An epigenetic blockade of cognitive functions in the neurodegenerating brain - Gräff, Johannes; Rei, Damien; Guan, Ji-Song; Wang, Wen-Yuan; Seo, Jinsoo; Hennig, Krista M.; Nieland, Thomas J. F.; Fass, Daniel M.; Kao, Patricia F.; Kahn, Martin; Su, Susan C.; Samiei, Alireza; et al. (Nature (London), 2012)
Keywords: 631/378/2584; 631/378/2591; 631/378/2649; 692/699/375/365; Acetylation - drug effects; Adult and adolescent clinical studies; Alzheimer Disease - complications; Alzheimer Disease - genetics; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - toxicity; Animals; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Brain - physiopathology; Causes of; Cognition disorders; Cognitive ability; Cyclin-dependent kinases; Degeneration; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Epigenesis, Genetic - drug effects; Epigenetic inheritance; Epigenetics; Gene Expression Regulation - drug effects; Gene Knockdown Techniques; Genetic aspects; Genetics; Health aspects; Hippocampus - drug effects; Hippocampus - metabolism; Histone Deacetylase 2 - deficiency; Histone Deacetylase 2 - genetics; Histone Deacetylase 2 - metabolism; Histones - metabolism; Humanities and Social Sciences; Humans; Hydrogen Peroxide - toxicity; Kinases; letter; Medical sciences; Memory Disorders - complications; Memory Disorders - genetics; Memory Disorders - physiopathology; Mice; multidisciplinary; Nervous system; Neurodegeneration; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - physiopathology; Neurology; Neuronal Plasticity - drug effects; Neuronal Plasticity - genetics; Organic mental disorders. Neuropsychology; Peptide Fragments - toxicity; Phosphorylation - drug effects; Plasticity; Promoter Regions, Genetic - drug effects; Promoter Regions, Genetic - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Glucocorticoid - metabolism; RNA polymerase; RNA Polymerase II - metabolism; Science; Science (multidisciplinary); United States; Nervous system diseases; Cognitive disorder; Alzheimer disease; Pathogenesis; Central nervous system disease; Degenerative disease; Genetic determinism; Cerebral disorder