Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve - Chignon, Arnaud; Argaud, Déborah; Boulanger, Marie-Chloé; Mkannez, Ghada; Bon-Baret, Valentin; Li, Zhonglin; Thériault, Sébastien; Bossé, Yohan; Mathieu, Patrick (PLoS genetics, 2022)
Keywords: Aged; Algorithms; Aorta; Aortic valve; Aortic Valve - metabolism; Aortic Valve - pathology; Aortic Valve Stenosis - genetics; Aortic Valve Stenosis - metabolism; Biology and Life Sciences; Calcinosis - genetics; Calcinosis - metabolism; Cell fate; Chromatin; Chromatin - metabolism; Chromatin Immunoprecipitation Sequencing; Chromosomes; Connective tissue growth factor; Connective Tissue Growth Factor - genetics; Enhancer Elements, Genetic; Enhancers; Extracellular matrix; Female; Fibrosis; Gene expression; Genome-wide association studies; Genomes; Humans; Immunoprecipitation; Male; Medicine and Health Sciences; Middle Aged; Non-coding RNA; Ontology; Physiological aspects; Promoter Regions, Genetic; Proteins; RNA, Long Noncoding - genetics; Signal Transduction; Transcription Factors - genetics; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b1; Transposase; Up-Regulation; Canada