Effect of Hemodialysis on Total and Free Lenvatinib Concentrations in a Patient With Metastatic Renal Cell Carcinoma

Saved in:
Bibliographic Details
Published inIJU case reports
Main Authors Ito, Takahiro, Yamashita, Shimpei, Suno, Manabu, Iwata, Ayaka, Kohjimoto, Yasuo, Matsubara, Kazuo
Format Journal Article
LanguageEnglish
Published 22.09.2025
Online AccessGet full text
ISSN2577-171X
2577-171X
DOI10.1002/iju5.70099

Cover

Author Yamashita, Shimpei
Ito, Takahiro
Suno, Manabu
Iwata, Ayaka
Matsubara, Kazuo
Kohjimoto, Yasuo
Author_xml – sequence: 1
  givenname: Takahiro
  surname: Ito
  fullname: Ito, Takahiro
  organization: School of Pharmaceutical Sciences Wakayama Medical University Wakayama Japan
– sequence: 2
  givenname: Shimpei
  orcidid: 0000-0001-7402-6164
  surname: Yamashita
  fullname: Yamashita, Shimpei
  organization: Department of Urology Wakayama Medical University Wakayama Japan
– sequence: 3
  givenname: Manabu
  orcidid: 0000-0002-1511-7725
  surname: Suno
  fullname: Suno, Manabu
  organization: School of Pharmaceutical Sciences Wakayama Medical University Wakayama Japan
– sequence: 4
  givenname: Ayaka
  surname: Iwata
  fullname: Iwata, Ayaka
  organization: School of Pharmaceutical Sciences Wakayama Medical University Wakayama Japan
– sequence: 5
  givenname: Yasuo
  surname: Kohjimoto
  fullname: Kohjimoto, Yasuo
  organization: Department of Urology Wakayama Medical University Wakayama Japan
– sequence: 6
  givenname: Kazuo
  surname: Matsubara
  fullname: Matsubara, Kazuo
  organization: School of Pharmaceutical Sciences Wakayama Medical University Wakayama Japan, Department of Pharmacy Wakayama Medical University Hospital Wakayama Japan
BookMark eNpNkEFLAzEQhYNUsNZe_AVzFrYmm02ye5SltcKKIgW9LdlsginbRJIo9N-bqgcvM_M-hsfMu0Qz551G6JrgFcG4vLX7T7YSGDfNGZqXTIiCCPI2-zdfoGWMe5yXMaG8KucorY3RKoE3sNUHP1o5HaON4B3sfJITSDfCJmgNnXZfMllnB2i9U9qlkKV3EawDCc9ZZAavNr3Do04ypkwUvGiXXVo95SKDss4f5BU6N3KKevnXF2i3We_abdE93T-0d12hBGmKgTBWYkVM2WBVVWoc6lHkw0fOK47NYHjNBK-potJIWmvCappf4yxzzAihC3Tza6uCjzFo038Ee5Dh2BPcnxLrT4n1P4nRb2BUX9c
Cites_doi 10.1016/j.jpba.2015.05.008
10.1200/JCO.22.00868
10.1007/s00280-021-04286-2
10.1007/s00280-020-04178-x
10.1016/j.jchromb.2012.01.004
10.1002/iju5.70011
10.1056/NEJMoa2035716
10.1016/j.cca.2025.120188
10.1002/ijc.23131
10.1158/1078-0432.CCR-10-2638
10.1007/s00280-015-2899-0
ContentType Journal Article
DBID AAYXX
CITATION
DOI 10.1002/iju5.70099
DatabaseName CrossRef
DatabaseTitle CrossRef
DeliveryMethod fulltext_linktorsrc
EISSN 2577-171X
ExternalDocumentID 10_1002_iju5_70099
GroupedDBID 0R~
1OC
24P
7RV
7X7
8FI
8FJ
AAMMB
AAYXX
ABUWG
ACCMX
ACXQS
ADBBV
ADKYN
ADPDF
ADZMN
AEFGJ
AFKRA
AGXDD
AIDQK
AIDYY
ALMA_UNASSIGNED_HOLDINGS
AVUZU
BCNDV
BENPR
CCPQU
CITATION
EBS
FYUFA
GROUPED_DOAJ
HMCUK
IAO
IHR
INH
ITC
M~E
NAPCQ
OK1
OVD
OVEED
PHGZM
PHGZT
PIMPY
PPXIY
PQQKQ
PUEGO
RPM
TEORI
UKHRP
WIN
ID FETCH-LOGICAL-c719-b15520c1f290c44cdb8d7201d66460fbf6857683c3afa38e15830006568505113
ISSN 2577-171X
IngestDate Thu Sep 25 00:47:19 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c719-b15520c1f290c44cdb8d7201d66460fbf6857683c3afa38e15830006568505113
ORCID 0000-0002-1511-7725
0000-0001-7402-6164
OpenAccessLink https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iju5.70099
ParticipantIDs crossref_primary_10_1002_iju5_70099
PublicationCentury 2000
PublicationDate 2025-09-22
PublicationDateYYYYMMDD 2025-09-22
PublicationDate_xml – month: 09
  year: 2025
  text: 2025-09-22
  day: 22
PublicationDecade 2020
PublicationTitle IJU case reports
PublicationYear 2025
References Noda S. (e_1_2_8_5_1) 2021; 88
Dubbelman A. C. (e_1_2_8_10_1) 2012; 887
