Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated “Big Bang” pathway to CRC in three of the four Lynch syndromes - Møller, Pål; Haupt, Saskia; Ahadova, Aysel; Kloor, Matthias; Sampson, Julian R.; Sunde, Lone; Seppälä, Toni; Burn, John; Bernstein, Inge; Capella, Gabriel; Evans, D. Gareth; Lindblom, Annika; et al. (Hereditary cancer in clinical practice, 2024)
Keywords: Adenoma; Age; Analysis; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Carcinoma; Colon; Colonoscopy; Colorectal cancer; dMMR; Genetic disorders; Human Genetics; Immune system; Malignancy; Medical prognosis; Mismatch repair; MLH1; MLH1 protein; MSH2; MSH2 protein; MSH6; MSH6 protein; MSI; Mutation; Mutation rates; Oncology; PMS2; Polyps; Prevention; Regression analysis; Surveillance; Tumors; dMMR; MSI; Colorectal; Colonoscopy; Sojourn time; cancer; Adenoma; Lynch syndromes; MSH6; MSH2; PMS2; MLH1