Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease

Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects,...

Full description

Saved in:
Bibliographic Details
Published inAlzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 11; no. 1; pp. 483 - 492
Main Authors Fossati, Silvia, Ramos Cejudo, Jaime, Debure, Ludovic, Pirraglia, Elizabeth, Sone, Je Yeong, Li, Yi, Chen, Jingyun, Butler, Tracy, Zetterberg, Henrik, Blennow, Kaj, de Leon, Mony J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2019
Elsevier
Wiley
Subjects
Online AccessGet full text
ISSN2352-8729
2352-8729
DOI10.1016/j.dadm.2019.05.001

Cover

Abstract Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. •Both plasma- and CSF-tau are elevated in patients with AD recruited at the NYU Center for Brain Health.•Plasma tau is correlated with cognition, but not with CSF tau, in AD.•Plasma tau increases diagnostic accuracy (AUC) when added to CSF-tau or P-tau.•SIMOA and ELISA assays performed in the same CSF samples are strongly correlated.•Plasma- and CSF-tau measures appear complementary. The reasons warrant further investigation.
AbstractList Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. •Both plasma- and CSF-tau are elevated in patients with AD recruited at the NYU Center for Brain Health.•Plasma tau is correlated with cognition, but not with CSF tau, in AD.•Plasma tau increases diagnostic accuracy (AUC) when added to CSF-tau or P-tau.•SIMOA and ELISA assays performed in the same CSF samples are strongly correlated.•Plasma- and CSF-tau measures appear complementary. The reasons warrant further investigation.
Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Plasma tau was higher in patients with AD than cognitively normal controls (  < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures.
Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear.INTRODUCTIONPlasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear.Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations.METHODSPlasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations.Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively.RESULTSPlasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively.Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures.DISCUSSIONPlasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures.
Introduction Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho‐tau (P‐tau) are still unclear. Methods Plasma‐tau, CSF‐tau, and P‐tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Results Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P‐tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P‐tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Discussion Plasma tau is higher in AD independently from CSF‐tau. Importantly, adding plasma tau to CSF tau or P‐tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. Highlights •Both plasma‐ and CSF‐tau are elevated in patients with AD recruited at the NYU Center for Brain Health. •Plasma tau is correlated with cognition, but not with CSF tau, in AD. •Plasma tau increases diagnostic accuracy (AUC) when added to CSF‐tau or P‐tau. •SIMOA and ELISA assays performed in the same CSF samples are strongly correlated. •Plasma‐ and CSF‐tau measures appear complementary. The reasons warrant further investigation.
• Both plasma- and CSF-tau are elevated in patients with AD recruited at the NYU Center for Brain Health. • Plasma tau is correlated with cognition, but not with CSF tau, in AD. • Plasma tau increases diagnostic accuracy (AUC) when added to CSF-tau or P-tau. • SIMOA and ELISA assays performed in the same CSF samples are strongly correlated. • Plasma- and CSF-tau measures appear complementary. The reasons warrant further investigation.
Abstract Introduction Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho‐tau (P‐tau) are still unclear. Methods Plasma‐tau, CSF‐tau, and P‐tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Results Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P‐tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P‐tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Discussion Plasma tau is higher in AD independently from CSF‐tau. Importantly, adding plasma tau to CSF tau or P‐tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures.
Introduction: Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Methods: Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Results: Plasma tau was higher in patients with AD than cognitively normal controls (P <.001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. Plasma and CSF tau measures were poorly correlated. Adding plasma tau to CSF tau or CSF P-tau significantly increased the areas under the receiver operating characteristic curve from 0.80 and 0.82 to 0.87 and 0.88, respectively. Discussion: Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures. © 2019 The Authors
Author Debure, Ludovic
Butler, Tracy
Fossati, Silvia
Ramos Cejudo, Jaime
Zetterberg, Henrik
Blennow, Kaj
Chen, Jingyun
Pirraglia, Elizabeth
Sone, Je Yeong
Li, Yi
de Leon, Mony J.
AuthorAffiliation d Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
b Department of Neurology, New York University, School of Medicine, New York, NY, USA
f UK Dementia Research Institute at UCL, London, United Kingdom
c Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
a Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
e Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom
AuthorAffiliation_xml – name: d Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
– name: a Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– name: c Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
– name: e Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom
– name: b Department of Neurology, New York University, School of Medicine, New York, NY, USA
– name: f UK Dementia Research Institute at UCL, London, United Kingdom
Author_xml – sequence: 1
  givenname: Silvia
  surname: Fossati
  fullname: Fossati, Silvia
  email: Silvia.Fossati@temple.edu
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– sequence: 2
  givenname: Jaime
  surname: Ramos Cejudo
  fullname: Ramos Cejudo, Jaime
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– sequence: 3
  givenname: Ludovic
  surname: Debure
  fullname: Debure, Ludovic
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– sequence: 4
  givenname: Elizabeth
  surname: Pirraglia
  fullname: Pirraglia, Elizabeth
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– sequence: 5
  givenname: Je Yeong
  surname: Sone
  fullname: Sone, Je Yeong
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– sequence: 6
  givenname: Yi
  surname: Li
  fullname: Li, Yi
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– sequence: 7
  givenname: Jingyun
  surname: Chen
  fullname: Chen, Jingyun
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– sequence: 8
  givenname: Tracy
  surname: Butler
  fullname: Butler, Tracy
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
– sequence: 9
  givenname: Henrik
  surname: Zetterberg
  fullname: Zetterberg, Henrik
  organization: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
– sequence: 10
  givenname: Kaj
  surname: Blennow
  fullname: Blennow, Kaj
  organization: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
– sequence: 11
  givenname: Mony J.
  surname: de Leon
  fullname: de Leon, Mony J.
