saito, Mikio, Yagi, Motohiro, Takanaka, Koichiro
Format	Journal Article
Language	English
Published	Japan The Pharmaceutical Society of Japan 01.02.2008 Pharmaceutical Society of Japan Japan Science and Technology Agency
Subjects	Adolescent Adult age and sex Aged Aged, 80 and over Aging - physiology Antibody Specificity Antigens - chemistry Antigens - isolation & purification causative drug Cell Migration Assays, Leukocyte Cell Separation Child Child, Preschool drug allergy Drug Hypersensitivity - diagnosis drug-induced lymphocyte stimulation test Female Humans hypersensitivity symptom Infant leukocyte migration test Lymphocyte Activation - drug effects Male Middle Aged Monocytes - drug effects Predictive Value of Tests Sex Characteristics
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ISSN	0918-6158 1347-5215 1347-5215
DOI	10.1248/bpb.31.299

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Abstract	In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the DLST and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the DLST (p<0.000001, χ2-test). In the 102 control patients, the positive rates on the DLST and LMT were 6.9%. In addition, the LMT showed a higher positive rate than the DLST for many hypersensitivity symptoms such as skin eruptions and hepatic injury, and for many drug efficacy categories of the suspected drugs such as antibacterial drugs, etc. Furthermore, the positive rate of the DLST did not change when adjusted for the patients' serum and sex, while that of the LMT increased when adjusted for the patients' serum and was found to be higher in females than in males. Our findings indicate that the LMT may be more useful than the DLST in identifying the causative drug in drug allergies and that its interpretation is influenced by the patient's serum and sex.
AbstractList	In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the DLST and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the DLST (p<0.000001, x2-test). In the 102 control patients, the positive rates on the DLST and LMT were 6.9%. In addition, the LMT showed a higher positive rate than the DLST for many hypersensitivity symptoms such as skin eruptions and hepatic injury, and for many drug efficacy categories of the suspected drugs such as antibacterial drugs, etc. Furthermore, the positive rate of the DLST did not change when adjusted for the patients' serum and sex, while that of the LMT increased when adjusted for the patients' serum and was found to be higher in females than in males. Our findings indicate that the LMT may be more useful than the DLST in identifying the causative drug in drug allergies and that its interpretation is influenced by the patient's serum and sex. In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the DLST and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the DLST (p<0.000001, chi super(2)-test). In the 102 control patients, the positive rates on the DLST and LMT were 6.9%. In addition, the LMT showed a higher positive rate than the DLST for many hypersensitivity symptoms such as skin eruptions and hepatic injury, and for many drug efficacy categories of the suspected drugs such as antibacterial drugs, etc. Furthermore, the positive rate of the DLST did not change when adjusted for the patients' serum and sex, while that of the LMT increased when adjusted for the