Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases
The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to...
Saved in:
| Published in | Neural regeneration research Vol. 16; no. 9; pp. 1711 - 1714 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Wolters Kluwer India Pvt. Ltd
01.09.2021
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany%Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA Wolters Kluwer - Medknow Wolters Kluwer Medknow Publications |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1673-5374 1876-7958 |
| DOI | 10.4103/1673-5374.306060 |
Cover
| Abstract | The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma. |
|---|---|
| AbstractList | The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma. The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma.The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma. |
| Audience | Academic |
| Author | Süβ, Patrick Lana, Addison Schlachetzki, Johannes |
| AuthorAffiliation | Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany%Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA |
| AuthorAffiliation_xml | – name: Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany%Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA – name: 1 Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany – name: 2 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA |
| Author_xml | – sequence: 1 givenname: Patrick surname: Süβ fullname: Süβ, Patrick organization: Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen – sequence: 2 givenname: Addison surname: Lana fullname: Lana, Addison organization: Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA – sequence: 3 givenname: Johannes surname: Schlachetzki fullname: Schlachetzki, Johannes organization: Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33510059$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kttr2zAUxs3oWC_b-56GYS-D4UwX25L3UChhl7LCXtZnIctHiVJHyiS7of3rd9IkXVPG0INt6ft-1jnnO82OfPCQZW8pmZSU8E-0FryouCgnnNS4XmQnVIq6EE0lj_B9f3ycnaa0IKSSDeOvsmPOK4pfzUl2PZ3H4J3JVxDdag5R97nzttfLpR5c8J9zna9CSq7tITfBD9G14xBiPoTcwxhDBzPwaBvcLeSdS6ATpNfZS6v7BG92z7Ps-uuXX9PvxdXPb5fTi6vCCCZiIbuu4oRXLdgWJCFcl5Y1moiGaVLWlouWC9OV1jJqW1nZRkIjiCVaMDSV_Cy73HK7oBdqFd1SxzsVtFMPGyHOlI6DMz2ojgtSQttJQpuSM97WldHWaElM2dWgkXW-Za3GdgmdAaxV9wfQwxPv5moWbpXkTAohEPBxC1hrb7WfqUUYo8fy1f0sLe7T3UIBI4ySBluP6g-738Xwe4Q0qKVLBvpeewhjUqyUXFIcKkfp-2fSRzKrOGtoI0T5VzXTWC7OMOAtzQaqLuqK8BLTQFE1-YcKVwdLh_MF63D_wPDuaVse-7GPEArqrcBEzEkEq4wbHrKDZNcrStQmq2oTRrUJo9pmFY3kmXHP_o_lx67FoR8gppt-XENUeK8bH9YHvuKJT1FBqdolXe2Tzv8A6hECpw |