  organization: Department of Psychiatry, New York University, School of Medicine, New York, NY, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31334328$$D View this record in MEDLINE/PubMed
https://gup.ub.gu.se/publication/282611$$DView record from Swedish Publication Index
BookMark eNqNks1u1DAUhSNUREvpC7BA2cEmg3_ixJEQ0jClUFTESHR_5dg3U4-SeLCTVuXpcZoWdVhUyJJtXZ_zXcs-L5OD3vWYJK8pWVBCi_fbhVGmWzBCqwURC0Los-SIccEyWbLq4NH-MDkJYUuiIq9YTsmL5JBTznPO5FGyXrcqdCod1Jhq1-1a7LAfQrr6eXZXU71J19m0s306XGFqrNr0LtiQuiZdtr-v0Hbo34Z4EFAFfJU8b1Qb8OR-PU4uzz5frr5mFz--nK-WF5kuKaNZhbWgSLCmuqhqI5GXplK1ZiXJjeFVI-NUCkVko4iuuZCUcNpIpiWiYvw4OZ-xxqkt7LztlL8FpyzcFZzfgPKD1S1CXoi6yI2oK4p5qXSlpWxqnstKaoGiiKxsZoUb3I31Hm0z7iCWNiMEBCZZQWnUf5z1Udyh0fHBvGr3bPsnvb2CjbuGomB5HBHw7h7g3a8RwwCdDRrbVvXoxgCMFTmjuaAiSt887vW3ycMPRoGcBdq7EDw2oO2gBuum1rYFSmDKC2xhygtMeQEiIKYhWtk_1gf6k6ZPs-nGtnj7Hw44XZ6yb3H6PhWJmCEfZgjGhFxb9BC0xV6jsR71EP_QPnWHP1eI7Gs
CitedBy_id crossref_primary_10_14283_jarlife_2021_2
crossref_primary_10_3389_fnagi_2022_942629
crossref_primary_10_1007_s12035_022_03164_z
crossref_primary_10_18632_aging_104057
crossref_primary_10_1080_14737159_2022_2104639
crossref_primary_10_1016_j_biopha_2022_113257
crossref_primary_10_3389_fneur_2022_748599
crossref_primary_10_3233_JAD_200900
crossref_primary_10_3233_JAD_240690
crossref_primary_10_1016_j_arr_2021_101446
crossref_primary_10_2217_bmm_2021_0219
crossref_primary_10_1007_s40120_019_00166_3
crossref_primary_10_1007_s00415_022_11182_z
crossref_primary_10_1212_WNL_0000000000200004
crossref_primary_10_2147_JIR_S334337
crossref_primary_10_1186_s40035_021_00234_5
crossref_primary_10_3233_JAD_201499
crossref_primary_10_1002_alz_12813
crossref_primary_10_3233_JAD_221202
crossref_primary_10_1038_s41467_020_19957_6
crossref_primary_10_1111_jsr_13566
crossref_primary_10_3390_jpm10030061
crossref_primary_10_1016_j_bja_2023_04_019
crossref_primary_10_1002_dad2_12104
crossref_primary_10_3233_JAD_200912
crossref_primary_10_1007_s00018_024_05225_z
crossref_primary_10_1016_j_isci_2021_103262
crossref_primary_10_1148_radiol_2020200028
crossref_primary_10_1016_j_neubiorev_2021_07_007
crossref_primary_10_1159_000531849
crossref_primary_10_1016_j_neurobiolaging_2022_10_016
crossref_primary_10_1016_j_actatropica_2020_105675
crossref_primary_10_1021_jasms_2c00289
crossref_primary_10_1039_D2SC03932J
crossref_primary_10_1021_acssensors_4c02037
crossref_primary_10_3390_jpm11080702
crossref_primary_10_1186_s13195_021_00805_8
crossref_primary_10_1002_dad2_12099
crossref_primary_10_3233_JAD_220216
crossref_primary_10_1038_s41598_023_30167_0
crossref_primary_10_3389_fnagi_2022_1055170
crossref_primary_10_1212_NXG_0000000000200053
crossref_primary_10_1002_ptr_8006
crossref_primary_10_1016_j_smrv_2020_101375
crossref_primary_10_3389_fpsyg_2021_774049
crossref_primary_10_1038_s42003_022_03287_y
crossref_primary_10_1038_s41398_021_01709_9
crossref_primary_10_3233_JAD_231320
crossref_primary_10_1016_j_neuropharm_2020_108081
crossref_primary_10_1016_j_impact_2020_100251
crossref_primary_10_1038_s41598_020_60777_x
crossref_primary_10_3389_fnmol_2020_00106
crossref_primary_10_3233_JAD_230799
crossref_primary_10_1016_j_physbeh_2022_113840
crossref_primary_10_3389_fneur_2020_573324
crossref_primary_10_2174_1381612828666220413094918
crossref_primary_10_3233_ADR_230029
crossref_primary_10_14283_jfa_2022_17
crossref_primary_10_1016_j_neuint_2024_105761
crossref_primary_10_1016_j_bionps_2025_100120
crossref_primary_10_1016_j_neulet_2020_135003
crossref_primary_10_3233_JAD_221266
crossref_primary_10_1016_j_arr_2022_101654
crossref_primary_10_3390_biomedicines10040850
crossref_primary_10_25122_jml_2022_0251
crossref_primary_10_3233_JAD_210692
crossref_primary_10_1016_j_jpsychires_2021_10_031
crossref_primary_10_1093_braincomms_fcaa132
Cites_doi 10.1016/j.neuroimage.2006.01.021
10.1186/alzrt163
10.1083/jcb.143.3.777
10.2967/jnumed.116.187211
10.1038/nrneurol.2015.119
10.1176/ajp.139.9.1136
10.3109/02699052.2012.750752
10.3389/fnagi.2018.00027
10.1212/WNL.34.7.939
10.1001/jamaneurol.2017.0655
10.1097/WAD.0b013e318191c7dd
10.1016/j.jalz.2011.03.005
10.1016/S0304-3940(00)01036-3
10.1016/j.jalz.2016.06.001
10.1111/nan.12378
10.1385/NMM:2:2:151
10.3233/JAD-179926
10.1186/s40478-018-0649-3
10.3233/JAD-161114
10.1037/0894-4105.22.4.469
10.1093/jnen/nlv001
10.1016/j.jalz.2014.02.004
10.1212/WNL.43.11.2412-a
10.1016/j.jalz.2011.03.008
10.1016/j.jalz.2014.08.099
10.1038/s41582-018-0079-7
10.3233/JAD-150704
10.1016/S0021-9258(17)38495-8
10.1038/s41591-018-0304-3
10.1007/s00401-018-1891-2
10.3233/JAD-160652
10.3233/JAD-150167
10.1212/WNL.0000000000003246
10.1001/jamaneurol.2017.4913
10.1016/j.jalz.2018.02.013
10.1001/jamaneurol.2015.1383
10.1007/s40120-017-0073-9
10.1001/jamaneurol.2017.1359
10.1016/0022-3956(75)90026-6
10.1007/BF02935561
10.1007/BF02815140
10.2174/1567205015666180404165915
10.3389/fnagi.2018.00175
ContentType Journal Article
Copyright 2019 The Authors
2019 The Authors.
2019 The Authors 2019
Copyright_xml – notice: 2019 The Authors
– notice: 2019 The Authors.
– notice: 2019 The Authors 2019
DBID 6I.
AAFTH
24P
AAYXX
CITATION
NPM
7X8
5PM
ADTPV
AOWAS
F1U
DOA
DOI 10.1016/j.dadm.2019.05.001
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Wiley Online Library Open Access
CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
SwePub
SwePub Articles
SWEPUB Göteborgs universitet
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
PubMed
MEDLINE - Academic




Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: 24P
  name: Wiley Online Library Open Access
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 2352-8729
EndPage 492
ExternalDocumentID oai_doaj_org_article_465b64d5b91e47ac9c88fb34898c5e56
oai_gup_ub_gu_se_282611
PMC6624242
31334328
10_1016_j_dadm_2019_05_001
DAD2JDADM201905001
S2352872919300387
Genre article
Journal Article
GrantInformation_xml – fundername: European Research Council
– fundername: National Center for Advancing Translational Sciences
– fundername: Hjärnfonden
– fundername: American Heart Association
  funderid: 13SDG16860017
– fundername: Swedish Alzheimer Foundation
– fundername: NIH
  funderid: NS104127
– fundername: NIH
  funderid: AG022374
– fundername: Swedish Research Council
– fundername: NIA NIH HHS
  grantid: R01 AG022374
– fundername: NIA NIH HHS
  grantid: R01 AG013616
– fundername: NINDS NIH HHS
  grantid: R01 NS104127
– fundername: NIA NIH HHS
  grantid: R01 AG057848
– fundername: NIA NIH HHS
  grantid: R01 AG062572
– fundername: NCATS NIH HHS
  grantid: UL1 TR001445
– fundername: NIA NIH HHS
  grantid: R01 AG012101
– fundername: NIA NIH HHS
  grantid: P30 AG008051
GroupedDBID 0R~
0SF
1OC
24P
457
53G
6I.
