A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes - Sharma, Sunita; Zhou, Xiaobo; Thibault, Derek M.; Himes, Blanca E.; Liu, Andy; Szefler, Stanley J.; Strunk, Robert; Castro, Mario; Hansel, Nadia N.; Diette, Gregory B.; Vonakis, Becky M.; Adkinson, N. Franklin; et al. (Journal of allergy and clinical immunology, 2014)
Keywords: Allergy and Immunology; alpha-N-Acetylgalactosaminidase - genetics; alpha-N-Acetylgalactosaminidase - immunology; Asthma; Asthma - epidemiology; Asthma - genetics; Asthma - immunology; Asthma - pathology; Biological and medical sciences; CD4+ lymphocytes; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - pathology; Child; Child, Preschool; Chronic obstructive pulmonary disease, asthma; Costa Rica; Disease; Double-Blind Method; Epidemiology; expression quantitative trait locus; Families & family life; Fatty Acid Desaturases - genetics; Fatty Acid Desaturases - immunology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene expression; Genome-Wide Association Study; Genomes; haplotype; Hospitals; Humans; Immunopathology; integrative genomics; Lymphocytes; Male; Medical sciences; Pneumology; Polymorphism, Single Nucleotide; regulatory variants; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Studies; Costa Rica; CD4+ lymphocytes; integrative genomics; haplotype; GWAS; Asthma BRIDGE; PUFA; regulatory variants; F13A1; NAGA; eQTL; ChIP; Asthma; FADS2; expression quantitative trait locus; SNP; FDR; FAIRE; LD; qPCR; CAMP; FADS1; eSNP; Linkage disequilibrium; Fatty acid desaturase 2; Formaldehyde-assisted isolation of regulatory elements; Fatty acid desaturase 1; Asthma Biorepository for Integrative Genomic Exploration; Genome-wide association study; N-acetyl-α-D-galactosaminidase; CD4 + lymphocytes; Chromatin immunoprecipitation; Childhood Asthma Management Program; Polyunsaturated fatty acid; Quantitative PCR; Factor XIII, A1; False discovery rate; Single nucleotide polymorphism; Expression-associated variant; Genetic variability; Quantitative character; Genomics; Immunology; Gene; T-Lymphocyte; Bronchus disease; Genetics; Obstructive pulmonary disease; Locus; Haplotype; Lung disease; Immunopathology; lymphocytes; Respiratory disease; Genetic variant; Genotype; Survey; CD4