Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency - Zhang, Jiasheng; Velmeshev, Dmitry; Hashimoto, Kei; Huang, Yu-Hsin; Hofmann, Jeffrey W.; Shi, Xiaoyu; Chen, Jiapei; Leidal, Andrew M.; Dishart, Julian G.; Cahill, Michelle K.; Kelley, Kevin W.; Liddelow, Shane A.; et al. (Nature (London), 2020)
Keywords: 13; 13/51; 14/19; 14/63; 38; 38/39; 38/91; 631/378/1689/364; 631/378/2596/1953; 64; 64/60; Age; Aging - genetics; Aging - pathology; Alzheimer's disease; Amyotrophic lateral sclerosis; Animals; Annotations; Binding proteins; Causes of; Cell adhesion & migration; Cell migration; Cell Nucleus - genetics; Cell Nucleus - pathology; Coagulation; Complement Activation - drug effects; Complement Activation - immunology; Complement C1q - antagonists & inhibitors; Complement C1q - immunology; Complement C3b - antagonists & inhibitors; Complement C3b - immunology; Culture Media, Conditioned - chemistry; Culture Media, Conditioned - pharmacology; CX3CR1 protein; Cysteine proteinase; Dendritic structure; Diagnosis; Disease Models, Animal; DNA-Binding Proteins - metabolism; Exocytosis; Female; Gene expression; Genes; Glycoproteins; Health aspects; Homeostasis; Humanities and Social Sciences; Kinases; Localization; Male; MAP kinase; Membrane proteins; Membranes; Mice; Microglia; Microglia - metabolism; Microglia - pathology; multidisciplinary; Neurodegeneration; Neurons; Neurons - metabolism; Neurons - pathology; Neurotoxicity; Neurotoxicity syndromes; Normalizing; Nuclear Pore - metabolism; Nuclear Pore - pathology; Phagocytosis; Physiological aspects; Progranulins - deficiency; Progranulins - genetics; Protease inhibitors; Protein deficiency; Protein kinase C; Protein transport; Protein-tyrosine kinase receptors; Proteinase inhibitors; Proteins; Ras protein; RNA-Seq; Science; Science (multidisciplinary); Signal transduction; Single-Cell Analysis; TDP-43 Proteinopathies - drug therapy; TDP-43 Proteinopathies - genetics; TDP-43 Proteinopathies - metabolism; TDP-43 Proteinopathies - pathology; Thalamus; Thalamus - metabolism; Thalamus - pathology; Transcriptome; Tyrosine; United States