7RV
7X7
8FI
8FJ
AACTN
AAEDW
AAFTH
AAHHS
AALRI
AAXUO
ABMAC
ABUWG
ACCFJ
ACGFS
ACXQS
ADBBV
ADEZE
ADKYN
ADPDF
ADRAZ
ADZMN
ADZOD
AEEZP
AEQDE
AEVXI
AEXQZ
AFKRA
AFTJW
AGHFR
AITUG
AIWBW
AJBDE
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
AOIJS
AVUZU
BAWUL
BENPR
CCPQU
EBS
EJD
EMOBN
FDB
FYUFA
GROUPED_DOAJ
HMCUK
HYE
IAO
INH
KQ8
M48
M~E
NAPCQ
NCXOZ
O9-
OK1
OVD
OVEED
PIMPY
ROL
RPM
SSZ
TEORI
UKHRP
WIN
ACCMX
ADVLN
ALIPV
ALUQN
IHR
ITC
AAYWO
AAYXX
CITATION
PHGZM
PHGZT
NPM
7X8
PPXIY
PUEGO
5PM
ADTPV
AOWAS
F1U
ID FETCH-LOGICAL-c7121-9eb51e0eb1c69bd8e37d9abc2704dd39f8d3975a08fa0cb3581031f82c8eea23
IEDL.DBID M48
ISSN 2352-8729
IngestDate Wed Aug 27 01:10:17 EDT 2025
Tue Sep 09 23:14:08 EDT 2025
Thu Aug 21 14:37:09 EDT 2025
Thu Sep 04 16:29:03 EDT 2025
Wed Feb 19 02:26:48 EST 2025
Tue Jul 01 02:13:34 EDT 2025
Thu Apr 24 22:51:32 EDT 2025
Wed Jan 22 16:36:35 EST 2025
Fri Feb 23 02:49:48 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords CSF tau
Plasma tau
Cognition
MRI
CSF P-Tau
Blood biomarkers
Language English
License This is an open access article under the CC BY-NC-ND license.
Attribution-NonCommercial-NoDerivs
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c7121-9eb51e0eb1c69bd8e37d9abc2704dd39f8d3975a08fa0cb3581031f82c8eea23
Notes silvia.fossati@temple.edu
Current address: Alzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19,140, USA.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Current address: Alzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19,140, USA. silvia.fossati@temple.edu
OpenAccessLink https://doaj.org/article/465b64d5b91e47ac9c88fb34898c5e56
PMID 31334328
PQID 2264214515
PQPubID 23479
PageCount 10
ParticipantIDs doaj_primary_oai_doaj_org_article_465b64d5b91e47ac9c88fb34898c5e56
swepub_primary_oai_gup_ub_gu_se_282611
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6624242
proquest_miscellaneous_2264214515
pubmed_primary_31334328
crossref_citationtrail_10_1016_j_dadm_2019_05_001
crossref_primary_10_1016_j_dadm_2019_05_001
wiley_primary_10_1016_j_dadm_2019_05_001_DAD2JDADM201905001
elsevier_sciencedirect_doi_10_1016_j_dadm_2019_05_001
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate December 2019
PublicationDateYYYYMMDD 2019-12-01
PublicationDate_xml – month: 12
  year: 2019
  text: December 2019
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Alzheimer's & dementia : diagnosis, assessment & disease monitoring
PublicationTitleAlternate Alzheimers Dement (Amst)
PublicationYear 2019
Publisher Elsevier Inc
Elsevier
Wiley
Publisher_xml – name: Elsevier Inc
– name: Elsevier
– name: Wiley
References McKhann, Drachman, Folstein, Katzman, Price, Stadlan (bib27) 1984; 34
Folstein, Folstein, McHugh (bib20) 1975; 12
Gmitrowicz, Kucharska (bib26) 1994; 28
De Santi, Pirraglia, Barr, Babb, Williams, Rogers (bib29) 2008; 22
Vanmechelen, Vanderstichele, Davidsson, Van Kerschaver, Van Der Perre, Sjogren (bib31) 2000; 285
Evered, Silbert, Scott, Zetterberg, Blennow (bib42) 2018; 75
Ebneth, Godemann, Stamer, Illenberger, Trinczek, Mandelkow (bib1) 1998; 143
Grundke-Iqbal, Iqbal, Quinlan, Tung, Zaidi, Wisniewski (bib5) 1986; 261
Hampel, O'Bryant, Molinuevo, Zetterberg, Masters, Lista (bib8) 2018; 14
Olivera, Lejbman, Jeromin, French, Kim, Cashion (bib41) 2015; 72
Ashton, Leuzy, Lim, Troakes, Hortobagyi, Hoglund (bib43) 2019; 7
Neselius, Zetterberg, Blennow, Randall, Wilson, Marcusson (bib40) 2013; 27
Zetterberg, Wilson, Andreasson, Minthon, Blennow, Randall (bib9) 2013; 5
Albert, DeKosky, Dickson, Dubois, Feldman, Fox (bib24) 2011; 7
McKhann, Knopman, Chertkow, Hyman, Jack, Kawas (bib23) 2011; 7
Rubenstein, Chang, Yue, Chiu, Winkler, Puccio (bib44) 2017; 74
Preische, Schultz, Apel, Kuhle, Kaeser, Barro (bib35) 2019; 25
Morris (bib21) 1993; 43
Wang, Jin, Bu, Zeng, Huang, Li (bib38) 2018; 136
Desikan, Segonne, Fischl, Quinn, Dickerson, Blacker (bib33) 2006; 31
Zetterberg (bib19) 2017; 43
Slachevsky, Guzman-Martinez, Delgado, Reyes, Farias, Munoz-Neira (bib11) 2017; 55
Blennow, Wallin, Agren, Spenger, Siegfried, Vanmechelen (bib32) 1995; 26
de Leon, Li, Okamura, Tsui, Saint-Louis, Glodzik (bib37) 2017; 58
Iqbal, Grundke-Iqbal (bib6) 1991; 5
Mukaetova-Ladinska, Abdell-All, Andrade, da Silva, Boksha, Burbaeva (bib10) 2018; 15
Zetterberg, Blennow (bib13) 2018; 64
Blennow, Dubois, Fagan, Lewczuk, de Leon, Hampel (bib7) 2015; 11
Dage, Wennberg, Airey, Hagen, Knopman, Machulda (bib15) 2016; 12
Spiegel, Pirraglia, Osorio, Glodzik, Li, Tsui (bib25) 2016; 49
Terwel, Dewachter, Van Leuven (bib2) 2002; 2
Reisberg, Ferris, de Leon, Crook (bib28) 1982; 139
Fan, Tzen, Chen, Chen, Lai, Yen (bib12) 2018; 10
O'Bryant, Gupta, Henriksen, Edwards, Jeromin, Lista (bib30) 2015; 11
Tarasoff-Conway, Carare, Osorio, Glodzik, Butler, Fieremans (bib36) 2015; 11
Deters, Risacher, Kim, Nho, West, Blennow (bib14) 2017; 58
Mielke, Hagen, Xu, Chai, Vemuri, Lowe (bib18) 2018; 14
Mielke, Hagen, Wennberg, Airey, Savica, Knopman (bib16) 2017; 74
Blennow (bib34) 2017; 6
Bolos, Llorens-Martin, Jurado-Arjona, Hernandez, Rabano, Avila (bib39) 2016; 50
Weintraub, Salmon, Mercaldo, Ferris, Graff-Radford, Chui (bib22) 2009; 23
Kanaan, Cox, Alvarez, Stein, Poncil, McKee (bib4) 2016; 75
Zhou, Shi, Chu, Hu, Guan, Gong (bib3) 2018; 10
Mattsson, Zetterberg, Janelidze, Insel, Andreasson, Stomrud (bib17) 2016; 87
2009; 23
2017; 6
2019; 7
2006; 31
2013; 27
2015; 72
2017; 43
1993; 43
2015; 11
2002; 2
2016; 75
1975; 12
2016; 50
1994; 28
2013; 5
2018; 64
2011; 7
2016; 12
1991; 5
2017; 74
2017; 58
1982; 139
1995; 26
2017; 55
1984; 34
1986; 261
2019; 25
2018; 136
2016; 87
2000; 285
2008; 22
1998; 143
2018; 10
2016; 49
2018; 75
2018; 15
2018; 14
e_1_2_7_5_2
e_1_2_7_4_2
e_1_2_7_3_2
e_1_2_7_2_2
e_1_2_7_9_2
e_1_2_7_8_2
e_1_2_7_7_2
e_1_2_7_6_2
e_1_2_7_19_2
e_1_2_7_18_2
e_1_2_7_17_2
e_1_2_7_16_2
e_1_2_7_15_2
e_1_2_7_14_2
e_1_2_7_40_2
e_1_2_7_41_2
Mukaetova‐Ladinska E.B. (e_1_2_7_11_2) 2018; 15
e_1_2_7_42_2
e_1_2_7_43_2
e_1_2_7_10_2
