Prothrombotic changes in patients with COVID‐19 are associated with disease severity and mortality
Patients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of...
Saved in:
| Published in | Research and practice in thrombosis and haemostasis Vol. 5; no. 1; pp. 132 - 141 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2021
Elsevier Limited John Wiley and Sons Inc Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2475-0379 2475-0379 |
| DOI | 10.1002/rth2.12462 |
Cover
| Abstract | Patients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID‐19 and determined their association with disease severity and 30‐day mortality.
We included 102 patients with COVID‐19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission.
Patients with COVID‐19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d‐dimer, thrombin‐antithrombin, and plasmin‐antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID‐19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID‐19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short‐term mortality.
Severe COVID‐19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy. |
|---|---|
| AbstractList | Background and Aims
Patients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID‐19 and determined their association with disease severity and 30‐day mortality.
Methods
We included 102 patients with COVID‐19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission.
Results
Patients with COVID‐19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d‐dimer, thrombin‐antithrombin, and plasmin‐antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID‐19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID‐19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short‐term mortality.
Conclusions
Severe COVID‐19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy. Abstract Background and Aims Patients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID‐19 and determined their association with disease severity and 30‐day mortality. Methods We included 102 patients with COVID‐19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission. Results Patients with COVID‐19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d‐dimer, thrombin‐antithrombin, and plasmin‐antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID‐19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID‐19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short‐term mortality. Conclusions Severe COVID‐19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy. Patients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID‐19 and determined their association with disease severity and 30‐day mortality. We included 102 patients with COVID‐19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission. Patients with COVID‐19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d‐dimer, thrombin‐antithrombin, and plasmin‐antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID‐19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID‐19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short‐term mortality. Severe COVID‐19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy. Background and AimsPatients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID‐19 and determined their association with disease severity and 30‐day mortality.MethodsWe included 102 patients with COVID‐19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission.ResultsPatients with COVID‐19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d‐dimer, thrombin‐antithrombin, and plasmin‐antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID‐19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID‐19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short‐term mortality.ConclusionsSevere COVID‐19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy. Patients with severe coronavirus disease 2019 (COVID-19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID-19 and determined their association with disease severity and 30-day mortality.BACKGROUND AND AIMSPatients with severe coronavirus disease 2019 (COVID-19) are at significant risk of thrombotic complications. However, their prothrombotic state is incompletely understood. Therefore, we measured in vivo activation markers of hemostasis, plasma levels of hemostatic proteins, and functional assays of coagulation and fibrinolysis in plasma from patients with COVID-19 and determined their association with disease severity and 30-day mortality.We included 102 patients with COVID-19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission.METHODSWe included 102 patients with COVID-19 receiving various levels of respiratory support admitted to general wards, intermediate units, or intensive care units and collected plasma samples shortly after hospital admission.Patients with COVID-19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d-dimer, thrombin-antithrombin, and plasmin-antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID-19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID-19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short-term mortality.RESULTSPatients with COVID-19 with higher respiratory support had increased in vivo activation of coagulation and fibrinolysis, as reflected by higher plasma levels of d-dimer, thrombin-antithrombin, and plasmin-antiplasmin complexes as compared to patients with no to minimal respiratory support and healthy controls. Moreover, the patients with COVID-19 with higher respiratory support exhibited substantial ex vivo thrombin generation and lower ex vivo fibrinolytic capacity, despite higher doses of anticoagulant therapy compared to less severely ill patients. Fibrinogen, factor VIII, and von Willebrand factor levels increased, and ADAMTS13 levels decreased with increasing respiratory support in patients with COVID-19. Low platelet count; low levels of prothrombin, antithrombin, and ADAMTS13; and high levels of von Willebrand factor were associated with short-term mortality.Severe COVID-19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy.CONCLUSIONSSevere COVID-19 is associated with prothrombotic changes with increased in vivo activation of coagulation and fibrinolysis, despite anticoagulant therapy. |
| Author | von Meijenfeldt, Fien A. Mackman, Nigel Lisman, Ton Magnusson, Maria Thalin, Charlotte Rudberg, Ann‐Sofie Lundström, Annika Havervall, Sebastian Adelmeijer, Jelle |
| AuthorAffiliation | 2 Division of Internal Medicine Department of Clinical Sciences Karolinska Institutet Danderyd Hospital Stockholm Sweden 1 Surgical Research Laboratory Department of Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands 3 Department of Neurology Danderyd Hospital Stockholm Sweden 5 Clinical Chemistry and Blood Coagulation Research MMK Department of Pediatrics Department of Hematology CLINTEC Karolinska Institutet Karolinska University Hospital Stockholm Sweden 4 Department of Clinical Neurosciences Karolinska Institutet Stockholm Sweden 6 UNC Blood Research Center Division of Hematology Department of Medicine University of North Carolina at Chapel Hill NC USA |