Rathmell W. K. (e_1_2_8_3_1) 2022; 40
Motzer R. (e_1_2_8_4_1) 2021; 384
Sueshige Y. (e_1_2_8_9_1) 2025; 569
Mano Y. (e_1_2_8_8_1) 2015; 114
Yamashita S. (e_1_2_8_7_1) 2025; 8
Hata K. (e_1_2_8_6_1) 2020; 86
e_1_2_8_11_1
Matsui J. (e_1_2_8_2_1) 2008; 122
Yamada K. (e_1_2_8_12_1) 2011; 17
Nakamichi S. (e_1_2_8_13_1) 2015; 76
References_xml – volume: 114
  start-page: 82
  year: 2015
  ident: e_1_2_8_8_1
  article-title: A Validated LC‐MS/MS Method of Total and Unbound Lenvatinib Quantification in Human Serum for Protein Binding Studies by Equilibrium Dialysis
  publication-title: Journal of Pharmaceutical and Biomedical Analysis
  doi: 10.1016/j.jpba.2015.05.008
– volume: 40
  start-page: 2957
  year: 2022
  ident: e_1_2_8_3_1
  article-title: Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline
  publication-title: Journal of Clinical Oncology
  doi: 10.1200/JCO.22.00868
– volume: 88
  start-page: 281
  year: 2021
  ident: e_1_2_8_5_1
  article-title: Exploratory Analysis of Target Concentration of Lenvatinib in the Treatment of Hepatocellular Carcinoma
  publication-title: Cancer Chemotherapy and Pharmacology
  doi: 10.1007/s00280-021-04286-2
– volume: 86
  start-page: 803
  year: 2020
  ident: e_1_2_8_6_1
  article-title: Association of Lenvatinib Plasma Concentration With Clinical Efficacy and Adverse Events in Patients With Hepatocellular Carcinoma
  publication-title: Cancer Chemotherapy and Pharmacology
  doi: 10.1007/s00280-020-04178-x
– volume: 887
  start-page: 25
  year: 2012
  ident: e_1_2_8_10_1
  article-title: Development and Validation of LC‐MS/MS Assays for the Quantification of E7080 and Metabolites in Various Human Biological Matrices
  publication-title: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
  doi: 10.1016/j.jchromb.2012.01.004
– volume: 8
  start-page: 223
  year: 2025
  ident: e_1_2_8_7_1
  article-title: Pembrolizumab Plus Lenvatinib for Metastatic Renal Cell Carcinoma in a Patient on Hemodialysis
  publication-title: IJU Case Reports
  doi: 10.1002/iju5.70011
– volume: 384
  start-page: 1289
  year: 2021
  ident: e_1_2_8_4_1
  article-title: Lenvatinib Plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma
  publication-title: New England Journal of Medicine
  doi: 10.1056/NEJMoa2035716
– volume: 569
  year: 2025
  ident: e_1_2_8_9_1
  article-title: Sensitive Quantification of Free Lenvatinib Using Ultra‐High Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry and the Clinical Significance of Measuring Free Lenvatinib Concentration
  publication-title: Clinica Chimica Acta
  doi: 10.1016/j.cca.2025.120188
– ident: e_1_2_8_11_1
– volume: 122
  start-page: 664
  year: 2008
  ident: e_1_2_8_2_1
  article-title: E7080, a Novel Inhibitor That Targets Multiple Kinases, Has Potent Antitumor Activities Against Stem Cell Factor Producing Human Small Cell Lung Cancer H146, Based on Angiogenesis Inhibition
  publication-title: International Journal of Cancer
  doi: 10.1002/ijc.23131
– volume: 17
  start-page: 2528
  year: 2011
  ident: e_1_2_8_12_1
  article-title: Phase I Dose‐Escalation Study and Biomarker Analysis of E7080 in Patients With Advanced Solid Tumors
  publication-title: Clinical Cancer Research
  doi: 10.1158/1078-0432.CCR-10-2638
– volume: 76
  start-page: 1153
  year: 2015
  ident: e_1_2_8_13_1
  article-title: A Phase 1 Study of Lenvatinib, Multiple Receptor Tyrosine Kinase Inhibitor, in Japanese Patients With Advanced Solid Tumors
  publication-title: Cancer Chemotherapy and Pharmacology
  doi: 10.1007/s00280-015-2899-0
SSID ssj0002013642
Score 2.3076215
SourceID crossref
SourceType Index Database