e_1_2_7_45_2
Leon M.J. (e_1_2_7_38_2) 2017; 58
e_1_2_7_26_2
e_1_2_7_28_2
e_1_2_7_29_2
Ashton N.J. (e_1_2_7_44_2) 2019; 7
Slachevsky A. (e_1_2_7_12_2) 2017; 55
e_1_2_7_25_2
e_1_2_7_24_2
e_1_2_7_30_2
e_1_2_7_23_2
e_1_2_7_31_2
e_1_2_7_22_2
Gmitrowicz A. (e_1_2_7_27_2) 1994; 28
e_1_2_7_32_2
e_1_2_7_21_2
e_1_2_7_33_2
Fan L.Y. (e_1_2_7_13_2) 2018; 10
e_1_2_7_20_2
e_1_2_7_34_2
e_1_2_7_35_2
e_1_2_7_36_2
e_1_2_7_37_2
e_1_2_7_39_2
References_xml – volume: 26
  start-page: 231
  year: 1995
  end-page: 245
  ident: bib32
  article-title: tau protein in cerebrospinal fluid - A biochemical marker for axonal degeneration in Alzheimer disease?
  publication-title: Mol Chem Neuropathol
– volume: 2
  start-page: 151
  year: 2002
  end-page: 165
  ident: bib2
  article-title: Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease
  publication-title: Neuromolecular Med
– volume: 72
  start-page: 1109
  year: 2015
  end-page: 1116
  ident: bib41
  article-title: Peripheral total tau in military personnel who sustain traumatic brain injuries during deployment
  publication-title: JAMA Neurol
– volume: 5
  start-page: 9
  year: 2013
  ident: bib9
  article-title: Plasma tau levels in Alzheimer's disease
  publication-title: Alzheimers Res Ther
– volume: 43
  start-page: 2412
  year: 1993
  end-page: 2414
  ident: bib21
  article-title: The Clinical Dementia Rating (CDR): current version and scoring rules
  publication-title: Neurology
– volume: 27
  start-page: 425
  year: 2013
  end-page: 433
  ident: bib40
  article-title: Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma
  publication-title: Brain Inj
– volume: 11
  start-page: 58
  year: 2015
  end-page: 69
  ident: bib7
  article-title: Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease
  publication-title: Alzheimers Dement
– volume: 6
  start-page: S15
  year: 2017
  end-page: S24
  ident: bib34
  article-title: A review of fluid biomarkers for Alzheimer's disease: moving from CSF to blood
  publication-title: Neurol Ther
– volume: 11
  start-page: 457
  year: 2015
  end-page: 470
  ident: bib36
  article-title: Clearance systems in the brain-implications for Alzheimer disease
  publication-title: Nat Rev Neurol
– volume: 25
  start-page: 277
  year: 2019
  end-page: 283
  ident: bib35
  article-title: Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease
  publication-title: Nat Med
– volume: 7
  start-page: 263
  year: 2011
  end-page: 269
  ident: bib23
  article-title: The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
  publication-title: Alzheimers Dement
– volume: 28
  start-page: 509
  year: 1994
  end-page: 521
  ident: bib26
  article-title: [Developmental disorders in the fourth edition of the American classification: diagnostic and statistical manual of mental disorders (DSM IV -- optional book)]
  publication-title: Psychiatria polska
– volume: 87
  start-page: 1827
  year: 2016
  end-page: 1835
  ident: bib17
  article-title: Plasma tau in Alzheimer disease
  publication-title: Neurology
– volume: 12
  start-page: 189
  year: 1975
  end-page: 198
  ident: bib20
  article-title: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician
  publication-title: J Psychiatr Res
– volume: 139
  start-page: 1136
  year: 1982
  end-page: 1139
  ident: bib28
  article-title: The Global Deterioration Scale for assessment of primary degenerative dementia
  publication-title: Am J Psychiatry
– volume: 23
  start-page: 91
  year: 2009
  end-page: 101
  ident: bib22
  article-title: The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery
  publication-title: Alzheimer Dis Assoc Disord
– volume: 75
  start-page: 19
  year: 2016
  end-page: 34
  ident: bib4
  article-title: Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy
  publication-title: J Neuropathol Exp Neurol
– volume: 22
  start-page: 469
  year: 2008
  end-page: 484
  ident: bib29
  article-title: Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline
  publication-title: Neuropsychology
– volume: 49
  start-page: 93
  year: 2016
  end-page: 100
  ident: bib25
  article-title: Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease
  publication-title: J Alzheimer's Dis: JAD
– volume: 285
  start-page: 49
  year: 2000
  end-page: 52
  ident: bib31
  article-title: Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization
  publication-title: Neurosci Lett
– volume: 10
  start-page: 27
  year: 2018
  ident: bib3
  article-title: Relevance of phosphorylation and truncation of tau to the etiopathogenesis of Alzheimer's disease
  publication-title: Front Aging Neurosci
– volume: 58
  start-page: 1471
  year: 2017
  end-page: 1476
  ident: bib37
  article-title: Cerebrospinal fluid clearance in Alzheimer disease measured with dynamic PET
  publication-title: J Nucl Med: Official Publ Soc Nucl Med
– volume: 7
  start-page: 270
  year: 2011
  end-page: 279
  ident: bib24
  article-title: The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
  publication-title: Alzheimers Dement
– volume: 31
  start-page: 968
  year: 2006
  end-page: 980
  ident: bib33
  article-title: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
  publication-title: NeuroImage
– volume: 143
  start-page: 777
  year: 1998
  end-page: 794
  ident: bib1
  article-title: Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease
  publication-title: J Cel Biol
– volume: 14
  start-page: 639
  year: 2018
  end-page: 652
  ident: bib8
  article-title: Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic
  publication-title: Nat Rev Neurol
– volume: 58
  start-page: 1245
  year: 2017
  end-page: 1254
  ident: bib14
  article-title: Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease
  publication-title: J Alzheimer's Dis: JAD
– volume: 64
  start-page: S271
  year: 2018
  end-page: S279
  ident: bib13
  article-title: From Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer's Disease