patients' serum and was found to be higher in females than in males. Our findings indicate that the LMT may be more useful than the DLST in identifying the causative drug in drug allergies and that its interpretation is influenced by the patient's serum and sex. In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the DLST and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the DLST (p<0.000001, χ2-test). In the 102 control patients, the positive rates on the DLST and LMT were 6.9%. In addition, the LMT showed a higher positive rate than the DLST for many hypersensitivity symptoms such as skin eruptions and hepatic injury, and for many drug efficacy categories of the suspected drugs such as antibacterial drugs, etc. Furthermore, the positive rate of the DLST did not change when adjusted for the patients' serum and sex, while that of the LMT increased when adjusted for the patients' serum and was found to be higher in females than in males. Our findings indicate that the LMT may be more useful than the DLST in identifying the causative drug in drug allergies and that its interpretation is influenced by the patient's serum and sex. In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the DLST and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the DLST (p<0.000001, chi(2)-test). In the 102 control patients, the positive rates on the DLST and LMT were 6.9%. In addition, the LMT showed a higher positive rate than the DLST for many hypersensitivity symptoms such as skin eruptions and hepatic injury, and for many drug efficacy categories of the suspected drugs such as antibacterial drugs, etc. Furthermore, the positive rate of the DLST did not change when adjusted for the patients' serum and sex, while that of the LMT increased when adjusted for the patients' serum and was found to be higher in females than in males. Our findings indicate that the LMT may be more useful than the DLST in identifying the causative drug in drug allergies and that its interpretation is influenced by the patient's serum and sex.In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the DLST and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the DLST (p<0.000001, chi(2)-test). In the 102 control patients, the positive rates on the DLST and LMT were 6.9%. In addition, the LMT showed a higher positive rate than the DLST for many hypersensitivity symptoms such as skin eruptions and hepatic injury, and for many drug efficacy categories of the suspected drugs such as antibacterial drugs, etc. Furthermore, the positive rate of the DLST did not change when adjusted for the patients' serum and sex, while that of the LMT increased when adjusted for the patients' serum and was found to be higher in females than in males. Our findings indicate that the LMT may be more useful than the DLST in identifying the causative drug in drug allergies and that its interpretation is influenced by the patient's serum and sex. In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the DLST and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the DLST (p<0.000001, chi(2)-test). In the 102 control patients, the positive rates on the DLST and LMT were 6.9%. In addition, the LMT showed a higher positive rate than the DLST for many hypersensitivity symptoms such as skin eruptions and hepatic injury, and for many drug efficacy categories of the suspected drugs such as antibacterial drugs, etc. Furthermore, the positive rate of the DLST did not change when adjusted for the patients' serum and sex, while that of the LMT increased when adjusted for the patients' serum and was found to be higher in females than in males. Our findings indicate that the LMT may be more useful than the DLST in identifying the causative drug in drug allergies and that its interpretation is influenced by the patient's serum and sex.