Title Effect of Hemodialysis on Total and Free Lenvatinib Concentrations in a Patient With Metastatic Renal Cell Carcinoma
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2577-171X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002013642
  issn: 2577-171X
  databaseCode: DOA
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources (ISSN International Center)
  customDbUrl:
  eissn: 2577-171X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002013642
  issn: 2577-171X
  databaseCode: M~E
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central (Free e-resource, activated by CARLI)
  customDbUrl:
  eissn: 2577-171X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002013642
  issn: 2577-171X
  databaseCode: RPM
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVOVD
  databaseName: Journals@Ovid LWW All Open Access Journal Collection Rolling
  customDbUrl:
  eissn: 2577-171X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002013642
  issn: 2577-171X
  databaseCode: OVEED
  dateStart: 20190301
  isFulltext: true
  titleUrlDefault: http://ovidsp.ovid.com/
  providerName: Ovid
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2577-171X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002013642
  issn: 2577-171X
  databaseCode: 7X7
  dateStart: 20190301
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 2577-171X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002013642
  issn: 2577-171X
  databaseCode: BENPR
  dateStart: 20190301
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVWIB
  databaseName: KBPluse Wiley Online Library: Open Access
  customDbUrl:
  eissn: 2577-171X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002013642
  issn: 2577-171X
  databaseCode: AVUZU
  dateStart: 20181101
  isFulltext: true
  titleUrlDefault: https://www.kbplus.ac.uk/kbplus7/publicExport/pkg/559
  providerName: Wiley-Blackwell
– providerCode: PRVWIB
  databaseName: Wiley Online Library Open Access (Activated by CARLI)
  customDbUrl:
  eissn: 2577-171X
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0002013642
  issn: 2577-171X
  databaseCode: 24P
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  providerName: Wiley-Blackwell
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3Pb9MwFMctGBcuCASI33oS3KqMxE6c5jhVTGPSuJBJu1W2Y6sZWjJVqRD89bxnp06gHAaXKLISt80nff7afj8Y-6BTp4WSRSKbyiZ5U6qkUipNtLSqEgYFbUbxzhdf5Nllfn5VXE0hBD66ZNDH5udf40r-hyq2IVeKkv0HsrFTbMBz5ItHJIzHOzEeUw_TWry96SkEJOQX6RZ1P4xJAE63loJ2Olp67VpNIX7BITM6kSvK009hkWgihs3iwg6Kwoy8hz1p1RUt762o5lDXj1Z8VLOfzy8XBofB_c5DfM98baZFrb6pTbvto2VRN1S6KejVr5sWFXs7bUr5GuDeHUfvYkffVbj65Af2NV-h4AW5U_DZoiVaBUpE6Uvj4Jhz2HZgxkNa2PZ6VxyXpGGnwWq_Qf_HGBY9C0MWZr6me9f-3vvsAS-l5LPp9rXfgM2E9LWV4leJ2Wv5x-mjZ3plJjzqx-zROGOAk4D_Cbtnu6dsCOihdzBHD30HHj0geiD0MKGH39FD24GCET0QepjQg0cPhB4i-mesPv1Ur86SsYBGYsqsSjSl10tN5niVmjw3jV42Jf7uRspc4n_UySXNNoURyimxtFmxFF6TYjva6kw8Z0dd39kXDHDWXnq9qITDGTnXtP1dFs44njrR2Jfs_f4prW9DmpT1IYpXd7rqNXs4vUVv2NGw3dm3qPwG_c4j_AWmVFrV
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+Hemodialysis+on+Total+and+Free+Lenvatinib+Concentrations+in+a+Patient+With+Metastatic+Renal+Cell+Carcinoma&rft.jtitle=IJU+case+reports&rft.au=Ito%2C+Takahiro&rft.au=Yamashita%2C+Shimpei&rft.au=Suno%2C+Manabu&rft.au=Iwata%2C+Ayaka&rft.date=2025-09-22&rft.issn=2577-171X&rft.eissn=2577-171X&rft_id=info:doi/10.1002%2Fiju5.70099&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_iju5_70099
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2577-171X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2577-171X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2577-171X&client=summon