  publication-title: J Alzheimers Dis
– volume: 34
  start-page: 939
  year: 1984
  end-page: 944
  ident: bib27
  article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
  publication-title: Neurology
– volume: 75
  start-page: 542
  year: 2018
  end-page: 547
  ident: bib42
  article-title: Association of changes in plasma neurofilament light and tau levels with anesthesia and surgery: results from the CAPACITY and ARCADIAN Studies
  publication-title: JAMA Neurol
– volume: 50
  start-page: 77
  year: 2016
  end-page: 87
  ident: bib39
  article-title: Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo
  publication-title: J Alzheimers Dis
– volume: 74
  start-page: 1063
  year: 2017
  end-page: 1072
  ident: bib44
  article-title: Comparing plasma phospho Tau, total tau, and phospho tau-total tau ratio as acute and chronic traumatic brain injury biomarkers
  publication-title: JAMA Neurol
– volume: 12
  start-page: 1226
  year: 2016
  end-page: 1234
  ident: bib15
  article-title: Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort
  publication-title: Alzheimers Dement
– volume: 261
  start-page: 6084
  year: 1986
  end-page: 6089
  ident: bib5
  article-title: Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
  publication-title: J Biol Chem
– volume: 43
  start-page: 194
  year: 2017
  end-page: 199
  ident: bib19
  article-title: Review: tau in biofluids - relation to pathology, imaging and clinical features
  publication-title: Neuropathol Appl Neurobiol
– volume: 136
  start-page: 525
  year: 2018
  end-page: 536
  ident: bib38
  article-title: Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies
  publication-title: Acta neuropathologica
– volume: 14
  start-page: 989
  year: 2018
  end-page: 997
  ident: bib18
  article-title: Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography
  publication-title: Alzheimer's Demen: J Alzheimer's Assoc
– volume: 5
  start-page: 399
  year: 1991
  end-page: 410
  ident: bib6
  article-title: Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease
  publication-title: Mol Neurobiol
– volume: 55
  start-page: 1595
  year: 2017
  end-page: 1603
  ident: bib11
  article-title: Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease
  publication-title: J Alzheimers Dis
– volume: 10
  start-page: 175
  year: 2018
  ident: bib12
  article-title: The Relation between brain amy o d deposition, cortical atrophy, and plasma biomarkers in amnesic mild cognitive impairment and Alzheimer's disease
  publication-title: Front Aging Neurosci
– volume: 7
  start-page: 5
  year: 2019
  ident: bib43
  article-title: Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration
  publication-title: Acta Neuropathologica Commun
– volume: 15
  start-page: 800
  year: 2018
  end-page: 808
  ident: bib10
  article-title: Platelet tau protein as a potential peripheral biomarker in Alzheimer's disease: an explorative study
  publication-title: Curr Alzheimer Res
– volume: 11
  start-page: 549
  year: 2015
  end-page: 560
  ident: bib30
  article-title: Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research
  publication-title: Alzheimers Demen
– volume: 74
  start-page: 1073
  year: 2017
  end-page: 1080
  ident: bib16
  article-title: Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging
  publication-title: JAMA Neurol
– volume: 5
  start-page: 399
  year: 1991
  end-page: 410
  article-title: Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease
  publication-title: Mol Neurobiol
– volume: 31
  start-page: 968
  year: 2006
  end-page: 980
  article-title: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
  publication-title: NeuroImage
– volume: 72
  start-page: 1109
  year: 2015
  end-page: 1116
  article-title: Peripheral total tau in military personnel who sustain traumatic brain injuries during deployment
  publication-title: JAMA Neurol
– volume: 58
  start-page: 1245
  year: 2017
  end-page: 1254
  article-title: Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease
  publication-title: J Alzheimer's Dis: JAD
– volume: 14
  start-page: 989
  year: 2018
  end-page: 997
  article-title: Plasma phospho‐tau181 increases with Alzheimer's disease clinical severity and is associated with tau‐ and amyloid‐positron emission tomography
  publication-title: Alzheimer's Demen: J Alzheimer's Assoc
– volume: 28
  start-page: 509
  year: 1994
  end-page: 521
  article-title: [Developmental disorders in the fourth edition of the American classification: diagnostic and statistical manual of mental disorders (DSM IV ‐‐ optional book)]
  publication-title: Psychiatria polska
– volume: 10
  start-page: 175
  year: 2018
  article-title: The Relation between brain amy o d deposition, cortical atrophy, and plasma biomarkers in amnesic mild cognitive impairment and Alzheimer's disease
  publication-title: Front Aging Neurosci
– volume: 143
  start-page: 777
  year: 1998
  end-page: 794
  article-title: Overexpression of tau protein inhibits kinesin‐dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease
  publication-title: J Cel Biol
– volume: 15
  start-page: 800
  year: 2018
  end-page: 808
  article-title: Platelet tau protein as a potential peripheral biomarker in Alzheimer's disease: an explorative study
  publication-title: Curr Alzheimer Res
– volume: 11
  start-page: 457
  year: 2015
  end-page: 470
  article-title: Clearance systems in the brain‐implications for Alzheimer disease
  publication-title: Nat Rev Neurol
– volume: 12
  start-page: 1226
  year: 2016
  end-page: 1234
  article-title: Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population‐based elderly cohort
  publication-title: Alzheimers Dement
– volume: 43
  start-page: 2412
  year: 1993
  end-page: 2414
  article-title: The Clinical Dementia Rating (CDR): current version and scoring rules
  publication-title: Neurology
– volume: 136
  start-page: 525
  year: 2018
  end-page: 536
