Microarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease
Background Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestina...
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| Published in | BMC microbiology Vol. 13; no. 1; p. 12 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
23.01.2013
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1471-2180 1471-2180 |
| DOI | 10.1186/1471-2180-13-12 |
Cover
| Abstract | Background
Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either
Lactobacillus rhamnosus
GG or placebo.
Results
Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson’s reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the
Clostridium
clusters IV and XIVa, which are typically abundant in adults. Probiotic
Lactobacillus rhamnosus
GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition.
Conclusion
A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. |
|---|---|
| AbstractList | Abstract Background Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo. Results Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson’s reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition. Conclusion A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. Background: Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo. Results: Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson's reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition. Conclusion: A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo. Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson's reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition. A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. BACKGROUND: Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo. RESULTS: Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson's reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition. CONCLUSION: A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema Doc number: 12 Abstract Background: Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo. Results: Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson's reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition. Conclusion: A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo. Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson's reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition. A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. Background Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo. Results Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson's reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition. Conclusion A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. Keywords: Infant, Intestinal microbiota, Microbiota diversity, Phylogenetic microarray, Eczema Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo.BACKGROUNDDeviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo.Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson's reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition.RESULTSChildren with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson's reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition.A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema.CONCLUSIONA diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. Background Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intestinal microbiota in infancy and to define specific bacterial signatures associated with eczema. Faecal microbiota at 6 and 18 months of age were analysed from 34 infants (15 with eczema and 19 healthy controls) selected from a prospective follow-up study based on the availability of faecal samples. The infants were originally randomized to receive either Lactobacillus rhamnosus GG or placebo. Results Children with eczema harboured a more diverse total microbiota than control subjects as assessed by the Simpson’s reciprocal diversity index of the microarray profiles. Composition of the microbiota did not differ between study groups at age of 6 months, but was significantly different at age of 18 months as assessed by MCPP (p=0.01). At this age healthy children harboured 3 -fold greater amount of members of the Bacteroidetes (p=0.01). Microbiota of children suffering from eczema had increased abundance of the Clostridium clusters IV and XIVa, which are typically abundant in adults. Probiotic Lactobacillus rhamnosus GG supplementation in early infancy was observed to have minor long-term effects on the microbiota composition. Conclusion A diverse and adult-type microbiota in early childhood is associated with eczema and it may contribute to the perpetuation of eczema. |
| Audience | Academic |
| Author | Rajilić-Stojanović, Mirjana Satokari, Reetta Nikkilä, Janne Kalliomäki, Marko Nylund, Lotta Isolauri, Erika de Vos, Willem M Salminen, Seppo |
| AuthorAffiliation | 1 Functional Foods Forum, University of Turku, Turku, FI-20014, Finland 5 Department for Biotechnology and Biochemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia 2 Department of Veterinary Biosciences and Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland 3 Finnish Red Cross Blood Service, Helsinki, Finland 6 Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland 4 Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands |
| AuthorAffiliation_xml | – name: 4 Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands – name: 6 Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland – name: 5 Department for Biotechnology and Biochemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia – name: 2 Department of Veterinary Biosciences and Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland – name: 3 Finnish Red Cross Blood Service, Helsinki, Finland – name: 1 Functional Foods Forum, University of Turku, Turku, FI-20014, Finland |
| Author_xml | – sequence: 1 givenname: Lotta surname: Nylund fullname: Nylund, Lotta email: lotta.nylund@utu.fi organization: Functional Foods Forum, University of Turku, Department of Veterinary Biosciences and Department of Bacteriology and Immunology, University of Helsinki – sequence: 2 givenname: Reetta surname: Satokari fullname: Satokari, Reetta organization: Functional Foods Forum, University of Turku, Department of Veterinary Biosciences and Department of Bacteriology and Immunology, University of Helsinki – sequence: 3 givenname: Janne surname: Nikkilä fullname: Nikkilä, Janne organization: Department of Veterinary Biosciences and Department of Bacteriology and Immunology, University of Helsinki, Finnish Red Cross Blood Service – sequence: 4 givenname: Mirjana surname: Rajilić-Stojanović fullname: Rajilić-Stojanović, Mirjana organization: Laboratory of Microbiology, Wageningen University, Department for Biotechnology and Biochemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade – sequence: 5 givenname: Marko surname: Kalliomäki fullname: Kalliomäki, Marko organization: Department of Pediatrics, University of Turku and Turku University Hospital – sequence: 6 givenname: Erika surname: Isolauri fullname: Isolauri, Erika organization: Department of Pediatrics, University of Turku and Turku University Hospital – sequence: 7 givenname: Seppo surname: Salminen fullname: Salminen, Seppo organization: Functional Foods Forum, University of Turku – sequence: 8 givenname: Willem M surname: de Vos fullname: de Vos, Willem M organization: Department of Veterinary Biosciences and Department of Bacteriology and Immunology, University of Helsinki, Laboratory of Microbiology, Wageningen University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23339708$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Nylund et al.; licensee BioMed Central Ltd. 2013 COPYRIGHT 2013 BioMed Central Ltd. 2013 Nylund et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright ©2013 Nylund et al.; licensee BioMed Central Ltd. 2013 Nylund et al.; licensee BioMed Central Ltd. Wageningen University & Research |
| Copyright_xml | – notice: Nylund et al.; licensee BioMed Central Ltd. 2013 – notice: COPYRIGHT 2013 BioMed Central Ltd. – notice: 2013 Nylund et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. – notice: Copyright ©2013 Nylund et al.; licensee BioMed Central Ltd. 2013 Nylund et al.; licensee BioMed Central Ltd. – notice: Wageningen University & Research |
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| DOI | 10.1186/1471-2180-13-12 |
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| Keywords | Infant Phylogenetic microarray Intestinal microbiota Microbiota diversity Eczema |
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Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic... Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema.... Background Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic... Doc number: 12 Abstract Background: Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development... Background: Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic... BACKGROUND: Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic... Abstract Background Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence... |
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| SubjectTerms | Age Allergies Asthma Bacteria Bacteria - classification Bacteria - genetics Biodiversity Biological Microscopy Biomedical and Life Sciences Care and treatment Clostridium Dermatitis, Atopic - microbiology Disease DNA microarrays double-blind Ecological and evolutionary microbiology Eczema fecal microbiota Female Follow-Up Studies galacto-oligosaccharides Gastrointestinal Tract - microbiology gastrointestinal-tract Genetic aspects gut microbiota Health aspects Humans immunoglobulin-e Infant Infants Intestinal microbiota Lactobacillus rhamnosus Life Sciences Male Metagenome Microarray Analysis Microbiology Microbiota (Symbiotic organisms) Microbiota diversity molecular analysis Mycology Parasitology Phylogenetic microarray Phylogenetics Phylogeny placebo-controlled trial Placebos - administration & dosage primary prevention Probiotics Probiotics - administration & dosage Randomized Controlled Trials as Topic Research Article Risk factors Skin diseases Technological change Virology |
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| Title | Microarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease |
| URI | https://link.springer.com/article/10.1186/1471-2180-13-12 https://www.ncbi.nlm.nih.gov/pubmed/23339708 https://www.proquest.com/docview/1283633361 https://www.proquest.com/docview/1284621984 https://www.proquest.com/docview/1291609151 https://pubmed.ncbi.nlm.nih.gov/PMC3563445 http://www.narcis.nl/publication/RecordID/oai:library.wur.nl:wurpubs%2F437392 https://doaj.org/article/a76c7805223a48dc88a43d17ae99706d |
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