Impulsivity across reactive, proactive and cognitive domains in Parkinson's disease on dopaminergic medication: Evidence for multiple domain impairment

• Published in: PloS one Vol. 14; no. 2; p. e0210880
• Main Authors: Canário, Nádia, Sousa, Mário, Moreira, Fradique, Duarte, Isabel Catarina, Oliveira, Francisco, Januário, Cristina, Castelo-Branco, Miguel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.02.2019; Public Library of Science (PLoS)
• Subjects: Addictive behaviors; Aged; Behavior; Biology and Life Sciences; Brain research; Care and treatment; Cognitive ability; Complications and side effects; Decision making; Diagnosis; Disease control; Dopamine; Dopamine Agents - administration & dosage; Dopamine Agents - adverse effects; Dopamine receptors; Drugs; Female; Gambling; Health informatics; Hospitals; Humans; Impairment; Impulse control disorders; Impulsive behavior; Impulsive Behavior - drug effects; Impulsivity; Laboratories; Life sciences; Male; Medical imaging; Medical research; Medicine and Health Sciences; Middle Aged; Motor Activity - drug effects; Movement disorders; Neurodegenerative diseases; Neurology; NMR; Non-Randomized Controlled Trials as Topic; Nuclear magnetic resonance; Parkinson disease; Parkinson Disease - drug therapy; Parkinson Disease - physiopathology; Parkinson's disease; Parkinsons disease; Patients; Physical Sciences; Reinforcement; Risk factors; Risk taking; Social Sciences; Strategy; Studies; Task Performance and Analysis; Portugal
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0210880

Impulse control disorders (ICD) may occur in Parkinson's disease (PD) although it remains to be understood if such deficits may occur even in the absence of a formal ICD diagnosis. Moreover, studies addressing simultaneously distinct neurobehavioral domains, such as cognitive, proactive and reactive motor impulsivity, are still lacking. Here, we aimed to investigate if reactive, proactive and cognitive impulsivity involving risk taking are concomitantly affected in medicated PD patients, and whether deficits were dependent on response strategies, such as speed accuracy tradeoffs, or the proportion of omission vs. commission errors. We assessed three different impulsivity domains in a sample of 21 PD patients and 13 matched controls. We found impaired impulsivity in both reactive (p = 0.042) and cognitive domains (p = 0.015) for the PD patients, irrespective of response strategy. For the latter, effect sizes were larger for the actions related with reward processing (p = 0.017, dCohen = 0.9). In the proactive impulsivity task, PD patients showed significantly increased number of omissions (p = 0.041), a response strategy which was associated with preserved number of commission errors. Moreover, the number of premature and proactive response errors were correlated with disease stage. Our findings suggest that PD ON medication is characterized compared to healthy controls by impairment across several impulsivity domains, which is moderated in the proactive domain by the response strategy.