| AuthorAffiliation_xml | – name: 4 Department of Clinical Neurosciences Karolinska Institutet Stockholm Sweden – name: 5 Clinical Chemistry and Blood Coagulation Research MMK Department of Pediatrics Department of Hematology CLINTEC Karolinska Institutet Karolinska University Hospital Stockholm Sweden – name: 2 Division of Internal Medicine Department of Clinical Sciences Karolinska Institutet Danderyd Hospital Stockholm Sweden – name: 1 Surgical Research Laboratory Department of Surgery University of Groningen University Medical Center Groningen Groningen The Netherlands – name: 3 Department of Neurology Danderyd Hospital Stockholm Sweden – name: 6 UNC Blood Research Center Division of Hematology Department of Medicine University of North Carolina at Chapel Hill NC USA |
| Author_xml | – sequence: 1 givenname: Fien A. surname: von Meijenfeldt fullname: von Meijenfeldt, Fien A. organization: Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands – sequence: 2 givenname: Sebastian surname: Havervall fullname: Havervall, Sebastian organization: Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden – sequence: 3 givenname: Jelle surname: Adelmeijer fullname: Adelmeijer, Jelle organization: Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands – sequence: 4 givenname: Annika surname: Lundström fullname: Lundström, Annika organization: Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden – sequence: 5 givenname: Ann‐Sofie surname: Rudberg fullname: Rudberg, Ann‐Sofie organization: Department of Neurology, Danderyd Hospital, Stockholm, Sweden – sequence: 6 givenname: Maria surname: Magnusson fullname: Magnusson, Maria organization: Clinical Chemistry and Blood Coagulation Research, MMK, Department of Pediatrics, Department of Hematology, CLINTEC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden – sequence: 7 givenname: Nigel surname: Mackman fullname: Mackman, Nigel organization: UNC Blood Research Center, Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, NC, USA – sequence: 8 givenname: Charlotte surname: Thalin fullname: Thalin, Charlotte organization: Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden – sequence: 9 givenname: Ton orcidid: 0000-0002-3503-7140 surname: Lisman fullname: Lisman, Ton email: j.a.lisman@umcg.nl organization: Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33537537$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kttqGzEQhkVJaVI3N32AstCbUnCq1WF3dVMo7iGGQEpJeyu0s7O23PXKkWQH3_UR-ox9ksrZJCQmLQh0-v5_Rpp5Tg561yMhL3N6klPK3vk4Zyc5EwV7Qo6YKOWY8lId3FsfkuMQFjTBlKUhn5FDziUv0zgizVfv4ty7Ze2ihQzmpp9hyGyfrUy02MeQXdk4zybnP6Yf__z6navMeMxMCA6sidgM140NaAJmATfobdxmpm-ypfPRdGn3gjxtTRfw-GYeke-fP11MTsdn51-mkw9nYyi5ZGNBawVY1Ey2rCpaVJTLQqhc5VXRVA2IilYtreoajExHwKFlUhZFqRCAIeMjMh18G2cWeuXt0vitdsbq6wPnZ9r49MwOdZ3sTE1l23AuapErqhSI3JSy4JKmyCPyfvBareslNpC-wpvugenDm97O9cxtdFkJSSueDN7cGHh3ucYQ9dIGwK4zPbp10ExUhUjJM5HQ13vowq19n75qRzEpSiV3hq_uZ3SXym0xE_B2AMC7EDy2d0hO9a5Z9K5Z9HWzJJjuwWBjKrnbvcZ2j0vyQXJlO9z-x1x_uzhltxoxaDDVfWPR6wCprQAb6xFiKox9PBTbk0Fnewum-5ki_0P0FzAQ874 |
| CitedBy_id | crossref_primary_10_1055_a_2238_4744 crossref_primary_10_18705_2782_3806_2022_2_3_119_128 crossref_primary_10_3390_jcm10184190 crossref_primary_10_1002_ajh_26085 crossref_primary_10_1016_j_rpth_2023_100182 crossref_primary_10_1055_a_1450_8414 crossref_primary_10_1055_s_0041_1727282 crossref_primary_10_15829_29_1560_4071_2022_4928 crossref_primary_10_1186_s12889_023_17477_8 crossref_primary_10_1371_journal_pone_0311921 crossref_primary_10_4103_ejh_ejh_21_23 crossref_primary_10_1002_rth2_12582 crossref_primary_10_1111_jth_15839 crossref_primary_10_17749_2313_7347_ob_gyn_rep_2023_388 crossref_primary_10_1016_j_labinv_2023_100179 crossref_primary_10_3889_oamjms_2022_9409 crossref_primary_10_1055_s_0041_1740182 crossref_primary_10_17116_Cardiobulletin20221703129 crossref_primary_10_1007_s10237_023_01803_5 crossref_primary_10_1155_2022_7777445 crossref_primary_10_2139_ssrn_4103383 crossref_primary_10_1161_ATVBAHA_120_315267 crossref_primary_10_1016_j_oret_2022_02_004 crossref_primary_10_1016_j_thromres_2023_06_008 crossref_primary_10_1111_liv_15728 crossref_primary_10_1055_s_0041_1736166 crossref_primary_10_1161_ATVBAHA_120_315547 crossref_primary_10_1016_j_thromres_2022_08_017 crossref_primary_10_3389_fimmu_2022_835104 crossref_primary_10_1038_s41598_021_93390_7 crossref_primary_10_1111_jth_15806 crossref_primary_10_1016_j_thromres_2022_12_019 crossref_primary_10_1111_febs_16808 crossref_primary_10_2147_IJGM_S404827 crossref_primary_10_1016_j_kisu_2021_12_001 crossref_primary_10_1186_s12959_023_00493_4 crossref_primary_10_3389_fmed_2024_1399335 crossref_primary_10_7759_cureus_18538 crossref_primary_10_1152_ajpheart_00204_2021 crossref_primary_10_2174_0929867331666230918092749 crossref_primary_10_3892_br_2023_1647 crossref_primary_10_1002_rmv_2442 crossref_primary_10_1016_j_thromres_2022_08_020 crossref_primary_10_1055_a_1755_8676 crossref_primary_10_3389_fcvm_2022_794092 crossref_primary_10_1111_bjh_18874 crossref_primary_10_15829_1560_4071_2022_4928 crossref_primary_10_1111_jth_15538 crossref_primary_10_1113_EP089404 crossref_primary_10_1016_j_ijid_2021_06_051 crossref_primary_10_1055_s_0042_1758791 crossref_primary_10_1080_17474086_2022_2104708 crossref_primary_10_1186_s12933_023_02097_8 crossref_primary_10_1097_MBC_0000000000001111 crossref_primary_10_1007_s10456_021_09805_6 crossref_primary_10_1007_s10238_021_00769_x crossref_primary_10_1055_s_0041_1735454 crossref_primary_10_24287_1726_1708_2021_20_3_147_155 crossref_primary_10_1016_j_rpth_2023_102195 crossref_primary_10_1038_s41598_021_04670_1 crossref_primary_10_1111_eci_14299 crossref_primary_10_1055_a_1962_5447 crossref_primary_10_1186_s13054_021_03749_5 crossref_primary_10_3389_fimmu_2022_837629 crossref_primary_10_1016_j_ijid_2022_02_019 crossref_primary_10_2196_45586 crossref_primary_10_1111_jth_15464 crossref_primary_10_1111_jth_15580 |
| Cites_doi | 10.1016/j.thromres.2020.04.024 10.1007/s11739-020-02394-0 10.1016/S0140-6736(20)30183-5 10.1007/s11239-020-02259-5 10.1002/rth2.12400 10.1016/j.eclinm.2020.100434 10.1016/S0140-6736(20)30937-5 10.1111/jth.14830 10.1097/SHK.0b013e3182908ea7 10.1111/bjh.17003 10.1182/blood.V98.9.2730 10.1111/jth.14850 10.1055/s-0040-1716379 10.1161/CIRCULATIONAHA.120.048488 10.1016/S0168-8278(20)30605-X 10.1007/s11239-020-02130-7 10.1016/j.mayocpiqo.2020.09.002 10.1111/jth.15043 10.1371/journal.pmed.0050097 10.1161/ATVBAHA.120.314514 10.3390/jcm9092875 10.1111/jth.14768 10.1016/j.jamcollsurg.2020.05.007 10.1016/S2352-3026(20)30217-9 10.1002/ajh.25962 10.1111/jth.14854 10.1159/000071636 10.1056/NEJMoa2015432 10.1097/MD.0000000000015833 10.1002/rth2.12439 10.1007/s11239-020-02145-0 10.3389/fimmu.2020.01446 10.1111/j.1365-2036.2007.03369.x 10.1182/blood.2020006520 10.1016/S2352-3026(20)30216-7 10.1111/jth.15016 10.1016/j.thromres.2020.07.053 10.1111/jth.15067 10.1001/jama.2020.13372 10.1111/jth.14888 10.1161/CIRCULATIONAHA.120.047430 |
| ContentType | Journal Article |