| CitedBy_id | crossref_primary_10_1080_19336950_2023_2253102 crossref_primary_10_3390_antiox12051117 crossref_primary_10_3389_fnagi_2022_1035437 crossref_primary_10_2174_1389201024666230824093927 crossref_primary_10_3389_fphar_2021_741219 crossref_primary_10_1016_j_pnpbp_2023_110817 crossref_primary_10_1515_revneuro_2023_0049 crossref_primary_10_3390_plants11141792 crossref_primary_10_1152_physiolgenomics_00134_2023 crossref_primary_10_3390_molecules27238481 crossref_primary_10_1186_s43162_025_00403_2 crossref_primary_10_1016_j_nbd_2022_105940 crossref_primary_10_1177_11795735211029113 crossref_primary_10_2174_1567202618666210603124814 crossref_primary_10_15407_ubj94_01_033 crossref_primary_10_3389_fimmu_2023_1148209 crossref_primary_10_1007_s12035_023_03679_z crossref_primary_10_14283_jpad_2022_23 crossref_primary_10_3233_JPD_213138 crossref_primary_10_3390_brainsci14050413 crossref_primary_10_1007_s00401_023_02675_w crossref_primary_10_1016_j_brainres_2024_149197 crossref_primary_10_3390_ijms251910692 crossref_primary_10_1007_s10067_023_06697_3 crossref_primary_10_3390_ijms23105832 crossref_primary_10_1038_s41582_022_00714_w crossref_primary_10_3389_fimmu_2022_921947 crossref_primary_10_3390_ijms22147544 crossref_primary_10_3233_JAD_231471 crossref_primary_10_2147_JIR_S338162 crossref_primary_10_3389_fncel_2024_1365448 crossref_primary_10_3390_ijms26062440 |
| Cites_doi | 10.1523/JNEUROSCI.2484-16.2017 10.1007/s40263-016-0374-z 10.1038/nn2015 10.1126/science.1249547 10.1097/NRL.0b013e318251e6f2 10.1186/1742-2094-9-151 10.1016/j.nbd.2017.02.010 10.1093/brain/awz364 10.1016/S1474-4422(11)70072-2 10.1371/journal.pone.0090523 10.1016/j.celrep.2020.107843 10.1111/j.1474-9726.2012.00851.x 10.1016/j.stem.2019.04.019 10.1016/j.neuron.2019.07.002 10.1126/science.aal3222 10.1212/WNL.0000000000007094 10.1038/nn2014 10.1126/science.aaw2622 10.1007/s00401-015-1504-2 10.1038/s41590-020-0776-4 10.1212/WNL.0b013e3181b6bb95 10.1084/jem.20191374 10.1523/JNEUROSCI.2868-05.2005 10.1016/j.cell.2017.05.018 10.1038/nm.3913 10.1016/j.bbi.2015.05.011 10.1001/jama.2010.1553 10.1001/jamaneurol.2018.0605 10.1016/j.celrep.2020.02.109 10.1038/s41586-019-1895-7 10.1038/s41586-018-0023-4 10.1038/nm.4397 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2021 Medknow Publications and Media Pvt. Ltd. 2021. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. Copyright: © 2021 Neural Regeneration Research 2021 |
| Copyright_xml | – notice: COPYRIGHT 2021 Medknow Publications and Media Pvt. Ltd. – notice: 2021. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. – notice: Copyright: © 2021 Neural Regeneration Research 2021 |
| DBID | AAYXX CITATION NPM K9. 7X8 2B. 4A8 92I 93N PSX TCJ 5PM DOA |
| DOI | 10.4103/1673-5374.306060 |
| DatabaseName | CrossRef PubMed ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1876-7958 |
| EndPage | 1714 |
| ExternalDocumentID | oai_doaj_org_article_d3704ebd80194323b65cafca80c4d6ea PMC8328777 zgsjzsyj_e202109005 A650341671 33510059 10_4103_1673_5374_306060 10.4103/1673-5374.306060_1711_Chronic peripher |
| Genre | Journal Article Review |
