Relationship between Deep White Matter Hyperintensities on Magnetic Resonance Imaging and Postoperative Cognitive Function Following Clipping of Unruptured Intracranial Aneurysm

• Published in: Neurologia medico-chirurgica Vol. 61; no. 2; pp. 152 - 161
• Main Authors: INOUE, Akihiro, KUMON, Yoshiaki, OHNISHI, Takanori, KUNIEDA, Takeharu, WATANABE, Hideaki, TAGAWA, Masahiko
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 2021; THE JAPAN NEUROSURGICAL SOCIETY; Japan Science and Technology Agency
• Subjects: Aneurysm; Aneurysms; Brain injury; clipping surgery; Cognitive ability; cognitive function; deep white matter hyperintensity; Intelligence; Magnetic resonance imaging; Neuroimaging; Original; Statistical analysis; Substantia alba; Surgery; unruptured intracranial aneurysm; cognitive function; unruptured intracranial aneurysm; clipping surgery; deep white matter hyperintensity
• ISSN: 0470-8105; 1349-8029; 1349-8029
• DOI: 10.2176/nmc.oa.2020-0290

To evaluate the effects on cognitive function of deep white matter hyperintensities (DWMHs) on magnetic resonance imaging (MRI) in patients treated surgically for unruptured intracranial aneurysms (UIAs). The subjects were 106 patients in whom a Wechsler adult intelligence scale-revised (WAIS-R) examination was performed 1 week before and 1 month after clipping surgery for asymptomatic UIAs. DWMH severity was evaluated on preoperative MR images by Fazekas scale, as follows: none (absence), mild (punctate foci), moderate (beginning confluence of foci), or severe (large confluent areas). A decrease of 7 or more points in intelligence quotient (IQ) postoperatively was considered deterioration. Fazekas score was none in 41 (none group), mild in 42 (mild group), moderate in 21, and severe in 2 patients (moderate/severe group). Patient characteristics, surgical factors, IQ change, and abnormal findings on postoperative MRI were compared among the groups. Although there was no statistically significant deterioration in IQ postoperatively in any group, the percentage of deteriorated patients was significantly higher in the moderate/severe group (34.8%) than in the other groups (4.9% in the none group, 7.1% in the mild group; p <0.01, p <0.05, respectively). Brain injury was observed more frequently on postoperative MR images in the moderate/severe group (17.4%) compared with the none group (2.4%; p = 0.052). The presence of moderate/severe DWMHs was an independent prognostic factor for postoperative cognitive dysfunction. In conclusion, the presence of moderate/severe DWMHs was a prognostic factor for postoperative cognitive dysfunction after surgery for UIAs.