| Copyright | 2020 Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. The Authors. 2020 published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. The Authors. 2020 Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2020 Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. – notice: The Authors. 2020 published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. – notice: The Authors. 2020 Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. – notice: 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 6I. AAFTH 24P AAYXX CITATION NPM 3V. 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU COVID DWQXO FYUFA GHDGH K9. M0S PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1002/rth2.12462 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Wiley Online Library Open Access CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Coronavirus Research Database ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals (WRLC) |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) Coronavirus Research Database ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | von MEIJENFELDT et al |
| EISSN | 2475-0379 |
| EndPage | 141 |
| ExternalDocumentID | oai_doaj_org_article_bdc4ab05fd334b419099c41a75635090 PMC7845083 33537537 10_1002_rth2_12462 RTH212462 S2475037922013139 |
| Genre | article Journal Article |
| GrantInformation_xml | – fundername: Knut & Alice Wallenberg foundation – fundername: Region Stockholm |
| GroupedDBID | .1- .FO 1OC 24P 53G 7X7 8FI 8FJ AALRI AAMMB AAXUO AAYWO ABUWG ACCMX ACVFH ACXQS ADBBV ADCNI ADKYN ADVLN ADZMN AEFGJ AEUPX AFJKZ AFKRA AFPUW AFRHN AGXDD AIDQK AIDYY AIGII AITUG AJAOE AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS ALUQN AMRAJ AOIJS APXCP AVUZU BCNDV BENPR BPHCQ BVXVI CCPQU EBS EJD FDB FYUFA GROUPED_DOAJ HMCUK HYE IAO IHR INH ITC M41 M~E O9- OK1 PHGZM PHGZT PIMPY PQQKQ PROAC PUEGO ROL RPM UKHRP WIN Z5R ZCN 0R~ 6I. AAFTH AAHHS ACCFJ AEEZP AEQDE AFCTW AIWBW AJBDE ALIPV AAYXX CITATION NPM 3V. 7XB 8FK AZQEC COVID DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c7352-40b9ce6b25f286fe903564919186d8dc4808f08bbca5186c3cf2556679ecc2e23 |
| IEDL.DBID | 24P |
| ISSN | 2475-0379 |
| IngestDate | Wed Aug 27 01:20:34 EDT 2025 Thu Aug 21 18:30:40 EDT 2025 Fri Sep 05 07:55:21 EDT 2025 Sat Aug 23 12:45:44 EDT 2025 Thu Apr 03 06:57:12 EDT 2025 Sun Aug 31 06:25:59 EDT 2025 Thu Apr 24 22:51:24 EDT 2025 Wed Jan 22 16:31:50 EST 2025 Fri Feb 23 02:40:21 EST 2024 Tue Aug 26 16:48:43 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | fibrinolysis thrombosis hemostasis COVID‐19 coagulation |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 Attribution-NonCommercial-NoDerivs The Authors. 2020 Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c7352-40b9ce6b25f286fe903564919186d8dc4808f08bbca5186c3cf2556679ecc2e23 |
| Notes | Funding information CT received funding for this study from Region Stockholm and the Knut & Alice Wallenberg Foundation. NM is funded by NIH R01 HL119523. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Charlotte Thalin and Ton Lisman Shared senior authors. |
| ORCID | 0000-0002-3503-7140 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Frth2.12462 |
| PMID | 33537537 |
| PQID | 2482547953 |
| PQPubID | 4370292 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_bdc4ab05fd334b419099c41a75635090 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7845083 proquest_miscellaneous_2486466724 proquest_journals_2482547953 pubmed_primary_33537537 crossref_primary_10_1002_rth2_12462 crossref_citationtrail_10_1002_rth2_12462 wiley_primary_10_1002_rth2_12462_RTH212462 elsevier_sciencedirect_doi_10_1002_rth2_12462 elsevier_clinicalkey_doi_10_1002_rth2_12462 |
| PublicationCentury | 2000 |
| PublicationDate | January 2021 |
| PublicationDateYYYYMMDD | 2021-01-01 |
| PublicationDate_xml | – month: 01 year: 2021 text: January 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Kidlington – name: Hoboken |
| PublicationTitle | Research and practice in thrombosis and haemostasis |
| PublicationTitleAlternate | Res Pract Thromb Haemost |
| PublicationYear | 2021 |
| Publisher | Elsevier Inc Elsevier Limited John Wiley and Sons Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier Limited – name: John Wiley and Sons Inc – name: Elsevier |
| References | Nougier, Benoit, Simon, Desmurs‐Clavel, Marcotte, Argaud (bb0100) 2020 Tang, Li, Wang, Sun (bb0105) 2020; 18 Zhang, Sun, Feng (bb0055) 2020; 43 Al‐Samkari, Song, Cott, Kuter, Rosovsky (bb0185) 2020 Huang, Wang, Li, Ren, Zhao, Hu (bb0210) 2020; 395 Tiscia, Favuzzi, De Laurenzo, Cappucci, Fischetti, di Mauro (bb0155) 2020; 4 Ragab, Salah Eldin, Taeimah, Khattab, Salem (bb0215) 2020; 16 Poissy, Goutay, Caplan, Parmentier, Duburcq, Lassalle (bb0050) 2020; 142 Lodigiani, Iapichino, Carenzo, Cecconi, Ferrazzi, Sebastian (bb0020) 2020; 191 Nopp, Moik, Jilma, Pabinger, Ay (bb0040) 2020; 4 Hemker, Giesen, Al Dieri, Regnault, de Smedt, Wagenvoord (bb0140) 2003; 33 Pavoni, Gianesello, Pazzi, Stera, Meconi, Frigieri (bb0130) 2020; 50 Blasi, von Meijenfeldt, Adelmeijer, Calvo, Ibañez, Perdomo (bb0095) 2020 White, MacDonald, Bull, Hayman, de Monteverde‐Robb, Sapsford (bb0195) 2020; 50 Ranucci, Ballotta, Di Dedda, Bayshnikova, Dei Poli, Resta (bb0115) 2020 Wright, Vogler, Moore, Moore, Wohlauer, Urban (bb0135) 2020 Liao, Zhou, Luo, Xu, Wang, Xia (bb0110) 2020 Driever, Stravitz, Zhang, Adelmeijer, Durkalski, Lee (bb0230) 2020 Varga, Flammer, Steiger, Haberecker, Andermatt, Zinkernagel (bb0090) 2020; 395 Tripodi, Caldwell, Hoffman, Trotter, Sanyal (bb0205) 2007; 26 Lisman, Thachil (bb0200) 2020 Wichmann, Sperhake, Latgehetmann, Steurer, Edler, Heinemann (bb0060) 2020 Levi, Hunt (bb0080) 2020; 4 Chistolini, Ruberto, Alessandri, Santoro, Barone, Cristina Puzzolo (bb0125) 2020 Lisman, Adelmeijer (bb0145) 2020; 194 Bazzan, Montaruli, Sciascia, Cosseddu, Norbiato, Roccatello (bb0160) 2020; 15 Meltzer, Lisman, Doggen, de Groot, Rosendaal (bb0150) 2008; 5 Rapkiewicz, Mai, Carsons, Pittaluga, Kleiner, Berger (bb0065) 2020; 25 Fukushima, Nishio, Asai, Watanabe, Seki, Matsui (bb0225) 2013; 39 Al‐Samkari, Karp Leaf, Dzik, Carlson, Fogerty, Waheed (bb0190) 2020 Middeldorp, Coppens, van Haaps, Foppen, Vlaar (bb0035) 2020 Zhang, Zhang, Mi, Wang, Zou, Chen (bb0045) 2019; 98 Goshua, Pine, Meizlish, Chang, Zhang, Bahel (bb0165) 2020; 7 Cui, Chen, Li, Liu, Wang (bb0025) 2020; 18 Panigada, Bottino, Tagliabue, Grasselli, Novembrino, Chantarangkul (bb0120) 2020 Spiezia, Campello, Cola, Poletto, Cerruti, Poretto (bb0240) 2020 Ackermann, Verleden, Kuehnel, Haverich, Welte, Laenger (bb0085) 2020 Rauch, Labreuche, Lassalle, Goutay, Caplan, Charbonnier (bb0170) 2020 Pawlowski, Wagner, Puranik, Murugadoss, Loscalzo, Venkatakrishnan (bb0235) 2020; 17 Bilaloglu, Aphinyanaphongs, Jones, Iturrate, Hochman, Berger (bb0030) 2020 Mannucci, Canciani, Forza, Lussana, Lattuada, Rossi (bb0220) 2001; 98 Klok, Kruip, van der Meer, Arbous, Gommers, Kant (bb0015) 2020 Umemura, Yamakawa, Kiguchi, Nishida, Kawada, Fujimi (bb0180) 2020; 9 Thachil, Srivastava (bb0075) 2020 Mackman, Antoniak, Wolberg, Kasthuri, Key (bb0010) 2020 Nicolai, Leunig, Brambs, Kaiser, Weinberger, Weigand (bb0070) 2020 White, MacDonald, Edwards, Bridgeman, Hayman, Sharp (bb0175) 2020 2020; 7 2020; 4 2013; 39 2020; 142 2020 2019; 98 2020; 395 2020; 50 2020; 191 2020; 194 2020; 9 2020; 17 2020; 16 2020; 15 2020; 25 2008; 5 2020; 43 2003; 33 2007; 