| GeographicLocations | Germany |
| GeographicLocations_xml | – name: Germany |
| GroupedDBID | --- -SE -S~ 0R~ 53G 5RS 5VR 5VS 7X7 8FI 92F 92I ACGFS ADBBV ADJBI AENEX AFKRA ALIPV ALMA_UNASSIGNED_HOLDINGS AZQEC BAWUL BENPR CAJEE CCEZO CHBEP CIEJG CS3 CW9 DIK DU5 FA0 FDB GROUPED_DOAJ GX1 H13 IAO IEA IHR ITC KQ8 M2M M48 M5~ NQ- O9- OK1 OVD PGMZT PIMPY Q-- RMW RPM TCJ TEORI TGQ U1G U5O W3E WFFXF --K 123 1B1 4.4 8FJ AAEDT AAKAS AALRI AAXUO AAYXX ABUWG ABWVN ACRPL ADMUD ADNMO ADRAZ ADZCM AFUIB CCPQU CITATION DWQXO EBS EJD EMOBN EO8 FYUFA GNUQQ HMCUK HYE HZ~ IHE IPNFZ M41 PHGZM PHGZT PSYQQ RIG ROL RPZ UKHRP 2B. 93N AAXDM ABXLX NPM K9. 7X8 4A8 PMFND PSX 5PM |
| ID | FETCH-LOGICAL-c727r-8dd53035befbe8003a4f29a0792a046f37b37cd4ff21fb85f98e970f0a725be43 |
| IEDL.DBID | M48 |
| ISSN | 1673-5374 |
| IngestDate | Wed Aug 27 00:17:27 EDT 2025 Thu Aug 21 14:00:21 EDT 2025 Thu May 29 04:06:14 EDT 2025 Thu Sep 04 16:28:39 EDT 2025 Fri Jul 25 04:32:45 EDT 2025 Tue Jun 17 21:01:40 EDT 2025 Tue Jun 10 20:19:49 EDT 2025 Thu Jan 02 22:58:28 EST 2025 Tue Jul 01 03:20:25 EDT 2025 Thu Apr 24 23:05:08 EDT 2025 Tue Jun 17 22:49:45 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | Alzheimer’s disease inflammation neurodegeneration aging microglia Parkinson’s disease innate immune system Parkinson's disease Alzheimer's disease |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c727r-8dd53035befbe8003a4f29a0792a046f37b37cd4ff21fb85f98e970f0a725be43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Author contributions: JCMS wrote the manuscript with contributions from PS and AJL. All authors approved the final version of the paper. |
| ORCID | 0000-0002-7801-9743 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.4103/1673-5374.306060 |
| PMID | 33510059 |
| PQID | 2532919774 |
| PQPubID | 4671210 |
| PageCount | 4 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_d3704ebd80194323b65cafca80c4d6ea pubmedcentral_primary_oai_pubmedcentral_nih_gov_8328777 wanfang_journals_zgsjzsyj_e202109005 proquest_miscellaneous_2483816063 proquest_journals_2532919774 gale_infotracmisc_A650341671 gale_infotracacademiconefile_A650341671 pubmed_primary_33510059 crossref_citationtrail_10_4103_1673_5374_306060 crossref_primary_10_4103_1673_5374_306060 wolterskluwer_medknow_10_4103_1673-5374_306060_1711_Chronic_peripher |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20210901 |
| PublicationDateYYYYMMDD | 2021-09-01 |
| PublicationDate_xml | – month: 9 year: 2021 text: 20210901 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | India |
| PublicationPlace_xml | – name: India – name: Mumbai |
| PublicationTitle | Neural regeneration research |
| PublicationTitleAlternate | Neural Regen Res |
| PublicationTitle_FL | Neural Regeneration Research |
| PublicationYear | 2021 |
