Insulin Clearance Is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans

• Published in: PloS one Vol. 11; no. 11; p. e0166263
• Main Authors: Labadzhyan, Artak, Cui, Jinrui, Péterfy, Miklós, Guo, Xiuqing, Chen, Yii-Der I., Hsueh, Willa A., Rotter, Jerome I., Goodarzi, Mark O.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.11.2016; Public Library of Science (PLoS)
• Subjects: Absorptiometry, Photon; Adipose tissue; Adiposity - genetics; Adiposity - physiology; Adult; Alanine; Alanine transaminase; Analysis; Anthropometry; Apolipoprotein A; Apolipoprotein A-I; Apolipoprotein A-I - blood; Atherosclerosis; Auletta; Biology and Life Sciences; Biomarkers; Biomedical research; Blood tests; Body fat; Body measurements; Cardiovascular disease; Cholesterol; Coronary artery; Coronary artery disease; Coronary heart disease; Coronary vessels; Correlation; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus - enzymology; Diabetes Mellitus - pathology; Dual energy X-ray absorptiometry; Endocrinology; Enzymes; Fasting; Fatty acids; Female; Genomes; Genomics; Glucose; Glucose tolerance; Glucose Tolerance Test; Heart diseases; Hispanic Americans; Homeostasis; Hormones; Humans; Insulin; Insulin - blood; Insulin - genetics; Insulin resistance; Insulin Resistance - genetics; Insulin secretion; Lipase; Lipase - blood; Lipase - genetics; Lipids; Lipids - blood; Lipoproteins; Liver; Liver - enzymology; Male; Medicine; Medicine and Health Sciences; Metabolic syndrome; Mexican Americans - genetics; Obesity; Obesity - blood; Obesity - physiopathology; Pathogenesis; Physical Sciences; Population; Proteins; Research and Analysis Methods; Rodents; Secretion; Social Sciences; Type 2 diabetes; Ultrasound; Los Angeles California; Ohio; California; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0166263

Reduction in insulin clearance plays an important role in the compensatory response to insulin resistance. Given the importance of this trait to the pathogenesis of diabetes, a deeper understanding of its regulation is warranted. Our goal was to identify metabolic and cardiovascular traits that are independently associated with metabolic clearance rate of insulin (MCRI). We conducted a cross-sectional analysis of metabolic and cardiovascular traits in 765 participants from the Mexican-American Coronary Artery Disease (MACAD) project who had undergone blood sampling, oral glucose tolerance test, euglycemic-hyperinsulinemic clamp, dual-energy X-ray absorptiometry, and carotid ultrasound. We assessed correlations of MCRI with traits from seven domains, including anthropometry, biomarkers, cardiovascular, glucose homeostasis, lipase activity, lipid profile, and liver function tests. We found inverse independent correlations between MCRI and hepatic lipase (P = 0.0004), insulin secretion (P = 0.0002), alanine aminotransferase (P = 0.0045), total fat mass (P = 0.014), and diabetes (P = 0.03). MCRI and apolipoprotein A-I exhibited a positive independent correlation (P = 0.035). These results generate a hypothesis that lipid and adiposity associated traits related to liver function may play a role in insulin clearance.