26 2020; 18 2001; 98 Mackman (10.1002/rth2.12462_bb0010) 2020 Pawlowski (10.1002/rth2.12462_bb0235) 2020; 17 Thachil (10.1002/rth2.12462_bb0075) 2020 Hemker (10.1002/rth2.12462_bb0140) 2003; 33 Lisman (10.1002/rth2.12462_bb0200) 2020 Chistolini (10.1002/rth2.12462_bb0125) 2020 Ragab (10.1002/rth2.12462_bb0215) 2020; 16 Zhang (10.1002/rth2.12462_bb0055) 2020; 43 Nicolai (10.1002/rth2.12462_bb0070) 2020 Panigada (10.1002/rth2.12462_bb0120) 2020 Lisman (10.1002/rth2.12462_bb0145) 2020; 194 Wright (10.1002/rth2.12462_bb0135) 2020 Bilaloglu (10.1002/rth2.12462_bb0030) 2020 Bazzan (10.1002/rth2.12462_bb0160) 2020; 15 Liao (10.1002/rth2.12462_bb0110) 2020 Meltzer (10.1002/rth2.12462_bb0150) 2008; 5 Tripodi (10.1002/rth2.12462_bb0205) 2007; 26 Rapkiewicz (10.1002/rth2.12462_bb0065) 2020; 25 Umemura (10.1002/rth2.12462_bb0180) 2020; 9 White (10.1002/rth2.12462_bb0175) 2020 Lodigiani (10.1002/rth2.12462_bb0020) 2020; 191 Wichmann (10.1002/rth2.12462_bb0060) 2020 Nougier (10.1002/rth2.12462_bb0100) 2020 Blasi (10.1002/rth2.12462_bb0095) 2020 Fukushima (10.1002/rth2.12462_bb0225) 2013; 39 Rauch (10.1002/rth2.12462_bb0170) 2020 Mannucci (10.1002/rth2.12462_bb0220) 2001; 98 Goshua (10.1002/rth2.12462_bb0165) 2020; 7 Levi (10.1002/rth2.12462_bb0080) 2020; 4 Poissy (10.1002/rth2.12462_bb0050) 2020; 142 Klok (10.1002/rth2.12462_bb0015) 2020 Huang (10.1002/rth2.12462_bb0210) 2020; 395 Zhang (10.1002/rth2.12462_bb0045) 2019; 98 Pavoni (10.1002/rth2.12462_bb0130) 2020; 50 Driever (10.1002/rth2.12462_bb0230) 2020 Nopp (10.1002/rth2.12462_bb0040) 2020; 4 Spiezia (10.1002/rth2.12462_bb0240) 2020 Tang (10.1002/rth2.12462_bb0105) 2020; 18 Al‐Samkari (10.1002/rth2.12462_bb0185) 2020 White (10.1002/rth2.12462_bb0195) 2020; 50 Ackermann (10.1002/rth2.12462_bb0085) 2020 Varga (10.1002/rth2.12462_bb0090) 2020; 395 Al‐Samkari (10.1002/rth2.12462_bb0190) 2020 Tiscia (10.1002/rth2.12462_bb0155) 2020; 4 Cui (10.1002/rth2.12462_bb0025) 2020; 18 Ranucci (10.1002/rth2.12462_bb0115) 2020 Middeldorp (10.1002/rth2.12462_bb0035) 2020 33742434 - Thromb Haemost. 2021 Dec;121(12):1668-1669 |
| References_xml | – volume: 16 start-page: 1446 year: 2020 ident: bb0215 article-title: The COVID‐19 cytokine storm: what we know so far publication-title: Front Immunol – year: 2020 ident: bb0240 article-title: More severe hypercoagulable state in acute COVID‐19 pneumonia as compared to other pneumonia publication-title: Mayo Clin Proc Innov Qual Outcomes – year: 2020 ident: bb0015 article-title: Incidence of thrombotic complications in critically ill ICU patients with COVID‐19 publication-title: Thromb Res – year: 2020 ident: bb0115 article-title: The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome publication-title: J Thromb Haemost – volume: 194 start-page: 237 year: 2020 end-page: 9 ident: bb0145 article-title: Preanalytical variables affect thrombomodulin‐modified thrombin generation in healthy volunteers publication-title: Thromb Res – year: 2020 ident: bb0230 article-title: VWF/ADAMTS13 imbalance, but not global coagulation or fibrinolysis, is associated with outcome and bleeding in acute liver failure publication-title: Hepatology – volume: 15 start-page: 861 year: 2020 end-page: 3 ident: bb0160 article-title: Low ADAMTS 13 plasma levels are predictors of mortality in COVID‐19 patients publication-title: Intern Emerg Med – year: 2020 ident: bb0125 article-title: Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19 publication-title: Br J Haematol – volume: 50 start-page: 281 year: 2020 end-page: 6 ident: bb0130 article-title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID‐19 pneumonia publication-title: J Thromb Thrombolysis – year: 2020 ident: bb0190 article-title: COVID and coagulation: bleeding and thrombotic manifestations of SARS‐CoV2 infection publication-title: Blood – volume: 9 start-page: 2875 year: 2020 ident: bb0180 article-title: Hematological phenotype of COVID‐19–induced coagulopathy: far from typical sepsis‐induced coagulopathy publication-title: J Clin Med – volume: 98 year: 2019 ident: bb0045 article-title: The cumulative venous thromboembolism incidence and risk factors in intensive care patients receiving the guideline‐recommended thromboprophylaxis publication-title: Medicine (Baltimore) – volume: 17: start-page: 9 year: 2020 ident: bb0235 article-title: Inference from longitudinal laboratory tests characterizes temporal evolution of COVID‐19‐associated coagulopathy (CAC) publication-title: Elife – year: 2020 ident: bb0095 article-title: In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation publication-title: J Thromb Haemost – volume: 395 start-page: 497 year: 2020 end-page: 506 ident: bb0210 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet – year: 2020 ident: bb0120 article-title: Hypercoagulability of COVID‐19 patients in intensive care unit. A report of thromboelastography findings and other parameters of hemostasis publication-title: J Thromb Haemost – volume: 18 start-page: 1421 year: 2020 end-page: 4 ident: bb0025 article-title: Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia publication-title: J Thromb Haemost – year: 2020 ident: bb0135 article-title: Fibrinolysis shutdown correlates to thromboembolic events in severe COVID‐19 infection publication-title: J Am Coll Surg – year: 2020 ident: bb0170 article-title: Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID‐19 publication-title: J Thromb Haemost – year: 2020 ident: bb0185 article-title: Evaluation of the prothrombin fragment 1.2 in patients with coronavirus disease 2019 (COVID‐19) publication-title: Am J Hematol – volume: 43 start-page: 496 year: 2020 end-page: 502 ident: bb0055 article-title: Comparison of clinical and pathological features between severe acute respiratory syndrome and coronavirus disease 2019 publication-title: Zhonghua Jie He He Hu Xi Za Zhi – year: 2020 ident: bb0175 article-title: Evaluation of COVID‐19 coagulopathy; laboratory characterization using thrombin generation and nonconventional haemostasis assays publication-title: Int J Lab Hematol – year: 2020 ident: bb0010 article-title: Coagulation abnormalities and thrombosis in patients infected with SARS‐CoV‐2 and other pandemic viruses publication-title: Arterioscler Thromb Vasc Biol – volume: 18 start-page: 844 year: 2020 end-page: 7 ident: bb0105 article-title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia publication-title: J Thromb Haemost – volume: 25 start-page: 100434 year: 2020 ident: bb0065 article-title: Megakaryocytes and platelet‐fibrin thrombi characterize multi‐organ thrombosis at autopsy in COVID‐19: a case series publication-title: EClinicalMedicine – year: 2020 ident: bb0070 article-title: Immunothrombotic dysregulation in COVID‐19 pneumonia is associated with respiratory failure and coagulopathy publication-title: Circulation – year: 2020 ident: bb0035 article-title: Incidence of venous thromboembolism in hospitalized patients with COVID‐19 publication-title: J Thromb Haemost – volume: 395 start-page: 1417 year: 2020 end-page: 8 ident: bb0090 article-title: Endothelial cell infection and endotheliitis in COVID‐19 publication-title: Lancet – volume: 