TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus - Guiducci, Cristiana; Gong, Mei; Xu, Zhaohui; Gill, Michelle; Chaussabel, Damien; Meeker, Thea; Chan, Jean H.; Wright, Tracey; Punaro, Marilynn; Bolland, Silvia; Soumelis, Vassili; Banchereau, Jacques; et al. (Nature (London), 2010)
Keywords: 631/250/262/2106/2108; 631/337; 631/80/86; 692/699/249/1313/1613; Adolescent; Animals; Apoptosis; Autoantibodies - immunology; Autoimmune diseases; Biological and medical sciences; Cell receptors; Cell Survival - drug effects; Cells, Cultured; Child; Dendritic Cells - drug effects; Disease; Disease control; Disease Models, Animal; Drug therapy; Female; Flow cytometry; Genetic aspects; Glucocorticoids - pharmacology; Health aspects; Humanities and Social Sciences; Humans; Immune system; Immunosuppressive agents; Interferon-alpha - immunology; Interferons - immunology; Kinases; letter; Lupus Erythematosus, Systemic - physiopathology; Male; Medical sciences; Membrane Glycoproteins - immunology; Mice; Mice, Inbred C57BL; multidisciplinary; NF-kappa B - immunology; Nucleic acids; Nucleic Acids - immunology; Physiological aspects; Proteins; Review boards; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Science; Science (multidisciplinary); Spleen; Systemic lupus erythematosus; Toll-Like Receptor 7 - immunology; Toll-Like Receptor 9 - immunology; Transcription factors; Up-Regulation; France; United States; Human; Toll like receptor 7; Immunopathology; Connective tissue disease; Skin disease; Rodentia; Autoimmune disease; Natural immunity; Glucocorticoid; Biological activity; Toll like receptor 9; Plasmacytoid dendritic cell; Vertebrata; Mammalia; Systemic lupus erythematosus; Treatment; Mouse; Animal; Systemic disease; Nucleic acid