Population Analysis of Escherichia coli Sequence Type 361 and Reduced Cefiderocol Susceptibility, France

• Published in: Emerging infectious diseases Vol. 29; no. 9; pp. 1877 - 1881
• Main Authors: Jousset, Agnès B., Bouabdallah, Laura, Birer, Aurélien, Rosinski-Chupin, Isabelle, Mariet, Jean-François, Oueslati, Saoussen, Emeraud, Cécile, Girlich, Delphine, Glaser, Philippe, Naas, Thierry, Bonnin, Rémy A., Dortet, Laurent
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.09.2023; Centers for Disease Control and Prevention
• Subjects: Analysis; Anti-infective agents; Antibiotics; Antimicrobial agents; antimicrobial resistance; Bacteria; Beta lactamases; carbapenemase; Care and treatment; Cefiderocol; Cephalosporins - pharmacology; Complications and side effects; Correlation analysis; Dispatch; Dosage and administration; E coli; enteric infections; Escherichia coli; Escherichia coli - genetics; Escherichia coli infections; Europe; food safety; France - epidemiology; Gammaproteobacteria; Genes; Genetic aspects; Genomes; Genomics; Gram-negative bacteria; Imipenem; Infection; Life Sciences; Mutation; Phylogenetics; Population Analysis of; Protein binding; Sequence Type 361 and Reduced Cefiderocol Susceptibility, France; Surveillance; France; Europe; India; cefiderocol; food safety; epidemiology; Enterobacterales; bacteria; antimicrobial resistance; Escherichia coli; enteric infections; carbapenemase; France
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid2909.230390

Cefiderocol resistance is increasingly reported in New Delhi metallo-β-lactamase-producing Enterobacterales. Genomic and phenotypic analysis of Escherichia coli sequence type 361, a primary clone causing carbapenemase spread in France, revealed mutations leading to cefiderocol resistance. Continued genomic surveillance of carbapenem-resistant Enterobacterales could clarify prevalence of cefiderocol-resistant E. coli in Europe.