4 start-page: 203 year: 2020 end-page: 6 ident: bb0155 article-title: Reduction of ADAMTS13 levels predicts mortality in SARS‐CoV‐2 patients publication-title: TH Open – year: 2020 ident: bb0060 article-title: Autopsy findings and venous thromboembolism in patients with COVID‐19 publication-title: Ann Intern Med – volume: 191 start-page: 9 year: 2020 end-page: 14 ident: bb0020 article-title: Venous and arterial thromboembolic complications in COVID‐19 patients admitted to an academic hospital in Milan, Italy publication-title: Thromb Res – year: 2020 ident: bb0200 article-title: Differentiating biochemical from clinical heparin resistance in COVID‐19 publication-title: J Thromb Thrombolysis – year: 2020 ident: bb0085 article-title: Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid‐19 publication-title: N Engl J Med – volume: 98 start-page: 2730 year: 2001 end-page: 5 ident: bb0220 article-title: Changes in health and disease of the metalloprotease that cleaves von Willebrand factor publication-title: Blood – volume: 4 start-page: 1178 year: 2020 end-page: 91 ident: bb0040 article-title: Risk of venous thromboembolism in patients with COVID‐19: A systematic review and meta‐analysis publication-title: Res Pract Thromb Haemost – volume: 50 start-page: 287 year: 2020 end-page: 91 ident: bb0195 article-title: Heparin resistance in COVID‐19 patients in the intensive care unit publication-title: J Thromb Thrombolysis – volume: 4 start-page: 744 year: 2020 end-page: 51 ident: bb0080 article-title: Thrombosis and coagulopathy in COVID‐19: an illustrated review publication-title: Res Pract Thromb Haemost – volume: 39 start-page: 409 year: 2013 end-page: 14 ident: bb0225 article-title: Ratio of von Willebrand factor propeptide to ADAMTS13 is associated with severity of sepsis publication-title: Shock – volume: 142 start-page: 184 year: 2020 end-page: 6 ident: bb0050 article-title: Pulmonary embolism in patients with COVID‐19: awareness of an increased prevalence publication-title: Circulation – year: 2020 ident: bb0075 article-title: SARS‐2 coronavirus‐associated hemostatic lung abnormality in COVID‐19: is it pulmonary thrombosis or pulmonary embolism? publication-title: Semin Thromb Hemost – year: 2020 ident: bb0110 article-title: Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID‐19: a retrospective cohort study publication-title: Lancet Haematol – volume: 5 year: 2008 ident: bb0150 article-title: Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis publication-title: PLoS Med – volume: 26 start-page: 141 year: 2007 end-page: 8 ident: bb0205 article-title: Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease publication-title: Aliment Pharmacol Ther – volume: 33 start-page: 4 year: 2003 end-page: 15 ident: bb0140 article-title: Calibrated automated thrombin generation measurement in clotting plasma publication-title: Pathophysiol Haemost Thromb – volume: 7 start-page: 575 year: 2020 end-page: 82 ident: bb0165 article-title: Endotheliopathy in COVID‐19‐associated coagulopathy: evidence from a single‐centre, cross‐sectional study publication-title: Lancet Haematol – year: 2020 ident: bb0100 article-title: Hypofibrinolytic state and high thrombin generation may play a major role in SARS‐CoV2 associated thrombosis publication-title: J Thromb Haemost – year: 2020 ident: bb0030 article-title: Thrombosis in Hospitalized Patients With COVID‐19 in a New York City Health System publication-title: JAMA – year: 2020 article-title: VWF/ADAMTS13 imbalance, but not global coagulation or fibrinolysis, is associated with outcome and bleeding in acute liver failure publication-title: Hepatology – volume: 194 start-page: 237 year: 2020 end-page: 9 article-title: Preanalytical variables affect thrombomodulin‐modified thrombin generation in healthy volunteers publication-title: Thromb Res – volume: 395 start-page: 1417 issue: 10234 year: 2020 end-page: 8 article-title: Endothelial cell infection and endotheliitis in COVID‐19 publication-title: Lancet – volume: 5 issue: 5 year: 2008 article-title: Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis publication-title: PLoS Med – year: 2020 article-title: Hypofibrinolytic state and high thrombin generation may play a major role in SARS‐CoV2 associated thrombosis publication-title: J Thromb Haemost – year: 2020 article-title: Hypercoagulability of COVID‐19 patients in intensive care unit. A report of thromboelastography findings and other parameters of hemostasis publication-title: J Thromb Haemost – year: 2020 article-title: Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID‐19 publication-title: J Thromb Haemost – volume: 16 start-page: 1446 issue: 11 year: 2020 article-title: The COVID‐19 cytokine storm: what we know so far publication-title: Front Immunol – year: 2020 article-title: Evaluation of the prothrombin fragment 1.2 in patients with coronavirus disease 2019 (COVID‐19) publication-title: Am J Hematol – volume: 26 start-page: 141 issue: 2 year: 2007 end-page: 8 article-title: Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease publication-title: Aliment Pharmacol Ther – year: 2020 article-title: COVID and coagulation: bleeding and thrombotic manifestations of SARS‐CoV2 infection publication-title: Blood – year: 2020 article-title: Evaluation of COVID‐19 coagulopathy; laboratory characterization using thrombin generation and nonconventional haemostasis assays publication-title: Int J Lab Hematol – volume: 9 start-page: 2875 issue: 9 year: 2020 article-title: Hematological phenotype of COVID‐19–induced coagulopathy: far from typical sepsis‐induced coagulopathy publication-title: J Clin Med – year: 2020 article-title: Autopsy findings and venous thromboembolism in patients with COVID‐19 publication-title: Ann Intern Med – year: 2020 article-title: Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19 publication-title: Br J Haematol – year: 2020 article-title: The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome publication-title: J Thromb Haemost – year: 2020 article-title: Immunothrombotic dysregulation in COVID‐19 pneumonia is associated with respiratory failure and coagulopathy publication-title: Circulation – volume: 18 start-page: 1421 issue: 6 year: 2020 end-page: 4 article-title: Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia publication-title: J Thromb Haemost – volume: 50 start-page: 281 issue: 2 year: 2020 end-page: 6 article-title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID‐19 pneumonia publication-title: J Thromb Thrombolysis – volume: 33 start-page: 4 issue: 1 year: 2003 end-page: 15 article-title: Calibrated automated thrombin generation measurement in clotting plasma publication-title: Pathophysiol Haemost Thromb – year: 2020 article-title: Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid‐19 publication-title: N Engl J Med – volume: 98 start-page: 2730 issue: 9 year: 2001 end-page: 5 article-title: Changes in health and disease of the metalloprotease that cleaves von Willebrand factor publication-title: Blood – volume: 15 start-page: 861 issue: 5 year: 2020 end-page: 3 article-title: Low ADAMTS 13 plasma levels are predictors