Author	Saito, Mikio Yagi, Motohiro Uno, Katsuji Takanaka, Koichiro
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References	20) Pichler W. J., Tilch J., Allergy, 59, 809—820 (2004). 27) Miyazawa T., Doi M., Mineshita M., Kurata T., Kitaguchi S., Furukawa N., Nihon Kyobu Shikkan Gakkai Zasshi, 31, 920—923 (1993). 43) Hiraoka K., Nagata N., Suzuki K., Kawajiri T., Kurokawa S., Kawamura T., Kido M., J. UOEH, 20, 145—151 (1998). 11) Clausen J. E., Acta Allergologica, 28, 351—369 (1973). 36) Uno K., Arerugi, 42, 656—664 (1993). 42) Halevy S., Cohen A., Livni E., Clin. Exp. Dermatol., 25, 652—524 (2000). 22) Maeda K., Komuta K., Hasegawa K., Ohtsuki M., Morishita H., Igarashi T., Nihon Kokyuki Gakkai Zasshi, 33, 745—749 (1995). 23) Beers M. H., Berkow R., “The Merck of Diagnosis and Therapy,” 17th ed., Merck & Co., Whitehouse Station, 1999, pp. 1064—1067. 30) Uno K., Arerugi, 41, 418—427 (1992). 17) Arima M., Kanoh T., Yamasaki A., Matsuda S., Kasuya H., Sunayama S., Kawai S., Okada R., Jpn. Circ. J., 62, 132—135 (1998). 16) Mochitomi Y., Inoue A., Kawabata H., Ishida S., Kanzaki T., J. Dermatol., 25, 662—665 (1998). 31) Abe M., Kurihara T., Uno K., Jpn. J. Pharm. Health Care Sci., 31, 32—40 (2006). 9) Su H., Watkins N. G., Zhang Y. X., Caldwell H. D., Infect. Immun., 58, 1017—1025 (1990). 28) Katagiri K., Takayasu S., J. Dermatol., 23, 623—627 (1996). 10) Namihisa T., Yamaguchi K., Kitami K., Yamada T., Takazakura Y., Nippon Shokakibyo Gakkai Zasshi, 71, 472—479 (1974). 14) Mori H., Yamanaka K., Kaketa M., Tamada K., Hakamada A., Isoda K., Yamanishi K., Mizutani H., J. Dermatol., 31, 731—736 (2004). 35) Sano N., Uno K., Arerugi, 47, 1198—1204 (1998). 26) Mantani N., Kogure T., Tamura J., Shimada Y., Terasawa K., Clin. Diagn. Lab. Immunol., 10, 479—480 (2003). 8) Uno K., Kondo A., Arerugi, 44, 1401—1409 (1995). 33) Chihara J., Yamado H., Takamura E., Nakajima S., Int. Arch. Allergy Immunol., 106, 428—429 (1995). 5) Muroi N., Jpn. J. Pharm. Health Care. Sci., 27, 93—104 (2001). 38) Leyva L., Torres M. J., Posadas S., Blanca M., Besso G., O'Valle F., del Moral R. G., J. Allergy Clin. Immunol., 105, 157—165 (2000). 19) Kardaun S. H., de Monchy J. G., J. Am. Acad. Dermatol., 55, 21—23 (2006). 32) Uno K., Yagi M., Suzuki Y., Sekine O., Chemotherapy, 44, 641—648 (1996). 1) Shimizu M., “Drug Eruption and Drug-related Skin Damage—Clinical Aspect and Prognosis of Drug Eruption,” Kanehara & Co. Ltd., Tokyo, 1999, pp. 105—116. 25) Maria V. A. J., Victorino R. M. M., Hepatology, 26, 664—669 (1997). 6) Yoshimura T., Kurita C., Hayata M., Nagai H., Biol. Pharm. Bull., 16, 686—689 (1993). 21) Kondo A., Kekkaku, 74, 33—41 (1999). 41) Brander C., Mauri-Hellweg D., Bettens F., Rolli H., Goldman M., Pichler W. J., J. Immunol., 155, 2670—2678 (1995). 37) Paquet P., Paquet F., Al Saleh W., Reper P., Vanderkelen A., Pierard G. E., Am. J. Dermatopathol., 22, 413—417 (2000). 