  article-title: Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies
  publication-title: Acta neuropathologica
– volume: 22
  start-page: 469
  year: 2008
  end-page: 484
  article-title: Robust and conventional neuropsychological norms: diagnosis and prediction of age‐related cognitive decline
  publication-title: Neuropsychology
– volume: 10
  start-page: 27
  year: 2018
  article-title: Relevance of phosphorylation and truncation of tau to the etiopathogenesis of Alzheimer's disease
  publication-title: Front Aging Neurosci
– volume: 5
  start-page: 9
  year: 2013
  article-title: Plasma tau levels in Alzheimer's disease
  publication-title: Alzheimers Res Ther
– volume: 43
  start-page: 194
  year: 2017
  end-page: 199
  article-title: Review: tau in biofluids ‐ relation to pathology, imaging and clinical features
  publication-title: Neuropathol Appl Neurobiol
– volume: 139
  start-page: 1136
  year: 1982
  end-page: 1139
  article-title: The Global Deterioration Scale for assessment of primary degenerative dementia
  publication-title: Am J Psychiatry
– volume: 7
  start-page: 5
  year: 2019
  article-title: Increased plasma neurofilament light chain concentration correlates with severity of post‐mortem neurofibrillary tangle pathology and neurodegeneration
  publication-title: Acta Neuropathologica Commun
– volume: 74
  start-page: 1063
  year: 2017
  end-page: 1072
  article-title: Comparing plasma phospho Tau, total tau, and phospho tau‐total tau ratio as acute and chronic traumatic brain injury biomarkers
  publication-title: JAMA Neurol
– volume: 7
  start-page: 270
  year: 2011
  end-page: 279
  article-title: The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
  publication-title: Alzheimers Dement
– volume: 11
  start-page: 549
  year: 2015
  end-page: 560
  article-title: Guidelines for the standardization of preanalytic variables for blood‐based biomarker studies in Alzheimer's disease research
  publication-title: Alzheimers Demen
– volume: 23
  start-page: 91
  year: 2009
  end-page: 101
  article-title: The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery
  publication-title: Alzheimer Dis Assoc Disord
– volume: 58
  start-page: 1471
  year: 2017
  end-page: 1476
  article-title: Cerebrospinal fluid clearance in Alzheimer disease measured with dynamic PET
  publication-title: J Nucl Med: Official Publ Soc Nucl Med
– volume: 34
  start-page: 939
  year: 1984
  end-page: 944
  article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS‐ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
  publication-title: Neurology
– volume: 12
  start-page: 189
  year: 1975
  end-page: 198
  article-title: “Mini‐mental state”. A practical method for grading the cognitive state of patients for the clinician
  publication-title: J Psychiatr Res
– volume: 87
  start-page: 1827
  year: 2016
  end-page: 1835
  article-title: Plasma tau in Alzheimer disease
  publication-title: Neurology
– volume: 75
  start-page: 19
  year: 2016
  end-page: 34
  article-title: Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy
  publication-title: J Neuropathol Exp Neurol
– volume: 75
  start-page: 542
  year: 2018
  end-page: 547
  article-title: Association of changes in plasma neurofilament light and tau levels with anesthesia and surgery: results from the CAPACITY and ARCADIAN Studies
  publication-title: JAMA Neurol
– volume: 74
  start-page: 1073
  year: 2017
  end-page: 1080
  article-title: Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging
  publication-title: JAMA Neurol
– volume: 7
  start-page: 263
  year: 2011
  end-page: 269
  article-title: The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
  publication-title: Alzheimers Dement
– volume: 49
  start-page: 93
  year: 2016
  end-page: 100
  article-title: Greater specificity for cerebrospinal fluid P‐tau231 over P‐tau181 in the differentiation of healthy controls from Alzheimer's disease
  publication-title: J Alzheimer's Dis: JAD
– volume: 27
  start-page: 425
  year: 2013
  end-page: 433
  article-title: Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma
  publication-title: Brain Inj
– volume: 25
  start-page: 277
  year: 2019
  end-page: 283
  article-title: Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease
  publication-title: Nat Med
– volume: 11
  start-page: 58
  year: 2015
  end-page: 69
  article-title: Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease
  publication-title: Alzheimers Dement
– volume: 6
  start-page: S15
  year: 2017
  end-page: S24
  article-title: A review of fluid biomarkers for Alzheimer's disease: moving from CSF to blood
  publication-title: Neurol Ther
– volume: 50
  start-page: 77
  year: 2016
  end-page: 87
  article-title: Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo
  publication-title: J Alzheimers Dis
– volume: 14
  start-page: 639
  year: 2018
  end-page: 652
  article-title: Blood‐based biomarkers for Alzheimer disease: mapping the road to the clinic
  publication-title: Nat Rev Neurol
– volume: 2
  start-page: 151
  year: 2002
  end-page: 165
  article-title: Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease
  publication-title: Neuromolecular Med
– volume: 64
  start-page: S271
  year: 2018
  end-page: S279
  article-title: From Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer's Disease
  publication-title: J Alzheimers Dis
– volume: 26
  start-page: 231
  year: 1995
  end-page: 245
  article-title: tau protein in cerebrospinal fluid ‐ A biochemical marker for axonal degeneration in Alzheimer disease?
  publication-title: Mol Chem Neuropathol
– volume: 55
  start-page: 1595
  year: 2017
  end-page: 1603
  article-title: Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease
  publication-title: J Alzheimers Dis
– volume: 285
  start-page: 49
  year: 2000
  end-page: 52
  article-title: Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization
