Combined Drug Action of 2-Phenylimidazo[2,1-b]Benzothiazole Derivatives on Cancer Cells According to Their Oncogenic Molecular Signatures - Furlan, Alessandro; Roux, Benjamin; Lamballe, Fabienne; Conti, Filippo; Issaly, Nathalie; Daian, Fabrice; Guillemot, Jean-François; Richelme, Sylvie; Contensin, Magali; Bosch, Joan; Passarella, Daniele; Piccolo, Oreste; et al. (PloS one, 2012)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Amino acids; Animals; Anticancer properties; Antineoplastic Agents; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacology; Antitumor agents; Benzothiazole; Benzothiazoles; Benzothiazoles - administration & dosage; Benzothiazoles - adverse effects; Benzothiazoles - pharmacology; Biology; c-Met protein; Cancer; Cancer cells; Cancer prevention; Cell Cycle; Cell Cycle - drug effects; Cell Cycle Proteins; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cell Proliferation; Cell Proliferation - drug effects; Cell Survival; Cell Survival - drug effects; Cell Transformation, Neoplastic; Cell Transformation, Neoplastic - drug effects; Cellular Biology; Càncer; Cèl·lules canceroses; Derivatives; Desenvolupament de medicaments; Dianes farmacològiques; Drug development; Drug screening; Drug targeting; Drug therapy; Drugs; Expressió gènica; Gene expression; Growth factors; Humans; Life Sciences; Medical screening; Medicaments antineoplàstics; Medicine; Metabolic Networks and Pathways; Metabolic Networks and Pathways - drug effects; Metabolic Networks and Pathways - genetics; Mice; Mice, Nude; Molecular Targeted Therapy; Mutation; Mutation, Missense; Neurons; Phosphorylation; Protein Interaction Maps; Protein Processing, Post-Translational; Protein Processing, Post-Translational - drug effects; Protein Transport; Protein Transport - drug effects; Protein-tyrosine kinase receptors; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-met - genetics; Proto-Oncogene Proteins c-met - metabolism; Receptors, Platelet-Derived Growth Factor; Receptors, Platelet-Derived Growth Factor - metabolism; Retina; Retinoblastoma; Side effects; Signal Transduction; Signal Transduction - drug effects; Signaling; Studies; Thiazoles; Tiazoles; Transcriptome; Transcriptome - drug effects; Tumor cell lines; Tumorigenesis; Tumors; Tyrosine; Xenograft Model Antitumor Assays; Phosphorylation; Toxicity; Cancer treatment; Oncogenic signaling; Drug screening; Bioinformatics; Carcinogenesis; Cell cycle and cell division