45) Mohri S., Watanabe T., Nariuchi H., Immunology, 46, 271—280 (1982). 29) Kawabata R., Koida M., Kanie S., Tanaka G., Ohuchida A., Yoshida T., Gan To Kagaku Ryoho, 33, 345—348 (2006). 34) Oneda K., Arerugi, 48, 13—22 (1999). 44) Yagi M., Uno K., Kurihara T., Suzuki Y., Sekine O., Hattori H., Yamaguchi F., J. Antimicrob. Chemother., 47, 190—195 (1999). 46) Knop J., Riechmann R., Macher E., J. Invest. Dermatol., 76, 193—196 (1981). 24) Danan G., Benichou C., J. Clin. Epidemiol., 46, 1323—1330 (1993). 18) Yoshioka S., Mukae H., Ishii H., Nakayama S., Hisatomi K., Ishimoto H., Kakugawa T., Sugiyama K., Ide M., Kohno S., Nihon Kokyuki Gakkai Zasshi, 43, 600—604 (2005). 4) Nagakura N., Shimizu T., Masuzawa T., Yanagihara Y., Chemotherapy, 38, 910—917 (1990). 7) Abe M., Uno K., Arerugi, 47, 1264—1272 (1998). 15) Kobashi Y., Okimoto N., Matsushima T., Abe T., Nishimura K., Shishido S., Kawahara S., Shigeto E., Takeyama H., Kuraoka T., Kekkaku, 75, 699—704 (2000). 2) Lammintausta K., Kortekangas-Savolainen O., Br. J. Dermatol., 152, 968—974 (2005). 40) Hertl M., Geisel J., Boecker C., Merk H. F., Br. J. Dermatol., 128, 619—626 (1993). 13) Uno K., Arerugi, 39, 1605—1611 (1990). 3) Uno K., Yamasaku F., J. Antimicrob. Chemother., 24, 241—250 (1989). 12) Abe M., Uno K., Jpn. J. Pharm. Health Cre. Sci., 27, 5—14 (2001). 39) Pirmohamed M., Lin K., Chadwick D., Park B. K., Neurology, 56, 890—896 (2001). Kawabata R., Koida M., Kanie S., Ta (29) 2006; 33 KONDO ARIYOSHI (21) 1999; 74 24 25 26 Brander C., Mauri-Hellweg D., Bette (41) 1995; 155 UNO KATSUJI (8) 1995; 44 ONEDA KAZUMI (34) 1999; 48 Leyva L., Torres M. J., Posadas S. (38) 2000; 105 Yagi M., Uno K., Kurihara T., Suzuk (44) 1999; 47 MOCHITOMI Y (16) 1998; 25 Lammintausta K., Kortekangas-Savola (2) 2005; 152 Muroi N. (5) 2001; 27 Su H., Watkins N. G., Zhang Y. X. (9) 1990; 58 Abe M., Kurihara T., Uno K. (31) 2006; 31 HIRAOKA K (43) 1998; 20 UNO KATSUJI (30) 1992; 41 Shimizu M. (1) 1999 Namihisa T., Yamaguchi K., Kitami K (10) 1974; 71 KOBASHI YOSHIHIRO (15) 2000; 75 Pirmohamed M., Lin K., Chadwick D. (39) 2001; 56 Knop J., Riechmann R., Macher E. (46) 1981; 76 37 Abe M., Uno K. (12) 2001; 27 17 ABE MANABU (7) 1998; 47 (45) 1982; 46 YOSHIOKA SUMAKO (18) 2005; 43 KATAGIRI K (28) 1996; 23 UNO KATSUJI (36) 1993; 42 Uno K., Yamasaku F. (3) 1989; 24 Uno K., Yagi M., Suzuki Y., Sekine (32) 1996; 44 Kardaun S. H., de Monchy J. G. (19) 2006; 55 Maeda K., Komuta K., Hasegawa K., O (22) 1995; 33 Chihara J., Yamado H., Takamura E. (33) 1995; 106 MORI H (14) 2004; 31 Clausen J. E. (11) 1973; 28 YOSHIMURA T (6) 1993; 16 Beers M. H., Berkow R. (23) 1999 MIYAZAWA TERUOMI (27) 1993; 31 UNO KATSUJI (13) 1990; 39 Nagakura N., Shimizu T., Masuzawa T (4) 1990; 38 40 20 SANO NAOMI (35) 1998; 47 42
References_xml	– reference: 27) Miyazawa T., Doi M., Mineshita M., Kurata T., Kitaguchi S., Furukawa N., Nihon Kyobu Shikkan Gakkai Zasshi, 31, 920—923 (1993). – reference: 42) Halevy S., Cohen A., Livni E., Clin. Exp. Dermatol., 25, 652—524 (2000). – reference: 32) Uno K., Yagi M., Suzuki Y., Sekine O., Chemotherapy, 44, 641—648 (1996). – reference: 16) Mochitomi Y., Inoue A., Kawabata H., Ishida S., Kanzaki T., J. Dermatol., 25, 662—665 (1998). – reference: 25) Maria V. A. J., Victorino R. M. M., Hepatology, 26, 664—669 (1997). – reference: 9) Su H., Watkins N. G., Zhang