  publication-title: Neurosci Lett
– volume: 261
  start-page: 6084
  year: 1986
  end-page: 6089
  article-title: Microtubule‐associated protein tau. A component of Alzheimer paired helical filaments
  publication-title: J Biol Chem
– ident: e_1_2_7_34_2
  doi: 10.1016/j.neuroimage.2006.01.021
– ident: e_1_2_7_10_2
  doi: 10.1186/alzrt163
– ident: e_1_2_7_2_2
  doi: 10.1083/jcb.143.3.777
– volume: 58
  start-page: 1471
  year: 2017
  ident: e_1_2_7_38_2
  article-title: Cerebrospinal fluid clearance in Alzheimer disease measured with dynamic PET
  publication-title: J Nucl Med: Official Publ Soc Nucl Med
  doi: 10.2967/jnumed.116.187211
– volume: 28
  start-page: 509
  year: 1994
  ident: e_1_2_7_27_2
  article-title: [Developmental disorders in the fourth edition of the American classification: diagnostic and statistical manual of mental disorders (DSM IV ‐‐ optional book)]
  publication-title: Psychiatria polska
– ident: e_1_2_7_37_2
  doi: 10.1038/nrneurol.2015.119
– ident: e_1_2_7_29_2
  doi: 10.1176/ajp.139.9.1136
– ident: e_1_2_7_41_2
  doi: 10.3109/02699052.2012.750752
– ident: e_1_2_7_4_2
  doi: 10.3389/fnagi.2018.00027
– ident: e_1_2_7_28_2
  doi: 10.1212/WNL.34.7.939
– ident: e_1_2_7_45_2
  doi: 10.1001/jamaneurol.2017.0655
– ident: e_1_2_7_23_2
  doi: 10.1097/WAD.0b013e318191c7dd
– ident: e_1_2_7_24_2
  doi: 10.1016/j.jalz.2011.03.005
– ident: e_1_2_7_32_2
  doi: 10.1016/S0304-3940(00)01036-3
– ident: e_1_2_7_16_2
  doi: 10.1016/j.jalz.2016.06.001
– ident: e_1_2_7_20_2
  doi: 10.1111/nan.12378
– ident: e_1_2_7_3_2
  doi: 10.1385/NMM:2:2:151
– ident: e_1_2_7_14_2
  doi: 10.3233/JAD-179926
– volume: 7
  start-page: 5
  year: 2019
  ident: e_1_2_7_44_2
  article-title: Increased plasma neurofilament light chain concentration correlates with severity of post‐mortem neurofibrillary tangle pathology and neurodegeneration
  publication-title: Acta Neuropathologica Commun
  doi: 10.1186/s40478-018-0649-3
– ident: e_1_2_7_15_2
  doi: 10.3233/JAD-161114
– ident: e_1_2_7_30_2
  doi: 10.1037/0894-4105.22.4.469
– ident: e_1_2_7_5_2
  doi: 10.1093/jnen/nlv001
– ident: e_1_2_7_8_2
  doi: 10.1016/j.jalz.2014.02.004
– ident: e_1_2_7_22_2
  doi: 10.1212/WNL.43.11.2412-a
– ident: e_1_2_7_25_2
  doi: 10.1016/j.jalz.2011.03.008
– ident: e_1_2_7_31_2
  doi: 10.1016/j.jalz.2014.08.099
– ident: e_1_2_7_9_2
  doi: 10.1038/s41582-018-0079-7
– ident: e_1_2_7_40_2
  doi: 10.3233/JAD-150704
– ident: e_1_2_7_6_2
  doi: 10.1016/S0021-9258(17)38495-8
– ident: e_1_2_7_36_2
  doi: 10.1038/s41591-018-0304-3
– ident: e_1_2_7_39_2
  doi: 10.1007/s00401-018-1891-2
– volume: 55
  start-page: 1595
  year: 2017
  ident: e_1_2_7_12_2
  article-title: Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-160652
– ident: e_1_2_7_26_2
  doi: 10.3233/JAD-150167
– ident: e_1_2_7_18_2
  doi: 10.1212/WNL.0000000000003246
– ident: e_1_2_7_43_2
  doi: 10.1001/jamaneurol.2017.4913
– ident: e_1_2_7_19_2
  doi: 10.1016/j.jalz.2018.02.013
– ident: e_1_2_7_42_2
  doi: 10.1001/jamaneurol.2015.1383
– ident: e_1_2_7_35_2
  doi: 10.1007/s40120-017-0073-9
– ident: e_1_2_7_17_2
  doi: 10.1001/jamaneurol.2017.1359
– ident: e_1_2_7_21_2
  doi: 10.1016/0022-3956(75)90026-6
– ident: e_1_2_7_7_2
  doi: 10.1007/BF02935561
– ident: e_1_2_7_33_2
  doi: 10.1007/BF02815140
– volume: 15
  start-page: 800
  year: 2018
  ident: e_1_2_7_11_2
  article-title: Platelet tau protein as a potential peripheral biomarker in Alzheimer's disease: an explorative study
  publication-title: Curr Alzheimer Res
  doi: 10.2174/1567205015666180404165915
– volume: 10
  start-page: 175
  year: 2018
  ident: e_1_2_7_13_2
  article-title: The Relation between brain amy o d deposition, cortical atrophy, and plasma biomarkers in amnesic mild cognitive impairment and Alzheimer's disease
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2018.00175
SSID ssj0001492410
Score 2.4759657
Snippet Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of...
Introduction Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and...
• Both plasma- and CSF-tau are elevated in patients with AD recruited at the NYU Center for Brain Health. • Plasma tau is correlated with cognition, but not...
Introduction: Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and...
Abstract Introduction Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF)...
SourceID doaj
swepub
pubmedcentral
proquest
pubmed
crossref
wiley
elsevier
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 483
SubjectTerms Blood biomarkers
Cognition
CSF P-Tau
CSF tau
MRI
Neurosciences
Neurovetenskaper
Plasma tau
Special Section: Blood-Based Biomarkers for Alzheimer's Disease & Related Dementias. (Editor: Henrik Zetterberg)
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9VAFB6kKzei-IovRhBdSDCPeYWurq2XUqgUrdDdMK-0KW1uaW42rvoT_I3-Es88cmkoVBduQjh5nzmT853km28QegcZzhJhWU6EEzmxrcmVIQoaxDKumKpdUNc_-Mr2fpD9Y3p8Y6ovzwmL8sDRcZ8Io5oRS3VTOsKVaYwQra6JaIShjgaxbUhjN4qps4j7ITUVaZRMJHRZZf3Q87IJUp1pFpgpEwXB_llCug04b_Mmk7roHNiGzLR8iB4kSIkX8VEeoXuuf4y-HQIsvlB4rUYcaOPhM-CAd74vg031Fh_-vv7l17seAwzENrLuugGvWrw4_3nqugt39WHA6SfOE3S0_HK0s5en-RNyw0vPvHCalq6At7FhjbbC1dw2SpuKF8TaumkFLDhVhWhVYbRXQoMu3orKCOdUVT9FW_2qd88RhqqLGF4po7UjhlSKa9uK1kLtRI2gIkPl5Eppkra4n-LiXE4ksjPp3S-9-2VBPZMuQx83x1xGZY079_7sW2izp1fFDgaIFZliRf4tVjJEp_aVCWBE4ACn6u68-NspGCT0Pv9LRfVuNQ7SD0P2Wu8lzdCzGBybW6yh_Cd1Bc7hs7CZPcN8S9-dBoVvFkbtVBl6HwNsdsjJeCnBdDLKwUmomFkJN7gdAvAfHCl3F7vVPiwOvLGgYHrxP3z7Et33J4xMn1doa301uteA19b6TeiafwAhnjyq
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Wiley Online Library Open Access
  dbid: 24P
