Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension - Long, Lu; Ormiston, Mark L; Yang, Xudong; Southwood, Mark; Gräf, Stefan; Machado, Rajiv D; Mueller, Matthias; Kinzel, Bernd; Yung, Lai Ming; Wilkinson, Janine M; Moore, Stephen D; Drake, Kylie M; et al. (Nature medicine, 2015)
Keywords: 13/106; 13/2; 13/21; 13/31; 13/51; 13/95; 14/1; 38/39; 38/61; 631/443/592/75/593; 64/60; 692/308/575; Aging - pathology; Animal models; Animals; Apoptosis - drug effects; Biomedicine; Blood; Bone Morphogenetic Protein Receptors, Type II - metabolism; Bone morphogenetic proteins; Cancer Research; Cell Membrane Permeability - drug effects; Cell receptors; Cellular signal transduction; Densitometry; Development and progression; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelial Cells - pathology; Gene Expression Profiling; Gene Knock-In Techniques; Genes; Genetic aspects; Growth Differentiation Factor 2 - pharmacology; Heart Ventricles - drug effects; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Humans; Hypertension; Hypertension, Pulmonary - genetics; Hypertension, Pulmonary - pathology; Hypertension, Pulmonary - physiopathology; Hypoxia; Immunoblotting; Infectious Diseases; JNK Mitogen-Activated Protein Kinases - metabolism; Male; Metabolic Diseases; Mice, Inbred C57BL; Molecular Medicine; Monocrotaline; Mutation; Neurosciences; Phosphorylation - drug effects; Physiological aspects; Pulmonary Artery - drug effects; Pulmonary Artery - pathology; Pulmonary Artery - physiopathology; Pulmonary hypertension; Rats; Rats, Sprague-Dawley; Rodents; Systole - drug effects; Transcription, Genetic - drug effects; United Kingdom