| Publisher | Wolters Kluwer India Pvt. Ltd Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany%Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA Wolters Kluwer - Medknow Wolters Kluwer Medknow Publications |
| Publisher_xml | – name: Wolters Kluwer India Pvt. Ltd – name: Medknow Publications and Media Pvt. Ltd – name: Medknow Publications & Media Pvt. Ltd – name: Department of Molecular Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany%Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA – name: Wolters Kluwer - Medknow – name: Wolters Kluwer Medknow Publications |
| References | key-10.4103/1673-5374.306060-15 key-10.4103/1673-5374.306060-14 key-10.4103/1673-5374.306060-13 key-10.4103/1673-5374.306060-12 key-10.4103/1673-5374.306060-19 key-10.4103/1673-5374.306060-18 key-10.4103/1673-5374.306060-17 key-10.4103/1673-5374.306060-16 key-10.4103/1673-5374.306060-9 key-10.4103/1673-5374.306060-11 key-10.4103/1673-5374.306060-10 key-10.4103/1673-5374.306060-32 key-10.4103/1673-5374.306060-7 key-10.4103/1673-5374.306060-31 key-10.4103/1673-5374.306060-8 key-10.4103/1673-5374.306060-30 key-10.4103/1673-5374.306060-5 key-10.4103/1673-5374.306060-6 key-10.4103/1673-5374.306060-3 key-10.4103/1673-5374.306060-4 key-10.4103/1673-5374.306060-1 key-10.4103/1673-5374.306060-2 key-10.4103/1673-5374.306060-26 key-10.4103/1673-5374.306060-25 key-10.4103/1673-5374.306060-24 key-10.4103/1673-5374.306060-23 key-10.4103/1673-5374.306060-29 key-10.4103/1673-5374.306060-28 key-10.4103/1673-5374.306060-27 key-10.4103/1673-5374.306060-22 key-10.4103/1673-5374.306060-21 key-10.4103/1673-5374.306060-20 |
| References_xml | – ident: key-10.4103/1673-5374.306060-20 doi: 10.1523/JNEUROSCI.2484-16.2017 – ident: key-10.4103/1673-5374.306060-5 doi: 10.1007/s40263-016-0374-z – ident: key-10.4103/1673-5374.306060-19 doi: 10.1038/nn2015 – ident: key-10.4103/1673-5374.306060-22 doi: 10.1126/science.1249547 – ident: key-10.4103/1673-5374.306060-32 doi: 10.1097/NRL.0b013e318251e6f2 – ident: key-10.4103/1673-5374.306060-17 doi: 10.1186/1742-2094-9-151 – ident: key-10.4103/1673-5374.306060-18 doi: 10.1016/j.nbd.2017.02.010 – ident: key-10.4103/1673-5374.306060-16 doi: 10.1093/brain/awz364 – ident: key-10.4103/1673-5374.306060-3 doi: 10.1016/S1474-4422(11)70072-2 – ident: key-10.4103/1673-5374.306060-8 doi: 10.1371/journal.pone.0090523 – ident: key-10.4103/1673-5374.306060-26 doi: 10.1016/j.celrep.2020.107843 – ident: key-10.4103/1673-5374.306060-10 doi: 10.1111/j.1474-9726.2012.00851.x – ident: key-10.4103/1673-5374.306060-25 doi: 10.1016/j.stem.2019.04.019 – ident: key-10.4103/1673-5374.306060-9 doi: 10.1016/j.neuron.2019.07.002 – ident: key-10.4103/1673-5374.306060-7 doi: 10.1126/science.aal3222 – ident: key-10.4103/1673-5374.306060-29 doi: 10.1212/WNL.0000000000007094 – ident: key-10.4103/1673-5374.306060-1 doi: 10.1038/nn2014 – ident: key-10.4103/1673-5374.306060-12 