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Li9RAEG6W9eJFFF9xVVoQPUggj-5OB0_jjsOysDLoCntr-pXZLLuZZTK5ePIn-Bv9JVZ1ktG4sAheQqhJJ5nqqtRXnaovhLyGCOeYdCJm0suYucrG2jINE-JEoYXOfWDXP_kkjr6y4zN-tkfmYy9Mzw-xW3BDzwjPa3Rwbdo_8s0LSIkd9pKnZeDexCauOymGf-R3ZsvfKy0McoxAS5AB2gD3z8qhe6Yv9Pr7NJMIFYj8J4HqJhC9WU85sI5OAW-IWIv75N4ANemst40HZM83D8nnJcDlK023uqOhnDwsD7b08MsiyHTj6PLn9x-4XzcU4CF1fTVe3dJ1RWeX3859feU3b1s6vNx5RE4XH08Pj-LhuwqxLVKsyPCGpz6Bp7QVpXHS54UrtbFZkTDn8rKSsCm4TmSlE2uQIQ1cv5KZld7rLH9M9pt1458SCtkYs0WmrTGeWZbpwrhKVg5yKm4llxFJR1UqO3CO46cvLtVYXHahUP0K1a8SjhV2EXm3G3PdM27cevQHnKHdkciWHQTrzUoNzqeY4EYwx02ZelZoW1opK5MzWUrLPRcR4eP8qgF49IACTlXfevFXozEo8Ep81aIbv-5ahe3JyAGf8og86Y1jd4t5mmM3LyinmJjN5D9Mf2nq88D8LUI3TxaRN72BTYasumsFolWnWq8gkxYp3OD7YID_oEg1n82zY9icoDDhIHr2X6MPyF3c70t_npP97abzLwDAbc3L4J-_ALFwPSs
  priority: 102
  providerName: Wiley-Blackwell
Title Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease
URI https://dx.doi.org/10.1016/j.dadm.2019.05.001
https://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.dadm.2019.05.001
https://www.ncbi.nlm.nih.gov/pubmed/31334328
https://www.proquest.com/docview/2264214515
https://pubmed.ncbi.nlm.nih.gov/PMC6624242
https://gup.ub.gu.se/publication/282611
https://doaj.org/article/465b64d5b91e47ac9c88fb34898c5e56
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: KQ8
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: KQ8
  dateStart: 20150301
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: DOA
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: M~E
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central Free
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: RPM
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVOVD
  databaseName: Journals@Ovid LWW All Open Access Journal Collection Rolling
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: OVEED
  dateStart: 20150301
  isFulltext: true
  titleUrlDefault: http://ovidsp.ovid.com/
  providerName: Ovid
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: BENPR
  dateStart: 20150901
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Health & Medical Collection
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: 7X7
  dateStart: 20150901
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVFZP
  databaseName: Scholars Portal: Open Access Journals [open access]
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 20250731
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: M48
  dateStart: 20150301
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
– providerCode: PRVWIB
  databaseName: KBPluse Wiley Online Library: Open Access
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: AVUZU
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.kbplus.ac.uk/kbplus7/publicExport/pkg/559
  providerName: Wiley-Blackwell
– providerCode: PRVWIB
  databaseName: Wiley Online Library Open Access
  customDbUrl:
  eissn: 2352-8729
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0001492410
  issn: 2352-8729
  databaseCode: 24P
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  providerName: Wiley-Blackwell
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3ra9swEBddC6NfRsde3rqgwdg-DA8_JEtmjJE-QimkhK2FfBN6OXVJnS5OYNtfv5NsZzPtyr4Ic5ZtWXfS3dl3v0PoLWg4Q7jJQsItD4kpdCg1kcAQkzGZydR6dP3xWXZyQU6ndLqFunJH7QTWd7p2rp7UxXL-8cf3n19gwX_-E6tlpHFZ5XHuUThdOtcOaKbESfm4NfevGm8AyJGvN0fdRpDkbR7N3bfZRQ9T8OFI6mq1_6W2PLp_T3vdtk5vB1m2UKR9K9irsdEeetTan3jYCMxjtGWrJ2gyARv6WuKVXGMfY-6_Gdb48NvI02Rl8CR0R2WFwWLEpgnQK2u8KPBw_uvSltd2-b7G7f-ep-h8dHx-eBK2pRZCzWIXpGEVjW0EG7fOcmW4TZnJpdIJi4gxaV5waBiVES9kpJUDTYPdoOCJ5tbKJH2GtqtFZV8gDA4a0SyRWilLNEkkU6bghQE3i2pOeYDibiKFbmHIXTWMuejiza6E44NwfBARdUF3AfqwueamAeG4t_eB48-mpwPQ9oTFciba9ShIRlVGDFV5bAmTOtecFyolPOeaWpoFiHbcFa0t0tgYcKvy3oe_6URBwEJ1f19kZRfrWriMZQcLH9MAPW9EYzPETsoCxHpC03uH_pmqvPRg4JlP8EkC9K4Rr94ls_WNANJsLWorwLnOYhjgJy9-_zGR4mh4lJxCM3bEiALp5T-H_grtul5NpM8-2l4t1_Y12GsrNUAPEjKBlk3ZAO0cHJ9Nvg78t4-BX56_AdPMPD8
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaqcoALAvHa8jISggNaKXFsxxGnpe1qKd1qBYvUm-VXtqnabLWPCyd-Ar-RX8KMk10IlSokLlE0iRNnPBN_48x8IeQ1zHCeKy_7XAXV5750feO4gQHxMjfSZCGy649P5OgrPzoVpzvkcFML0_BDbBfc0DPi-xodHBek_wg4zyEm9lhMnhaRfBOruG5xyRI0bsYnv5daOAQZkZeAAdwA_2dFWz7TZHr9fZnOFBWZ_Dsz1XUkej2hsqUd7SLeOGUN75G7Ldakg8Y47pOdUD8gnyeAly8NXZk1jfnkcX1wSfe_DKPM1J5Ofn7_gftVTQEfUt-k41VLOi_p4OLbWaguw-LtkrZfdx6S6fBwuj_qtz9W6Ls8xZSMYEUaEnhNO1lYr0KW-8JYx_KEe58VpYJNLkyiSpM4ixRp4PulYk6FYFj2iOzW8zo8IRTCMe5yZpy1gTvOTG59qUoPQZVwSqgeSTeq1K4lHcd_X1zoTXbZuUb1a1S_TgSm2PXIu22bq4Zy48azP-AIbc9EuuwomC9muvU-zaWwknthizTw3LjCKVXajKtCORGE7BGxGV_dIo8GUcClqhtv_mpjDBrcEr-1mDrM10uN9clIAp-KHnncGMe2i1maYTkvKCfvmE3nGbpH6uosUn_LWM7DeuRNY2CdJrP1lQbRbK2XQUMoLVPo4PtogP-gSH0wOGBHsBmjMBEg2vuv1i_J7dF0fKyPP558ekruoLzJA3pGdleLdXgOaG5lX0Rf_QXM0UCa
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaqIiEuCMQr5WUkBAcUKQ87ccRp6bIqhVYrKFJvll_Zpmqzq83mwomfwG_klzDjJAuhUoXEJYomceKMZ-JvnJkvhLyEGc4yYbOQCSdCZksTKsMUDIjNcpWp1Hl2_aPj7OArOzzlpztkOtTCdPwQ2wU39Az_vkYHX9nyj3jzHEJii7XkceG5N7GI6wZD7hbkd2bz3ystDGIMT0uQANoA90-KvnqmS_T6-zKjGcoT-Y8mqqtA9Go-Zc86Oga8fsaa3SG3e6hJJ51t3CU7rr5HPs8BLl8qulEt9enkfnmwoftfZl6makvnP7__wP2qpgAPqe2y8aqGLks6ufh25qpLt37d0P7jzn1yMnt_sn8Q9v9VCE0eY0aG0zx2EbylTVZoK1ya20Jpk-QRszYtSgGbnKtIlCoyGhnSwPVLkRjhnErSB2S3XtbuEaEQjTGTJ8po7Zhhicq1LUVpIabiRnARkHhQpTQ95zj--uJCDsll5xLVL1H9MuKYYReQN9s2q45x49qz3-EIbc9EtmwvWK4Xsnc-yTKuM2a5LmLHcmUKI0SpUyYKYbjjWUD4ML6yBx4doIBLVdfe_MVgDBK8Ej-1qNot20ZieTJywMc8IA8749h2MY1TrOYF5eQjsxk9w_hIXZ155u_MV_MkAXnVGdioyaJdSRAtWtk4CZF0FkMH33oD_AdFyulkmhzC5giFEQfR3n-1fk5uzqcz-enD8cfH5BaKuyygJ2R3s27dU8ByG_3Mu-ovs5I_zA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Plasma+tau+complements+CSF+tau+and+P-tau+in+the+diagnosis+of+Alzheimer%27s+disease&rft.jtitle=Alzheimer%27s+%26+dementia+%3A+diagnosis%2C+assessment+%26+disease+monitoring&rft.au=Fossati%2C+Silvia&rft.au=Ramos+Cejudo%2C+Jaime&rft.au=Debure%2C+Ludovic&rft.au=Pirraglia%2C+Elizabeth&rft.date=2019-12-01&rft.issn=2352-8729&rft.eissn=2352-8729&rft.volume=11&rft.spage=483&rft_id=info:doi/10.1016%2Fj.dadm.2019.05.001&rft_id=info%3Apmid%2F31334328&rft.externalDocID=31334328
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2352-8729&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2352-8729&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2352-8729&client=summon