Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease
Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects,...
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Published in | Alzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 11; no. 1; pp. 483 - 492 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.12.2019
Elsevier Wiley |
Subjects | |
Online Access | Get full text |
ISSN | 2352-8729 2352-8729 |
DOI | 10.1016/j.dadm.2019.05.001 |
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Abstract | Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear.
Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations.
Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively.
Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures.
•Both plasma- and CSF-tau are elevated in patients with AD recruited at the NYU Center for Brain Health.•Plasma tau is correlated with cognition, but not with CSF tau, in AD.•Plasma tau increases diagnostic accuracy (AUC) when added to CSF-tau or P-tau.•SIMOA and ELISA assays performed in the same CSF samples are strongly correlated.•Plasma- and CSF-tau measures appear complementary. The reasons warrant further investigation. |
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AbstractList | Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear.
Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations.
Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively.
Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures.
•Both plasma- and CSF-tau are elevated in patients with AD recruited at the NYU Center for Brain Health.•Plasma tau is correlated with cognition, but not with CSF tau, in AD.•Plasma tau increases diagnostic accuracy (AUC) when added to CSF-tau or P-tau.•SIMOA and ELISA assays performed in the same CSF samples are strongly correlated.•Plasma- and CSF-tau measures appear complementary. The reasons warrant further investigation. Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Plasma tau was higher in patients with AD than cognitively normal controls ( < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear.INTRODUCTIONPlasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear.Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations.METHODSPlasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations.Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively.RESULTSPlasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively.Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures.DISCUSSIONPlasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. Introduction Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho‐tau (P‐tau) are still unclear. Methods Plasma‐tau, CSF‐tau, and P‐tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Results Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P‐tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P‐tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Discussion Plasma tau is higher in AD independently from CSF‐tau. Importantly, adding plasma tau to CSF tau or P‐tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. Highlights •Both plasma‐ and CSF‐tau are elevated in patients with AD recruited at the NYU Center for Brain Health. •Plasma tau is correlated with cognition, but not with CSF tau, in AD. •Plasma tau increases diagnostic accuracy (AUC) when added to CSF‐tau or P‐tau. •SIMOA and ELISA assays performed in the same CSF samples are strongly correlated. •Plasma‐ and CSF‐tau measures appear complementary. The reasons warrant further investigation. • Both plasma- and CSF-tau are elevated in patients with AD recruited at the NYU Center for Brain Health. • Plasma tau is correlated with cognition, but not with CSF tau, in AD. • Plasma tau increases diagnostic accuracy (AUC) when added to CSF-tau or P-tau. • SIMOA and ELISA assays performed in the same CSF samples are strongly correlated. • Plasma- and CSF-tau measures appear complementary. The reasons warrant further investigation. Abstract Introduction Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho‐tau (P‐tau) are still unclear. Methods Plasma‐tau, CSF‐tau, and P‐tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Results Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P‐tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P‐tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Discussion Plasma tau is higher in AD independently from CSF‐tau. Importantly, adding plasma tau to CSF tau or P‐tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. Introduction: Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Methods: Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Results: Plasma tau was higher in patients with AD than cognitively normal controls (P <.001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Discussion: Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. © 2019 The Authors |
Author | Debure, Ludovic Butler, Tracy Fossati, Silvia Ramos Cejudo, Jaime Zetterberg, Henrik Blennow, Kaj Chen, Jingyun Pirraglia, Elizabeth Sone, Je Yeong Li, Yi de Leon, Mony J. |
AuthorAffiliation | d Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden b Department of Neurology, New York University, School of Medicine, New York, NY, USA f UK Dementia Research Institute at UCL, London, United Kingdom c Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden a Department of Psychiatry, New York University, School of Medicine, New York, NY, USA e Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom |
AuthorAffiliation_xml | – name: d Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden – name: a Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – name: c Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden – name: e Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom – name: b Department of Neurology, New York University, School of Medicine, New York, NY, USA – name: f UK Dementia Research Institute at UCL, London, United Kingdom |
Author_xml | – sequence: 1 givenname: Silvia surname: Fossati fullname: Fossati, Silvia email: Silvia.Fossati@temple.edu organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – sequence: 2 givenname: Jaime surname: Ramos Cejudo fullname: Ramos Cejudo, Jaime organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – sequence: 3 givenname: Ludovic surname: Debure fullname: Debure, Ludovic organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – sequence: 4 givenname: Elizabeth surname: Pirraglia fullname: Pirraglia, Elizabeth organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – sequence: 5 givenname: Je Yeong surname: Sone fullname: Sone, Je Yeong organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – sequence: 6 givenname: Yi surname: Li fullname: Li, Yi organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – sequence: 7 givenname: Jingyun surname: Chen fullname: Chen, Jingyun organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – sequence: 8 givenname: Tracy surname: Butler fullname: Butler, Tracy organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA – sequence: 9 givenname: Henrik surname: Zetterberg fullname: Zetterberg, Henrik organization: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden – sequence: 10 givenname: Kaj surname: Blennow fullname: Blennow, Kaj organization: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden – sequence: 11 givenname: Mony J. surname: de Leon fullname: de Leon, Mony J. organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31334328$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/282611$$DView record from Swedish Publication Index |
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Keywords | CSF tau Plasma tau Cognition MRI CSF P-Tau Blood biomarkers |
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Notes | silvia.fossati@temple.edu Current address: Alzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19,140, USA. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Current address: Alzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19,140, USA. silvia.fossati@temple.edu |
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Snippet | Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of... Introduction Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and... • Both plasma- and CSF-tau are elevated in patients with AD recruited at the NYU Center for Brain Health. • Plasma tau is correlated with cognition, but not... Introduction: Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and... Abstract Introduction Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF)... |
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SubjectTerms | Blood biomarkers Cognition CSF P-Tau CSF tau MRI Neurosciences Neurovetenskaper Plasma tau Special Section: Blood-Based Biomarkers for Alzheimer's Disease & Related Dementias. (Editor: Henrik Zetterberg) |
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Title | Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease |
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