doi: 10.1126/science.aaw2622 – ident: key-10.4103/1673-5374.306060-4 doi: 10.1007/s00401-015-1504-2 – ident: key-10.4103/1673-5374.306060-2 doi: 10.1038/s41590-020-0776-4 – ident: key-10.4103/1673-5374.306060-11 doi: 10.1212/WNL.0b013e3181b6bb95 – ident: key-10.4103/1673-5374.306060-23 doi: 10.1084/jem.20191374 – ident: key-10.4103/1673-5374.306060-15 doi: 10.1523/JNEUROSCI.2868-05.2005 – ident: key-10.4103/1673-5374.306060-14 doi: 10.1016/j.cell.2017.05.018 – ident: key-10.4103/1673-5374.306060-31 doi: 10.1038/nm.3913 – ident: key-10.4103/1673-5374.306060-27 doi: 10.1016/j.bbi.2015.05.011 – ident: key-10.4103/1673-5374.306060-13 doi: 10.1001/jama.2010.1553 – ident: key-10.4103/1673-5374.306060-21 doi: 10.1001/jamaneurol.2018.0605 – ident: key-10.4103/1673-5374.306060-28 doi: 10.1016/j.celrep.2020.02.109 – ident: key-10.4103/1673-5374.306060-6 doi: 10.1038/s41586-019-1895-7 – ident: key-10.4103/1673-5374.306060-30 doi: 10.1038/s41586-018-0023-4 – ident: key-10.4103/1673-5374.306060-24 doi: 10.1038/nm.4397 |
| SSID | ssj0058923 |
| Score | 2.3980064 |
| SecondaryResourceType | review_article |
| Snippet | The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the... The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question.Sustained activation of the... |
| SourceID | doaj pubmedcentral wanfang proquest gale pubmed crossref wolterskluwer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1711 |
| SubjectTerms | aging; alzheimer’s disease; inflammation; innate immune system; microglia; neurodegeneration; parkinson’s disease Complications and side effects Degeneration Development and progression Inflammation Nervous system Neurodegeneration Pathogenesis Peripheral nerve diseases Review |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuCCiPQEFGqkAcwjqxHcfclkdVIcGJlXqzbMdeKNuk2t2qan89M052uwEJLlxjW7FnPo9n7PFnQg5VItmDSDV6qXPBFctdEDovZSldsMw2Hi8nf_laHc_E5xN5svPUF-aE9fTAveAmDTQXwTVgSbXgJXeV9DZ6WzMvmiok14hptgmmehssa50edisqxXPJlegPKEXB-GT77S10kSVqypsFKfH2_2mdd5an31Mnb1_aNtp2DiWXHR5wr36m_PadVeroHrk7uJd02g_rPrkV2gdkf9pCaH12RV_RlPCZdtL3yWwgxqVIdpzYBRYU8AYQ6a8zvqOWnnc4ZxaBppR2fBurW9J1RxMNZhPmibQaLSYdTnpWD8ns6NO3D8f58MpC7sF3WeZ100hYx0Az0QVwH7kVsdSWKV1aCJ4jV44r34gYyyK6WkZdB61YZFahOgV_RPbarg1PCHVMetB8U_HSQ9xY2TpW0Vkvg9PIa5aRyUbUxg8U5PgSxsJAKILKMagcg8oxvXIy8mbb4ryn3_hL3feovW09JM5OHwBOZoCT-RecMvIadW9wekPXvB1uKcAAkSjLTMGjhYW_UkVGDkY1YVr6cfEGPWYwCytTSl7qAl3ujLzcFmNLTHVrQ3cBdUSNh7ngOmbkcQ-27ZA4BxPKUJBqBMPRmMcl7Y_viTQcLDdSP2bkcADsTa-u56vT69XVqQkl7gBo-ENGPo7QbM76y5kj4ec7wjeFgkhywK3Z4Pbp_1DJM3IH-9Un9h2QvfXyIjwHT3DtXqRJ_wszVFkB priority: 102 providerName: Directory of Open Access Journals – databaseName: Medknow Open Access Journals dbid: W3E