of mortality in COVID‐19 patients publication-title: Intern Emerg Med – year: 2020 article-title: Thrombosis in Hospitalized Patients With COVID‐19 in a New York City Health System publication-title: JAMA – volume: 98 issue: 23 year: 2019 article-title: The cumulative venous thromboembolism incidence and risk factors in intensive care patients receiving the guideline‐recommended thromboprophylaxis publication-title: Medicine (Baltimore) – volume: 43 start-page: 496 issue: 6 year: 2020 end-page: 502 article-title: Comparison of clinical and pathological features between severe acute respiratory syndrome and coronavirus disease 2019 publication-title: Zhonghua Jie He He Hu Xi Za Zhi – volume: 4 start-page: 1178 issue: 7 year: 2020 end-page: 91 article-title: Risk of venous thromboembolism in patients with COVID‐19: A systematic review and meta‐analysis publication-title: Res Pract Thromb Haemost – volume: 4 start-page: 203 issue: 3 year: 2020 end-page: 6 article-title: Reduction of ADAMTS13 levels predicts mortality in SARS‐CoV‐2 patients publication-title: TH Open – volume: 191 start-page: 9 year: 2020 end-page: 14 article-title: Venous and arterial thromboembolic complications in COVID‐19 patients admitted to an academic hospital in Milan, Italy publication-title: Thromb Res – volume: 18 start-page: 844 issue: 4 year: 2020 end-page: 7 article-title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia publication-title: J Thromb Haemost – volume: 395 start-page: 497 issue: 10223 year: 2020 end-page: 506 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet – year: 2020 article-title: Coagulation abnormalities and thrombosis in patients infected with SARS‐CoV‐2 and other pandemic viruses publication-title: Arterioscler Thromb Vasc Biol – volume: 142 start-page: 184 issue: 2 year: 2020 end-page: 6 article-title: Pulmonary embolism in patients with COVID‐19: awareness of an increased prevalence publication-title: Circulation – year: 2020 article-title: Fibrinolysis shutdown correlates to thromboembolic events in severe COVID‐19 infection publication-title: J Am Coll Surg – volume: 39 start-page: 409 issue: 5 year: 2013 end-page: 14 article-title: Ratio of von Willebrand factor propeptide to ADAMTS13 is associated with severity of sepsis publication-title: Shock – year: 2020 article-title: SARS‐2 coronavirus‐associated hemostatic lung abnormality in COVID‐19: is it pulmonary thrombosis or pulmonary embolism? publication-title: Semin Thromb Hemost – volume: 50 start-page: 287 issue: 2 year: 2020 end-page: 91 article-title: Heparin resistance in COVID‐19 patients in the intensive care unit publication-title: J Thromb Thrombolysis – year: 2020 article-title: In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation publication-title: J Thromb Haemost – year: 2020 article-title: Differentiating biochemical from clinical heparin resistance in COVID‐19 publication-title: J Thromb Thrombolysis – year: 2020 article-title: Incidence of venous thromboembolism in hospitalized patients with COVID‐19 publication-title: J Thromb Haemost – year: 2020 article-title: Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID‐19: a retrospective cohort study publication-title: Lancet Haematol – year: 2020 article-title: Incidence of thrombotic complications in critically ill ICU patients with COVID‐19 publication-title: Thromb Res – year: 2020 article-title: More severe hypercoagulable state in acute COVID‐19 pneumonia as compared to other pneumonia publication-title: Mayo Clin Proc Innov Qual Outcomes – volume: 4 start-page: 744 issue: 5 year: 2020 end-page: 51 article-title: Thrombosis and coagulopathy in COVID‐19: an illustrated review publication-title: Res Pract Thromb Haemost – volume: 7 start-page: 575 issue: 8 year: 2020 end-page: 82 article-title: Endotheliopathy in COVID‐19‐associated coagulopathy: evidence from a single‐centre, cross‐sectional study publication-title: Lancet Haematol – volume: 17: start-page: 9 year: 2020 article-title: Inference from longitudinal laboratory tests characterizes temporal evolution of COVID‐19‐associated coagulopathy (CAC) publication-title: Elife – volume: 25 start-page: 100434 issue: 24 year: 2020 article-title: Megakaryocytes and platelet‐fibrin thrombi characterize multi‐organ thrombosis at autopsy in COVID‐19: a case series publication-title: EClinicalMedicine – year: 2020 ident: 10.1002/rth2.12462_bb0075 article-title: SARS‐2 coronavirus‐associated hemostatic lung abnormality in COVID‐19: is it pulmonary thrombosis or pulmonary embolism? publication-title: Semin Thromb Hemost – volume: 17: start-page: 9 year: 2020 ident: 10.1002/rth2.12462_bb0235 article-title: Inference from longitudinal laboratory tests characterizes temporal evolution of COVID‐19‐associated coagulopathy (CAC) publication-title: Elife – volume: 191 start-page: 9 year: 2020 ident: 10.1002/rth2.12462_bb0020 article-title: Venous and arterial thromboembolic complications in COVID‐19 patients admitted to an academic hospital in Milan, Italy publication-title: Thromb Res doi: 10.1016/j.thromres.2020.04.024 – volume: 15 start-page: 861 issue: 5 year: 2020 ident: 10.1002/rth2.12462_bb0160 article-title: Low ADAMTS 13 plasma levels are predictors of mortality in COVID‐19 patients publication-title: Intern Emerg Med doi: 10.1007/s11739-020-02394-0 – volume: 395 start-page: 497 issue: 10223 year: 2020 ident: 10.1002/rth2.12462_bb0210 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 – year: 2020 ident: 10.1002/rth2.12462_bb0200 article-title: Differentiating biochemical from clinical heparin resistance in COVID‐19 publication-title: J Thromb Thrombolysis doi: 10.1007/s11239-020-02259-5 – volume: 4 start-page: 744 issue: 5 year: 2020 ident: 10.1002/rth2.12462_bb0080 article-title: Thrombosis and coagulopathy in COVID‐19: an illustrated review publication-title: Res Pract Thromb Haemost doi: 10.1002/rth2.12400 – volume: 25 start-page: 100434 issue: 24 year: 2020 ident: 10.1002/rth2.12462_bb0065 article-title: Megakaryocytes and platelet‐fibrin thrombi characterize multi‐organ thrombosis at autopsy in COVID‐19: a case series publication-title: EClinicalMedicine doi: 10.1016/j.eclinm.2020.100434 – volume: 395 start-page: 1417 issue: 10234 year: 2020 ident: 10.1002/rth2.12462_bb0090 article-title: Endothelial cell infection and endotheliitis in COVID‐19 publication-title: Lancet doi: 10.1016/S0140-6736(20)30937-5 – volume: 18 start-page: 1421 issue: 6 year: 2020 ident: 10.1002/rth2.12462_bb0025 article-title: Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia publication-title: J Thromb Haemost doi: 10.1111/jth.14830 – volume: 39 start-page: 409 issue: 5 year: 2013 ident: 10.1002/rth2.12462_bb0225 article-title: Ratio of von Willebrand factor propeptide to ADAMTS13 is associated with severity of sepsis publication-title: Shock doi: 10.1097/SHK.0b013e3182908ea7 – year: 2020 ident: 10.1002/rth2.12462_bb0060 article-title: Autopsy findings and venous thromboembolism in patients with COVID‐19 publication-title: Ann Intern Med – year: 2020 ident: 10.1002/rth2.12462_bb0125 article-title: Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19 