Y. X., Caldwell H. D., Infect. Immun., 58, 1017—1025 (1990). – reference: 23) Beers M. H., Berkow R., “The Merck of Diagnosis and Therapy,” 17th ed., Merck & Co., Whitehouse Station, 1999, pp. 1064—1067. – reference: 35) Sano N., Uno K., Arerugi, 47, 1198—1204 (1998). – reference: 44) Yagi M., Uno K., Kurihara T., Suzuki Y., Sekine O., Hattori H., Yamaguchi F., J. Antimicrob. Chemother., 47, 190—195 (1999). – reference: 19) Kardaun S. H., de Monchy J. G., J. Am. Acad. Dermatol., 55, 21—23 (2006). – reference: 46) Knop J., Riechmann R., Macher E., J. Invest. Dermatol., 76, 193—196 (1981). – reference: 31) Abe M., Kurihara T., Uno K., Jpn. J. Pharm. Health Care Sci., 31, 32—40 (2006). – reference: 43) Hiraoka K., Nagata N., Suzuki K., Kawajiri T., Kurokawa S., Kawamura T., Kido M., J. UOEH, 20, 145—151 (1998). – reference: 38) Leyva L., Torres M. J., Posadas S., Blanca M., Besso G., O'Valle F., del Moral R. G., J. Allergy Clin. Immunol., 105, 157—165 (2000). – reference: 3) Uno K., Yamasaku F., J. Antimicrob. Chemother., 24, 241—250 (1989). – reference: 18) Yoshioka S., Mukae H., Ishii H., Nakayama S., Hisatomi K., Ishimoto H., Kakugawa T., Sugiyama K., Ide M., Kohno S., Nihon Kokyuki Gakkai Zasshi, 43, 600—604 (2005). – reference: 13) Uno K., Arerugi, 39, 1605—1611 (1990). – reference: 1) Shimizu M., “Drug Eruption and Drug-related Skin Damage—Clinical Aspect and Prognosis of Drug Eruption,” Kanehara & Co. Ltd., Tokyo, 1999, pp. 105—116. – reference: 34) Oneda K., Arerugi, 48, 13—22 (1999). – reference: 12) Abe M., Uno K., Jpn. J. Pharm. Health Cre. Sci., 27, 5—14 (2001). – reference: 14) Mori H., Yamanaka K., Kaketa M., Tamada K., Hakamada A., Isoda K., Yamanishi K., Mizutani H., J. Dermatol., 31, 731—736 (2004). – reference: 39) Pirmohamed M., Lin K., Chadwick D., Park B. K., Neurology, 56, 890—896 (2001). – reference: 10) Namihisa T., Yamaguchi K., Kitami K., Yamada T., Takazakura Y., Nippon Shokakibyo Gakkai Zasshi, 71, 472—479 (1974). – reference: 15) Kobashi Y., Okimoto N., Matsushima T., Abe T., Nishimura K., Shishido S., Kawahara S., Shigeto E., Takeyama H., Kuraoka T., Kekkaku, 75, 699—704 (2000). – reference: 8) Uno K., Kondo A., Arerugi, 44, 1401—1409 (1995). – reference: 26) Mantani N., Kogure T., Tamura J., Shimada Y., Terasawa K., Clin. Diagn. Lab. Immunol., 10, 479—480 (2003). – reference: 33) Chihara J., Yamado H., Takamura E., Nakajima S., Int. Arch. Allergy Immunol., 106, 428—429 (1995). – reference: 40) Hertl M., Geisel J., Boecker C., Merk H. F., Br. J. Dermatol., 128, 619—626 (1993). – reference: 17) Arima M., Kanoh T., Yamasaki A., Matsuda S., Kasuya H., Sunayama S., Kawai S., Okada R., Jpn. Circ. J., 62, 132—135 (1998). – reference: 22) Maeda K., Komuta K., Hasegawa K., Ohtsuki M., Morishita H., Igarashi T., Nihon Kokyuki Gakkai Zasshi, 33, 745—749 (1995). – reference: 2) Lammintausta K., Kortekangas-Savolainen O., Br. J. Dermatol., 152, 968—974 (2005). – reference: 41) Brander C., Mauri-Hellweg D., Bettens F., Rolli H., Goldman M., Pichler W. J., J. Immunol., 155, 2670—2678 (1995). – reference: 30) Uno K., Arerugi, 41, 418—427 (1992). – reference: 7) Abe M., Uno K., Arerugi, 47, 1264—1272 (1998). – reference: 36) Uno K., Arerugi, 42, 656—664 (1993). – reference: 20) Pichler W. J., Tilch J., Allergy, 59, 809—820 (2004). – reference: 21) Kondo A., Kekkaku, 74, 33—41 (1999). – reference: 11) Clausen J. E., Acta Allergologica, 28, 351—369 (1973). – reference: 45) Mohri S., Watanabe T., Nariuchi H., Immunology, 46, 271—280 (1982). – reference: 24) Danan G., Benichou C., J. Clin. Epidemiol., 46, 1323—1330 (1993). – reference: 28) Katagiri K., Takayasu S., J. Dermatol., 23, 623—627 (1996). – reference: 37) Paquet P., Paquet F., Al Saleh W., Reper P., Vanderkelen A., Pierard G. E., Am. J. Dermatopathol., 22, 413—417 (2000). – reference: 29) Kawabata R., Koida M., Kanie S., Tanaka G., Ohuchida A., Yoshida T., Gan To Kagaku Ryoho, 33, 345—348 (2006). – reference: 5) Muroi N., Jpn. J. Pharm. Health Care. Sci., 27, 93—104 (2001). – reference: 6) Yoshimura T., Kurita C., Hayata M., Nagai H., Biol. Pharm. Bull., 16, 686—689 (1993). – reference: 4) Nagakura N., Shimizu T., Masuzawa T., Yanagihara Y., Chemotherapy, 38, 910—917 (1990). – volume: 42 start-page: 656 issn: 0021-4884 issue: 5 year: 1993 ident: 36 publication-title: Arerugi – volume: 47 start-page: 1264 issn: 0021-4884 issue: 12 year: 1998 ident: 7 publication-title: Arerugi – volume: 38 start-page: 910 issn: 0009-3157 year: 1990 ident: 4 publication-title: Chemotherapy – ident: 25 doi: 10.1053/jhep.1997.v26.pm0009303497 – ident: 24 doi: 10.1016/0895-4356(93)90101-6 – volume: 33 start-page: 345 issn: 0022-7625 year: 2006 ident: 29 publication-title: Gan To Kagaku Ryoho – volume: 71 start-page: 472 issn: 0446-6586 year: 1974 ident: 10 publication-title: Nippon Shokakibyo Gakkai Zasshi – volume: 43 start-page: 600 issn: 1343-3490 issue: 10 year: 2005 ident: 18 publication-title: Nihon Kokyuki Gakkai Zasshi – ident: 37 doi: 10.1097/00000372-200010000-00005 – volume: 56 start-page: 890 issn: 0028-3878 year: 2001 ident: 39 publication-title: Neurology doi: 10.1212/WNL.56.7.890 – ident: 40 doi: 10.1111/j.1365-2133.1993.tb00255.x – volume: 31 start-page: 32 year: 2006 ident: 31 publication-title: Jpn. J. Pharm. Health Care Sci. – volume: 155 start-page: 2670 year: 1995 ident: 41 publication-title: J. Immunol. doi: 10.4049/jimmunol.155.5.2670 – volume: 46 start-page: 271 issn: 0019-2805 issue: 2 year: 1982 ident: 45 publication-title: Immunology – volume: 39 start-page: 1605 issn: 0021-4884 issue: 12 year: 1990 ident: 13 publication-title: Arerugi – volume: 23 start-page: 623 issn: 0385-2407 issue: 9 year: 1996 ident: 28 publication-title: J. Dermatol. doi: 10.1111/j.1346-8138.1996.tb02666.x – volume: 58 start-page: 1017 issn: 0019-9567 year: 1990 ident: 9 publication-title: Infect. Immun. doi: 10.1128/IAI.58.4.1017-1025.1990 – volume: 106 start-page: 428 issn: 1018-2438 year: 1995 ident: 33 publication-title: Int. Arch. Allergy Immunol. doi: 10.1159/000236878 – volume: 152 start-page: 968 issn: 0007-0963 year: 2005 ident: 2 publication-title: Br. J. Dermatol. doi: 10.1111/j.1365-2133.2005.06429.x – volume: 24 start-page: 241 year: 1989 ident: 3 publication-title: J. Antimicrob. Chemother. doi: 10.1093/jac/24.2.241 – volume: 31 start-page: 920 issn: 0301-1542 issue: 8 year: 1993 ident: 27 publication-title: Nihon Kyobu Shikkan Gakkai Zasshi – volume: 75 start-page: 699 issn: 0022-9776 issue: 12 year: 2000 ident: 15 publication-title: Kekkaku – volume: 33 start-page: 745 issn: 1343-3490 year: 1995 ident: 22 publication-title: Nihon Kokyuki Gakkai Zasshi – volume: 20 start-page: 145 issn: 0387-821X issue: 2 year: 1998 ident: 43 