link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELaqIiQuCCiPQEFB6oI4hCaxE8dEHLalqwoJLrCiN8tx7C1lm632oWr765mxk-0GJE7cothJ7Jlv7Jl4_JmQA-5I9iBStToTEaM8jirDRJRmaVYZFata4-bkL1_z0zH7fJad7ZDuV7rL2Z_PPUuEpwn2AnTburyJ5pxGGeWsXAMWICROk7Kz5Lz0rRWlN8eEJ0lpuktWqhW4pMuP3waj4wGebUgFywf0qHQERRD430l5ItA2ftCTbjzPCuEOidt81y92siSmh5t776G7saO5vJ3c3BkAf4_0W1Pdn2mYd69VY1UzgZLrGS6WL365XPmtGW_0gNxvXdVw6EXzkOyY5hHZGzYQpl-uwzehSx51f-X3yLgl2Q2RONkxFUxDwC7AzW-N_BCq8GqG9jc1oUuPx3O2ZvNwOQsdpWZtJo4AG0ffsF01Wjwm49HJ9-PTqD2xIdLgB82joq4zmBNBy7Yy4IpSxWwqVMxFqiAQt5RXlOuaWZsmtioyKwojeGxjxREajD4hu82sMc9IWMWZBhTVOU01xKC5KmxuK6UzUwnkSAvIYSdqqVs6czxVYyohrEHlSFSOROVIr5yAvNs8ceWpPP5R9wi1t6mHJNzuBkBStpCUNSCbmaqGSV4wmtIqz7SyWhWxZnVuVEDeou4lDhXQNK3aHQ_QQSTdkkPwjsGJyHkSkP1eTTBx3S_u0CPbIWYh04ymIkH3PSCvN8X4JKbNNWa2gjqswIVhcEMD8tSDbdMlSmE4jlGQvAfDXp_7Jc3Pc0dADrMA0kgG5KAF7G2rbiaLi5vF-kIaNMxYwBcC8qmHZnnpN3r2hB9tCV-i2coWt7LD7fP_85oX5B62zKcJ7pPd5XxlXoJfuaxeObP_DUQScWs priority: 102 providerName: Wolters Kluwer Health |
| Title | Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases |
| URI | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=9;spage=1711;epage=1714;aulast=S%FC%26%23946%3B;type=0 https://www.ncbi.nlm.nih.gov/pubmed/33510059 https://www.proquest.com/docview/2532919774 https://www.proquest.com/docview/2483816063 https://d.wanfangdata.com.cn/periodical/zgsjzsyj-e202109005 https://pubmed.ncbi.nlm.nih.gov/PMC8328777 https://doaj.org/article/d3704ebd80194323b65cafca80c4d6ea |
| Volume | 16 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELZgCLQXBIwfgTEZaQLxkC2J7TjmBRXYNCHBExV7sxzHLowuGW2n0f313Dlp1sDEA6rUh9ppbN9n353v_JmQXRlI9sBT9VaomDOZxKXjKs5EJkpnElNZPJz86XN-NOYfj8Xx1fHobgDn17p2eJ_UeDbd-_Vz-RYmPNivezxN2H6aSxYLJvkevBQ-N8mtEC3CRD7exxREocJlb33tNmh57T9skjuMAVoDhemavgq0_n8v3mva68_MytsXpvamnkDJRYPx7_mPkP6-psQO75G7nfVJRy1c7pMbrn5AtkY1eN6nS_qShnzQsNG-RcYdby5FLuRAPjClMECAoPa04xtq6FmDU2rqaMh4x6uzmhldNDSwZFZuEjitcUGlXSBo_pCMDw--vD-Ku0sYYgumzSwuqkqAmgPB-dKBdckM95kyiVSZAd_aM1kyaSvufZb6shBeFU7JxCdGorQ5e0Q26qZ2TwgtE2EBGFXOMgtuZW4Kn_vSWOFKhbRnEdlfDbW2HUM5XpQx1eCpoJw0ykmjnHQrp4i87p84a9k5_lH3HUqvr4e82uGHZjbR3TTVFYCVu7ICva04y1iZC2u8NUVieZU7E5FXKHuNeISmWdMdYoAOIo-WHoHBC3ZBLtOIbA9qwqy1w-IVevQK9DoTLFMpWuQRedEX45OYCVe75hzq8AJjvWBZRuRxC7a-SyvMRkQOYDjo87Ck_v4tcIrDwo7MkBHZ7QB71arLyfzkcr480S7DDQIFb4jIhwGa9Wl7dnMw-PHa4OtUgqPZ4VavcPv0v9v5jGxiY9pkv22ysZidu-dgHS7KnbCrshOmPnx_ZQe_AWXWYYE |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chronic+peripheral+inflammation%3A+a+possible+contributor+to+neurodegenerative+diseases&rft.jtitle=Neural+regeneration+research&rft.au=S%C3%BC%CE%B2%2C+Patrick&rft.au=Lana%2C+Addison+J.&rft.au=Schlachetzki%2C+Johannes+C.+M.&rft.date=2021-09-01&rft.pub=Wolters+Kluwer+-+Medknow&rft.issn=1673-5374&rft.eissn=1876-7958&rft.volume=16&rft.issue=9&rft.spage=1711&rft.epage=1714&rft_id=info:doi/10.4103%2F1673-5374.306060&rft_id=info%3Apmid%2F33510059&rft.externalDocID=PMC8328777 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzgsjzsyj-e%2Fzgsjzsyj-e.jpg |