publication-title: Br J Haematol doi: 10.1111/bjh.17003 – volume: 98 start-page: 2730 issue: 9 year: 2001 ident: 10.1002/rth2.12462_bb0220 article-title: Changes in health and disease of the metalloprotease that cleaves von Willebrand factor publication-title: Blood doi: 10.1182/blood.V98.9.2730 – year: 2020 ident: 10.1002/rth2.12462_bb0120 article-title: Hypercoagulability of COVID‐19 patients in intensive care unit. A report of thromboelastography findings and other parameters of hemostasis publication-title: J Thromb Haemost doi: 10.1111/jth.14850 – volume: 4 start-page: 203 issue: 3 year: 2020 ident: 10.1002/rth2.12462_bb0155 article-title: Reduction of ADAMTS13 levels predicts mortality in SARS‐CoV‐2 patients publication-title: TH Open doi: 10.1055/s-0040-1716379 – year: 2020 ident: 10.1002/rth2.12462_bb0070 article-title: Immunothrombotic dysregulation in COVID‐19 pneumonia is associated with respiratory failure and coagulopathy publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.048488 – year: 2020 ident: 10.1002/rth2.12462_bb0230 article-title: VWF/ADAMTS13 imbalance, but not global coagulation or fibrinolysis, is associated with outcome and bleeding in acute liver failure publication-title: Hepatology doi: 10.1016/S0168-8278(20)30605-X – volume: 50 start-page: 281 issue: 2 year: 2020 ident: 10.1002/rth2.12462_bb0130 article-title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID‐19 pneumonia publication-title: J Thromb Thrombolysis doi: 10.1007/s11239-020-02130-7 – year: 2020 ident: 10.1002/rth2.12462_bb0240 article-title: More severe hypercoagulable state in acute COVID‐19 pneumonia as compared to other pneumonia publication-title: Mayo Clin Proc Innov Qual Outcomes doi: 10.1016/j.mayocpiqo.2020.09.002 – year: 2020 ident: 10.1002/rth2.12462_bb0015 article-title: Incidence of thrombotic complications in critically ill ICU patients with COVID‐19 publication-title: Thromb Res – year: 2020 ident: 10.1002/rth2.12462_bb0095 article-title: In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation publication-title: J Thromb Haemost doi: 10.1111/jth.15043 – volume: 5 issue: 5 year: 2008 ident: 10.1002/rth2.12462_bb0150 article-title: Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis publication-title: PLoS Med doi: 10.1371/journal.pmed.0050097 – year: 2020 ident: 10.1002/rth2.12462_bb0175 article-title: Evaluation of COVID‐19 coagulopathy; laboratory characterization using thrombin generation and nonconventional haemostasis assays publication-title: Int J Lab Hematol – year: 2020 ident: 10.1002/rth2.12462_bb0010 article-title: Coagulation abnormalities and thrombosis in patients infected with SARS‐CoV‐2 and other pandemic viruses publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.120.314514 – volume: 9 start-page: 2875 issue: 9 year: 2020 ident: 10.1002/rth2.12462_bb0180 article-title: Hematological phenotype of COVID‐19–induced coagulopathy: far from typical sepsis‐induced coagulopathy publication-title: J Clin Med doi: 10.3390/jcm9092875 – volume: 18 start-page: 844 issue: 4 year: 2020 ident: 10.1002/rth2.12462_bb0105 article-title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia publication-title: J Thromb Haemost doi: 10.1111/jth.14768 – year: 2020 ident: 10.1002/rth2.12462_bb0135 article-title: Fibrinolysis shutdown correlates to thromboembolic events in severe COVID‐19 infection publication-title: J Am Coll Surg doi: 10.1016/j.jamcollsurg.2020.05.007 – year: 2020 ident: 10.1002/rth2.12462_bb0110 article-title: Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID‐19: a retrospective cohort study publication-title: Lancet Haematol doi: 10.1016/S2352-3026(20)30217-9 – year: 2020 ident: 10.1002/rth2.12462_bb0185 article-title: Evaluation of the prothrombin fragment 1.2 in patients with coronavirus disease 2019 (COVID‐19) publication-title: Am J Hematol doi: 10.1002/ajh.25962 – year: 2020 ident: 10.1002/rth2.12462_bb0115 article-title: The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome publication-title: J Thromb Haemost doi: 10.1111/jth.14854 – volume: 33 start-page: 4 issue: 1 year: 2003 ident: 10.1002/rth2.12462_bb0140 article-title: Calibrated automated thrombin generation measurement in clotting plasma publication-title: Pathophysiol Haemost Thromb doi: 10.1159/000071636 – year: 2020 ident: 10.1002/rth2.12462_bb0085 article-title: Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid‐19 publication-title: N Engl J Med doi: 10.1056/NEJMoa2015432 – volume: 98 issue: 23 year: 2019 ident: 10.1002/rth2.12462_bb0045 article-title: The cumulative venous thromboembolism incidence and risk factors in intensive care patients receiving the guideline‐recommended thromboprophylaxis publication-title: Medicine (Baltimore) doi: 10.1097/MD.0000000000015833 – volume: 4 start-page: 1178 issue: 7 year: 2020 ident: 10.1002/rth2.12462_bb0040 article-title: Risk of venous thromboembolism in patients with COVID‐19: A systematic review and meta‐analysis publication-title: Res Pract Thromb Haemost doi: 10.1002/rth2.12439 – volume: 50 start-page: 287 issue: 2 year: 2020 ident: 10.1002/rth2.12462_bb0195 article-title: Heparin resistance in COVID‐19 patients in the intensive care unit publication-title: J Thromb Thrombolysis doi: 10.1007/s11239-020-02145-0 – volume: 16 start-page: 1446 issue: 11 year: 2020 ident: 10.1002/rth2.12462_bb0215 article-title: The COVID‐19 cytokine storm: what we know so far publication-title: Front Immunol doi: 10.3389/fimmu.2020.01446 – volume: 26 start-page: 141 issue: 2 year: 2007 ident: 10.1002/rth2.12462_bb0205 article-title: Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2007.03369.x – year: 2020 ident: 10.1002/rth2.12462_bb0190 article-title: COVID and coagulation: bleeding and thrombotic manifestations of SARS‐CoV2 infection publication-title: Blood doi: 10.1182/blood.2020006520 – volume: 7 start-page: 575 issue: 8 year: 2020 ident: 10.1002/rth2.12462_bb0165 article-title: Endotheliopathy in COVID‐19‐associated coagulopathy: evidence from a single‐centre, cross‐sectional study publication-title: Lancet Haematol doi: 10.1016/S2352-3026(20)30216-7 – year: 2020 ident: 10.1002/rth2.12462_bb0100 article-title: Hypofibrinolytic state and high thrombin generation may play a major role in SARS‐CoV2 associated thrombosis publication-title: J Thromb Haemost doi: 10.1111/jth.15016 – volume: 194 start-page: 237 year: 2020 ident: 10.1002/rth2.12462_bb0145 article-title: Preanalytical variables affect thrombomodulin‐modified thrombin generation in healthy volunteers publication-title: Thromb Res doi: 10.1016/j.thromres.2020.07.053 – year: 2020 ident: 10.1002/rth2.12462_bb0170 article-title: Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID‐19 publication-title: J Thromb Haemost doi: 10.1111/jth.15067 – year: 2020 ident: 10.1002/rth2.12462_bb0030 article-title: Thrombosis in Hospitalized Patients With COVID‐19 in a New York City Health System publication-title: JAMA doi: 10.1001/jama.2020.13372 – year: 2020 ident: 10.1002/rth2.12462_bb0035 article-title: Incidence of venous thromboembolism in hospitalized patients with COVID‐19 publication-title: J Thromb Haemost doi: 10.1111/jth.14888 – volume: 142 start-page: 184 issue: 2 year: 2020 ident: 10.1002/rth2.12462_bb0050 article-title: Pulmonary embolism in patients with COVID‐19: awareness of an increased prevalence publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.047430 – volume: 43 start-page: 496 issue: 6 year: 2020 ident: 10.1002/rth2.12462_bb0055 article-title: Comparison of clinical and pathological features between severe acute respiratory syndrome and coronavirus disease 2019 publication-title: Zhonghua Jie He He Hu Xi Za Zhi – reference: 33742434 - Thromb Haemost. 2021 Dec;121(12):1668-1669 |