publication-title: J. UOEH doi: 10.7888/juoeh.20.145 – volume: 28 start-page: 351 issn: 0001-5148 year: 1973 ident: 11 publication-title: Acta Allergologica doi: 10.1111/j.1398-9995.1973.tb01452.x – volume: 31 start-page: 731 issn: 0385-2407 issue: 9 year: 2004 ident: 14 publication-title: J. Dermatol. doi: 10.1111/j.1346-8138.2004.tb00586.x – volume: 76 start-page: 193 issn: 0022-202X year: 1981 ident: 46 publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12525719 – start-page: 105 issn: 0560-2076 year: 1999 ident: 1 publication-title: Drug Eruption and Drug-related Skin Damage-Clinical Aspect and Prognosis of Drug Eruption – ident: 26 doi: 10.1128/CDLI.10.3.479-480.2003 – volume: 44 start-page: 1401 issn: 0021-4884 issue: 12 year: 1995 ident: 8 publication-title: Arerugi – ident: 20 doi: 10.1111/j.1398-9995.2004.00547.x – ident: 17 doi: 10.1253/jcj.62.132 – volume: 41 start-page: 418 issn: 0021-4884 issue: 3 year: 1992 ident: 30 publication-title: Arerugi – volume: 25 start-page: 662 issn: 0385-2407 issue: 10 year: 1998 ident: 16 publication-title: J. Dermatol. doi: 10.1111/j.1346-8138.1998.tb02477.x – volume: 27 start-page: 93 year: 2001 ident: 5 publication-title: Jpn. J. Pharm. Health Care. Sci. doi: 10.5649/jjphcs.27.93 – volume: 47 start-page: 190 year: 1999 ident: 44 publication-title: J. Antimicrob. Chemother. – volume: 55 start-page: 21 issn: 0190-9622 year: 2006 ident: 19 publication-title: J. Am. Acad. Dermatol. doi: 10.1016/j.jaad.2006.02.032 – volume: 27 start-page: 5 year: 2001 ident: 12 publication-title: Jpn. J. Pharm. Health Cre. Sci. doi: 10.5649/jjphcs.27.5 – volume: 16 start-page: 686 issn: 0918-6158 issue: 7 year: 1993 ident: 6 publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.16.686 – start-page: 1064 issn: 1475-0708 year: 1999 ident: 23 publication-title: The Merck of Diagnosis and Therapy – volume: 74 start-page: 33 issn: 0022-9776 issue: 1 year: 1999 ident: 21 publication-title: Kekkaku – volume: 48 start-page: 13 issn: 0021-4884 issue: 1 year: 1999 ident: 34 publication-title: Arerugi – volume: 105 start-page: 157 issn: 0091-6749 year: 2000 ident: 38 publication-title: J. Allergy Clin. Immunol. doi: 10.1016/S0091-6749(00)90191-X – volume: 44 start-page: 641 issn: 0009-3157 year: 1996 ident: 32 publication-title: Chemotherapy – volume: 47 start-page: 1198 issn: 0021-4884 issue: 11 year: 1998 ident: 35 publication-title: Arerugi – ident: 42 doi: 10.1046/j.1365-2230.2000.00729.x
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Snippet	In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was...
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SubjectTerms	Adolescent Adult age and sex Aged Aged, 80 and over Aging - physiology Antibody Specificity Antigens - chemistry Antigens - isolation & purification causative drug Cell Migration Assays, Leukocyte Cell Separation Child Child, Preschool drug allergy Drug Hypersensitivity - diagnosis drug-induced lymphocyte stimulation test Female Humans hypersensitivity symptom Infant leukocyte migration test Lymphocyte Activation - drug effects Male Middle Aged Monocytes - drug effects Predictive Value of Tests Sex Characteristics
Title	Comparative Study of the Usefulness of the Drug-Induced Lymphocyte Stimulation Test and the Leukocyte Migration Test in Drug Allergies
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