LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction - Sanders, Laurie H.; Laganière, Josée; Cooper, Oliver; Mak, Sally K.; Vu, B. Joseph; Huang, Y. Anne; Paschon, David E.; Vangipuram, Malini; Sundararajan, Ramya; Urnov, Fyodor D.; Langston, J. William; Gregory, Philip D.; et al. (Neurobiology of disease, 2014)
Keywords: Adult; Aged; DNA Damage; DNA Repair; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Female; Humans; Induced Pluripotent Stem Cells - metabolism; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; LRRK2; Male; Middle Aged; Mitochondrial DNA damage; Mutation; Neural Stem Cells - metabolism; Neurology; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson's disease; Protein-Serine-Threonine Kinases - genetics; Stem cells; Targeted Gene Repair; Zinc Fingers; Parkinson's disease; LRRK2; Mitochondrial DNA damage; Stem cells