| SSID | ssj0002022025 |
| Score | 2.4196239 |
| Snippet | Patients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic state is... Background and Aims Patients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic... Patients with severe coronavirus disease 2019 (COVID-19) are at significant risk of thrombotic complications. However, their prothrombotic state is... Background and AimsPatients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their prothrombotic... Abstract Background and Aims Patients with severe coronavirus disease 2019 (COVID‐19) are at significant risk of thrombotic complications. However, their... |
| SourceID | doaj pubmedcentral proquest pubmed crossref wiley elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 132 |
| SubjectTerms | Anticoagulants Blood Body mass index coagulation Coronaviruses COVID-19 Cytokine storm Diabetes Drug dosages fibrinolysis hemostasis Intensive care Intubation Laboratories Mortality Original Original ‐ Thrombosis Patients Plasma Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Thromboembolism thrombosis Variables |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals (WRLC) dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB6hnrggUHkESmUEF0ChiV-Jj1CoFiQeQi3qzbIdR11Es2h3e-cn8Bv5JYwfG23UAhekSEnsUeLMjD0ztvMNwBNbt75zypfKc4MBihJlyxkOhtaiRklBOxfmId9_kLMT_u5UnG6l-gp7whI8cGLcgUViYyvRd4xxy9F-KeV4bRqBprJSMVrH01Yw9TUur1E8xIhHSg-W6zP6Ao2ZpBMLFIH6J4bosqN5eb_kth8bDdHRTbiRPUjyMrX8Flzzwy50n5aLkPHg3C6wmKTfeVdkPpAMnLoiYcaVHH788vb1rx8_a0XM0hOTheO7VJ2Xawi20oesdsQMHTmPHjre3YaTozfHh7MyJ1AoXYOOFbLeKuelpaKnrey9qpiQXGGI1squRca2VdtXKBZnBBY55vqASCYbhYKlnrI7sDMsBn8PSG983SvX2wDAb7gwrqmpw2iQe2dY5wp4umGqdhldPCS5-KYTLjLVQQA6CqCAxyPt94SpcSXVqyCbkSLgYMcC1A6dtUP_SzsKeL6RrN78aoqDIz5ofuUry5E6OyDJsfgj_d5GWXTu-itNeQi6GyVYAY_Gauy0YSXGDH5xEWkkRz5TXsDdpFvjdzImGMaQTQHNROsmjJjWDPOzCAzetDyg-xfwLOrnX5irPx_PaLy6_z_Y_ACu07DXJ05N7cHOennhH6Kztrb7sV_-BuXrPO0 priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagXLigIl6BgozgAig08TM-IShUCxIPoRbtzbIdh65Ekza7vfMT-I38EsaOE4haetvYo2zsGdvfjO1vEHpqy8rXTvlceWbAQVE8rxiFydBasCjBSe1CHPLjJ7E4ZB-WfJkCbut0rHKcE-NEXXcuxMh3CQu-jFScvjo5zUPWqLC7mlJoXEXXSkAiIXWDXMopxkLCNVLCJ1ZSsttvjshLWNIEma1Dka5_thydh5vnT03-i2bjcrS_jW4kHIlfD4q_ia749haqv_RdyHtwbDsoxsOl3jVetTjRp65xiLvivc_f3r_9_fNXqbDpPTZJRb4eqtOmDYav9CG3HTZtjY8jToen2-hw_93B3iJPaRRyJwFegQKscl5YwhtSicargnLBFDhqlagr0EVVVE0BynGGQ5Gjrgm8ZEIqUC_xhN5BW23X-nsIN8aXjXKNDTT8hnHjZEkc-ITMO0Nrl6FnY6dqlzjGQ6qLH3pgRyY6KEBHBWToySR7MjBrXCj1Juhmkghs2LGg67_rNLi0hUYYW_CmppRZBhhHKcdKIznAqUIVGXoxalaPF05hioQXrS78y3ySTjBkgBf_ld8ZjUWnCWCt_5prhh5P1TB0w36MaX13FmUEg34mLEN3B9ua2kkpp-BJygzJmdXNOmJe066OIj24rFjg-M_Q82ifl3Su_nqwIPHX_cvb8ABdJ-EsTww97aCtTX_mHwIY29hHccT9AQ7gNTM priority: 102 providerName: ProQuest |
| Title | Prothrombotic changes in patients with COVID‐19 are associated with disease severity and mortality |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S2475037922013139 https://dx.doi.org/10.1002/rth2.12462 https://onlinelibrary.wiley.com/doi/abs/10.1002%2Frth2.12462 https://www.ncbi.nlm.nih.gov/pubmed/33537537 https://www.proquest.com/docview/2482547953 https://www.proquest.com/docview/2486466724 https://pubmed.ncbi.nlm.nih.gov/PMC7845083 https://doaj.org/article/bdc4ab05fd334b419099c41a75635090 |
| Volume | 5 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NbtQwELaq9sIFgfgLlJURXACFJv6JY4kLLa0WJMqqatHeLNtx6Eo0QdntnUfgGXkSxo6TErUgcVll7Ul24xmPv5nE3yD0wuSlq6x0qXRMQ4AieVoyCs7QGLCogpPK-jzkp-NifsY-LvlyC70d9sL0_BBjws3PjOCv_QTXZr13RRrabc7JG1idvAPeAVRPvX0TthgzLMRvIg1VVwkTPM2okCM_Kdm7On2yIgXi_snCdB14Xn9_8k9cGxamozvodkSU-F1vAnfRlmvuoWrRtb4CwoVpoRn323vXeNXgSKS6xj4Diw8-f_nw_tePn7nEunNYR2W5qu-Oj28w_Evnq9xh3VT4IiB2-HYfnR0dnh7M01hQIbUCgBaowkjrCkN4TcqidjKjvGASQrayqErQSpmVdQZqsppDk6W29gxlhZCgaOIIfYC2m7ZxjxCutctraWvjCfk149qKnFiIDpmzmlY2QS-HQVU2so37ohffVM-TTJRXgAoKSNDzUfZ7z7Fxo9S-180o4XmxQ0PbfVVxmikDN6FNxuuKUmYYoB0pLcu14ACsMpkl6PWgWTVsPQVnCRda3fiT6SgdAUkPNP4qvzsYi4quYK0I80G4kJwm6NnYDZPYP5nRjWsvg0zBYJwJS9DD3rbG-6SUU4gpRYLExOomAzHtaVbngShclMyz_SfoVbDPfwyuOjmdk3D0-H-En6BbxL_jE1JSu2h70126pwDSNmYW5iJ8iqWYoZ39w-PFySwkPH4DKU87SQ |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQw0Kq2B7ggEK9AASPgACg0cewkPlSIvrRL26Wqtqg3YzsOXYkmJbsV4sYn8EV8DF_C2HECq5beetvEo6w9M56XPTMIPVdxbgrNTcgNleCgcBbmNAFhqBRwVMpIoW0ccm-cDg_p-yN2tIR-dbkw9lplJxOdoC5qbWPkq4RaXybjLHl7-jW0XaPs6WrXQkP61grFmisx5hM7dsz3b-DCzdZGm0DvF4Rsb002hqHvMhDqDKwPmJ_i2qSKsJLkaWl4lLCUcvBj8rTIYap5lJcRzF1L-HKqE13asl1pxmH1xNjCB6AClqkNoAzQ8vrWeP-gj_IQm8hKWF8Xlaw282PyBpRqShY0oWsYsKAQzxu85-9t_mtPO4W4fRPd8JYsftey3i20ZKrbqNhvatt54UTV8Bq3acUzPK2wL-A6wzbyizc-fBxt_v7xM-ZYNgZLzySmaIf9sRGGWRrbXQ_LqsAnzlOApzvo8EpQfBcNqroy9xEupYlLrktlGwFIyqTOYqLBK6VGy6TQAXrZIVVoX-XcNtv4Itr6zERYAghHgAA962FP29oeF0KtW9r0ELYet3tRN5-F395CwSKkilhZJAlVFKwszjWNZcbAoIt4FKDXHWVFl_IKQho-NL3wL8Me2htCrYHzX_iVjlmEF0Ez8XfDBOhpPwzCw54IycrUZw4mpYBnQgN0r-Wtfp1JwhLwZbMAZQtct4CIxZFqeuwKlGc5tV0GAvTK8eclyBUHkyFxvx5cvoYn6NpwsrcrdkfjnYfoOrE3i1wgbAUN5s2ZeQSm4Vw99vsPo09XveX_APfbd20 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELaqIiEuCMRroYARcAC0ZNeP9fqAEDRECYVSoRbl5tpeL41Ed0uSCnHjJ_B7-Dn8EsbeB0QtvfWW2KPE9jw8M7bnQ-iRSXNXWOli6ZiGAEXyOGcUjKExIFEZJ4X1ecj329l4j72d8uka-tW9hfHXKjubGAx1UVufIx8Q5mMZITkdlO21iJ3h6OXR19gjSPmT1g5OoxGRLff9G4RvixeTIfD6MSGjN7ub47hFGIitAM8DxmakdZkhvCR5VjqZUJ4xCTFMnhU5DDNP8jKBcVvNoclSW_qSXZmQMHPifNEDMP8XBGXMw0aIqejzO8Q_YSW8r4hKBvPlAXkO22lGVvbAABWwshWedHVP3tj815MOW-HoCrrc-rD4VSN0V9Gaq66hYmdee8yFQ1NDM24eFC_wrMJt6dYF9jlfvPnh02T4-8fPVGI9d1i34uGKprs9MMIwSudx9bCuCnwYYgT4dh3tncsC30DrVV25WwiX2qWltKXxEACacW1FSizEo8xZTQsboSfdoirb1jf3MBtfVFOZmSjPABUYEKGHPe1RU9XjVKrXnjc9ha_EHRrq-WfVKrYyMAltEl4WlDLDwL-S0rJUCw6uXCKTCD3rOKu6x65gnuGHZqf-ZdxTty5Q49r8l36jExbVGp-F-qsqEXrQd4PZ8GdBunL1caDJGKwzYRG62chWP09KOYUoVkRIrEjdykKs9lSzg1CaXOTM4wtE6GmQzzMWV33cHZPw6fbZc7iPLoKiq3eT7a076BLxV4pCBmwDrS_nx-4u-IRLcy8oH0b7563tfwC8d3UJ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prothrombotic+changes+in+patients+with+COVID%E2%80%9019+are+associated+with+disease+severity+and+mortality&rft.jtitle=Research+and+practice+in+thrombosis+and+haemostasis&rft.au=Meijenfeldt%2C+Fien+A.&rft.au=Havervall%2C+Sebastian&rft.au=Adelmeijer%2C+Jelle&rft.au=Lundstr%C3%B6m%2C+Annika&rft.date=2021-01-01&rft.issn=2475-0379&rft.eissn=2475-0379&rft.volume=5&rft.issue=1&rft.spage=132&rft.epage=141&rft_id=info:doi/10.1002%2Frth2.12462&rft.externalDBID=10.1002%252Frth2.12462&rft.externalDocID=RTH212462 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2475-0379&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2475-0379&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2475-0379&client=summon |